HowardSHochsterMD

Oncology • New Brunswick, NJ

Gastrointestinal Cancer, Hematologic Oncology

Distinguished Professor of Medicine, Rutgers RWJ School of Medicine

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Office
195 Little Albany Street
Room 2004
New Brunswick, NJ 08901
Phone+1 732-235-5912

Fax+1 732-235-6797
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Education & Training

NYU Grossman School of MedicineFellowship, Hematology and Medical Oncology, 1983 - 1986
NYU Grossman School of MedicineResidency, Internal Medicine, 1980 - 1983
Yale School of MedicineClass of 1980

Certifications & Licensure

NJ State Medical License 2018 - 2025
CT State Medical License 2010 - 2018
NY State Medical License 1981 - 2016
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors for Cancer Castle Connolly, 2005-2019
America's Top Doctors Castle Connolly, 2004-2019
Top Doctors: New York Metro Area Castle Connolly, 2002-2014
New York Magazine: Top Doctors Castle Connolly, 2002-2007, 2011-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
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Clinical Trials

A Phase II Multicenter, Randomized, Placebo Controlled, Double Blinded Clinical Study of KD018 as a Modulator of Irinotecan Chemotherapy in Patients With Metastatic Colorectal Cancer Start of enrollment: 2008 Dec 01
Completed
Phase 2
A Prospective Study for the Assessment of Recurrence Risk in Stage II Colon Cancer Patients Using ColoPrint Start of enrollment: 2008 Sep 01
Active, not recruiting
The Effect of Sorafenib on Portal Pressure Start of enrollment: 2011 Aug 01
Completed
Phase 2
Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer Start of enrollment: 2012 Nov 23
Completed
Phase 2
Pilot Trial of KD018 With Neo-Adjuvant Concurrent Chemo-Radiation Therapy in Patients With Locally Advanced Rectal Cancer Start of enrollment: 2014 Jul 01
Completed
Phase 1
A Study of Abemaciclib (LY2835219) Alone or in Combination With Other Agents in Participants With Previously Treated Pancreatic Ductal Adenocarcinoma Start of enrollment: 2017 Jan 12
Completed
Phase 2
Phase II Anetumab Ravtansine in Pre-treated Mesothelin-expressing Pancreatic Cancer Start of enrollment: 2017 May 11
Completed
Phase 2
TAS-102 and Oxaliplatin for the Treatment of Refractory Stage IV Colon Cancer Start of enrollment: 2019 Feb 12
Active, not recruiting
Phase 2
Adjuvant Gemcitabine and Capecitabine Chemotherapy in Resected Pancreatic Cancer Following Neoadjuvant Chemotherapy Start of enrollment: 2022 Jul 29
Recruiting
Phase 2
Roles: Contact
Microbiotic Product to Promote Microbiome Health and Improve Chemotherapy Delivery Start of enrollment: 2022 May 03
Recruiting
Phase 2
Roles: Contact, Principal Investigator, Sponsor-Investigator
Investigating Targetable Metabolic Pathways Sustaining Pancreatic Cancer Start of enrollment: 2022 Mar 14
Recruiting
Not Applicable
Roles: Principal Investigator, Contact
Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer Start of enrollment: 2023 May 17
Recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Gene Expression Levels Are Predictive and Prognostic in Patients With Metastatic Colorectal Cancer Enrolled in CALGB/SWOG 80405.
Battaglin, F., Ou, F., Qu, X., Niedzwiecki, D., Zemla, T., Blanke, C., Kabbarah, O., Innocenti, F., Hochster, H., Goldberg, R., Mayer, R., Ashouri, K., Venook, A., Len...> ;Journal of Clinical Oncology. 2024 Mar 8
1 citations
Evolving paradigms in locally advanced rectal cancer: the means justify the ends.
Salma K Jabbour, Howard S Hochster> ;Journal of the National Cancer Institute. 2023 Dec 6
1 citations
Efficacy and safety of abemaciclib alone and with PI3K/mTOR inhibitor LY3023414 or galunisertib versus chemotherapy in previously treated metastatic pancreatic adenoca...
E Gabriela Chiorean, Vincent Picozzi, Chung-Pin Li, Marc Peeters, Joan Maurel, Jaswinder Singh, Talia Golan, Jean-Frédéric Blanc, Sonya C Chapman, Anwar M Hussain, Eri...> ;Cancer Medicine. 2023 Oct 1
1 citations
Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research.
Ritesh Kumar, Jongmyung Kim, Matthew P Deek, Mariam F Eskander, Prateek Gulhati, Haejin In, Timothy Kennedy, Mihir M Shah, Miral S Grandhi, Lyudmyla Berim, Kristen R S...> ;Current Oncology. 2023 Jul 5
17 citations
Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study.
Dasari, A., Lonardi, S., Garcia-Carbonero, R., Elez, E., Yoshino, T., Sobrero, A., Yao, J., García-Alfonso, P., Kocsis, J., Cubillo Gracian, A., Sartore-Bianchi, A., S...> ;Lancet. 2023 Jul 1
RoutineGenetic Testing.
Howard S Hochster> ;Journal of Clinical Oncology. 2023 Apr 10
3 citations
Dietary fat in relation to all-cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data from CALGB 80405 (Alliance)/SWOG 8...
Van Blarigan, E., Ma, C., Ou, F., Bainter, T., Venook, A., Ng, K., Niedzwiecki, D., Giovannucci, E., Lenz, H., Polite, B., Hochster, H., Goldberg, R., Mayer, R., Blank...> ;International Journal of Cancer. 2023 Jan 15
5 citations
Trifluridine/tipiracil with or without bevacizumab in metastatic colorectal cancer: results of a systematic review and meta-analysis.
Takayuki Yoshino, Julien Taieb, Yasutoshi Kuboki, Per Pfeiffer, Amit Kumar, Howard S Hochster> ;Therapeutic Advances in Medical Oncology. 2023 Jan 1
1 citations
Pooled safety analysis from phase III studies of trifluridine/tipiracil in patients with metastatic gastric or gastroesophageal junction cancer and metastatic colorect...
E Van Cutsem, H Hochster, K Shitara, R Mayer, A Ohtsu, A Falcone, T Yoshino, T Doi, D H Ilson, H-T Arkenau, B George, K A Benhadji, L Makris, J Tabernero> ;ESMO Open. 2022 Dec 1
7 citations
A Phase II Study Investigating Cabozantinib in Patients with Refractory Metastatic Colorectal Cancer (AGICC 17CRC01).
Aaron J Scott, Atrayee Basu Mallick, Efrat Dotan, Steven J Cohen, Philip J Gold, Howard S Hochster, Somasundaram Subramaniam, Afsaneh Barzi, George S Watts, Patrick J ...> ;Cancer Research Communications. 2022 Oct 1
2 citations
Bias and Pancreatic Cancer Reporting.
Howard S Hochster, H Richard Alexander> ;Journal of the National Cancer Institute. 2022 May 9
2 citations
Age and comorbidity association with survival outcomes in metastatic colorectal cancer: CALGB 80405 analysis.
Nadine J McCleary, Sui Zhang, Chao Ma, Fang-Shu Ou, Tiffany M Bainter, Alan P Venook, Donna Niedzwiecki, Heinz-Josef Lenz, Federico Innocenti, Bert H O'Neil, Blase N P...> ;Journal of Geriatric Oncology. 2022 May 1
12 citations
Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer.
Robert H Shoemaker, Reynold A Panettieri Jr, Steven K Libutti, Howard S Hochster, Norman R Watts, Paul T Wingfield, Philipp Starkl, Lisabeth Pimenov, Riem Gawish, Anas...> ;Plos One. 2022 Jan 1
Comparing Acute Toxicities of Patients With Unresectable Hepatocellular Carcinoma Treated With Definitive Proton vs. Photon-Based Radiotherapy.
Swati Mamidanna, Shane S. Neibart, Anupama Chundury, Mutlay Sayan, H.R. Alexander, David A. August, L.D. Berim, Patrick M Boland, Miral S. Grandhi, P. Gulhati, K. Gupt...> ;International Journal of Radiation Oncology Biology Physics. 2021 Nov 1
Survival Outcomes of Patients With Borderline Resectable and Resectable Pancreatic Adenocarcinoma Treated With Neoadjuvant Short-Course Chemoradiotherapy With Capecita...
Shane S. Neibart, Swati Mamidanna, Anupama Chundury, Mutlay Sayan, H.R. Alexander, David A. August, L.D. Berim, Patrick M Boland, Miral S. Grandhi, P. Gulhati, Howard ...> ;International Journal of Radiation Oncology Biology Physics. 2021 Nov 1
Survival Outcomes of Patients With Unresectable Hepatocellular Carcinoma Secondary to Viral vs. Non-Viral Etiologies Treated with Definitive Radiotherapy.
Swati Mamidanna, Shane S. Neibart, Anupama Chundury, Mutlay Sayan, H.R. Alexander, David A. August, L.D. Berim, Patrick M Boland, Miral S. Grandhi, P. Gulhati, K. Gupt...> ;International Journal of Radiation Oncology Biology Physics. 2021 Nov 1
45 citations
Validation of POD24 As a Robust Early Clinical Endpoint of Poor Survival in FL from 5,225 Patients on 13 Clinical Trials.
Carla Casulo, Jesse G. Dixon, Jennifer Le-Rademacher, Eva Hoster, Howard S. Hochster, Wolfgang Hiddemann, Robert Marcus, Eva Kimby, Michael Herold, Catherine Sebban, E...> ;Blood. 2021 Oct 6
15 citations
Randomized Phase II Study of PARP Inhibitor ABT-888 (Veliparib) with Modified FOLFIRI versus FOLFIRI as Second-line Treatment of Metastatic Pancreatic Cancer: SWOG S1513.
E. Gabriela Chiorean, Katherine A. Guthrie, Philip A. Philip, Elizabeth M. Swisher, Florencia Jalikis, Michael J. Pishvaian, Jordan Berlin, Marcus Smith Noel, Jennifer...> ;Clinical Cancer Research. 2021 Sep 27
5 citations
Development of a novel, pan-variant aerosol intervention for COVID-19
Robert H. Shoemaker, Reynold A. Panettieri, Steven K. Libutti, Howard S. Hochster, Norman R. Watts, Paul T. Wingfield, Philipp Starkl, Lisabeth Pimenov, Riem Gawish, A...> ;Biorxiv. 2021 Sep 14
5 citations
Early-Onset Colorectal Cancer: The Mystery Remains.
Cathy Eng, Howard S. Hochster> ;Journal of the National Cancer Institute. 2021 Aug 18
1 citations
The Unhappy Intersection of Cancer and COVID-19.
Howard S. Hochster> ;Oncology. 2021 Aug 9
6 citations
Delayed cytokine release syndrome after neoadjuvant nivolumab: a case report and literature review.
Aaron Ciner, Howard S. Hochster, David A. August, Darren R. Carpizo, Kristen Spencer> ;Immunotherapy. 2021 Jul 21
Messenger RNA: A Technology of the Moment.
Howard S. Hochster> ;Oncology. 2021 Apr 16
54 citations
Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer: The CALGB/SWOG 80702 (Alliance) ...
Jeffrey A. Meyerhardt, Qian Shi, Charles S. Fuchs, Jeffrey G. Meyer, Donna Niedzwiecki, Tyler Zemla, Priya Kumthekar, Katherine A. Guthrie, Félix Couture, Philip Kuebl...> ;JAMA. 2021 Apr 6
2 citations
Outcomes of older patients with follicular lymphoma using individual data from 5922 patients in 18 randomized controlled trials.
Carla Casulo, Jesse G. Dixon, Fang-Shu Ou, Eva Hoster, Bruce A. Peterson, Howard S. Hochster, Pauline Brice, Marco Ladetto, Wolfgang Hiddemann, Robert Marcus, Eva Kimb...> ;Blood Advances. 2021 Mar 23
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Journal Articles

Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma
Andrea Wang-Gillam, Howard S Hochster, JAMA Oncology
Association of Diet Quality with Survival Among People with Metastatic Colorectal Cancer in the Cancer and Leukemia B and Southwest Oncology Group 80405 Trial
Kimmie Ng, Chloe Atreya, Howard S Hochster, James N Atkins, Richard M Goldberg, Charles D Blanke, Jeffrey A Meyerhardt, JAMA Network Open
Antiangiogenesis in Early-Stage Colon Cancer—Microscopically Busted
Howard Hochster, MD, JAMA Network Open

Abstracts/Posters

A Multistate Survival Analysis for Patients with Follicular Lymphoma (FL) Using 13 First-Line Randomized Trials from FL Analysis of Surrogate Hypothesis (FLASH) Group
Howard Hochster, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

Randomized trial of irinotecan and cetuximab (IC) versus irinotecan, cetuximab and ramucirumab (ICR) as 2nd line therapy of advanced colorectal cancer (CRC) following ...
2018 ASCO Annual Meeting - Chicago, Illinois - 06/5/2018
Yale Cancer Center Evening Oncology Series: Gastrointestinal Cancers
Yale CME, New Haven, Connecticut - 9/20/2012

Press Mentions

More Younger People Being Diagnosed with Colorectal CancerMarch 7th, 2023
Increase in Colorectal Cancer Among Younger Individuals Continues to RiseFebruary 28th, 2023
Enhancing Awareness and Participation of Black Breast Cancer Patients in Clinical TrialsJuly 18th, 2022
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