IanFrankMD

Infectious Disease • Philadelphia, PA

HIV/AIDS Medicine

Professor, Medicine, Perelman School of Medicine

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Office
3610 Hamilton Walk
502 Johnson Pavilion
Philadelphia, PA 19104
Phone+1 215-662-7419

Fax+1 215-349-8011
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Education & Training

Geisel School of Medicine at DartmouthClass of 2012
University of Pennsylvania Health SystemFellowship, Infectious Disease, 1984 - 1989
Graduate HospitalResidency, Internal Medicine, 1981 - 1983
St. Joseph Medical CenterInternship, Internal Medicine, 1980 - 1981

Certifications & Licensure

PA State Medical License 1981 - 2024
ME State Medical License Active through 1996
TX State Medical License 1981 - 1981
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease

Awards, Honors, & Recognition

Philadelphia Magazine Castle Connolly, 2004-2014
America's Top Doctors Castle Connolly, 2002-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Super Doctor SuperDoctors.com
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Clinical Trials

The Safety and Effectiveness of Hydroxyurea and ddI Used Individually or Together in HIV-Infected Patients
Completed
Phase 1
Vaccine (ALVAC-HIV vCP1452) Use and Intermittent Withdrawal of Anti-HIV Drugs in Patients With HIV Start of enrollment: 2001 Feb 01
Completed
Phase 1, Phase 2
Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection Start of enrollment: 2014 Apr 28
Completed
Phase 2
Evaluating the Safety and Immunogenicity of Env (A,B,C,A/E)/Gag (C) DNA and gp120 (A,B,C,A/E) Protein/GLA-SE HIV Vaccines, Given Individually or Co-administered, in Healthy, HIV-1-Uninfected Adults Start of enrollment: 2018 Mar 16
Completed
Phase 1
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Publications & Presentations

PubMed

Safety and immunogenicity of a polyvalent DNA-protein HIV vaccine with matched Env immunogens delivered as a prime-boost regimen or coadministered in HIV-uninfected ad...
Ian Frank, Shuying S Li, Nicole Grunenberg, Edgar T Overton, Samuel T Robinson, Hua Zheng, Kelly E Seaton, Jack R Heptinstall, Mary A Allen, Kenneth H Mayer, Daniel A ...> ;The Lancet. HIV. 2024 May 1
3 citations
Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition.
Kelly E Seaton, Yunda Huang, Shelly Karuna, Jack R Heptinstall, Caroline Brackett, Kelvin Chiong, Lily Zhang, Nicole L Yates, Mark Sampson, Erika Rudnicki, Michal Jura...> ;Ebiomedicine. 2023 Jul 1
3 citations
Using a patient portal as a recruitment tool to diversify the pool of participants in COVID-19 vaccine clinical trials.
Tiffany Yuh, Tuhina Srivastava, Danielle Fiore, Harald Schmidt, Ian Frank, David Metzger, Florence Momplaisir> ;JAMIA Open. 2022 Dec 1
8 citations
Nucleocapsid-specific antibody function is associated with therapeutic benefits from COVID-19 convalescent plasma therapy.
Jonathan D Herman, Chuangqi Wang, John Stephen Burke, Yonatan Zur, Hacheming Compere, Jaewon Kang, Ryan Macvicar, Sabian Taylor, Sally Shin, Ian Frank, Don Siegel, Pab...> ;Cell Reports. Medicine. 2022 Nov 15
19 citations
SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations.
Elizabeth M Anderson, Shuk Hang Li, Moses Awofolaju, Theresa Eilola, Eileen Goodwin, Marcus J Bolton, Sigrid Gouma, Tomaz B Manzoni, Philip Hicks, Rishi R Goel, Mark M...> ;Cell Reports. 2022 Oct 18
5 citations
Lower SARS-CoV-2-specific humoral immunity in people living with HIV-1 recovered from nonhospitalized COVID-19.
Daniel J Schuster, Shelly Karuna, Caroline Brackett, Martina Wesley, Shuying S Li, Nathan Eisel, DeAnna Tenney, Sir'Tauria Hilliard, Nicole L Yates, Jack R Heptinstall...> ;JCI Insight. 2022 Nov 8
2 citations
Sexual behavior and medication adherence in men who have sex with men participating in a pre-exposure prophylaxis study of combinations of Maraviroc, Tenofovir Disopro...
Kenneth H Mayer, Krista Yuhas, K Rivet Amico, Timothy Wilkin, Raphael J Landovitz, Paul Richardson, Mark A Marzinke, Craig W Hendrix, Susan H Eshleman, Leslie M Cottle...> ;AIDS and Behavior. 2022 Dec 1
5 citations
A phase I trial of cyclosporine for hospitalized patients with COVID-19.
Emily A Blumberg, Julia Han Noll, Pablo Tebas, Joseph A Fraietta, Ian Frank, Amy Marshall, Anne Chew, Elizabeth A Veloso, Alison Carulli, Walter Rogal, Avery L Gaymon,...> ;JCI Insight. 2022 Jun 8
19 citations
Initial analysis of viral dynamics and circulating viral variants during the mRNA-1273 Phase 3 COVE trial.
Rolando Pajon, Yamuna D Paila, Bethany Girard, Groves Dixon, Katherine Kacena, Lindsey R Baden, Hana M El Sahly, Brandon Essink, Kathleen M Mullane, Ian Frank, Douglas...> ;Nature Medicine. 2022 Apr 1
3 citations
A retrospective study of HIV pre-exposure prophylaxis counselling among non-Hispanic Black youth diagnosed with bacterial sexually transmitted infections in the United...
Dovie L Watson, Pamela A Shaw, Danielle T Petsis, Julia Pickel, José A Bauermeister, Ian Frank, Sarah M Wood, Robert Gross> ;Journal of the International AIDS Society. 2022 Feb 1
24 citations
Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19.
Sokratis A Apostolidis, Amrita Sarkar, Heather M Giannini, Rishi R Goel, Divij Mathew, Aae Suzuki, Amy E Baxter, Allison R Greenplate, Cécile Alanio, Mohamed Abdel-Hak...> ;Frontiers in Immunology. 2022 Jan 1
15 citations
Neutralizing antibody responses over time in demographically and clinically diverse individuals recovered from SARS-CoV-2 infection in the United States and Peru: A co...
Shelly Karuna, Shuying Sue Li, Shannon Grant, Stephen R Walsh, Ian Frank, Martin Casapia, Meg Trahey, Ollivier Hyrien, Leigh Fisher, Maurine D Miner, April K Randhawa,...> ;Plos Medicine. 2021 Dec 1
39 citations
A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia.
Katharine J. Bar, Pamela A. Shaw, Grace H Choi, Nicole A. Aqui, Andrew D. Fesnak, Jasper B Yang, Haideliza Soto-Calderon, Lizette Grajales, Julie Starr, Michelle Andro...> ;The Journal of Clinical Investigation. 2021 Nov 17
502 citations
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.
Rishi R. Goel, Mark M Painter, Sokratis A. Apostolidis, Divij Mathew, Wenzhao Meng, Aaron M. Rosenfeld, Kendall A. Lundgreen, Arnold Reynaldi, David S. Khoury, Ajinkya...> ;Science. 2021 Oct 14
3 citations
Effects of a Health Promotion Intervention on Physical Activity in African American Men Living with HIV: Randomized Controlled Trial.
John B. Jemmott, Loretta Sweet Jemmott, Jingwen Zhang, Larry D. Icard, Terri-Ann Kelly, Ian Frank, Scarlett L. Bellamy> ;AIDS Patient Care and Stds. 2021 Oct 8
47 citations
mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern
Rishi R. Goel, Mark M Painter, Sokratis A. Apostolidis, Divij Mathew, Wenzhao Meng, Aaron M. Rosenfeld, Kendall A. Lundgreen, Arnold Reynaldi, David S. Khoury, Ajinkya...> ;Biorxiv. 2021 Aug 23
15 citations
Health care worker seromonitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration.
Sigrid Gouma, Madison E. Weirick, Marcus J. Bolton, Claudia P. Arevalo, Eileen C. Goodwin, Elizabeth M. Anderson, Christopher M McAllister, Shannon R. Christensen, Deb...> ;JCI Insight. 2021 Aug 23
16 citations
Rectal and vaginal tissue from intravenous VRC01 recipients show protection against ex vivo HIV-1 challenge
Rena D. Astronomo, Maria P. Lemos, Sandeep Narpala, Julie Czartoski, Lamar Ballweber Fleming, Kelly E. Seaton, Madhu Prabhakaran, Yunda Huang, Yiwen Lu, Katharine West...> ;The Journal of Clinical Investigation. 2021 Aug 16
252 citations
Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women
Raphael J. Landovitz, Deborah Donnell, Meredith E. Clement, Brett Hanscom, Leslie Cottle, Lara E. Coelho, Robinson Cabello, Suwat Chariyalertsak, Eileen F. Dunne, Ian ...> ;The New England Journal of Medicine. 2021 Aug 11
76 citations
Racial/Ethnic Differences in COVID-19 Vaccine Hesitancy Among Health Care Workers in 2 Large Academic Hospitals.
Florence Momplaisir, Barbara J. Kuter, Fatemeh Ghadimi, Safa Browne, Hervette Nkwihoreze, Kristen A. Feemster, Ian Frank, Walter Faig, Angela K. Shen, Paul A. Offit, J...> ;JAMA Network Open. 2021 Aug 2
132 citations
Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial
Myron S. Cohen, Ajay Nirula, Mark J. Mulligan, Richard M. Novak, Mary A. Marovich, Catherine Yen, Alexander Stemer, Stockton Mayer, David A. Wohl, Blair Brengle, Brian...> ;JAMA. 2021 Jul 6
5 citations
Identification of the predominant human NK cell effector subset mediating ADCC against HIV-infected targets coated with BNAbs or plasma from PLWH
Costin Tomescu, Kyle Kroll, Krystal Colon, Emmanouil Papasavvas, Ian Frank, Pablo Tebas, Karam Mounzer, Roger Keith Reeves, Luis J. Montaner> ;European Journal of Immunology. 2021 Jun 4
14 citations
Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19
Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Allison R. Greenplate, Cécile Alanio, Mohamed S. A...> ;Biorxiv. 2021 May 3
74 citations
Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1-2, dos...
Paul A. Goepfert, Bo Fu, Anne-Laure Chabanon, Matthew Bonaparte, Matthew Davis, Brandon Essink, Ian Frank, Owen Haney, Helene Janosczyk, Michael C. Keefer, Marguerite ...> ;The Lancet. Infectious Diseases. 2021 Apr 19
8 citations
Higher colorectal tissue HIV infectivity in cisgender women compared with MSM before and during oral preexposure prophylaxis.
Rogers Sekabira, Ian McGowan, Krista Yuhas, Rhonda M. Brand, Mark A. Marzinke, Yukari C. Manabe, Ian Frank, Joseph J. Eron, Raphael J. Landovitz, Peter A. Anton, Ross ...> ;AIDS. 2021 Apr 6
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Journal Articles

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-Exposure SARS-CoV-2 Prophylaxis Among Health Care Workers
Matthew C Hyman, Ian Frank, Scott E Hensley, Saar Gill, Dan T Vogl, Ivan Maillard, Daria V Babushok, Alexander C Huang, Sunita D Nasta, Jennifer C Walsh, Michael C Mil..., JAMA Internal Medicine

Press Mentions

Pro-Vaccine Study in ‘Science’ Linked to Pharmaceutical IndustryOctober 21st, 2021
Dogs Can Sniff Out COVID-19 CasesApril 18th, 2021
With Impressive Accuracy, Dogs Can Sniff Out CoronavirusApril 15th, 2021
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Hospital Affiliations

Hospital of the University of PennsylvaniaPhiladelphia, Pennsylvania
Penn Presbyterian Medical CenterPhiladelphia, Pennsylvania