HowardRSmithMD

Rheumatology • Cleveland, OH

Lupus & Related, Myositis, Rheumatoid Arthritis & Related, Scleroderma & Related

Cleveland Clinic

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Office
Director of Lupus Clinic Cleveland Clinic
9500 Euclid Ave A-50
Cleveland, OH 44112
Phone+1 216-444-4555

Fax+1 216-445-7965
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Education & Training

National Institutes of Health Clinical CenterFellowship, Rheumatology, 1980 - 1985
Boston VA Healthcare System (Brockton-West Roxbury)Residency, Internal Medicine, 1977 - 1980
Boston University School of MedicineClass of 1977

Certifications & Licensure

OH State Medical License 1989 - 2026
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Rheumatology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Publications & Presentations

PubMed

15 citations
Low Levels of Vitamin D Promote Memory B Cells in Lupus
Erin A. Yamamoto, Jane K. Nguyen, Jessica Liu, Emma J. Keller, Nicole Campbell, Cun-Jin Zhang, Howard Smith, Xiaoxia Li, Trine N. Jørgensen> ;Nutrients. 2020 Jan 22
30 citations
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3
Cun Jin Zhang, Chenhui Wang, Meiling Jiang, Chunfang Gu, Jianxin Xiao, Xing Chen, Bradley N. Martin, Fangqiang Tang, Erin Yamamoto, Yibo Xian, Han Wang, Fengling Li, R...> ;Nature Communications. 2018 Jul 16
9 citations
Long-lasting effectiveness of intravenous immunoglobulin in a patient with inclusion-body myositis.
Beejadi N. Mukunda, P. Dileep Kumar, Howard R. Smith> ;Annals of Internal Medicine. 2001 Jun 19
43 citations
Familial antiphospholipid antibody syndrome: Criteria for disease and evidence for autosomal dominant inheritance
Niti Goel, Thomas L. Ortel, Deeksha Bali, Joshua P. Anderson, Ian Gourley, Howard Smith, Colleen A. Morris, Muriel DeSimone, D. Ware Branch, P. M. Ford, Donald Berdeau...> ;Arthritis and Rheumatism. 1999 Feb 1
23 citations
Hepatitis C virus antibodies in systemic lupus erythematosus.
Kris V. Kowdley, David E. Subler, James Scheffel, Bonnie Moore, Howard R. Smith> ;Journal of Clinical Gastroenterology. 1997 Sep 1
1 citations
Outpatient management of systemic lupus erythematosus.
Gerald N. Sims, Howard R. Smith> ;Cleveland Clinic Journal of Medicine. 1996 Mar 1
2 citations
Do silicone breast implants cause autoimmune rheumatic diseases
Howard R. Smith> ;Journal of Biomaterials Science. Polymer Edition. 1996 Jan 1
5 citations
Palpable purpura and uveitis precipitated by splenectomy in an atypical case of Cogan's syndrome.
Jeffrey R. Wohlgethan, M M Stilmant, Howard R. Smith> ;The Journal of Rheumatology. 1991 Jul 1
2 citations
Effects of Induced Anemia in Normal and Autoimmune Mice
Elizabeth Raveche, Howard R. Smith, Phil Noguchi, Thomas M. Chused, Alfred D. Steinberg> ;Immunological Investigations. 1990 Aug 1
Nonsteroidal antiinflammatory drugs and the lupus anticoagulant.
Jeffrey R. Wohlgethan, Howard R. Smith> ;Arthritis and Rheumatism. 1990 Jul 1
3 citations
Acute non-infectious arthritis of the hip in rheumatoid arthritis: synovial membrane findings.
Jeffrey R. Wohlgethan, M M Stilmant, J M Harris, Howard R. Smith> ;Annals of the Rheumatic Diseases. 1989 Mar 1
87 citations
Angioimmunoblastic Lymphadenopathy with Dysproteinemia
Alfred D. Steinberg, Michael F. Seldin, Elaine S. Jaffe, Howard R. Smith, Dennis M. Klinman, Arthur M. Krieg, Jeffrey Cossman> ;Annals of Internal Medicine. 1988 Apr 1
122 citations
Clonality of angioimmunoblastic lymphadenopathy and implications for its evolution to malignant lymphoma.
Edward H. Lipford, Howard R. Smith, Stefania Pittaluga, Elaine S. Jaffe, Alfred D. Steinberg, Jeffrey Cossman> ;The Journal of Clinical Investigation. 1987 Feb 1
81 citations
CS-A therapy in MRL-lpr/lpr mice: amelioration of immunopathology despite autoantibody production.
John D. Mountz, Howard R. Smith, R L Wilder, J P Reeves, A D Steinberg> ;Journal of Immunology. 1987 Jan 1
1 citations
Studies of the Effects of Y Chromosome Factors on the Expression of Autoimmune Disease
Alfred D. Steinberg, Kathleen H. Triem, Howard R. Smith, Carl A. Laskin, Yvonne J. Rosenberg, Dennis M. Klinman, J. Frederic Mushinski, John D. Mountz> ;Annals of the New York Academy of Sciences. 1986 Jul 1
Splenic migration of xid and non-xid splenic B cells
Howard R. Smith, Nancy Littell, Alfred D. Steinberg> ;Clinical Immunology and Immunopathology. 1986 Jun 1
10 citations
Evidence that Lyb-5 is a differentiation antigen in normal and xid mice.
Howard R. Smith, L J Yaffe, D L Kastner, A D Steinberg> ;Journal of Immunology. 1986 Feb 15
18 citations
Modulation of c-myb transcription in autoimmune disease by cyclophosphamide.
John D. Mountz, J F Mushinski, Howard R. Smith, Dennis M. Klinman, A D Steinberg> ;Journal of Immunology. 1985 Oct 1
HLA antigens in angioimmunoblastic lymphadenopathy.
Howard R. Smith, Michael F. Seldin, Alfred D. Steinberg, Josef S. Smolen, Wolfgang R. Mayr, Richard J. Davey, Elaine S. Jaffe> ;Annals of Internal Medicine. 1985 Sep 1
11 citations
Analysis of B-cell subpopulations. I. Relationships among splenic xid, Ly 1+, and Lyb 5+ B cells.
Howard R. Smith, L. J. Yaffe, Thomas M. Chused, E S Raveche, Dennis M. Klinman, Alfred D. Steinberg> ;Cellular Immunology. 1985 Apr 15
66 citations
Autoimmunity and increased c-myb transcription.
John D. Mountz, A D Steinberg, Dennis M. Klinman, Howard R. Smith, J F Mushinski> ;Science. 1984 Nov 30
98 citations
Systemic Lupus Erythematosus: Insights from Animal Models
Alfred D. Steinberg, E S Raveche, Carl A. Laskin, Howard R. Smith, Thomas J. Santoro, Michael L. Miller, Paul H. Plotz> ;Annals of Internal Medicine. 1984 May 1
43 citations
Cyclophosphamide-induced changes in the MRL-lpr/lpr mouse: effects upon cellular composition, immune function, and disease.
Howard R. Smith, Thomas M. Chused, Alfred D. Steinberg> ;Clinical Immunology and Immunopathology. 1984 Jan 1
5 citations
Cyclophosphamide therapy in murine lupus: effect of combining multiple subsets into a single randomized study
Ellen B. Steinberg, Howard R. Smith, Alfred D. Steinberg> ;Arthritis and Rheumatism. 1983 Oct 1
26 citations
The effect of the X-linked immune deficiency gene (xid) upon the Y chromosome-related disease of BXSB mice.
Howard R. Smith, Thomas M. Chused, A D Steinberg> ;Journal of Immunology. 1983 Sep 1
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