HowardARockmanMD

Cardiology • Durham, NC

Adult Congenital Heart Disease

Professor, Medicine, Duke University School of Medicine

Join to view full profile

Dr. Rockman is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Rockman's full profile

Already have an account?

Office
6301 Herndon Rd
Durham, NC 27713
Phone+1 919-681-5816
Is this information wrong?

Education & Training

University of California (San Diego) Medical CenterFellowship, Cardiovascular Disease, 1987 - 1988
McGill University Faculty Medicine HospitalInternal Medicine, 1984 - 1987
McGill University Faculty of MedicineClass of 1983

Certifications & Licensure

NC State Medical License 1997 - 2025
CA State Medical License 1987 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Elected Member The American Society for Clinical Investigation, 1999

Publications & Presentations

PubMed

1 citations
How carvedilol does not activate β-adrenoceptors.
Robert J Lefkowitz, Howard A Rockman, Paul J Shim, Samuel Liu, Seungkirl Ahn, Biswaranjan Pani, Sudarshan Rajagopal, Sudha K Shenoy, Michel Bouvier, Jeffrey L Benovic,...> ;Nature Communications. 2023 Nov 30
7 citations
Pathophysiology and pharmacology of G protein-coupled receptors in the heart.
Alyssa Grogan, Emilio Y Lucero, Haoran Jiang, Howard A Rockman> ;Cardiovascular Research. 2023 May 22
18 citations
G protein-coupled receptor signaling: transducers and effectors.
Haoran Jiang, Daniella Galtes, Jialu Wang, Howard A Rockman> ;American Journal of Physiology. Cell Physiology. 2022 Sep 1
6 citations
Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.
Muath Bishawi, Franklin H Lee, Dennis M Abraham, Carolyn Glass, Stephanie J Blocker, Daniel J Cox, Zachary D Brown, Howard A Rockman, Lan Mao, Tony C Slaba, Mark W Dew...> ;Iscience. 2022 Apr 15
4 citations
Proximity labeling for investigating protein-protein interactions.
Conrad T Pfeiffer, Joao A Paulo, Steven P Gygi, Howard A Rockman> ;Methods in Cell Biology. 2022 Jan 1
17 citations
β-Arrestin-Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection.
Jialu Wang, Biswaranjan Pani, Ilhan Gokhan, Xinyu Xiong, Alem W. Kahsai, Haoran Jiang, Seungkirl Ahn, Robert J. Lefkowitz, Howard A. Rockman> ;Molecular Pharmacology. 2021 Sep 24
8 citations
Mapping Angiotensin II Type 1 Receptor-Biased Signaling Using Proximity Labeling and Proteomics Identifies Diverse Actions of Biased Agonists.
Conrad T Pfeiffer, Jialu Wang, Joao A. Paulo, Xue Jiang, Steven P. Gygi, Howard A. Rockman> ;Journal of Proteome Research. 2021 May 5
28 citations
Synthetic nanobodies as angiotensin receptor blockers.
Conor McMahon, Dean P. Staus, Laura M. Wingler, Jialu Wang, Meredith A. Skiba, Matthias Elgeti, Wayne L. Hubbell, Howard A. Rockman, Andrew C. Kruse, Robert J. Lefkowitz> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Aug 18
15 citations
β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19
Aashish Manglik, Laura M. Wingler, Howard A. Rockman, Robert J. Lefkowitz> ;Circulation. 2020 Jul 28
16 citations
The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility
Jihee Kim, Chad A. Grotegut, James W. Wisler, Lan Mao, Paul B. Rosenberg, Howard A. Rockman, Robert J. Lefkowitz> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 May 15
12 citations
A murine model of increased coronary sinus pressure induces myocardial edema with cardiac lymphatic dilation and fibrosis.
Natalie R Nielsen, Krsna V Rangarajan, Lan Mao, Howard A. Rockman, Kathleen M. Caron> ;American Journal of Physiology. Heart and Circulatory Physiology. 2020 Mar 6
Come sail away
Howard A. Rockman> ;JCI Insight. 2019 Aug 8
16 citations
The deubiquitinase ubiquitin–specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling
Samuel Mon-Wei Yu, Pierre-Yves Jean-Charles, Dennis M. Abraham, Suneet Kaur, Clarice Gareri, Lan Mao, Howard A. Rockman, Sudha K. Shenoy> ;The Journal of Biological Chemistry. 2019 Feb 15
28 citations
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.
Jihee Kim, Chad A. Grotegut, James W. Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B. Rosenberg, Howard A. Rockman, Robert J. Lefkowitz> ;Skeletal Muscle. 2018 Dec 27
48 citations
The two-pore-domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction
Dennis M. Abraham, Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad S. Chandok, Hong-Gang Wang, Stephan Frangakis, Geoffrey S. Pitt, Svati H. Shah, Matthew J. Wolf, H...> ;The Journal of Clinical Investigation. 2018 Nov 1
124 citations
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9
Louis M. Luttrell, Jialu Wang, Bianca Plouffe, Jeffrey S. Smith, Lama Yamani, Suneet Kaur, Pierre Yves Jean-Charles, Christophe Gauthier, Mi Hye Lee, Biswaranjan Pani,...> ;Science Signaling. 2018 Sep 25
139 citations
G-Protein-Coupled Receptors in Heart Disease.
Jialu Wang, Clarice Gareri, Howard A. Rockman> ;Circulation Research. 2018 Aug 31
48 citations
Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery.
James W. Wisler, Howard A. Rockman, Robert J. Lefkowitz> ;Circulation. 2018 May 29
36 citations
Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling
Jialu Wang, Kenji Hanada, Clarice Gareri, Howard A. Rockman> ;Journal of Cellular Biochemistry. 2018 Jan 4
We're listening.
Howard A. Rockman> ;JCI Insight. 2018 Jan 25
56 citations
Gα i is required for carvedilol-induced β 1 adrenergic receptor β-arrestin biased signaling
Jialu Wang, Kenji Hanada, Dean P. Staus, Michael A. Makara, Giri Raj Dahal, Qiang Chen, Andrea Ahles, Stefan Engelhardt, Howard A. Rockman> ;Nature Communications. 2017 Nov 22
15 citations
Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling
Pierre-Yves Jean-Charles, Samuel Mon-Wei Yu, Dennis M. Abraham, Reddy Peera Kommaddi, Lan Mao, Ryan T. Strachan, Zhu-Shan Zhang, Dawn E. Bowles, Leigh Brian, Jonathan ...> ;JCI Insight. 2017 Sep 7
A successful launch.
Howard A. Rockman> ;JCI Insight. 2017 Jan 26
35 citations
β-Arrestin mediates the Frank–Starling mechanism of cardiac contractility
Dennis M. Abraham, Robert T. Davis, Chad M. Warren, Lan Mao, Beata M. Wolska, R. John Solaro, Howard A. Rockman> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Dec 13
18 citations
Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation.
Lewis J. Watson, Kevin M. Alexander, Maradumane L. Mohan, Amber L. Bowman, Supachoke Mangmool, Kunhong Xiao, Sathyamangla V. Naga Prasad, Howard A. Rockman> ;Cellular Signalling. 2016 Oct 1
Join now to see all

Press Mentions

Dr. John Ross Jr.: Following a Long, Successful Career in Which He Invented Retrograde Needle Catheterization of the Left Ventricle and Mentored Many Physicians John Ross Jr Departed This World in April 2019July 1st, 2019