HowardKSurksMD

PubMed

• 2 citations
  First-in-human study with SAR445088: A novel selective classical complement pathway inhibitor.
  Timothy Chow, Pirouz Shamszad, Christopher Vinnard, Esther Yoon, Julia Belinski, Irene Karpenko, Laurent Perrin, Kristen Auwarter, Michael Storek, Howard Surks, Nancy ...> ;Clinical and Translational Science. 2023 Apr 1
• Clinical pharmacology of alemtuzumab, an anti-CD52 immunomodulator, in multiple sclerosis.
  Li, Z.,Richards, S.,Surks, H. K.,Jacobs, A.,Panzara, M. A.> ;Clin. Exp. Immunol.. 2018 Aug 26
• 94 citations
  Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials
  Kishan S. Parikh, Kavita Sharma, Mona Fiuzat, Howard K. Surks, Jyothis T. George, Narimon Honarpour, Christopher Depre, Patrice Desvigne-Nickens, Richard Nkulikiyinka,...> ;JACC. Heart Failure. 2018 Aug 1
• 13 citations
  Safety of Insulin Lispro and a Biosimilar Insulin Lispro When Administered Through an Insulin Pump.
  James Thrasher, Howard Surks, Irene Nowotny, Suzanne Pierre, Baerbel Rotthaeuser, Karin Wernicke-Panten, Satish K. Garg> ;Journal of Diabetes Science and Technology. 2018 Jan 23
• 9 citations
  A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics.
  Jeffrey E Ming, Ruth E. Abrams, Derek W. Bartlett, Mengdi Tao, Tu Nguyen, Howard K. Surks, Katherine Kudrycki, Ananth Kadambi, Christina M. Friedrich, Nassim Djebli, B...> ;Gene Regulation and Systems Biology. 2017 Jun 22
• 166 citations
  Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans
  Gissette Reyes-Soffer, Marianna Pavlyha, Colleen Ngai, Tiffany Thomas, Stephen Holleran, Rajasekhar Ramakrishnan, Wahida Karmally, Renu Nandakumar, Nelson Fontanez, Jo...> ;Circulation. 2017 Jan 24
• 37 citations
  Relationship Between Low‐Density Lipoprotein Cholesterol, Free Proprotein Convertase Subtilisin/Kexin Type 9, and Alirocumab Levels After Different Lipid‐Lowering Stra...
  Jacques Rey, Franck Poitiers, Tobias Paehler, Aurélie Brunet, A. Thomas DiCioccio, Christopher P. Cannon, Howard K. Surks, Jean-Louis Pinquier, Corinne Hanotin, Willia...> ;Journal of the American Heart Association. 2016 Jun 1
• 35 citations
  Pericyte contractility controls endothelial cell cycle progression and sprouting: insights into angiogenic switch mechanics
  Jennifer T. Durham, Howard K. Surks, Brian M. Dulmovits, Ira M. Herman> ;American Journal of Physiology. Cell Physiology. 2014 Nov 1
• 9 citations
  Steroid-sensitive gene 1 is a novel cyclic GMP-dependent protein kinase I substrate in vascular smooth muscle cells.
  Guang-rong Wang, Howard K. Surks, K. Mary Tang, Yan Zhu, Michael E. Mendelsohn, Robert M. Blanton> ;The Journal of Biological Chemistry. 2013 Aug 23
• 25 citations
  Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib in Japanese patients with dyslipidemia.
  Tamio Teramoto, Masayoshi Shirakawa, Masashi Kikuchi, Mariko Nakagomi, Satoko Tamura, Howard K. Surks, Christine McCrary Sisk, Hirotaka Numaguchi> ;Atherosclerosis. 2013 Sep 1
• 44 citations
  Anacetrapib, a Novel CETP Inhibitor: Pursuing a New Approach to Cardiovascular Risk Reduction
  David E. Gutstein, Rajesh Krishna, Douglas G. Johns, Howard K. Surks, H M Dansky, Sonia Shah, Yale B. Mitchel, J Arena, John A. Wagner> ;Clinical Pharmacology and Therapeutics. 2012 Jan 1
• 2 citations
  Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells
  Maria Claudia Montefusco, Kristen Merlo, Crystal D Bryan, Howard K. Surks, Steven E. Reis, Michael E. Mendelsohn, Gordon S. Huggins> ;BMC Genetics. 2010 Apr 14
• 190 citations
  ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells
  Yuepeng Wang, Xiaoyu Rayne Zheng, Nadeene Riddick, Meredith Bryden, Wendy Baur, Xin Zhang, Howard K. Surks> ;Circulation Research. 2009 Feb 27
• 54 citations
  Probing the Interaction between the Coiled Coil Leucine Zipper of cGMP-dependent Protein Kinase Iα and the C Terminus of the Myosin Binding Subunit of the Myosin Light...
  Alok K. Sharma, Guo-Ping Zhou, Joseph Kupferman, Howard K. Surks, Eva N. Christensen, James J. Chou, Michael E. Mendelsohn, Alan C. Rigby> ;The Journal of Biological Chemistry. 2008 Nov 21
• 99 citations
  High blood pressure arising from a defect in vascular function
  Simon K. Michael, Howard K. Surks, Yuepeng Wang, Yan Zhu, Robert M. Blanton, Michelle Jamnongjit, Mark Aronovitz, Wendy Baur, Ken-ichi Ohtani, Michael K. Wilkerson, Ad...> ;Proceedings of the National Academy of Sciences of the United States of America. 2008 May 6
• 48 citations
  Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase.
  Nadeene Riddick, Ken-ichi Ohtani, Howard K. Surks> ;Journal of Cellular Biochemistry. 2008 Mar 1
• 60 citations
  cGMP-Dependent Protein Kinase I and Smooth Muscle Relaxation: A Tale of Two Isoforms
  Howard K. Surks> ;Circulation Research. 2007 Nov 26
• 62 citations
  Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state.
  Matthew E. Kutcher, Alexey Y. Kolyada, Howard K. Surks, Ira M. Herman> ;The American Journal of Pathology. 2007 Aug 1
• 50 citations
  M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells.
  Howard K. Surks, Nadeene Riddick, Ken-ichi Ohtani> ;The Journal of Biological Chemistry. 2005 Dec 30
• 212 citations
  Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor α
  Qing Lu, David C. Pallas, Howard K. Surks, Wendy Baur, Michael E. Mendelsohn, Richard H. Karas> ;Proceedings of the National Academy of Sciences of the United States of America. 2004 Dec 7
• 40 citations
  Identification and Characterization of Zipper-interacting Protein Kinase as the Unique Vascular Smooth Muscle Myosin Phosphatase-associated Kinase
  Akira Endo, Howard K. Surks, Seibu Mochizuki, Naoki Mochizuki, Michael E. Mendelsohn> ;The Journal of Biological Chemistry. 2004 Oct 1
• 30 citations
  Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells.
  Yuepeng Wang, Mohamad R. El-Zaru, Howard K. Surks, Michael E. Mendelsohn> ;The Journal of Biological Chemistry. 2004 Jun 4
• 73 citations
  Myosin Phosphatase-Rho Interacting Protein A NEW MEMBER OF THE MYOSIN PHOSPHATASE COMPLEX THAT DIRECTLY BINDS RhoA
  Howard K. Surks, Christopher T. Richards, Michael E. Mendelsohn> ;The Journal of Biological Chemistry. 2003 Dec 19
• 41 citations
  Dimerization of cGMP-dependent protein kinase 1α and the myosin-binding subunit of myosin phosphatase: role of leucine zipper domains
  Howard K. Surks, Michael E. Mendelsohn> ;Cellular Signalling. 2003 Oct 1
• 54 citations
  Regulation of Estrogen Receptor α-mediated Transcription by a Direct Interaction with Protein Phosphatase 2A
  Qing Lu, Howard K. Surks, Heather Ebling, Wendy Baur, Donald J. Brown, David C. Pallas, Richard H. Karas> ;The Journal of Biological Chemistry. 2003 Feb 14
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Journal Articles

• Heart Failure with Preserved Ejection Fraction Expert Panel Report  
  Kishan S Parikh, Howard K Surks, Sanjiv J Shah, Marvin A Konstam, Margaret M Redfield, Robert M Califf, Kavita Sharma, Narimon Honarpour, Gregory D Lewis, Scott D Solo..., ScienceDirect