IanRGrahamMD

PubMed

• 1 citations
  A risk-based approach to reducing exposure of staff to laboratory animal allergens.
  Westall, L., Graham, I. R., Bussell, J.> ;Lab animal. 2014 Dec 20
• 622 citations
  ESC/EAS Guidelines for the management of dyslipidaemias
  Alberico L. Catapano, Željko Reiner, Guy De Backer, Ian D. Graham, Marja-Riitta Taskinen, Olov Wiklund, Stefan Agewall, Eduardo Alegria, M. John Chapman, Paul N. Durri...> ;Atherosclerosis. 2011 Jul 1
• 4 citations
  Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle
  Vanessa C. Evans, Ian R. Graham, Takis Athanasopoulos, Deborah J. Galley, Christopher L. Jackson, Jonathan Paul Simons, George Dickson, James S. Owen> ;Metabolism. 2011 Apr 1
• 7 citations
  Bioinformatic and functional optimization of antisense phosphorodiamidate morpholino oligomers (PMOs) for therapeutic modulation of RNA splicing in muscle.
  Linda Popplewell, Ian R. Graham, Alberto Malerba, George Dickson> ;Methods in Molecular Biology. 2011 Jan 1
• 79 citations
  Chronic systemic therapy with low-dose morpholino oligomers ameliorates the pathology and normalizes locomotor behavior in mdx mice.
  Alberto Malerba, Paul S. Sharp, Ian R. Graham, Virginia Arechavala-Gomeza, Keith Foster, Francesco Muntoni, Dominic J. Wells, George Dickson> ;Molecular Therapy. 2011 Feb 1
• 25 citations
  Transcriptomic analysis of dystrophin RNAi knockdown reveals a central role for dystrophin in muscle differentiation and contractile apparatus organization.
  Mohammad Mahdi Ghahramani Seno, Capucine Trollet, Takis Athanasopoulos, Ian R. Graham, Pingzhao Hu, George Dickson> ;BMC Genomics. 2010 Jun 1
• 33 citations
  Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials.
  Linda Popplewell, C. Adkin, Virginia Arechavala-Gomeza, Annemieke Aartsma-Rus, Christa L. de Winter, Steve D. Wilton, Jennifer E. Morgan, Francesco Muntoni, Ian R. Gra...> ;Neuromuscular Disorders. 2010 Feb 1
• 2 citations
  Efficient liver-directed gene transfer by in situ generation of retroviral vector from adenoviral templates.
  Julian D. Harris, Michael L. Roberts, Dhayaneethie Perumal, Ian R. Graham, Steve Patterson, George Dickson> ;In Vivo. 2009 Nov 1
• 493 citations
  Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, p...
  Maria Kinali, Virginia Arechavala-Gomeza, Lucy Feng, Sebahattin Cirak, D. Hunt, C. Adkin, Michela Guglieri, Emma J. Ashton, Stephen Abbs, Petros Nihoyannopoulos, M. E....> ;The Lancet. Neurology. 2009 Oct 1
• 47 citations
  Dosing regimen has a significant impact on the efficiency of morpholino oligomer-induced exon skipping in mdx mice.
  Alberto Malerba, Francesca C. Thorogood, George Dickson, Ian R. Graham> ;Human Gene Therapy. 2009 Jul 2
• 58 citations
  Molecular, cellular and physiological investigation of myostatin propeptide-mediated muscle growth in adult mice.
  Antonios Matsakas, Keith Foster, Anthony Otto, Raymond Macharia, Mohamed I. Elashry, S. A. Feist, Ian R. Graham, Helen Foster, Paul J. Yaworsky, Frank S. Walsh, George...> ;Neuromuscular Disorders. 2009 Jul 1
• 27 citations
  Adeno-associated virus-8-mediated intravenous transfer of myostatin propeptide leads to systemic functional improvements of slow but not fast muscle.
  Keith Foster, Ian R. Graham, Anthony Otto, Helen Foster, Capucine Trollet, Paul J. Yaworsky, Frank S. Walsh, Dale C. Bickham, Nancy A. Curtin, Susannah L. Kawar, Ketan...> ;Rejuvenation Research. 2009 May 6
• 13 citations
  Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient m...
  Eyman Osman, Vanessa C. Evans, Ian R. Graham, Takis Athanasopoulos, Jenny McIntosh, Amit C. Nathwani, J. Paul Simons, George Dickson, James S. Owen> ;Atherosclerosis. 2009 May 1
• 60 citations
  Design of Phosphorodiamidate Morpholino Oligomers (PMOs) for the Induction of Exon Skipping of the Human DMD Gene
  Linda Popplewell, Capucine Trollet, George Dickson, Ian R. Graham> ;Molecular Therapy. 2009 Mar 1
• 87 citations
  Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer
  Helen Foster, Paul S. Sharp, Takis Athanasopoulos, Capucine Trollet, Ian R. Graham, Keith Foster, Dominic J. Wells, George Dickson> ;Molecular Therapy. 2008 Nov 1
• 5 citations
  Adenovirus-based targeting in myoblasts is hampered by nonhomologous vector integration.
  Olga Isman, Michael L. Roberts, Jennifer E. Morgan, Ian R. Graham, Kirstin Goldring, Diana J. Lawrence-Watt, Qi Long Lu, Matthew G. Dunckley, Andrew C.G. Porter, Teren...> ;Human Gene Therapy. 2008 Oct 28
• Adenovirus-based targeting in myoblasts is hampered by non-homologous vector integration.
  Isman, O., Roberts, M., Morgan, J., Graham, I.R., Goldring, K., Watt, D.J., Lu, Q., Dunckley, M.G., Porter, A.G., Partridge, T.A., Dickson, G.> ;Hum Gene Ther. 2008-08-05
• 12 citations
  Human apolipoprotein E expression from mouse skeletal muscle by electrotransfer of nonviral DNA (plasmid) and pseudotyped recombinant adeno-associated virus (AAV2/7)
  Vanessa C. Evans, Helen Foster, Ian R. Graham, Keith Foster, Takis Athanasopoulos, J. Paul Simons, George Dickson, James S. Owen> ;Human Gene Therapy. 2008 Jun 25
• 33 citations
  RNAi-mediated knockdown of dystrophin expression in adult mice does not lead to overt muscular dystrophy pathology
  Mohammad Mahdi Ghahramani Seno, Ian R. Graham, Takis Athanasopoulos, Capucine Trollet, Marita Pohlschmidt, Mark R. Crompton, George Dickson> ;Human Molecular Genetics. 2008 Sep 1
• 119 citations
  Comparative analysis of antisense oligonucleotide sequences for targeted skipping of exon 51 during dystrophin pre-mRNA splicing in human muscle
  Virginia Arechavala-Gomeza, Ian R. Graham, Linda Popplewell, Abbie M. Adams, Annemieke Aartsma-Rus, Maria Kinali, Jennifer E. Morgan, J.C. Van Deutekom, Steve D. Wilto...> ;Human Gene Therapy. 2007 Oct 4
• 453 citations
  European guidelines on cardiovascular disease prevention in clinical practice: executive summary.
  Ian D. Graham> ;Atherosclerosis. 2007 Sep 1
• 10 citations
  Apolipoprotein E delivery by peritoneal implantation of encapsulated recombinant cells improves the hyperlipidaemic profile in apoE-deficient mice.
  Aristides D. Tagalakis, Ivan Diakonov, Ian R. Graham, Karen A Heald, Julian D. Harris, Jane V Mulcahy, George Dickson, James S. Owen> ;Biochimica Et Biophysica Acta. 2005 Jan 5
• 23 citations
  Towards a therapeutic inhibition of dystrophin exon 23 splicing in mdx mouse muscle induced by antisense oligoribonucleotides (splicomers): target sequence optimisatio...
  Ian R. Graham, Vanessa J. Hill, Muthiah Manoharan, Gopal B. Inamati, George Dickson> ;The Journal of Gene Medicine. 2004 Oct 1
• 47 citations
  Recombinant adeno-associated viral (rAAV) vectors as therapeutic tools for Duchenne muscular dystrophy (DMD)
  Takis Athanasopoulos, Ian R. Graham, Helen Foster, George Dickson> ;Gene Therapy. 2004 Oct 1
• 427 citations
  European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevent...
  Guy De Backer, Ettore Ambrosioni, Knut Borch-Johnsen, Carlos Brotons, Renata Cifkova, Jean Dallongeville, Shah Ebrahim, Ole Faergeman, I. M. Graham, Giuseppe Mancia, V...> ;Atherosclerosis. 2004 Apr 1
• Join now to see all