Hyun-SikYangMD

PubMed

• Vascular contributions to cognitive decline: Beyond amyloid and tau in the Harvard aging brain study.
  Zahra Shirzadi, Rory Boyle, Wai-Ying W Yau, Gillian Coughlan, Jessie Fanglu Fu, Michael J Properzi, Rachel F Buckley, Hyun-Sik Yang, Catherine E Scanlon, Stephanie Hsi...> ;Journal of Cerebral Blood Flow and Metabolism. 2024 Mar 7
• Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians.
  Pei-Chuan Ho, Wai Haung Yu, Boon Lead Tee, Wan-Ping Lee, Clara Li, Yian Gu, Jennifer S Yokoyama, Dolly Reyes-Dumeyer, Yun-Beom Choi, Hyun-Sik Yang, Badri N Vardarajan,...> ;Alzheimer's & Dementia. 2024 Mar 1
• Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease.
  Hyun-Sik Yang, Wai-Ying W Yau, Becky C Carlyle, Bianca A Trombetta, Can Zhang, Zahra Shirzadi, Aaron P Schultz, Jeremy J Pruzin, Colleen D Fitzpatrick, Dylan R Kirn, J...> ;Brain. 2024 Feb 5
• Study Partner Report of Apathy in Older Adults is Associated with AD Biomarkers: Findings from the Harvard Aging Brain Study.
  Burling, J., Katz, Z., Yuan, Z., Munro, C., Mimmack, K., Ma, G., Hanseeuw, B., Papp, K., Amariglio, R., Vannini, P., Rentz, D., Quiroz, Y., Johnson, K., Sperling, R., ...> ;The American Journal of Geriatric Psychiatry. 2024 Jan 28
• Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults.
  Bernard J Hanseeuw, Heidi I L Jacobs, Aaron P Schultz, Rachel F Buckley, Michelle E Farrell, Nicolas J Guehl, John A Becker, Michael Properzi, Justin S Sanchez, Yakeel...> ;Neurology. 2023 Dec 12
• Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease.
  Hyun-Sik Yang, Ling Teng, Daniel Kang, Vilas Menon, Tian Ge, Hilary K Finucane, Aaron P Schultz, Michael Properzi, Hans-Ulrich Klein, Lori B Chibnik, Julie A Schneider...> ;Nature Communications. 2023 Nov 30
• 2 citations
  Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer's disease.
  Stephanie Langella, N Gil Barksdale, Daniel Vasquez, David Aguillon, Yinghua Chen, Yi Su, Natalia Acosta-Baena, Juliana Acosta-Uribe, Ana Y Baena, Gloria Garcia-Ospina...> ;Nature Communications. 2023 Aug 23
• Using community-based geographical information system (GIS) to recruit older Asian Americans in an Alzheimer's disease study.
  Haeok Lee, Hoehun Ha, Sejung Yim, Hyun-Sik Yang, Veronica Lee, Eunju Hong, Tiffany W Chow, Van Ta Park, Li-San Wang, Gyungah Jun, Yun-Beom Choi> ;BMJ Open. 2023 Aug 3
• 31 citations
  Multicellular communities are perturbed in the aging human brain and Alzheimer's disease.
  Anael Cain, Mariko Taga, Cristin McCabe, Gilad S Green, Idan Hekselman, Charles C White, Dylan I Lee, Pallavi Gaur, Orit Rozenblatt-Rosen, Feng Zhang, Esti Yeger-Lotem...> ;Nature Neuroscience. 2023 Jul 1
• Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease.
  Hyun-Sik Yang, Ling Teng, Daniel Kang, Vilas Menon, Tian Ge, Hilary K Finucane, Aaron P Schultz, Michael Properzi, Hans-Ulrich Klein, Lori B Chibnik, Julie A Schneider...> ;Medrxiv. 2023 Jun 5
• 4 citations
  Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.
  Muhammad Ali, Derek B Archer, Priyanka Gorijala, Daniel Western, Jigyasha Timsina, Maria V Fernández, Ting-Chen Wang, Claudia L Satizabal, Qiong Yang, Alexa S Beiser, ...> ;Acta Neuropathologica Communications. 2023 Apr 26
• 5 citations
  Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau.
  Maxime Van Egroo, Joost M Riphagen, Nicholas J Ashton, Shorena Janelidze, Reisa A Sperling, Keith A Johnson, Hyun-Sik Yang, David A Bennett, Kaj Blennow, Oskar Hansson...> ;Molecular Psychiatry. 2023 Jun 1
• 1 citations
  Utility of Amyloid Positron Emission Tomography Imaging in Older Adults With Epilepsy and Cognitive Decline.
  Rani A Sarkis, Seth A Gale, Hyun-Sik Yang, Alice D Lam, Tarun Singhal, Steven Cicero, Kim Willment, Scott M McGinnis> ;American Journal of Alzheimer's Disease and Other Dementias. 2023 Mar 9
• 35 citations
  LATE-NC staging in routine neuropathologic diagnosis: an update.
  White, C. L., Peter T Nelson, Edward B Lee, Matthew D Cykowski, Irina Alafuzoff, Konstantinos Arfanakis, Johannes Attems, Carol Brayne, Maria M Corrada, Brittany N Dug...> ;Acta Neuropathologica. 2023 Feb 1
• Case Study 6: The Diagnostic Challenge of a 75-Year-Old Man Who Had, Then Didn't Have, Then Did Have Alzheimer's Disease.
  Sergio A Ramírez-Salazar, Cassie MacRae, Mel B Feany, Michael Miller, Hyun-Sik Yang, Mary-Ellen Meadows, Scott M McGinnis, David Silbersweig, Seth A Gale, Kirk R Daffner> ;The Journal of Neuropsychiatry and Clinical Neurosciences. 2023 Jan 1
• 7 citations
  Tau Mediates Synergistic Influence of Vascular Risk and Aβ on Cognitive Decline.
  Wai-Ying Wendy Yau, Zahra Shirzadi, Hyun-Sik Yang, Akpevweoghene P Ikoba, Jennifer S Rabin, Michael J Properzi, Dylan R Kirn, Aaron P Schultz, Dorene M Rentz, Keith A ...> ;Annals of Neurology. 2022 Nov 1
• 1 citations
  Human Genetics Clarifies the Relationship Between Depression and Alzheimer's Disease.
  Hyun-Sik Yang> ;Biological Psychiatry. 2022 Jul 1
• 23 citations
  Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.
  Jaclyn M Eissman, Logan Dumitrescu, Emily R Mahoney, Alexandra N Smith, Shubhabrata Mukherjee, Michael L Lee, Phoebe Scollard, Seo Eun Choi, William S Bush, Corinne D ...> ;Brain. 2022 Jul 29
• 6 citations
  Association of β-Amyloid and Vascular Risk on Longitudinal Patterns of Brain Atrophy.
  Jennifer S Rabin, Jeremy Pruzin, Matthew Scott, Hyun-Sik Yang, Olivia Hampton, Stephanie Hsieh, Aaron P Schultz, Rachel F Buckley, Trey Hedden, Dorene Rentz, Keith A J...> ;Neurology. 2022 Jul 18
• 6 citations
  Brain microRNAs are associated with variation in cognitive trajectory in advanced age.
  Aliza P Wingo, Mengli Wang, Jiaqi Liu, Michael S Breen, Hyun-Sik Yang, Beisha Tang, Julie A Schneider, Nicholas T Seyfried, James J Lah, Allan I Levey, David A Bennett...> ;Translational Psychiatry. 2022 Feb 1
• 2 citations
  Physical activity is associated with increased resting-state functional connectivity in networks predictive of cognitive decline in clinically unimpaired older adults.
  Jeremy J Pruzin, Hannah Klein, Jennifer S Rabin, Aaron P Schultz, Dylan R Kirn, Hyun-Sik Yang, Rachel F Buckley, Mathew R Scott, Michael Properzi, Dorene M Rentz, Keit...> ;Alzheimer's & Dementia. 2022 Jan 1
• 38 citations
  Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer's disease brain.
  Hans-Ulrich Klein, Caroline Trumpff, Hyun-Sik Yang, Annie J. Lee, Martin Picard, David A. Bennett, Philip L. De Jager> ;Molecular Neurodegeneration. 2021 Nov 6
• 37 citations
  Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults.
  Hyun-Sik Yang, Can Zhang, Becky C. Carlyle, Sherri Y Zhen, Bianca A. Trombetta, Aaron P. Schultz, Jeremy J. Pruzin, Colleen D. Fitzpatrick, Wai-Ying W Yau, Dylan Kirn,...> ;Alzheimer's & Dementia. 2021 Jun 23
• 9 citations
  KL∗VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗4 carriers.
  Michael E. Belloy, Sarah J. Eger, Yann Le Guen, Valerio Napolioni, Kacie D. Deters, Hyun-Sik Yang, Marzia Antonella Scelsi, Tenielle Porter, Sarah-Naomi James, Andrew ...> ;Neurobiology of Aging. 2021 Jan 23
• 36 citations
  Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals.
  Jasmeer P. Chhatwal, Aaron P. Schultz, Yifan Dang, Beth L. Ostaszewski, Lei Liu, Hyun-Sik Yang, Keith A. Johnson, Reisa A. Sperling, Dennis J. Selkoe> ;Nature Communications. 2020 Nov 27
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Journal Articles

• Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease  
  Hyun-Sik Yang, Reisa Sperling, Matthew Schrag, Richard Mayeux, JAMA Neurology