IkuoHiranoMD

Gastroenterology • Chicago, IL

Esophagus Disease

Professor in Medicine-Gastroenterology and Hepatology, Northwestern University Medical School

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Office
259 East Erie (Lavin Building)
Suite 1600
Chicago, IL 60611
Phone+1 312-695-5620

Fax+1 312-695-3999
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Summary

Dr. Ikuo Hirano is a gastroenterologist in Chicago, IL and is affiliated with Northwestern Memorial Hospital. He received his medical degree from Perelman School of Medicine at the University of Pennsylvania and has been in practice 27 years. He specializes in esophagus disease and is experienced in general gastroenterology, colonoscopy, biliary tract disease, esophageal disease, and pancreatic disease. He has more than 100 publications and over 500 citings.

Education & Training

Beth Israel Deaconess Medical CenterFellowship, Gastroenterology, 1992 - 1995
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1990 - 1992
Perelman School of Medicine at the University of PennsylvaniaClass of 1990

Certifications & Licensure

IL State Medical License 1998 - 2026
MA State Medical License 1992 - 2004
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Feinberg Academy of Medical Educators (FAME) Outstanding Teacher Award Northwestern University Feinberg School of Medicine, 2015
Gastroenterology and Hepatology Fellowship Teaching Award Northwestern University Feinberg School of Medicine, 2015
David Graham Lecture American College of Gastroenterology, 2015
Distinguished Service Award Division of Gastroenterology Northwestern University, 2013
Northwestern University School of Medicine Outstanding Achievement in Gastroenterology Northwestern University School of Medicine, 2002
Fellow (AGAF) American Gastroenterological Association, 2012
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2011
Member Best Doctors
Super Doctor SuperDoctors.com
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Clinical Trials

Development, Validation and Evaluation of an Adult and Pediatric Eosinophilic Esophagitis Activity Index Start of enrollment: 2011 Jan 01
Unknown status
Registry for Eosinophilic Gastrointestinal Disorders (REGID) Start of enrollment: 2012 Nov 01
Completed
Safety and Tolerability Study of Oral EUR-1100 to Treat Eosinophilic Esophagitis Start of enrollment: 2011 Sep 01
Completed
Phase 1, Phase 2
A Six Month, Safety Follow-up Study in Eosinophilic Esophagitis Subjects Who Completed Study PR-021 Start of enrollment: 2012 Jan 01
Completed
OBS in Adolescent and Adults With EOE: A Phase II, Randomized, Double-Blind, Placebo Controlled, Study With an Open Label Extension Start of enrollment: 2012 Jul 23
Completed
Phase 2
Esophageal String Test in Eosinophilic Esophagitis Start of enrollment: 2009 Jan 01
Active, not recruiting
OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages Start of enrollment: 2015 Jul 17
Recruiting
SOFEED: Six Food vs. One Food Eosinophilic Esophagitis Diet Study Start of enrollment: 2016 May 20
Completed
Phase 2, Phase 3
An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE) Start of enrollment: 2017 May 23
Completed
Phase 2
Mepo for Eosinophilic Esophagitis (EoE) Study Start of enrollment: 2019 Mar 20
Completed
Phase 2
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Publications & Presentations

PubMed

A Multicenter Long-Term Cohort Study of Eosinophilic Esophagitis Variants and Their Progression to Eosinophilic Esophagitis Over Time.
Thomas Greuter, Alex Straumann, Yuniel Fernandez-Marrero, Nina Germic, Aref Hosseini, Apinya Chanwangpong, Shida Yousefi, Dagmar Simon, Margaret H Collins, Christian B...> ;Clinical and Translational Gastroenterology. 2024 Apr 1
Tapinarof validates the aryl hydrocarbon receptor as a therapeutic target: A clinical review.
Jonathan I Silverberg, Mark Boguniewicz, Francisco J Quintana, Rachael A Clark, Lara Gross, Ikuo Hirano, Anna M Tallman, Philip M Brown, Doral Fredericks, David S Rube...> ;The Journal of Allergy and Clinical Immunology. 2023 Dec 27
2 citations
Dupilumab demonstrated efficacy and was well tolerated regardless of prior use of swallowed topical corticosteroids in adolescent and adult patients with eosinophilic ...
Bredenoord, A., Lucendo, A., Schlag, C., Sun, X., Mannent, L., Maloney, J., Laws, E., Mortensen, E., Shabbir, A., Hirano, I., Glotfelty, L., Dellon, E.> ;Gut. 2024 Feb 23
1 citations
Composite score of physiomechanical esophageal function using functional lumen imaging probe panometry in eosinophilic esophagitis.
Dustin A Carlson, Ikuo Hirano, Nirmala Gonsalves, Peter J Kahrilas, Isis K Araujo, Mira Yang, Marie-Pier Tetreault, John E Pandolfino> ;Gastrointestinal Endoscopy. 2024 Apr 1
1 citations
Pooled Phase 2 and 3 Efficacy and Safety Data on Budesonide Oral Suspension in Adolescents with Eosinophilic Esophagitis.
Vincent A Mukkada, Sandeep K Gupta, Benjamin D Gold, Evan S Dellon, Margaret H Collins, David A Katzka, Gary W Falk, James Williams, Wenwen Zhang, Mena Boules, Ikuo Hi...> ;Journal of Pediatric Gastroenterology and Nutrition. 2023 Dec 1
Comparing the relative efficacy of therapeutics for eosinophilic oesophagitis: is counting eosinophils the right target?
Ikuo Hirano, David Katzka> ;Gut. 2023 Nov 1
1 citations
Ascending to New Heights for Novel Therapeutics for Eosinophilic Esophagitis.
Ikuo Hirano, Evan S Dellon, Gary W Falk, Nirmala P Gonsalves, Glenn T Furuta, Albert J Bredenoord> ;Gastroenterology. 2024 Jan 1
3 citations
Efficacy and safety of dupilumab up to 52 weeks in adults and adolescents with eosinophilic oesophagitis (LIBERTY EoE TREET study): a multicentre, double-blind, random...
Marc E Rothenberg, Evan S Dellon, Margaret H Collins, Ikuo Hirano, Mirna Chehade, Albert J Bredenoord, Alfredo J Lucendo, Jonathan M Spergel, Xian Sun, Jennifer D Hami...> ;The Lancet. Gastroenterology & Hepatology. 2023 Nov 1
7 citations
Prospective study of an amino acid-based elemental diet in an eosinophilic gastritis and gastroenteritis nutrition trial.
Nirmala Gonsalves, Bethany Doerfler, Angelika Zalewski, Guang-Yu Yang, Lisa J Martin, Xue Zhang, Tetsuo Shoda, Michael Brusilovsky, Seema Aceves, Kathy Thompson, Amand...> ;The Journal of Allergy and Clinical Immunology. 2023 Sep 1
11 citations
Mepolizumab for treatment of adolescents and adults with eosinophilic oesophagitis: a multicentre, randomised, double-blind, placebo-controlled clinical trial.
Evan S Dellon, Kathryn A Peterson, Benjamin L Mitlyng, Alina Iuga, Christine E Bookhout, Lindsay M Cortright, Kacie B Walker, Timothy S Gee, Sarah J McGee, Brenderia A...> ;Gut. 2023 Oct 1
1 citations
A PhysioMechanical Model of Esophageal Function in Eosinophilic Esophagitis.
Dustin A Carlson, Ikuo Hirano, Nirmala Gonsalves, Peter J Kahrilas, Isis K Araujo, Mira Yang, Marie-Pier Tetreault, John E Pandolfino> ;Gastroenterology. 2023 Sep 1
Bulk T-cell receptor sequencing confirms clonality in pediatric eosinophilic esophagitis and identifies a food-specific repertoire.
Rethavathi Janarthanam, Fei Li Kuang, Angelika Zalewski, Katie Amsden, Ming-Yu Wang, Lorena Ostilla, Kaitlyn Keeley, Ikuo Hirano, Amir Kagalwalla, Barry K Wershil, Nir...> ;Allergy. 2023 Sep 1
3 citations
Epidemiologic Burden and Projections for Eosinophilic Esophagitis-Associated Emergency Department Visits in the United States: 2009-2030.
Angela Y Lam, Jeffrey K Lee, Stephanie Coward, Gilaad G Kaplan, Evan S Dellon, Albert J Bredenoord, Vipul Jairath, Eileen Crowley, Milli Gupta, Humberto Jijon, Yasmin ...> ;Clinical Gastroenterology and Hepatology. 2023 Nov 1
2 citations
The Severity of Reduced Esophageal Distensibility Parallels Eosinophilic Esophagitis Disease Duration.
Isis K Araujo, Cristina Shehata, Ikuo Hirano, Nimala Gonsalves, Peter J Kahrilas, Marie-Pier Tetreault, Jacob M Schauer, Domenico Farina, Stephanie Peterson, Wenjun Ko...> ;Clinical Gastroenterology and Hepatology. 2024 Mar 1
Editorial: safety of topical steroids designed specifically for eosinophilic oesophagitis - new data bring new questions. Authors' reply.
Ikuo Hirano, Evan S Dellon, Sandeep K Gupta, David A Katzka, Margaret H Collins, Abigail M Wojtowicz, Brian Terreri, Wenwen Zhang, Mena Boules, Siddharth Bhatia, Nirav...> ;Alimentary Pharmacology & Therapeutics. 2023 May 1
2 citations
Esophageal Epithelium and Lamina Propria Are Unevenly Involved in Eosinophilic Esophagitis.
Girish Hiremath, Lili Sun, Margaret H Collins, Peter A Bonis, Nicoleta C Arva, Kelley E Capocelli, Mirna Chehade, Carla M Davis, Gary W Falk, Nirmala Gonsalves, Sandee...> ;Clinical Gastroenterology and Hepatology. 2023 Oct 1
6 citations
Safety of an investigational formulation of budesonide (budesonide oral suspension) for eosinophilic oesophagitis: an integrated safety analysis of six phase 1-3 clini...
Ikuo Hirano, Evan S Dellon, Sandeep K Gupta, David A Katzka, Margaret H Collins, Abigail M Wojtowicz, Brian Terreri, Wenwen Zhang, Mena Boules, Siddharth Bhatia, Nirav...> ;Alimentary Pharmacology & Therapeutics. 2023 May 1
15 citations
One-food versus six-food elimination diet therapy for the treatment of eosinophilic oesophagitis: a multicentre, randomised, open-label trial.
Kara L Kliewer, Nirmala Gonsalves, Evan S Dellon, David A Katzka, Juan P Abonia, Seema S Aceves, Nicoleta C Arva, John A Besse, Peter A Bonis, Julie M Caldwell, Kelley...> ;The Lancet. Gastroenterology & Hepatology. 2023 May 1
3 citations
Dysphagia Days as an Assessment of Clinical Treatment Outcome in Eosinophilic Esophagitis.
Ikuo Hirano, Marc E Rothenberg, Sandra Zhang, Claudia de Oliveira, Christina M Charriez, Karin S Coyne, Elizabeth Dansie Bacci, Evan S Dellon> ;The American Journal of Gastroenterology. 2023 Apr 1
2 citations
Quality Indicators for the Diagnosis and Management of Eosinophilic Esophagitis.
David A Leiman, Afrin N Kamal, Fouad Otaki, Albert J Bredenoord, Evan S Dellon, Gary W Falk, Nielsen Q Fernandez-Becker, Nirmala Gonsalves, Ikuo Hirano, David A Katzka...> ;The American Journal of Gastroenterology. 2023 Jun 1
3 citations
Measuring esophageal compliance using functional lumen imaging probe to assess remodeling in eosinophilic esophagitis.
Sarvee Moosavi, Christina Shehata, Wenjun Kou, Ikuo Hirano, Nirmala Gonsalves, Stephanie Peterson, John E Pandolfino, Dustin A Carlson> ;Neurogastroenterology and Motility. 2023 Apr 1
12 citations
Monitoring Patients With Eosinophilic Esophagitis in Routine Clinical Practice - International Expert Recommendations.
Ulrike von Arnim, Luc Biedermann, Seema S Aceves, Peter A Bonis, Margaret H Collins, Evan S Dellon, Glenn T Furuta, Nirmala Gonsalves, Sandeep Gupta, Ikuo Hirano, Alfr...> ;Clinical Gastroenterology and Hepatology. 2023 Sep 1
3 citations
Mucosal Microbiota Associated With Eosinophilic Esophagitis and Eosinophilic Gastritis.
Glenn T Furuta, Sophie A Fillon, Kayla M Williamson, Charles E Robertson, Mark J Stevens, Seema S Aceves, Nicoleta C Arva, Mirna Chehade, Margaret H Collins, Carla M D...> ;Journal of Pediatric Gastroenterology and Nutrition. 2023 Mar 1
16 citations
Clinical guidance for the use of dupilumab in eosinophilic esophagitis: A yardstick.
Seema S Aceves, Evan S Dellon, Matthew Greenhawt, Ikuo Hirano, Chris A Liacouras, Jonathan M Spergel> ;Annals of Allergy, Asthma & Immunology. 2023 Mar 1
3 citations
"Imaging Findings of Eosinophilic Gastrointestinal Diseases in Adults".
Camila Lopes Vendrami, Linda Kelahan, David J Escobar, Lori Goodhartz, Nancy Hammond, Paul Nikolaidis, Guang-Yu Yang, Ikuo Hirano, Frank H Miller> ;Current Problems in Diagnostic Radiology. 2022 Nov 22
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Journal Articles

Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis
Evan S Dellon, Kathryn A Peterson, Gary W Falk, Nirmala Gonsalves, Michael Vaezi, Adam C Bledsoe, Alan T Chang, Ikuo Hirano, The New England Journal of Medicine
RPC4046 in Patients with Eosinophilic Esophagitis
Evan S Dellon, Ikuo Hirano, Clinical Gastroenterology and Hepatology

Lectures