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Office
3060 Pegasus Park
Bldg 6
Dallas, TX 75247Phone+1 858-365-5923Fax+1 858-365-5923- Is this information wrong?
Summary
- • C-level officer in the biotech/pharmaceutical industry, with 12 years of executive track record in both public and private companies and pivotal roles in initial/follow-on public offerings.
• Research & development experience across multiple therapeutic areas, with 10 additional years of basic research and teaching record in academia.
• Skilled in communicating with diverse audiences, including scientific and medical communities, board members, investors and analysts.
• Successfully designed and executed the clinical, nonclinical, and regulatory strategy for Bonsity® (PF708), a teriparatide injectable for the treatment of high-risk osteoporosis, leading to NDA approval in 2019.
• Experienced in negotiating with multiple regulatory agencies (US FDA, EMA, Japan’s PMDA, Health Canada), with a passion for translating scientific breakthroughs and proposing accelerated development programs.
Education & Training
- Gladstone Institute of Cardiovascular DiseasePost-Doctoral Fellowship, Cardiovascular Disease, 1999 - 2002
- University of California (San Francisco)Fellowship, Endocrinology, Diabetes, and Metabolism, 1998 - 2002
- Massachusetts General HospitalResidency, Internal Medicine, 1995 - 1998
- Columbia University Vagelos College of Physicians and SurgeonsClass of 1995
Certifications & Licensure
- CA State Medical License 1998 - 2026
Awards, Honors, & Recognition
- Professor of the Year Master of Science Program in Drug Development & Product Management, UCSD, 2019, 2021
Clinical Trials
- Study to Examine Safety, Tolerability and Effect on Body Weight of Subcutaneous AC2307 in Obese or Overweight Subjects Start of enrollment: 2008 Dec 01
- Phase 1 Safety Study of ALRN-5281 in Healthy Subjects Start of enrollment: 2013 Jan 01
- Safety Study of PF582 Versus Lucentis in Patients With Age Related Macular Degeneration Start of enrollment: 2013 Nov 01
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Publications & Presentations
PubMed
- 10 citationsWeek 4 Liver Fat Reduction on MRI as an Early Predictor of Treatment Response in Participants with Nonalcoholic Steatohepatitis.Hanyu Jiang, Hubert Chen, Kyle Lafata, Mustafa R. Bashir> ;Radiology. 2021 Jun 1
- 75 citationsA structurally optimized FXR agonist, MET409, reduced liver fat content over 12 weeks in patients with non-alcoholic steatohepatitis.Stephen A. Harrison, Mustafa R. Bashir, Kyoung Jin Lee, Jennifer Shim-Lopez, Jonathan Lee, Brandee Wagner, Nicholas D. Smith, Hubert Chen, Eric Lawitz> ;Journal of Hepatology. 2021 Jul 1
- 19 citationsEnhancing energy and glucose metabolism by disrupting triglyceride synthesis: Lessons from mice lacking DGAT1Hubert C. Chen> ;Nutrition & Metabolism. 2006 Jan 31
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Press Mentions
- Metacrine Appoints Hubert Chen, M.D. As Chief Medical Officer and Andrew Guggenhime to the Board of DirectorsSeptember 6th, 2018
Grant Support
- Increased Leptin Sensitivity In DGAT -/- MiceNational Institute Of Diabetes And Digestive And Kidney Diseases2002–2003
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