HugoFernandezMD

Hematology • Hollywood, FL

Hematologic Oncology, Myeloproliferative Disorder Hematology-Oncology

Professor, Oncologic Sciences, USF-Morsani

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Office
603 N Flamingo Rd
Ste 151
Hollywood, FL 33028
Phone+1 954-265-4325

Fax+1 954-443-4747
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Education & Training

University of Miami/Jackson Health SystemFellowship, Hematology and Medical Oncology, 1991 - 1994
University of Miami/Jackson Health SystemResidency, Internal Medicine, 1987 - 1991
University of Florida College of MedicineClass of 1987

Certifications & Licensure

FL State Medical License 1988 - 2025

Clinical Trials

Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With AML Leukemia Start of enrollment: 2002 Dec 19
Completed
Phase 3
Dosing Study of Ara-C/EL625/Idarubicin in Refractory and Relapsed AML Start of enrollment: 2004 Apr 01
Completed
Phase 2
Melphalan+Bortezomib as a Conditioning Regimen for Autologous and Allogeneic Stem Cell Transplants in Multiple Myeloma Start of enrollment: 2009 Jun 18
Completed
Phase 2
Histone Deacetylase Inhibitor LBH589 in Addition to Corticosteroids in Patients With Acute Graft Versus Host Disease (GVHD) Start of enrollment: 2010 Apr 01
Completed
Phase 1, Phase 2
Reduced Intensity Regimen vs Myeloablative Regimen for Myeloid Leukemia or Myelodysplastic Syndrome (BMT CTN 0901) Start of enrollment: 2011 Jun 01
Terminated
Phase 3
Ofatumumab as Primary Therapy of Chronic Graft Versus Host Disease Start of enrollment: 2012 Nov 14
Completed
Phase 1, Phase 2
Ex-vivo Expanded Donor Regulatory T Cells for Prevention of Acute Graft-Versus-Host Disease Start of enrollment: 2014 Oct 29
Completed
Phase 1
Standard of Care +/- Midostaurin to Prevent Relapse Post Stem Cell Transplant in Patients With FLT3-ITD Mutated AML Start of enrollment: 2014 Feb 06
Completed
Phase 2
In Vivo Treg Expansion and Graft-Versus-Host Disease Prophylaxis Start of enrollment: 2014 Mar 25
Completed
Phase 2
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Publications & Presentations

PubMed

Sirolimus Is an Acceptable Alternative to Tacrolimus for Graft-versus-Host Disease Prophylaxis after Haploidentical Peripheral Blood Stem Cell Transplantation with Pos...
Elmariah, H., Otoukesh, S., Kumar, A., Ali, H., Arslan, S., Shouse, G., Pourhassan, H., Nishihori, T., Faramand, R., Mishra, A., Khimani, F., Fernandez, H., Lazaryan, ...> ;Transplantation and Cellular Therapy. 2024 Feb 1
Correction: Integrative analysis identifies an older female-linked AML patient group with better risk in ECOG-ACRIN Cancer Research Group's clinical trial E3999.
Franck Rapaport, Kenneth Seier, Yaseswini Neelamraju, Duane Hassane, Timour Baslan, Daniel T Gildea, Samuel Haddox, Tak Lee, H Moses Murdock, Caroline Sheridan, Alexis...> ;Blood Cancer Journal. 2023 Jul 6
1 citations
Obesity in adult acute myeloid leukemia is not associated with inferior response or survival even when dose capping anthracyclines: An ECOG-ACRIN analysis.
James M Foran, Zhuoxin Sun, Catherine Lai, Hugo F Fernandez, Larry D Cripe, Rhett P Ketterling, Janis Racevskis, Selina M Luger, Elisabeth Paietta, Hillard M Lazarus, ...> ;Cancer. 2023 Aug 15
1 citations
DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.
Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-B...> ;Blood. 2023 May 11
1 citations
Measurable residual disease by flow cytometry in acute myeloid leukemia is prognostic, independent of genomic profiling.
Chezi Ganzel, Zhuoxin Sun, Timour Baslan, Yanming Zhang, Mithat Gönen, Omar I Abdel-Wahab, Janis Racevskis, Francine Garrett-Bakelman, Scott W Lowe, Hugo F Fernandez, ...> ;Leukemia Research. 2022 Dec 1
51 citations
Eprenetapopt Plus Azacitidine After Allogeneic Hematopoietic Stem-Cell Transplantation for-Mutant Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Asmita Mishra, Roni Tamari, Amy E DeZern, Michael T Byrne, Mahasweta Gooptu, Yi-Bin Chen, H Joachim Deeg, David Sallman, Phillip Gallacher, Anders Wennborg, Denice K H...> ;Journal of Clinical Oncology. 2022 Dec 1
1 citations
Integrative analysis identifies an older female-linked AML patient group with better risk in ECOG-ACRIN Cancer Research Group's clinical trial E3999.
Franck Rapaport, Kenneth Seier, Yaseswini Neelamraju, Duane Hassane, Timour Baslan, Daniel T Gildea, Samuel Haddox, Tak Lee, H Moses Murdock, Caroline Sheridan, Alexis...> ;Blood Cancer Journal. 2022 Sep 23
5 citations
Variational autoencoders learn transferrable representations of metabolomics data.
Daniel P Gomari, Annalise Schweickart, Leandro Cerchietti, Elisabeth Paietta, Hugo Fernandez, Hassen Al-Amin, Karsten Suhre, Jan Krumsiek> ;Communications Biology. 2022 Jun 30
12 citations
CNS involvement in AML at diagnosis is rare and does not affect response or survival: data from 11 ECOG-ACRIN trials.
Chezi Ganzel, Ju-Whei Lee, Hugo F. Fernandez, Elisabeth Paietta, Selina M. Luger, Hillard M. Lazarus, Larry D. Cripe, Dan Douer, Peter H. Wiernik, Jacob M. Rowe, Marti...> ;Blood Advances. 2021 Nov 23
3 citations
Phase 2 multicenter trial of ofatumumab and prednisone as initial therapy of chronic graft-vs-host disease
Aleksandr Lazaryan, Stephanie J. Lee, Mukta Arora, Jongphil Kim, Brian C. Betts, Farhad Khimani, Taiga Nishihori, Nelli Bejanyan, Hien Liu, Mohamed A. Kharfan-Dabaja, ...> ;Blood Advances. 2021 Oct 14
9 citations
Objective and subjective physical function in allogeneic hematopoietic stem cell transplant recipients.
Asmita Mishra, Joseph Pidala, Ram Thapa, Brian C. Betts, Hugo F. Fernandez, Frederick L. Locke, Taiga Nishihori, Lia Perez, Xuefeng Wang, Claudio Anasetti, Heather S.L...> ;Bone Marrow Transplantation. 2021 Aug 11
5 citations
A phase 2 trial of the histone deacetylase inhibitor panobinostat for graft-versus-host disease prevention.
Lia Perez, Hugo F. Fernandez, Mohamed A. Kharfan-Dabaja, Farhad Khimani, Brian C. Betts, Asmita Mishra, Ernesto Ayala, Frederick L. Locke, Leonel Ochoa-Bayona, Michael...> ;Blood Advances. 2021 Jul 13
15 citations
TET2 and DNMT3A mutations exert divergent effects on DNA repair and sensitivity of leukemia cells to PARP inhibitors
Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Konstantin Golovine, Katherine Sullivan-Reed, Wangisa M.B. Dunuwille, Joseph Nacson, Michael Hulse, Kelsey ...> ;Cancer Research. 2021 Jul 2
8 citations
Prognostic effect of gender on outcome of treatment for adults with acute myeloid leukaemia.
Peter H. Wiernik, Zhuoxin Sun, Larry D. Cripe, Jacob M. Rowe, Hugo F. Fernandez, Selina M. Luger, Hillard M. Lazarus, Elisabeth Paietta, Martin S. Tallman, Mark R. Litzow> ;British Journal of Haematology. 2021 Jun 17
20 citations
A phase 2 trial of GVHD prophylaxis with PTCy, sirolimus, and MMF after peripheral blood haploidentical transplantation
Nelli Bejanyan, Joseph Pidala, Xuefeng Wang, Ram Thapa, Taiga Nishihori, Hany Elmariah, Aleksandr Lazaryan, Farhad Khimani, Marco L. Davila, Asmita Mishra, Rawan Faram...> ;Blood Advances. 2021 Mar 9
11 citations
ELN 2017 Genetic Risk Stratification Predicts Survival of Acute Myeloid Leukemia Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation
Doris K. Hansen, Jongphil Kim, Zachary J. Thompson, Mohammad Hussaini, Taiga Nishihori, Anam Ahmad, Hany Elmariah, Rawan Faramand, Asmita Mishra, Marco L. Davila, Farh...> ;Transplantation and Cellular Therapy. 2021 Mar 1
48 citations
Myeloablative versus Reduced-Intensity Conditioning for Hematopoietic Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndromes-Long-Term Follow...
Bart L. Scott, Marcelo C. Pasquini, Mingwei Fei, Raphael Fraser, Juan Wu, Steve Devine, David L. Porter, Richard T. Maziarz, Erica D. Warlick, Hugo F. Fernandez, Rober...> ;Transplantation and Cellular Therapy. 2021 Feb 26
15 citations
Impact of Conditioning Intensity and Genomics on Relapse After Allogeneic Transplantation for Patients With Myelodysplastic Syndrome
Laura W. Dillon, Gege Gui, Brent R. Logan, Mingwei Fei, Jack Ghannam, Yuesheng Li, Abel Licon, Edwin P. Alyea, Asad Bashey, Steven M. Devine, Hugo F. Fernandez, Sergio...> ;JCO Precision Oncology. 2021 Jan 25
75 citations
Midostaurin after allogeneic stem cell transplant in patients with FLT3-internal tandem duplication-positive acute myeloid leukemia.
Richard T. Maziarz, Mark Levis, Mrinal M. Patnaik, Bart L. Scott, Sanjay R. Mohan, Abhinav Deol, Scott D. Rowley, Dennis Dong Hwan Kim, Daniela Hernandez, Trivikram Ra...> ;Bone Marrow Transplantation. 2021 May 1
11 citations
TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment.
Bac Viet Le, Paulina Podszywalow-Bartnicka, Silvia Maifrede, Katherine Sullivan-Reed, Margaret Nieborowska-Skorska, Konstantin Golovine, Juo-Chin Yao, Reza Nejati, Kat...> ;Cell Reports. 2020 Oct 6
2 citations
Sole Upfront Therapy with Beclomethasone and Budesonide for Upper Gastrointestinal Acute Graft-versus-Host Disease
Chiara Frairia, Maura Nicolosi, J. Shapiro, Jongphil Kim, Brian C. Betts, Hugo F. Fernandez, Frederick L. Locke, Asmita Mishra, Taiga Nishihori, Jose L. Ochoa-Bayona, ...> ;Biology of Blood and Marrow Transplantation. 2020 Jul 1
233 citations
Impact of Conditioning Intensity of Allogeneic Transplantation for Acute Myeloid Leukemia With Genomic Evidence of Residual Disease
Christopher S. Hourigan, Laura W. Dillon, Gege Gui, Brent R. Logan, Mingwei Fei, Jack Ghannam, Yuesheng Li, Abel Licon, Edwin P. Alyea, Asad Bashey, H. Joachim Deeg, S...> ;Journal of Clinical Oncology. 2020 Apr 20
6 citations
Reduced-intensity fludarabine/melphalan confers similar survival to busulfan/fludarabine myeloablative regimens for patients with acute myeloid leukemia and myelodyspl...
Elizabeth DiMaggio, Jun-Min Zhou, Ryan J. Caddell, Rebecca Tombleson, Janelle Perkins, Claudio Anasetti, Farhad Khimani, Joseph Pidala, Taiga Nishihori, Lia Perez, Bri...> ;Leukemia & Lymphoma. 2020 Mar 5
1 citations
Complete Response of Primary Refractory ALK-Positive Large B-Cell Lymphoma Treated With Single-Agent Nivolumab.
Jose Sandoval-Sus, Amanda Brahim, Alina Khan, Yehuda E. Deutsch, Barbara Raphael, Ali Ansari-Lari, Hugo F. Fernandez, Luis E. Raez> ;Clinical Lymphoma, Myeloma & Leukemia. 2020 Mar 1
10 citations
Inhibition of the mutated c-KIT kinase in AML1-ETO–positive leukemia cells restores sensitivity to PARP inhibitor
Margaret Nieborowska-Skorska, Elisabeth Paietta, Ross L. Levine, Hugo F. Fernandez, Martin S. Tallman, Mark R. Litzow, Tomasz Skorski> ;Blood Advances. 2019 Dec 10
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Abstracts/Posters

Safety and Efficacy of Midostaurin in Combination with High-Dose Daunorubicin in 7+3 Induction for Acute Myeloid Leukemia with FLT3 Mutation
Hugo F. Fernandez, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Outcomes of Patients with Relapsed or Refractory Acute Myeloid Leukemia Receiving Hypomethylating Agent and Venetoclax
Hugo F. Fernandez, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Hypomethylating Agent and Venetoclax Combination Yields Comparable Outcomes to CPX-351 in Newly Diagnosed Acute Myeloid Leukemia
Hugo F. Fernandez, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Comparison of Overall Responses after Standard Induction with High Dose Daunorubicin Versus Standard Dose Daunorubicin with Gemtuzumab Ozogamicin in Favorable Risk Acu...
Hugo F. Fernandez, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Hypomethylating Agent and Venetoclax Combination Yields Comparable Outcomes to CPX-351 in Newly Diagnosed Acute Myeloid Leukemia
Hugo F. Fernandez, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Hepatic Veno-Occlusive Disease Following Sirolimus-Based Immune Suppression
Hugo Fernandez, MD, Nature, Orlando, FL, 12/9/2019
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Press Mentions

New Memorial Cancer Institute Puts World-Class Care Under One RoofOctober 19th, 2023
Health | Memorial Healthcare Unveils Its New, High-Tech Cancer Center in West BrowardNovember 24th, 2023

Hospital Affiliations

H. Lee Moffitt Cancer Center and Research InstituteTampa, Florida
Memorial Regional HospitalHollywood, Florida