HsinlinTChengMDPh

PubMed

• COVID-19-induced headache in Boston and the vicinity.
  Bart K Chwalisz, Vi K Le, Jennifer R Cheng, Aayushee Jain, M Brandon Westover, Hsinlin T Cheng> ;Journal of Clinical Virology Plus. 2023 Jun 1
• 11 citations
  Interleukin-10 Reduces Neurogenic Inflammation and Pain Behavior in a Mouse Model of Type 2 Diabetes
  Brandon M. Yanik, Jacqueline R. Dauch, Hsinlin T. Cheng> ;Journal of Pain Research. 2020 Dec 29
• 24 citations
  Cytokine-mediated inflammation mediates painful neuropathy from metabolic syndrome
  Can Zhang, Joseph Ward, Jacqueline R. Dauch, Rudolph E. Tanzi, Hsinlin T. Cheng> ;Plos One. 2018 Feb 6
• Acidic FGF promotes neurite outgrowth of cortical neurons and improves neuroprotective effect in a cerebral ischemic rat model.
  Tsai MJ, Tsai SK, Huang MC, Liou DY, Huang SL, Hsieh WH, Huang WC, Huang SS, Cheng H> ;Neuroscience. 2015-10-01
• Systematic differences in the response of genetic variation to pedigree and genome-based selection methods.
  Heidaritabar, M.,Vereijken, A.,Muir, W. M.,Meuwissen, T.,Cheng, H.,Megens, H. J.,Groenen, M. A.,Bastiaansen, J. W.> ;Heredity (Edinb). 2014 Jul 31
• 78 citations
  Increased axonal regeneration and swellings in intraepidermal nerve fibers characterize painful phenotypes of diabetic neuropathy
  Hsinlin T. Cheng, Jacqueline R. Dauch, Michael T. Porzio, Brandon M. Yanik, Wilson Hsieh, A. Gordon Smith, J. Robinson Singleton, Eva L. Feldman> ;The Journal of Pain. 2013 Sep 1
• 25 citations
  Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia
  Jacqueline R. Dauch, Diane E. Bender, Lucía A Luna-Wong, Wilson Hsieh, Brandon M. Yanik, Zachary A Kelly, Hsinlin T. Cheng> ;Journal of Neuroinflammation. 2013 May 14
• 3 citations
  Three-dimensional imaging of nociceptive intraepidermal nerve fibers in human skin biopsies.
  Jacqueline R. Dauch, Chelsea N. Lindblad, John M. Hayes, Stephen I. Lentz, Hsinlin T. Cheng> ;Journal of Visualized Experiments. 2013 Apr 29
• Highly variable El Niño-Southern Oscillation throughout the Holocene.
  Cobb, K. M.,Westphal, N.,Sayani, H. R.,Watson, J. T.,Di Lorenzo, E.,Cheng, H.,Edwards, R. L.,Charles, C. D.> ;Science. 2013 Jan 4
• 31 citations
  Neuron-Astrocyte Signaling Network in Spinal Cord Dorsal Horn Mediates Painful Neuropathy of Type 2 Diabetes
  Jacqueline R. Dauch, Brandon M. Yanik, Wilson Hsieh, Sang Su Oh, Hsinlin T. Cheng> ;Glia. 2012 Sep 1
• 604 citations
  Diabetic neuropathy: clinical manifestations and current treatments
  Brian C. Callaghan, Hsinlin T. Cheng, Catherine L. Stables, Andrea L. Smith, Eva L. Feldman> ;The Lancet. Neurology. 2012 Jun 1
• 43 citations
  Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes.
  Hsinlin T. Cheng, Jacqueline R. Dauch, John M. Hayes, Brandon M. Yanik, Eva L. Feldman> ;Neurobiology of Disease. 2012 Jan 1
• Involvement of microglial cells in infrasonic noise-induced stress via upregulated expression of corticotrophin releasing hormone type 1 receptor.
  Du F, Yin L, Shi M, Cheng H, Xu X, Liu Z, Zhang G, Wu Z, Feng G, Zhao G> ;Neuroscience. 2010-05-19
• 51 citations
  p38 mediates mechanical allodynia in a mouse model of type 2 diabetes
  Hsinlin T. Cheng, Jacqueline R. Dauch, Sang Su Oh, John M. Hayes, Yu Hong, Eva L. Feldman> ;Molecular Pain. 2010 May 19
• 30 citations
  Spinal cord mechanisms of chronic pain and clinical implications.
  Hsinlin Thomas Cheng> ;Current Pain and Headache Reports. 2010 May 12
• 77 citations
  Nerve growth factor mediates mechanical allodynia in a mouse model of type 2 diabetes.
  Hsinlin T. Cheng, Jacqueline R. Dauch, John M. Hayes, Yu Hong, Eva L. Feldman> ;Journal of Neuropathology and Experimental Neurology. 2009 Nov 1
• 449 citations
  Diabetic neuropathy: mechanisms to management.
  James L. Edwards, Andrea M. Vincent, Hsinlin T. Cheng, Eva L. Feldman> ;Pharmacology & Therapeutics. 2008 Oct 1
• 32 citations
  INFLAMMATORY PAIN-INDUCED SIGNALING EVENTS FOLLOWING A CONDITIONAL DELETION OF THE N-METHYL-D-ASPARTATE RECEPTOR IN SPINAL CORD DORSAL HORN
  Hsinlin T Cheng, Masahiro Suzuki, Deborah M. Hegarty, Qinghao Xu, Amanda R. Weyerbacher, Samantha M. South, Megumi Ohata, Charles E. Inturrisi> ;Neuroscience. 2008 Aug 26
• 35 citations
  Cyclooxygenase-2 pathway as a potential therapeutic target in diabetic peripheral neuropathy.
  Aaron P. Kellogg, Hsinlin Thomas Cheng, Rodica Pop-Busui> ;Current Drug Targets. 2008 Jan 1
• 32 citations
  IGF-I increases IGFBP-5 and collagen α1(I) mRNAs by the MAPK pathway in rat intestinal smooth muscle cells
  Xiping Xin, Yong Tai Hou, Lina Li, Phyllissa Schmiedlin-Ren, Gregory M. Christman, Hsin-Lin Cheng, Khalil N. Bitar, Ellen M. Zimmermann> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2004 May 1
• 37 citations
  Regulation of insulin-like growth factor-binding protein-5 expression during Schwann cell differentiation.
  Hsin-Lin Cheng, Michael E. Shy, Eva L. Feldman> ;Endocrinology. 1999 Oct 1
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Journal Articles

• 3-Dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies  
  Dauch JR, Lindblad CN, Hayes JM, Lentz SI, Cheng HT, The Journal of Visualized Experiments, 1/1/2013
• Neurogenic factor-induced Langerhans cell activation in painful diabetic neuropathy  
  Dauch JR, Bender D, Luna-Wong LA, Hsieh W, Yanik BM, Kelly ZA, Cheng HT, Journal of Neuroinflammation, 1/1/2013
• Increased Peptidergic Intraepidermal Nerve Fiber Densities during Mechanical Allodynia in an Animal Model of Type 2 Diabetes  
  Cheng HT, Dauch JR, Hayes JM, Yanik BM, Feldman EL, Neurobiology of Disease, 1/1/2012
• Neuron-astrocyte signaling network in spinal cord dorsal horn mediates painful neuropathy of type 2 diabetes  
  Dauch JR, Yanik BM, Oh S, Hsieh W, Cheng HT, Glia, 1/1/2012
• Diabetic neuropathy: Clinical manifestations and current treatment  
  Callanghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL, Lancet Neurology, 1/1/2012
• P38 Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes  
  Cheng HT, Dauch JR, Oh S, Hayes JM, Hong Y, Feldman EL, Molecular Pain, 1/1/2010
• Feldman EL Insulin-like growth factor-I and over-expression of Bcl-xL prevent glucose-mediated apoptosis in Schwann cells  
  Delaney CL. Russell JW. Cheng HL, Journal of Neuropathology & Experimental Neurology, 1/1/2001
• Insulin-like growth factor-I and Bcl-X(L) inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosis  
  Cheng HL. Steinway ML. Xin X. Feldman EL, Journal of Neurochemistry, 1/1/2001
• IGF-I promotes Schwann cell motility and survival via activation of Akt  
  Cheng HL. Steinway M. Delaney CL. Franke TF. Feldman EL, Molecular & Cellular Endocrinology, 1/1/2000
• GTPases and phosphatidylinositol 3-kinase are critical for insulin-like growth factor-I-mediated Schwann cell motility  
  Cheng HL. Steinway ML. Russell JW. Feldman EL, Journal of Biological Chemistry, 1/1/2000
• Caveolin-1 expression in Schwann cells  
  Mikol DD, Hong H, Cheng H-L, Feldman EL, Glia, 1/1/1999
• IGF-I promotes peripheral nervous system myelination  
  Cheng H-L, Russell JW, Feldman EL, Annals of the New York Academy of Sciences, 1/1/1999
• Insulin-like growth factor-I prevents caspase mediated apoptosis in Schwann cells  
  Delaney CL, Cheng H-L, Feldman EL, Journal of Neurobiology, 1/1/1999
• Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I  
  Cheng H-L, Feldman EL, Journal of Biological Chemistry, 1/1/1998
• Insulin receptor substrate-2 and Shc play different roles in insulin-like growth factor-I signaling  
  Kim B, Cheng H-L, Margolis B, Feldman EL, Journal of Biological Chemistry, 1/1/1998
• Insulin-like growth factor-I (IGF-I) and IGF binding protein-5 in Schwann cell differentiation  
  Cheng H-L, Feldman EL, Journal of Cellular Physiology, 1/1/1997
• Characterization of insulin-like growth factor-I (IGF-I), IGF-I receptor and binding proteins in transected nerves and cultured Schwann cells  
  Cheng H-L, Randolph A, Yee D, Delafontaine P, Tennekoon G, Feldman EL, Journal of Neurochemistry, 1/1/1996
• Immunohistochemical localization of insulin-like growth factor binding protein-5 in the developing rat nervous system  
  Cheng H-L, Sullivan KA, Feldman EL, Developmental Brain Research, 1/1/1996
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Books/Book Chapters

• Atlas of Neuromuscular Diseases 
  Chapter: Chronic Pain in Neuromuscular Disease. (Chapter 4) 
  Page 37 - 41Cheng HT, Oaklander ALEdition 2nd,2014
• Neuropathic Pain: Mechanisms, Diagnosis and Treatment 
  Chapter: Painful Diabetic Neuropathy. (Chapter 11) 
  Page 165 - 189Cheng HT, Callanghan B, Dauch JR, Feldman ELEditors: David Simpson, Justin McArthur, and David Dworkin.2012
• Encyclopedia of Pain 
  Chapter: Diabetic Neuropathy. 
  Cheng HT, Oaklander ALEdition 2nd,2012
• Cytoskeleton of the Nervous System 
  Chapter: Cytoskeleton, Axonal Transport, and the Mechanisms of Peripheral Neuropathy. (Chapter 27) 
  Page 657 - 678Cheng HT, Callanghan B, Dauch JR, Feldman ELEditors: Ralph A. Nixon and Aidong Yuan.2011
• Neural Plasticity in Chronic Pain 
  Chapter: Spinal Cord Neural Plasticity in Chronic Pain and Its Clinical Implication Pain. (Chapter 3) 
  Dauch JR, Cheng HT2011
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Abstracts/Posters

• Dysregulation of cytokines mediates painful diabetic neuropathy.
  Yanik BM, Dauch JR, Bruno E, Feldman EL, Cheng HT, American Academy of Neurology, 1/1/2015
• Analgesic effects of IL-10 in a murine model of painful diabetic neuropathy.
  Yanik BM, Dauch JR, Bruno E, Feldman EL, Cheng HT, Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB), 1/1/2014
• High fat diet induces impaired glucose tolerance and painful peripheral neuropathy.
  Dauch JR, Cheng HT, Hayes JM, Oh S, and Feldman EL, Peripheral Nerve Society, 1/1/2013
• Useful biomarkers for the diagnosis of painful diabetic neuropathy.
  Cheng HT, Dauch JR, Porzio M, Yanik BM, Hsieh W, Smith GA, Singleton RJ, and Feldman EL, American Academy of Neurology, 1/1/2012
• High fat diet induces impaired glucose tolerance and painful peripheral neuropathy.
  Cheng HT, Dauch JR, Hayes J, Oh S, and Feldman EL, American Neurological Association, 1/1/2012
• Spinal Cord Neuorn-glial Interactions Mediate Pain in Type 2 Diabetes.
  Dauch JR, Yanik BM, and Cheng HT, American Society for Neurochemistry, 1/1/2011
• Characterization of Intraepidermal Nerve Fiber Morphology in Pain Associated with Diabetic Neuropathy and Impaired Glucose Tolerance.
  Cheng HT, Dauch JR, Smith GA, Singleton RJ, Yanik BM, and Feldman EL, Peripheral Nerve Society, 1/1/2011
• The use of skin biopsy for the diagnosis of painful diabetic neuropathy.
  Cheng HT, Dauch JR, Smith GA, Singleton RJ, Yanik BM, and Feldman EL, Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB), 1/1/2011
• Characterization of intraepidermal nerve fiber morphology in pain associated with diabetic neuropathy and impaired glucose tolerance.
  Cheng HT, Dauch JR, Smith GA, Singleton RJ, Yanik BM, and Feldman EL, American Neurological Association, 1/1/2011
• “The use of skin biopsy for the diagnosis of painful diabetic neuropathy”
  Cheng HT, Platform presentation, Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB), Porto, Portugal, 1/1/2011
• “Characterization of intraepidermal nerve fiber morphology in pain associated with diabetic neuropathy and impaired glucose tolerance”
  Cheng HT, American Neurological Association, SIG for headache and neuropathic pain, platform presentation, San Diego, CA, 1/1/2011
• P38 Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes.
  Cheng HT, Dauch JR, Hayes J, Hong Y, and Feldman EL, American Pain Society, 1/1/2010
• Nerve Growth Factor and P38 Mediate Increased Peptidergic Intraepidermal Nerve Fibers and Mechanical Allodynia in Type 2 Diabetes.
  Cheng HT, Dauch JR, Hayes J, Hong Y, and Feldman EL, American Neurological Association, 1/1/2010
• P38 Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes.
  Cheng HT, Dauch JR, Oh S, Hong Y, and Feldman EL, American Neurological Association, 1/1/2010
• Increased Peptidergic Intraepidermal Nerve Fiber Densities during Mechanical Allodynia in Type 2 Diabetes.
  Cheng HT, Dauch JR, Oh S, Hong Y, and Feldman EL, Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB), 1/1/2010
• “Nerve growth factor and p38 mediate increased peptidergic intraepidermal nerve fibers and mechanical allodynia in type 2 diabetes”
  Cheng HT, American Neurological Association, SIG for headache and neuropathic pain, platform presentation, San Francisco, CA, 1/1/2010
• The roles of mitogen activated protein kinases in painful neuropathy of type 2 diabetes.
  Cheng HT, Hayes J, Hong Y, and Feldman EL, Society of Neuroscience, 1/1/2009
• Upregulation of nerve growth factor signaling in painful neuropathy of type 2 diabetes.
  Cheng HT, Hayes J, Hong Y, and Feldman EL, American Pain Society, 1/1/2008
• The essential role of nerve growth factor in painful neuropathy of type 2 diabetes.
  Cheng HT, Hayes J, Hong Y, and Feldman EL, Society of Neuroscience, 1/1/2008
• "Upregulation of nerve growth factor signaling in painful neuropathy of type 2 diabetes”
  Cheng HT, American Pain Society, platform presentation, Tampa, FL, 1/1/2008
• “The essential role of nerve growth factor in painful neuropathy of type 2 diabetes”
  Cheng HT, Society for Neuroscience, platform presentation, Washington, DC, 1/1/2008
• Activation of mitogen activated protein kinases in painful diabetic neuropathy.
  Cheng HT, Hayes J, Hong Y, and Feldman EL, Society of Neuroscience, 1/1/2007
• N -Methyl-D-Aspartate receptor dependent and independent signaling pathways in the spinal cord mediate inflammatory pain.
  Cheng HT, Suzuki M, Hegarty DM, Xu Q, South SM, Ohata M and Inturrisi CE, American Pain Society, 1/1/2006
• Methyl-D-Aspartate receptor dependent and independent signaling pathways in the spinal cord mediate inflammatory pain.
  Cheng HT, Suzuki M, Hegarty DM, Xu Q, South SM, Ohata M and Inturrisi CE, Society of Neuroscience, 1/1/2005
• Insulin-like growth factor-I prevents caspase mediated programmed cell death in Schwann cells.
  Delaney CL, Cheng H-L, Daum J, Feldman EL, The Endocrine Society Abstract, 1/1/1999
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Lectures

• "The use of skin biopsy for the diagnosis of painful diabetic neuropathy” 
  Department of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan - 1/1/2012
• "Useful biomarkers for the diagnosis of painful diabetic neuropathy” 
  New Orleans - 1/1/2012
• “Painful diabetic neuropathy: Not just a peripheral nerve disease” 
  Department of Neurology, Cleveland Clinic, Cleveland, OH - 1/1/2011
• “Peripheral mechanisms for painful diabetic neuropathy of type 2 diabetes” 
  Department of Endocrinology, Wayne State University, Detroit, MI - 1/1/2010
• “Botulinum toxin for neuropathic pain”. 
  Department of Neurology, Memorial Sloan Kettering Cancer Center, New York - 1/1/2006
• “N -Methyl-D-Aspartate receptor dependent and independent signaling pathways in the spinal cord mediate inflammatory pain”. 
  Department of Neurology, Memorial Sloan Kettering Cancer Center, New York - 1/1/2005
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Other

• The role of the insulin-like growth factor family in the nervous system. (Thesis) 
  Cheng H-L, The University of Michigan
  Ann Arbor, MI - 1/1/1996