HughYoungRienhoffJr.MD

PubMed

• 8 citations
  Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.
  Claire C Homan, Michael W Drazer, Kai Yu, David M Lawrence, Jinghua Feng, Luis Arriola-Martinez, Matthew J Pozsgai, Kelsey E McNeely, Thuong Ha, Parvathy Venugopal, Pe...> ;Blood Advances. 2023 Oct 24
• 4 citations
  Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
  Qu Jiang, Johanna Stachelscheid, Johannes Bloehdorn, Alicja Pacholewska, Christoph Aszyk, Francien Grotenhuijs, Tony Müller, Ozlem Onder, Prerana Wagle, Carmen D Herli...> ;Blood. 2023 Jul 6
• 23 citations
  Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.
  Joseph B Hiatt, Holly Sandborg, Sarah M Garrison, Henry U Arnold, Sheng-You Liao, Justin P Norton, Travis J Friesen, Feinan Wu, Kate D Sutherland, Hugh Y Rienhoff, Ren...> ;Clinical Cancer Research. 2022 Oct 14
• 17 citations
  The RUNX1 Database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid ...
  Claire C. Homan, Sarah L King-Smith, David Lawrence, Peer Arts, Jinghua Feng, James Andrews, Mark Armstrong, Thuong Ha, Julia Dobbins, Michael W. Drazer, Kai Yu, Csaba...> ;Haematologica. 2021 Jul 8
• 3 citations
  Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss.
  Parvathy Venugopal, Lucia Gagliardi, Cecily Forsyth, Jinghua Feng, Kerry Phillips, Milena Babic, Nicola Poplawski, Hugh Y. Rienhoff, Andreas W. Schreiber, Christopher ...> ;BMC Medical Genetics. 2020 Feb 17
• 19 citations
  Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition
  Sheng F. Cai, S. Haihua Chu, Aaron D Goldberg, Salma Parvin, Richard Koche, Jacob L. Glass, Eytan M. Stein, Martin S. Tallman, Filiz Sen, Christopher Famulare, Monica ...> ;Cancer Discovery. 2020 Oct 1
• 62 citations
  LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone.
  Jonas S. Jutzi, Maria Kleppe, Jennifer Dias, Hans F. Staehle, Kaitlyn Shank, Julie Teruya-Feldstein, Sudheer Madan Mohan Gambheer, Christine Dierks, Hugh Y. Rienhoff, ...> ;Hemasphere. 2018 Jun 1
• 73 citations
  LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML.
  Monica Cusan, Sheng F. Cai, Helai P. Mohammad, Andrei V. Krivtsov, Alan Chramiec, Evangelia Loizou, Matthew Witkin, Kimberly N. Smitheman, Daniel G. Tenen, Min Ye, Bri...> ;Blood. 2018 Apr 12
• 3 citations
  Reflections on my daughter's DNA
  Hugh Young Rienhoff> ;Applied & Translational Genomics. 2016 Feb 1
• 48 citations
  Liver MRI is more precise than liver biopsy for assessing total body iron balance: a comparison of MRI relaxometry with simulated liver biopsy results.
  John C. Wood, Pinggao Zhang, Hugh Y. Rienhoff, Walid Abi-Saab, Ellis J. Neufeld> ;Magnetic Resonance Imaging. 2015 Jul 1
• 7 citations
  Cardiac R2* values are independent of the image analysis approach employed.
  Antonella Meloni, Hugh Y. Rienhoff, Amber Jones, Alessia Pepe, Massimo Lombardi, John C. Wood> ;Magnetic Resonance in Medicine. 2014 Aug 1
• 5 citations
  Response to "De novo mutation of the TGFB3 latency-associated peptide domain in a patient with overgrowth and Loeys-Dietz syndrome features".
  Hugh Young Rienhoff> ;American Journal of Medical Genetics. Part A. 2014 Aug 1
• 28 citations
  R2 and R2* are equally effective in evaluating chronic response to iron chelation
  John C. Wood, Pinggao Zhang, Hugh Y. Rienhoff, Walid Abi-Saab, Ellis J. Neufeld> ;American Journal of Hematology. 2014 May 1
• 65 citations
  A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Di...
  Hugh Young Rienhoff, Chang Yeol Yeo, Rachel Morissette, Irina Khrebtukova, Jonathan S. Melnick, Shujun Luo, Nan Leng, Yeon Jin Kim, Gary P. Schroth, John Westwick, Han...> ;American Journal of Medical Genetics. Part A. 2013 Aug 1
• 12 citations
  Fast approximation to pixelwise relaxivity maps: validation in iron overloaded subjects.
  Antonella Meloni, Heather Zmyewski, Hugh Y. Rienhoff, Amber Jones, Alessia Pepe, Massimo Lombardi, John C. Wood> ;Magnetic Resonance Imaging. 2013 Sep 1
• 69 citations
  The use of appropriate calibration curves corrects for systematic differences in liver R2* values measured using different software packages.
  Antonella Meloni, Hugh Y. Rienhoff, Amber Jones, Alessia Pepe, Massimo Lombardi, John C. Wood> ;British Journal of Haematology. 2013 Mar 18
• 137 citations
  A public resource facilitating clinical use of genomes
  Madeleine Ball, Joseph V. Thakuria, Alexander Wait Zaranek, Tom Clegg, Abraham M. Rosenbaum, Xiaodi Wu, Misha Angrist, Jong Bhak, Jason Bobe, Matthew J. Callow, Carlos...> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul 24
• 31 citations
  Antimalarial Iron Chelator, FBS0701, Shows Asexual and Gametocyte Plasmodium falciparum Activity and Single Oral Dose Cure in a Murine Malaria Model
  Patricia Ferrer, Abhai K. Tripathi, Martha A. Clark, Carla Cerami Hand, Hugh Young Rienhoff, David J. Sullivan> ;Plos One. 2012 May 21
• 38 citations
  A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload
  Ellis J. Neufeld, Renzo Galanello, Vip Viprakasit, Yesim Aydinok, Antonio Piga, Paul Harmatz, Gian Luca Forni, Farrukh Shah, Rachael F. Grace, John B. Porter, John C. ...> ;Blood. 2012 Apr 5
• 30 citations
  A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload
  Hugh Y. Rienhoff, Vip Viprakasit, Lay Tay, Paul Harmatz, Elliott Vichinsky, Deborah Chirnomas, Janet L. Kwiatkowski, Amy E. Tapper, William Kramer, John B. Porter, Ell...> ;Haematologica. 2011 Apr 1
• 1 citations
  Genomewide association studies and assessment of risk of disease.
  Hugh Young Rienhoff> ;The New England Journal of Medicine. 2010 Nov 18
• 122 citations
  Dietary iron restriction or iron chelation protects from diabetes and loss of β-cell function in the obese (ob/ob lep−/−) mouse
  Robert C. Cooksey, Deborah Jones, Scott Gabrielsen, Jingyu Huang, Judith Simcox, Bai Luo, Yudi Soesanto, Hugh Rienhoff, E. Dale Abel, Donald A. McClain> ;American Journal of Physiology. Endocrinology and Metabolism. 2010 Mar 30
• 4 citations
  Iron-overload-related disease in HFE hereditary hemochromatosis.
  Hugh Young Rienhoff> ;The New England Journal of Medicine. 2008 May 22
• Will genetics revolutionize medicine?
  Sotos JG, Rienhoff HY> ;N. Engl. J. Med.. 2000-11-16
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Abstracts/Posters

• Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism
  Hugh Young Rienhoff Jr., 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Lectures

• The Fifth Annual Consumer Genetics Conference (CGC) 
  Consumer Genetics Conference (CGC), Boston, Massachusetts - 9/25/2013