HowardMarkKatzensteinMD

Pediatric Hematology & Oncology • Wilmington, DE

Division Director, Pediatric Hematology/Oncology

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Office
1600 Rockland Avenue
Wilmington, DE 19801
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Education & Training

McGaw Medical Center of Northwestern UniversityFellowship, Pediatric Hematology/Oncology, 1994 - 1997
UPMC Children's Hospital of PittsburghResidency, Pediatrics, 1991 - 1994
University of Illinois College of MedicineClass of 1991

Certifications & Licensure

FL State Medical License 2017 - 2025
DE State Medical License 2018 - 2025
TN State Medical License 2013 - 2019
GA State Medical License 2002 - 2015
IL State Medical License 1994 - 2002
PA State Medical License 1993 - 1994
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Combination Chemotherapy With or Without Amifostine in Treating Young Patients With Liver Cancer Start of enrollment: 1999 Mar 01
Completed
Phase 3
Cyclophosphamide and Prednisone With or Without Immunoglobulin in Treating Abnormal Muscle Movement in Children With Neuroblastoma Start of enrollment: 2004 Mar 15
Completed
Phase 3
Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma Start of enrollment: 2004 Sep 04
Completed
Phase 3
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Start of enrollment: 2004 Mar 25
Recruiting
Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma Start of enrollment: 2004 Apr 01
Active, not recruiting
Phase 3
Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Start of enrollment: 2005 Nov 14
Completed
Phase 3
Hepatoblastoma Biology Study and Tissue Bank Start of enrollment: 2005 Sep 01
Withdrawn
Not Applicable
National Wilm's Tumor Study Late Effects Start of enrollment: 2005 Sep 01
Withdrawn
Not Applicable
Study to Assess Compliance With Long-Term Mercaptopurine Treatment in Young Patients With Acute Lymphoblastic Leukemia in Remission Start of enrollment: 2005 May 30
Completed
Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer Start of enrollment: 2006 Feb 20
Completed
Phase 3
N2004-04: Fenretinide LXS in Treating Patients With Recurrent, Refractory, or Persistent Neuroblastoma Start of enrollment: 2005 Dec 01
Completed
Phase 1
Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell Transplant Start of enrollment: 2006 Apr 01
Completed
Phase 2
Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Start of enrollment: 2006 Jun 01
Completed
Phase 2
Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor Start of enrollment: 2006 Nov 06
Active, not recruiting
Phase 3
Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Start of enrollment: 2006 Dec 26
Completed
Phase 3
Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes Start of enrollment: 2007 Mar 01
Completed
Phase 3
Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer Start of enrollment: 2007 May 01
Completed
Phase 3
Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia Start of enrollment: 2007 Mar 01
Completed
Phase 1, Phase 2
Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission Start of enrollment: 2007 Mar 01
Completed
Phase 3
Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia Start of enrollment: 2007 Jan 01
Completed
Donor Stem Cell Transplant in Treating Young Patients With Acute Myeloid Leukemia With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory or Relapsed Acute Myelogenous Leukemia Start of enrollment: 2008 Jan 01
Completed
Phase 2
Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma Start of enrollment: 2008 Feb 04
Active, not recruiting
Phase 3
N2004-03: Intravenous Fenretinide in Treating Young Patients With Recurrent or Resistant Neuroblastoma Start of enrollment: 2006 Dec 01
Completed
Phase 1
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies Start of enrollment: 2008 Jul 17
Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors Start of enrollment: 2009 Jan 01
Completed
Phase 2
Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Start of enrollment: 2009 Mar 01
Completed
Phase 2
N2007-02:Bevacizumab,Cyclophosphamide,& Zoledronic Acid in Patients W/ Recurrent or Refractory High-Risk Neuroblastoma Start of enrollment: 2009 Dec 01
Completed
Phase 1
Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer Start of enrollment: 2003 Oct 13
Completed
Study of Kidney Tumors in Younger Patients Start of enrollment: 2006 Feb 27
Recruiting
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Start of enrollment: 2008 Feb 04
Completed
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Start of enrollment: 2000 Nov 06
Recruiting
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Start of enrollment: 2004 Feb 16
Completed
Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Start of enrollment: 2009 Jul 13
Active, not recruiting
Phase 3
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
N2007-03: Vorinostat and 131-I MIBG in Treating Patients With Resistant or Relapsed Neuroblastoma Start of enrollment: 2010 Mar 01
Completed
Phase 1
Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2009 Dec 21
Completed
Phase 3
Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Start of enrollment: 2010 May 07
Active, not recruiting
Phase 3
Vorinostat and Isotretinoin in Treating Patients With High-Risk Refractory or Recurrent Neuroblastoma Start of enrollment: 2010 Dec 01
Completed
Phase 1
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
Aflac ST1001 Prolonged Isotretinoin Start of enrollment: 2011 Mar 01
Withdrawn
Phase 1
Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors Start of enrollment: 2011 Apr 01
Completed
Phase 1
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Start of enrollment: 2012 Jun 01
Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Start of enrollment: 2012 Jun 27
Active, not recruiting
Phase 2
Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK) Start of enrollment: 2013 Aug 28
Completed
Phase 1
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
Yttrium-90 (TARE-Y90) in Children, Adolescents, and Young Adults With Liver Tumors Start of enrollment: 2021 Feb 11
Recruiting
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

10 citations
Small Cell Undifferentiated Histology Does Not Adversely Affect Outcome in Hepatoblastoma: A Report From the Children's Oncology Group (COG) AHEP0731 Study Committee.
Angela Trobaugh-Lotrario, Howard M Katzenstein, Sarangarajan Ranganathan, Dolores Lopez-Terrada, Mark D Krailo, Jin Piao, Nadia Chung, Jessica Randazzo, Marcio H Malog...> ;Journal of Clinical Oncology. 2022 Feb 10
12 citations
Doxorubicin in combination with cisplatin, 5-flourouracil, and vincristine is feasible and effective in unresectable hepatoblastoma: A Children's Oncology Group study
Howard M. Katzenstein, Marcio H. Malogolowkin, Mark Krailo, Jin Piao, Alexander J. Towbin, M. Beth McCarville, Gregory M. Tiao, Stephen P. Dunn, Max R. Langham, Eugene...> ;Cancer. 2021 Nov 11
12 citations
Multiscale-omic assessment of EWSR1-NFATc2 fusion positive sarcomas identifies the mTOR pathway as a potential therapeutic target.
Nathan D. Seligson, Richard D Maradiaga, Colin M Stets, Howard M. Katzenstein, Sherri Z. Millis, Alan Rogers, John L. Hays, James L. Chen> ;NPJ Precision Oncology. 2021 May 21
8 citations
Vaping the Venom: Oral Cavity Cancer in a Young Adult With Extensive Electronic Cigarette Use.
Darren Klawinski, Issa Hanna, Nathaniel K. Breslin, Howard M. Katzenstein, Daniel J. Indelicato> ;Pediatrics. 2021 May 1
1 citations
Neonatal Liver Tumors.
Howard M Katzenstein, Bradley Cheek, Renee Gresh, Allison Aguado> ;Clinics in Perinatology. 2021 Mar 1
15 citations
A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma
Karen Wright, Xiaopan Yao, Wendy B. London, Pei Chi Kao, Lia Gore, Stephen P. Hunger, Russ Geyer, Kenneth J. Cohen, Jeffrey C. Allen, Howard M. Katzenstein, Amy Smith,...> ;Pediatric Blood & Cancer. 2021 Feb 1
1 citations
Pediatric HCT in Florida (2014 -2016): A report from the FPBCC
Deepak Chellapandian, Gauri Sunkersett, Benjamin Oshrine, Jorge Galvez Silva, Edward Ziga, Warren Alperstein, Michael Joyce, Howard M. Katzenstein, Kamar Godder, Paul ...> ;Pediatric Transplantation. 2021 Aug 1
13 citations
Successful use of transarterial radioembolization with yttrium-90 (TARE-Y90) in two children with hepatoblastoma.
Stephen P. Dunn, Lauren W. Averill, Kudakwashe R. Chikwava, Renee Gresh, Deborah Rabinowitz, Howard M. Katzenstein, Allison Aguado> ;Pediatric Blood & Cancer. 2020 Jun 30
9 citations
Concurrent Imatinib Dosing With High-dose Methotrexate Leads to Acute Kidney Injury and Delayed Methotrexate Clearance in Pediatric Patients With Philadelphia Chromoso...
Lauren Pommert, Nicole Liberio, John S Ng, Tosha A Egelund, Molly J Siver, Howard M. Katzenstein, Michael J. Burke> ;Journal of Pediatric Hematology/oncology. 2021 Mar 1
75 citations
Irinotecan, Temozolomide, and Dinutuximab With GM-CSF in Children With Refractory or Relapsed Neuroblastoma: A Report From the Children's Oncology Group.
Rajen Mody, Alice L. Yu, Arlene Naranjo, Fan F Zhang, Wendy B. London, Barry L. Shulkin, Marguerite T. Parisi, Sabah-E-Noor Servaes, Mitchell B. Diccianni, Jacquelyn A...> ;Journal of Clinical Oncology. 2020 Apr 28
1 citations
Irradiating Residual Disease to 30 Gy with Proton Therapy in Pediatric Mediastinal Hodgkin Lymphoma
Bradford S. Hoppe, Raymond B. Mailhot Vega, Nancy P. Mendenhall, Eric Sandler, William B. Slayton, Howard M. Katzenstein, Michael Joyce, Zuofeng Li, S. Flampouri> ;International Journal of Particle Therapy. 2020 Mar 1
19 citations
A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors.
Muna Qayed, Thomas Cash, Mourad Tighiouart, Tobey J. MacDonald, Kelly C. Goldsmith, Rachel Tanos, Leslie S. Kean, Benjamin Watkins, Yvonne Suessmuth, Cynthia Wetmore, ...> ;Pediatric Blood & Cancer. 2020 Apr 1
15 citations
Evaluation of the diagnostic biopsy approach for children with hepatoblastoma: A report from the Children's Oncology Group AHEP 0731 Liver Tumor Committee
Christopher B. Weldon, Arin L. Madenci, Gregory M. Tiao, Stephen P. Dunn, Max R. Langham, Eugene D. McGahren, Sarangarajan Ranganathan, Dolores Lopez-Terrada, Milton J...> ;Journal of Pediatric Surgery. 2020 Apr 1
2 citations
Routine Surveillance Imaging Is Associated with Improved Postrelapse Survival in Patients with Ewing Sarcoma.
Thomas Cash, Erika L. Bettermann, Sarah Mitchell, Courtney McCracken, Muna Qayed, Danielle Wolfe, Adina Alazraki, Thomas A. Olson, Howard M. Katzenstein> ;Journal of Adolescent and Young Adult Oncology. 2020 Jan 9
7 citations
Proton therapy following induction chemotherapy for pediatric and adolescent nasopharyngeal carcinoma.
Haruka Uezono, Daniel J. Indelicato, Ronny L. Rotondo, Eric Sandler, Howard M. Katzenstein, Roi Dagan, William M. Mendenhall, Raymond B. Mailhot Vega, Bernadette Brenn...> ;Pediatric Blood & Cancer. 2019 Sep 16
41 citations
Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children's Oncology Group, multicentre, phase 3 trial.
Howard M. Katzenstein, Max R Langham, Marcio H. Malogolowkin, Mark Krailo, Alexander J. Towbin, Mary Beth McCarville, Milton J. Finegold, Sarangarajan Ranganathan, Ste...> ;The Lancet. Oncology. 2019 May 1
23 citations
Cardiac-Sparing Whole Lung IMRT in Patients With Pediatric Tumors and Lung Metastasis: Final Report of a Prospective Multicenter Clinical Trial.
John A. Kalapurakal, Mahesh Gopalakrishnan, David O. Walterhouse, Cynthia K. Rigsby, Alfred Rademaker, Irene Helenowski, Sandy Kessel, Karen Morano, Fran Laurie, Kenne...> ;International Journal of Radiation Oncology, Biology, Physics. 2019 Jan 1
4 citations
Case 3: Priapism in a 13-year-old Boy.
Amanda J. Clark, Peter Hsu, Anne Darves-Bornoz, Stacy T. Tanaka, Emily F. Mason, Howard M. Katzenstein> ;Pediatrics in Review. 2018 Dec 1
3 citations
High-dose Chemotherapy is Efficacious and Well Tolerated in a Toddler With Aicardi Syndrome and Malignant Sacrococcygeal Teratoma.
Jessica D. Wharton, Shaina Johnson, James A. Connelly, Tracy Hills, Lauren Gingles, Margaret Wood, Gabriella L. Crane, Howard M. Katzenstein> ;Journal of Pediatric Hematology/oncology. 2018 Oct 1
1 citations
Pulmonary Relapse of Osteosarcoma Following Presentation With a Pneumomediastinum and Localized Disease at Diagnosis.
Sarayu Kumar, Adina Alazraki, Bradley George, Melissa Martin, Howard M. Katzenstein, Thomas Cash> ;Journal of Pediatric Hematology/oncology. 2017 Nov 1
39 citations
Characterization of Pulmonary Metastases in Children With Hepatoblastoma Treated on Children's Oncology Group Protocol AHEP0731 (The Treatment of Children With All Sta...
Allison F. O'Neill, Alexander J. Towbin, Mark Krailo, Caihong Xia, Yun Gao, M. Beth McCarville, Rebecka L. Meyers, Eugene D. McGahren, Greg Tiao, Stephen P. Dunn, Max ...> ;Journal of Clinical Oncology. 2017 Sep 11
3 citations
Heart transplantation for anthracycline cardiomyopathy: Pump up the volume
Rustin Meister, Howard M. Katzenstein> ;Pediatric Transplantation. 2017 Jun 26
3 citations
Correlation of Ezrin Expression Pattern and Clinical Outcomes in Ewing Sarcoma.
Thomas Cash, Hong Yin, Courtney McCracken, Zhi Geng, Steven G. DuBois, Bahig M. Shehata, Thomas A. Olson, Howard M. Katzenstein, Cynthia Wetmore> ;Sarcoma. 2017 Jan 26
44 citations
Upfront window vincristine/irinotecan treatment of high-risk hepatoblastoma: A report from the Children's Oncology Group AHEP0731 study committee
Howard M. Katzenstein, Wayne L. Furman, Marcio H. Malogolowkin, Mark Krailo, M. Beth McCarville, Alexander J. Towbin, Greg Tiao, Milton J. Finegold, Sarangarajan Ranga...> ;Cancer. 2017 Jun 15
2 citations
Respiratory Difficulties in Children With Underlying Asthma During Immunotherapy for High-risk Neuroblastoma.
Laura K. Metrock, Muna Qayed, Dawn Simon, Thomas Cash, Michael G. O’Connor, Shaina Johnson, Natia Esiashvili, Howard M. Katzenstein> ;Journal of Pediatric Hematology/oncology. 2017 Nov 1
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Press Mentions

When Chemo and Surgery Fails, Targeted Radiation Is an Option for Kids with Liver CancerDecember 7th, 2018
Commitment to Service Excellence RecognizedNovember 3rd, 2016
No Small Feat - Radiology Today MagazineApril 9th, 2019