HowardB.GutsteinMDFAAP, FASA

Anesthesiology • Farmington, CT

Pain Medicine, Pediatric Anesthesiology

Professor and Chair, Department of Anesthesiology, University of Connecticut

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Office
263 Farmington Avenue
Farmington, CT 06030
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Education & Training

University of California (San Francisco)Residency, Anesthesiology, 1985 - 1987
University of California (San Francisco)Residency, Surgery, 1982 - 1984
Johns Hopkins University School of MedicineClass of 1982

Certifications & Licensure

CT State Medical License 2022 - 2024
PA State Medical License 2015 - 2022
TX State Medical License 1999 - 2015
CA State Medical License 1983 - 2012
MI State Medical License 1989 - 2002
American Board of Anesthesiology Anesthesiology

Awards, Honors, & Recognition

Fellow (FASA) American Society of Anesthesiologists
Fellow (FAAP) American Academy of Pediatrics

Publications & Presentations

PubMed

Chronic Morphine Modulates PDGFR-β and PDGF-B Expression and Distribution in Dorsal Root Ganglia and Spinal Cord in Male Rats.
Stephanie Puig, Howard B Gutstein> ;Neuroscience. 2023 May 21
Preventing spread of aerosolized infectious particles during medical procedures: A lab-based analysis of an inexpensive plastic enclosure.
Luke W Monroe, Jack S Johnson, Howard B Gutstein, John P Lawrence, Keith Lejeune, Ryan C Sullivan, Coty N Jen> ;Plos One. 2022 Jan 1
2 citations
Subanalgesic morphine doses augment fentanyl analgesia by interacting with delta opioid receptors in male rats.
Katherine E. Barker, Alynn J. Lecznar, Jill M. Schumacher, Jeffrey S. Morris, Howard B. Gutstein> ;Journal of Neuroscience Research. 2021 Sep 14
23 citations
Neuropathic pain generates silent synapses in thalamic projection to anterior cingulate cortex.
Yao Q. Wang, Junshi Wang, Sun-hui Xia, Howard B. Gutstein, Yanhua H. Huang, Oliver M. Schlüter, Jun-Li Cao, Yan Dong> ;Pain. 2021 May 1
8 citations
USE OF HEALTHCARE RESOURCES IN PATIENTS WITH LOW BACK PAIN AND COMORBID DEPRESSION OR ANXIETY
Anna H. Bailes, Rohit Navlani, Stephen Koscumb, Amanda Malecky, Oscar C. Marroquin, Ajay D. Wasan, Howard B. Gutstein, Anthony Delitto, Christina K Zigler, Nam Vo, Gwe...> ;The Spine Journal. 2021 Mar 27
1 citations
Artificial hyperventilation normalizes haemodynamics and arterial oxygen content in hypoxic rats.
Diego De Villalobos, Andres Laserna, Cosmo Fowler, John Cuenca, Peyton Martin, Michele Guindani, Wenli Dong, Howard B. Gutstein, Kristen Price, Joseph L. Nates> ;Anaesthesiology Intensive Therapy. 2021 Jan 1
11 citations
EGFR Signaling Causes Morphine Tolerance and Mechanical Sensitization in Rats.
Stephanie Puig, Courtney L. Donica, Howard B. Gutstein> ;Eneuro. 2020 Mar 1
7 citations
Spinal Opioid Tolerance Depends upon Platelet-Derived Growth Factor Receptor-β Signaling, Not μ-Opioid Receptor Internalization.
Stephanie Puig, Katherine E Barker, Shelby R Szott, Peter T Kann, Jeffrey S. Morris, Howard B. Gutstein> ;Molecular Pharmacology. 2020 Jul 28
19 citations
An assay for chemical nociception in Drosophila larvae.
Roger López-Bellido, Nathaniel J. Himmel, Howard B. Gutstein, Daniel N. Cox, Michael J. Galko> ;Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 2019 Nov 11
15 citations
Growth Factor Signaling Regulates Mechanical Nociception in Flies and Vertebrates.
Roger López-Bellido, Stephanie Puig, Patrick J. Huang, Chang Ru Tsai, Heather N. Turner, Michael J. Galko, Howard B. Gutstein> ;The Journal of Neuroscience. 2019 Jul 24
18 citations
Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain.
Omer Barkai, Stephanie Puig, Shaya Lev, Ben Title, Ben Katz, Luba Eli-Berchoer, Howard B. Gutstein, Alexander M. Binshtok> ;Pain. 2019 Jun 1
4 citations
A “tail” of opioid receptor variants
Stephanie Puig, Howard B. Gutstein> ;The Journal of Clinical Investigation. 2017 Apr 3
10 citations
Opioids: keeping the good, eliminating the bad
Stephanie Puig, Howard B. Gutstein> ;Nature Medicine. 2017 Jan 30
1 citations
Detection and Quantification of Protein Spots by Pinnacle.
Jeffrey S. Morris, Howard B. Gutstein> ;Methods in Molecular Biology. 2016 Jan 1
138 citations
Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics
Tuan Trang, Ream Al-Hasani, Daniela Salvemini, Michael W. Salter, Howard B. Gutstein, Catherine M. Cahill> ;The Journal of Neuroscience. 2015 Oct 14
14 citations
Platelet-Derived Growth Factor Receptor-β Antagonism Restores Morphine Analgesic Potency against Neuropathic Pain
Courtney L. Donica, Yan Cui, Shanping Shi, Howard B. Gutstein> ;Plos One. 2014 May 12
50 citations
Blockade of PDGFR-β activation eliminates morphine analgesic tolerance.
Yan Wang, Katherine E. Barker, Shanping Shi, Miguel F. Diaz, Bing Mo, Howard B. Gutstein> ;Nature Medicine. 2012 Mar 1
84 citations
Hedgehog signaling regulates nociceptive sensitization.
Daniel T. Babcock, Shanping Shi, Ju-Yeon Jo, Michael Shaw, Howard B. Gutstein, Michael J. Galko> ;Current Biology. 2011 Sep 27
AUTOMATED ANALYSIS OF QUANTITATIVE IMAGE DATA USING ISOMORPHIC FUNCTIONAL MIXED MODELS, WITH APPLICATION TO PROTEOMICS DATA.
Morris JS, Baladandayuthapani V, Herrick RC, Sanna P, Gutstein H> ;Ann Appl Stat. 2011-01-01
125 citations
Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain.
Joseph Shurman, George F. Koob, Howard B. Gutstein> ;Pain Medicine. 2010 Jul 1
13 citations
Statistical Contributions to Proteomic Research
Jeffrey S. Morris, Keith A. Baggerly, Howard B. Gutstein, Kevin R. Coombes> ;Methods in Molecular Biology. 2010 Jan 1
21 citations
Evaluating the performance of new approaches to spot quantification and differential expression in 2-dimensional gel electrophoresis studies.
Jeffrey S. Morris, Brittan N. Clark, Wei Wei, Howard B. Gutstein> ;Journal of Proteome Research. 2010 Jan 4
12 citations
Informatics and statistics for analyzing 2-d gel electrophoresis images.
Andrew W. Dowsey, Jeffrey S. Morris, Howard B. Gutstein, Guang-Zhong Yang> ;Methods in Molecular Biology. 2010 Jan 1
67 citations
SIMS and MALDI MS imaging of the spinal cord.
Eric B. Monroe, Suresh P. Annangudi, Nathan G. Hatcher, Howard B. Gutstein, Stanislav S. Rubakhin, Jonathan V. Sweedler> ;Proteomics. 2008 Sep 1
30 citations
Guidelines for reporting the use of gel electrophoresis in proteomics.
Frank Gibson, Leigh Anderson, Gyorgy Babnigg, Mark Baker, Matthias Berth, Pierre-Alain Binz, Andy Borthwick, Phil Cash, Billy W Day, David B Friedman, Donita Garland, ...> ;Nature Biotechnology. 2008 Aug 1
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Grant Support

Brain Biomarkers Of Alcoholism And AbstinenceNational Institute On Alcohol Abuse And Alcoholism2006–2010
Proteomic Approaches To AlcoholismNational Institute On Alcohol Abuse And Alcoholism2005–2006
From Drug Use To Addiction: Unearthing The SwitchesNational Institute On Drug Abuse2002–2005
ERK Signaling And Acute Opioid ToleranceNational Institute On Drug Abuse1998–1999
Behavioral And Neural Correlates Of Pain And AnalgesiaNational Institute On Drug Abuse1998
Behavioral And Neural Correlates Of Pain And AnalgesiaNational Institute On Drug Abuse1994–1997

Professional Memberships

American Academy of Pediatrics - AAP
Fellow
American Society of Anesthesiologists - ASA
Fellow

Hospital Affiliations

UConn, John Dempsey HospitalFarmington, Connecticut