IanMichealAhearnMDPhD

PubMed

• 2 citations
  Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation.
  David Liang, Liping Jiang, Sameer Ahmed Bhat, Sonia Missiroli, Mariasole Perrone, Angela Lauriola, Ritika Adhikari, Anish Gudur, Zahra Vasi, Ian Ahearn, Daniele Guarda...> ;Cell Reports. 2023 Jan 31
• 60 citations
  ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer
  Jiehui Deng, Aatish Thennavan, Igor Dolgalev, Ting Chen, Jie Li, Antonio Marzio, John T. Poirier, David H. Peng, Mirna Bulatović, Subhadip Mukhopadhyay, Heather Silver...> ;Nature Cancer. 2021 May 1
• 6 citations
  NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane.
  Ian M. Ahearn, Helen Court, Farid Ahmad Siddiqui, Daniel Abankwa, Mark R. Philips> ;Life Science Alliance. 2021 Feb 12
• 18 citations
  A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells.
  Xue Chen, Haidong Yao, Muhammad Kashif, Gwladys Revêchon, Maria Eriksson, Jianjiang Hu, Ting Wang, Yiran Liu, Elin Tüksammel, Staffan Strömblad, Ian M. Ahearn, Mark R....> ;Elife. 2021 Feb 2
• 8 citations
  Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.
  Mo Zhou, Leena Kuruvilla, Xiarong Shi, Stephen Viviano, Ian M. Ahearn, Caroline R. Amendola, Wenjuan Su, Sana Badri, James P. Mahaffey, Nicole Fehrenbacher, Jane A. Sk...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Dec 15
• 47 citations
  The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals.
  Elliot A. Philips, Antonio Garcia-España, Anna S Tocheva, Ian M. Ahearn, Kieran Adam, Ruimin Pan, Adam Mor, Xiang-Peng Kong> ;The Journal of Biological Chemistry. 2020 Apr 3
• 115 citations
  KRAS4A directly regulates hexokinase 1
  Caroline R. Amendola, James P. Mahaffey, Seth J. Parker, Ian M. Ahearn, Wei-Ching Chen, Mo Zhou, Helen Court, Jie Shi, Sebastian L. Mendoza, Michael J. Morten, Eli Rot...> ;Nature. 2019 Dec 11
• 55 citations
  Posttranslational Modifications of RAS Proteins
  Ian M. Ahearn, Mo Zhou, Mark R. Philips> ;Cold Spring Harbor Perspectives in Medicine. 2018 Nov 1
• 14 citations
  Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT
  Helen Court, Ian M. Ahearn, Marc Amoyel, Erika A. Bach, Mark R. Philips> ;The Journal of Cell Biology. 2017 Dec 4
• 41 citations
  VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking
  Mo Zhou, Heidi H. Wiener, Wenjuan Su, Yong Zhou, Caroline Liot, Ian M. Ahearn, John F. Hancock, Mark R. Philips> ;The Journal of Cell Biology. 2016 Aug 15
• 2 citations
  Linear atrophoderma of Moulin.
  Ian M. Ahearn, Julia K. Gittler, Marianna Shvartsbeyn, Shane A Meehan, Miriam Keltz Pomeranz> ;Dermatology Online Journal. 2015 Dec 16
• 12 citations
  Primary cutaneous follicle-center lymphoma.
  Ian M. Ahearn, Stephanie W Hu, Shane A Meehan, Jo-Ann Latkowski> ;Dermatology Online Journal. 2015 Jan 1
• 9 citations
  Metabolic labeling of Ras with tritiated palmitate to monitor palmitoylation and depalmitoylation.
  Frederick D. Tsai, Joseph Wynne, Ian M. Ahearn, Mark R. Philips> ;Methods in Molecular Biology. 2014 Jan 1
• 396 citations
  Regulating the regulator: post-translational modification of RAS
  Ian M. Ahearn, Kevin M. Haigis, Dafna Bar-Sagi, Mark R. Philips> ;Nature Reviews. Molecular Cell Biology. 2012 Jan 1
• 123 citations
  Single-walled carbon nanotubes deliver peptide antigen into dendritic cells and enhance IgG responses to tumor-associated antigens.
  Carlos H. Villa, Tao Dao, Ian M. Ahearn, Nicole Fehrenbacher, Emily Casey, Diego A. Rey, Tatyana Korontsvit, Victoriya Zakhaleva, Carl A. Batt, Mark R. Philips, David ...> ;ACS Nano. 2011 Jul 26
• 96 citations
  FKBP12 Binds to Acylated H-Ras and Promotes Depalmitoylation
  Ian M. Ahearn, Frederick D. Tsai, Helen Court, Mo Zhou, Benjamin C. Jennings, Mahiuddin Ahmed, Nicole Fehrenbacher, Maurine E. Linder, Mark R. Philips> ;Molecular Cell. 2011 Jan 21
• 35 citations
  Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane.
  Adam Mor, Joseph Wynne, Ian M. Ahearn, Michael L. Dustin, Guangwei Du, Mark R. Philips> ;Molecular and Cellular Biology. 2009 Jun 15
• 25 citations
  Topology of Mammalian Isoprenylcysteine Carboxyl Methyltransferase Determined in Live Cells with a Fluorescent Probe
  Latasha Wright, Helen Court, Adam Mor, Ian M. Ahearn, Patrick J. Casey, Mark R. Philips> ;Molecular and Cellular Biology. 2009 Apr 1
• 144 citations
  Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division
  David Michaelson, Wasif M. Abidi, Daniele Guardavaccaro, Mo Zhou, Ian M. Ahearn, Michele Pagano, Mark R. Philips> ;The Journal of Cell Biology. 2008 May 5
• 12 citations
  Analysis of K‐Ras Phosphorylation, Translocation, and Induction of Apoptosis
  Steven E. Quatela, Pamela J. Sung, Ian M. Ahearn, Trever G. Bivona, Mark R. Philips> ;Methods in Enzymology. 2008 Jan 1
• 377 citations
  PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.
  Trever G. Bivona, Steven E. Quatela, Brian O. Bodemann, Ian M. Ahearn, Michael J. Soskis, Adam Mor, John Miura, Heidi H. Wiener, Latasha Wright, Shahryar G Saba, Duke ...> ;Molecular Cell. 2006 Feb 17
• 146 citations
  Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion.
  Trever G. Bivona, Heidi H. Wiener, Ian M. Ahearn, Joseph Silletti, Vi K. Chiu, Mark R. Philips> ;The Journal of Cell Biology. 2004 Feb 2
• 339 citations
  Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1
  Trever G. Bivona, Ignacio Pérez de Castro, Ian M. Ahearn, Theresa M. Grana, Vi K. Chiu, Peter J. Lockyer, Peter J. Cullen, Angel Pellicer, Adrienne D. Cox, Mark R. Phi...> ;Nature. 2003 Aug 7
• 112 citations
  Membrane Trafficking of Heterotrimeric G Proteins via the Endoplasmic Reticulum and Golgi
  David Michaelson, Ian M. Ahearn, Martin O. Bergo, Stephen G. Young, Mark R. Philips> ;Molecular Biology of the Cell. 2002 Sep 1
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