Ira Jay Goldberg MD

PubMed

• Cardiac ischemia/reperfusion increases cardiomyocyte KLF5 in pigs and mice that aggravates tissue injury and remodeling.
  Nikolaos Mylonas, Georgios Siokatas, Effimia Zacharia, Christine Pol, Tyler Rolland
  Cardiovascular Research. 2025-03-13
• Temporal Effects of Plozasiran on Lipids and Lipoproteins in Persistent Chylomicronemia.
  Gerald F Watts, Robert A Hegele, Robert S Rosenson, Ira J Goldberg, Antonio Gallo
  Circulation. 2025-03-11
• Microvascular insulin resistance with enhanced muscle glucose disposal in CD36 deficiency.
  Cyndya A Shibao, Vivek S Peche, Terri A Pietka, Dmitri Samovski, Ian M Williams
  Diabetologia. 2025-03-01

Journal Articles

• Myeloperoxidase: A Therapeutic Target for Preventing Insulin Resistance and the Metabolic Sequelae of Obesity?  
  Heinecke JW, Goldberg IJ, Diabetes, 1/1/2014
• Cardiac Metabolic Compensation to Hypertension Requires Lipoprotein Lipase  
  Yamashita H, KG. Bharadwaj, S Ikeda, T-S Park, IJ Goldberg, A J Physio, Endo/Metab, 1/1/2008
• In vivo arterial lipoprotein lipase expression augments inflammatory responses and impairs vascular dilatation  
  Takahashi M, M Yokoyama, Y Hiyama, Y Hu, K Melford, A Bensadoun, IJ Goldberg, ATVB, 1/1/2008
• Decreased lipoprotein clearance is responsible for increased cholesterol in streptozotocin treated LDL receptor knockout mice  
  Goldberg IJ, Y Hu, HL Noh, J Wei, LA Huggins, MG. Rackmill, H Hamai, BN Reid, WS Blaner L-S Huang, Diabetes, 1/1/2008
• Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice  
  Mzhavia N, S Yu, S Ikeda, TT Chu, IJ Goldberg, HM Dansky, Diabetes, 1/1/2008
• Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids and Ame...  
  Reid BN, GP Ables, OA Otlivanchik, G Schoiswohl, R Zechner, WS Blaner, IJ Goldberg, RF Schwabe, SC Chua, Jr., L-S Huang, J Biol Chem, 1/1/2008
• ABCG1 and HDL protect against endothelial dysfunction induced by a high-cholesterol diet  
  Terasaka N, S Yu, L Yvan-Charvet, N Wang, N Mzhavia, R Langlois, T Pagler, R Li, CL Welch, IJ Goldberg, AR. Tall, J Clin Invest, 1/1/2008
• Hypertriglyceridemia-induced pancreatitis created by oral estrogen and in vitro fertilization ovulation induction  
  Lee, J, IJ Goldberg, J Clin Lipid, 1/1/2008
• Challenges to the diagnosis, evaluation, treatment and management of clustered cardiometabolic risk factors  
  Wilson PWF, HR Black, A Fabricatore, IJ Goldberg, Journal of the CardioMetabolic Syndrome, 1/1/2008
• Lipoprotein lipase-derived fatty acids  
  Lee J, IJ Goldberg, Physiology and Dysfunction Current Hypertension Reports, 1/1/2008
• Effects of diabetes on murine lipoproteins and vascular disease  
  Dansky, HM, IJ Goldberg, Curr Drug Targets, 1/1/2007
• Lipids in the heart, a source of fuel and a source of toxins  
  Park, T-S, H Yamashita, WS Blaner, IJ Goldberg, Current Opinion in Lipidology, 1/1/2007
• Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction  
  Son N-H, K Okajima, H Yamashita, M Yokoyama, LA Huggins, S Homma, MJ Szabolcs, L-S Huang, IJ Goldberg, J Clin Invest, 1/1/2007
• Cholesterol uptake into heart and skeletal muscle of lipoprotein lipase transgenic mice: Evidence that statin therapy increases muscle lipid uptake  
  Yokoyama M, T Seo, T-S Park, H Yagyu, Y Hu, N-H Son, AS Augustus, RK Vikramadithyan, R Ramakrishnan, LK Pulawa, R H. Eckel, IJ Goldberg, J Lipid Res, 1/1/2007
• Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction  
  Noh H-L, K Okajima, JD Molkentin, S Homma, IJ Goldberg, A J Physio Endo/Metab, 1/1/2006
• Glucose intolerance in mice with dominant-negative mutation of CEACAM1  
  Park S-Y, Y-R Cho, H-J Kim, E-G Hong, T Higashimori, S J Lee, IJ Goldberg, GI Shulman, SM Najar, JK Kim, A J Physio Endo/Metab, 1/1/2006
• Diabetic vascular disease, an experimental objective  
  Goldberg IJ, HM Dansky, Arterio Thromb Vasc Biol, 1/1/2006
• Ins and outs modulating hepatic triglyceride and development of non-alcoholic fatty liver disease  
  Goldberg IJ and HN Ginsberg, Gastro, 1/1/2006
• Addition of dietary fat to cholesterol in the diets of LDL receptor knockout mice: Effects on plasma insulin, lipoproteins and atherosclerosis  
  Wu L, R Vikramadithyan, S Yu, C Pau, Y Hu, IJ Goldberg, HM Dansky, J Lipid Res, 1/1/2006
• Inhibition of pancreatic lipase by poloxamer 407 may provide an adjunct treatment strategy for weight loss  
  Johnston TP, IJ Goldberg, J Pharmacy Pharmacology, 1/1/2006
• Novel inflammatory role for glycogen synthase-3beta in the inhibition of TNF-alpha and IL-1beta induced inflammatory gene expression  
  Vines A, S Cahoon, I Goldberg, U Saxena U, S Pillarisetti, J. Biol Chem, 1/1/2006
• Commentary on OmniHeart Trial  
  Karmally W, and IJ Goldberg, Nature Clinical Practice Cardiovascular Medicine, 1/1/2006
• Perfusion of hearts with artificial lipid emulsions reproduces the metabolic abnormalities in lipotoxic cardiomyopathy  
  Pillutla P, YC Hwang, T Wright, A Augustus, M Yokoyama, TP Johnston, R Ramasamy, IJ Goldberg, Am J Physiol Endocrinol Metab, 1/1/2005
• Retinoid absorption and storage is impaired in mice lacking lecithin:retinal acyltransferase (LRAT)  
  O’Byrne SM, N Wong, JM Libien, S Vogel, IJ Goldberg, W Baehr, K Palczewski, WS Blaner, J Biol Chem, 1/1/2005
• Peroxisome Proliferator Activated Receptor Agonists Modulate Heart Function in Transgenic Mice with Lipotoxic Cardiomyopathy  
  Vikramadithyan RK, K Hirata, H Yagyu, A Augustus, Y Hu, S Homma, IJ Goldberg, J Pharmacol Exp Ther, 1/1/2005
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Books/Book Chapters

• Cardiac Energy Metabolism in Health and Disease. 
  Chapter: Lipoproteins: A Source of Cardiac Lipids. 
  Page 15 - 33K Drosatos, IJ GoldbergEditors: Gary D. Lopaschuk, Naranjan S.Dhalla.Springer2014
• Williams Endocrinology 
  Chapter: Chapter 37: Lipid and lipoprotein disorders. 
  Page 1633 - 1674Semenkovich C, A Goldberg, IJ Goldberg2011
• Therapeutic Lipidology 
  Chapter: Management of Hypertriglyceridemia. 
  Page 201 - 220Labossiere R and IJ GoldbergEditors: MH Davidson, PP Toth, KC Maki.Humana Press2007
• Difficult cases in endocrinology. 
  Chapter: Disorders of lipoprotein metabolism. 
  Goldberg IJ, Bukberg PEditors: M. Molitch.Humana Press2002
• Principles of Diabetes Mellitus. 
  Chapter: Chapter 11: Hyperlipidemia: pathogenesis and management in diabetes mellitus. 
  Page 459 - 472Goldberg IJEditors: L Poretsky.Kluwer, Boston, MA2002
• Harrison's Principles of Internal Medicine 
  Chapter: Chapter 344: Disorders of Lipoprotein Metabolism. 
  Page 2245 - 2256Ginsberg H.N. and I.J. GoldbergEditors: Fauci AS, E Braunwald, KJ Isselbacher, L Jameson, JB Martin, DL Kasper, SL Hauser and DL Longo.Edition 15th,2001
• Principles and Practice of Endocrinology and Metabolism 
  Chapter: Chapter 165: Endocrine effects on lipids, 
  Page 1538 - 1543Ginsberg HN, IJ Goldberg, C TuckEditors: KL Becker.Lippincott Williams and Wilkins; Silverchair Science and Communications, Inc., Philadelphia, PA; Chalottesville, VA2001
• Handbook of Physiology 
  Chapter: The pancreas and lipoprotein metabolism. 
  Page 675 - 706Ginsberg HN and IJ Goldberg2001
• Lipoproteins in Health and Diseases 
  Chapter: The VLDL cascade system. The assembly, secretion, and intravascular metabolism of apoprotein B containing lipoproteins. 
  Page 55 - 70Ginsberg HN, JL Dixon and IJ GoldbergEditors: Bretteridge JD, DR Illingsworth, and J Shephard.Arnold1999
• Plasma lipids and their role in disease. 
  Chapter: Endothelial lipases in disease. 
  Page 203 - 216Goldberg IJ and CH TuckEditors: P Barter and K-A Rye.Harwood Academic Publishers1999
• Atherosclerosis XI 
  Chapter: Lipoprotein association with cells and matrix: modulation by lipase and proteoglycans. 
  Page 887 - 894Goldberg IJ, S Pillarisetti, WS Blaner, WD Wagner and JC RutledgeEditors: Jacotot B, D. Mathe, J-C Fuchart.Elsevier, Amsterdam1998
• Harrison's Principles of Internal Medicine 
  Chapter: Disorders of Lipoprotein Metabolism. 
  Page 2138 - 2149Ginsberg H.N. and IJ GoldbergEditors: Fauci AS, E Braunwald, KJ Isselbacher, JD Wilson, JB Martin, DL Kasper, SL Hauser and DL Longo.Edition 14th,1997
• Atlas of Heart Disease 
  Chapter: Diabetes and vascular disease risk. 
  Goldberg, IJ and HN GinsbergEditors: W.V.Brown (Section Editor); E. Braunwald (Series Editor).Current Medicine, Philadelphia, PA1996
• Atherosclerosis X 
  Chapter: Lipoprotein lipse binding to endothelial cells: Specific protein-protein and protein glycosaminoglycan interactions. 
  Page 1075 - 1079Goldberg IJ, P Sivaram, SY Choi, N Parthasarathy, and WD WagnerEditors: FP Woodford, J Davignon, and A. Sniderman.Elsevier, Amsterdam1995
• Lipoprotein Disorders. 
  Chapter: Medical Knowledge Self-Assessment Program (MKSAP) X - Endo-crinology & Metabolism Section, 
  Page 1075 - 1079Goldberg IJEditors: L. Landsberg.American College of Physicians, Philadelphia, PA1995
• High density lipoproteins and atherosclerosis III. 
  Chapter: Role of the kidney in increased clearance of apolipoprotein A-I in subjects with reduced high density lipoprotein cholesterol concentrations. 
  Page 215 - 222Horowitz BS, IJ Goldberg, J Merab, T Vanni, R Ramakrishnan and HN GinsbergEditors: NE Miller and AR Tall.Elsevier Science Publishers BN1992
• Clinical management of high blood cholesterol and other lipid disorders: A case-oriented teaching program for the practicing physician. 
  Goldberg IJ, P Bukberg, L Clark, D Gemson, W Karmally, and S SheaAmerican Heart Association, New York City Affiliate1991
• Cardiovascular Pharmacology 
  Chapter: Pathophysiology and Therapy of Hyperlipidemia. 
  Page 485 - 514Ginsberg HN, Y Arad and IJ GoldbergEditors: J. Antonnaccio.Raven PressEdition 3rd,1990
• Clinical Biochemistry 
  Chapter: Dyslipoproteinemias in thyroid disease. 
  Page 231 - 244Ginsberg HN and IJ GoldbergEditors: JC Furchart and J Shepherd.Walter de Gruyter, New York1989
• Principals of Diabetes Management 
  Chapter: Pathophysiology and treatment of disorders of lipoprotein metabolism in diabetes mellitus. 
  Page 159 - 173Goldberg IJ and Ginsberg HNEditors: M. Bergman.Medical Examination Publishing Company, New York1987
• Lipid Research Methodology 
  Chapter: Measurements of heparin-releasable triacylglycerol lipases. 
  Page 241 - 286Gibson JC, JR Paterniti, Jr. and IJ GoldbergEditors: T. Storey. Alan R. Liss.New York1984
• Atherosclerosis 
  Chapter: The role of hepatic triglyceride lipase in primates. 
  Page 623 - 627Goldberg IJ, NA Le, JR Paterniti, HN Ginsberg, FT Lindgren and WV BrownEditors: G. Schettler.Springer-Verlag, New YorkEdition 6th,1983
• Encyclopedia of Science and Technology, Biochemistry 
  Chapter: Lipoproteins 
  Goldberg IJEditors: McGraw-Hill.McGraw-Hill
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Lectures

• Diabetes and Hypertriglyceridemia: Cardiovascular Risk, Mechanisms, and Indications for Treatment 
  ENDO 2019 - New Orleans, LA - 3/26/2019
• Hepatic Substrate Metabolism and Cardiometabolic Disease 
  ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/18/2018
• Endocrinology Board Review, Endocrinology Society 
  San Francisco - 9/2/2014
• Lipid metabolism in the heart. Invited Talk 
  1/1/2014
• Healthcare integrated biobanking and multiomics biomarker analysis. 
  Germany - 1/1/2014
• R Levine Diabetes Symposium 
  Los Angeles, CA - 1/1/2014
• 16th Annual Endocrinology & Metabolism Board Review 
  Cleveland Clinic Foundation Center for Continuing Medical Education, Cleveland, Ohio - 8/16/2013
• W.V. Brown Lecture 
  Callaway Gardens, GA - 1/1/2013
• Metabolism, obesity and obesity related diseases. 
  Suzhou, China - 1/1/2013
• Peter T. Kuo M.D. Lecture in Cardiology 
  R.W. Johnson Med School, New Brunswick, NJ - 1/1/2013
• Lipoprotein Metabolism (Speaker and Session Chair) 
  1/1/2012
• Lipotoxicity 
  Killarney, Ireland - 1/1/2011
• Basic CV Science 
  1/1/2011
• McGill Lipid Research Lecture 
  Montreal, Canada - 1/1/2009
• Frontiers of Clinical Investigation 
  San Diego, CA - 1/1/2009
• Targeting heart failure. 
  Keystone, CO - 1/1/2008
• Triglycerides in the circulation, on the artery and in the heart. Plenary Talk 
  Atlanta, GA - 1/1/2008
• Vascular Biology, Invited Talks 
  Washington, DC - 1/1/2007
• Cardiac Energy Metabolism in Heart Failure 
  Semiahmoo, WA - 9/1/2006
• Botanicals and Cardiovascular Risk. 
  Baton Rouge - 1/1/2006
• Severence Hospital Diabetes Symposium 
  Seoul, Korea - 1/1/2006
• Berrie Diabetes Symposium 
  New York, NY; Jerusalem (Sep 2005) - 11/1/2005
• Lipid delivery, from blood to cardiomyocyte (Inaugural lecture). 
  St. Louis, MO - 1/1/2004
• Feeding the heart with fat. 
  Hyderabad, India - 1/1/2004
• Science of diabetes complications. 
  University of Toronto - 1/1/2004
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