IraJayGoldbergMD

PubMed

• Can another lipid, sphingosine-1-phosphate, treat atherosclerosis?
  Waqas Younis, Ira J Goldberg> ;Cardiovascular Research. 2024 Apr 2
• Microvascular insulin resistance associates with enhanced muscle glucose disposal in CD36 deficiency.
  Peche, V., Williams, I., Samovski, D., Pietka, T., Gamazon, E., Wasserman, D., Abumrad, N., Shibao, C., Abumrad, N., Goldberg, I.> ;Medrxiv. 2024 Feb 18
• 2 citations
  ANGPTL3 deficiency impairs lipoprotein production and produces adaptive changes in hepatic lipid metabolism.
  Burks, K., Xie, Y., Gildea, M., Jung, I., Mukherjee, S., Pudupakkam, U., Wagoner, R., Patel, V., Santana, K., Alisio, A., Finck, B., Fisher, E., Lee, P., Goldberg, I.,...> ;Journal of Lipid Research. 2024 Feb 1
• 5 citations
  Cardiac lipid metabolism, mitochondrial function, and heart failure.
  Lorenzo Da Dalt, Ainara G Cabodevilla, Ira J Goldberg, Giuseppe Danilo Norata> ;Cardiovascular Research. 2023 Aug 19
• 5 citations
  Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion.
  Emma Guilbaud, Thibault Barouillet, Marius Ilie, Coraline Borowczyk, Stoyan Ivanov, Vincent Sarrazy, Nathalie Vaillant, Marion Ayrault, Alexia Castiglione, Guylène Rig...> ;Cell Stem Cell. 2023 Jun 1
• 3 citations
  Obesity and Overweight: Probing Causes, Consequences, and Novel Therapeutic Approaches Through the American Heart Association's Strategically Focused Research Network.
  Jeanne M Clark, W Timothy Garvey, Kevin D Niswender, Ann Marie Schmidt, Rexford S Ahima, Jose O Aleman, Ashley N Battarbee, Joshua Beckman, Wendy L Bennett, Nancy J Br...> ;Journal of the American Heart Association. 2023 Feb 21
• 12 citations
  Broadening the Scope of Dyslipidemia Therapy by Targeting APOC3 (Apolipoprotein C3) and ANGPTL3 (Angiopoietin-Like Protein 3).
  Henry N Ginsberg, Ira J Goldberg> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Mar 1
• 13 citations
  Guidance for the diagnosis and treatment of hypolipidemia disorders.
  Cindy Bredefeld, M Mahmood Hussain, Maurizio Averna, Dennis D Black, Mitchell F Brin, John R Burnett, Sybil Charrière, Charlotte Cuerq, Nicholas O Davidson, Richard J ...> ;Journal of Clinical Lipidology. 2022 Sep 29
• 2 citations
  Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency.
  Jide Oluwadare, Ainara G Cabodevilla, Ni-Huiping Son, Yunying Hu, Adam E Mullick, Michael Verano, Jose O Alemán, Ravichandran Ramasamy, Ira J Goldberg> ;Journal of Lipid Research. 2022 Nov 1
• 1 citations
  Big Fish or No Fish; Eicosapentaenoic Acid and Cardiovascular Disease.
  Ira J Goldberg, Jana Gjini, Edward A Fisher> ;Endocrinology and Metabolism Clinics of North America. 2022 Sep 1
• 9 citations
  Angiopoietin-like 3: An important protein in regulating lipoprotein levels.
  Kendall H Burks, Debapriya Basu, Ira J Goldberg, Nathan O Stitziel> ;Best Practice & Research. Clinical Endocrinology & Metabolism. 2023 May 1
• 1 citations
  Continuous glucose monitoring and 1-h plasma glucose identifies glycemic variability and dysglycemia in high-risk individuals with HbA1c < 5.7%: a pilot study.
  Brenda Dorcely, Eliud Sifonte, Collin Popp, Anjana Divakaran, Karin Katz, Sarah Musleh, Ram Jagannathan, Margaret Curran, Mary Ann Sevick, José O Aleman, Ira J Goldber...> ;Endocrine. 2022 Aug 1
• 18 citations
  Management of dyslipidemia and atherosclerotic cardiovascular risk in prediabetes.
  João Sérgio Neves, Connie Newman, John A Bostrom, Martin Buysschaert, Jonathan D Newman, José Luiz Medina, Ira J Goldberg, Michael Bergman> ;Diabetes Research and Clinical Practice. 2022 Aug 1
• 32 citations
  Addressing dyslipidemic risk beyond LDL-cholesterol.
  Alan R Tall, David G Thomas, Ainara G Gonzalez-Cabodevilla, Ira J Goldberg> ;The Journal of Clinical Investigation. 2022 Jan 4
• 2 citations
  Cardiac immune cell infiltration associates with abnormal lipid metabolism.
  Vincenza Cifarelli, Ondrej Kuda, Kui Yang, Xinping Liu, Richard W Gross, Terri A Pietka, Gyu Seong Heo, Deborah Sultan, Hannah Luehmann, Josie Lesser, Morgan Ross, Ira...> ;Frontiers in Cardiovascular Medicine. 2022 Jan 1
• 8 citations
  CREBH normalizes dyslipidemia and halts atherosclerosis in diabetes by decreasing circulating remnant lipoproteins
  Masami Shimizu-Albergine, Debapriya Basu, Jenny E. Kanter, Farah Kramer, Vishal Kothari, Shelley Barnhart, Carissa Thornock, Adam E. Mullick, Noemie Clouet-Foraison, T...> ;The Journal of Clinical Investigation. 2021 Nov 15
• 72 citations
  Cardiovascular disease in diabetes, beyond glucose.
  Robert H. Eckel, Karin E. Bornfeldt, Ira J. Goldberg> ;Cell Metabolism. 2021 Aug 3
• 11 citations
  Eruptive xanthoma model reveals endothelial cells internalize and metabolize chylomicrons, leading to extravascular triglyceride accumulation
  Ainara G. Cabodevilla, Songtao Tang, Sungwoon Lee, Adam E. Mullick, Jose O. Aleman, M. Mahmood Hussain, William C. Sessa, Nada A. Abumrad, Ira J. Goldberg> ;The Journal of Clinical Investigation. 2021 Jun 15
• 11 citations
  Lipolytic enzymes and free fatty acids at the endothelial interface.
  Ira J. Goldberg, Ainara G. Cabodevilla, Dmitri Samovski, Vincenza Cifarelli, Debapriya Basu, Nada A. Abumrad> ;Atherosclerosis. 2021 May 28
• 2 citations
  Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice.
  Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A Nikain, Tatjana Josefs, Melanie Mahe, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela ...> ;Communications Biology. 2021 Mar 26
• 1 citations
  Response to Letter to the Editor: "Lipid Management in Patients With Endocrine Disorders: An Endocrine Society Clinical Practice Guideline".
  Connie B. Newman, Lisa R. Tannock, Ira J. Goldberg> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Mar 25
• John Calvert Rutledge, MD, 1949-2021.
  Ira J. Goldberg> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 Mar 24
• 6 citations
  Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI–Mediated High-Density Lipoprotein Uptake
  Hao Xu, Michael J. Thomas, Sushma Kaul, Rachel Kallinger, Amber B. Ouweneel, Elisa Maruko, Sabrina M. Oussaada, Aldo Jongejan, Huib A. Cense, Max Nieuwdorp, Mireille J...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 Mar 21
• 21 citations
  Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy.
  Matthew Hoffman, Dimitra Palioura, Ioannis D. Kyriazis, Maria Cimini, Rachit Badolia, Sudarsan Rajan, Erhe Gao, Nikolas Nikolaidis, P. Christian Schulze, Ira J. Goldbe...> ;Circulation. 2021 Mar 16
• 36 citations
  Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism.
  Nada A. Abumrad, Ainara G. Cabodevilla, Dmitri Samovski, Terri A. Pietka, Debapriya Basu, Ira J. Goldberg> ;Circulation Research. 2021 Feb 5
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Journal Articles

• Myeloperoxidase: A Therapeutic Target for Preventing Insulin Resistance and the Metabolic Sequelae of Obesity?  
  Heinecke JW, Goldberg IJ, Diabetes, 1/1/2014
• Cardiac Metabolic Compensation to Hypertension Requires Lipoprotein Lipase  
  Yamashita H, KG. Bharadwaj, S Ikeda, T-S Park, IJ Goldberg, A J Physio, Endo/Metab, 1/1/2008
• In vivo arterial lipoprotein lipase expression augments inflammatory responses and impairs vascular dilatation  
  Takahashi M, M Yokoyama, Y Hiyama, Y Hu, K Melford, A Bensadoun, IJ Goldberg, ATVB, 1/1/2008
• Decreased lipoprotein clearance is responsible for increased cholesterol in streptozotocin treated LDL receptor knockout mice  
  Goldberg IJ, Y Hu, HL Noh, J Wei, LA Huggins, MG. Rackmill, H Hamai, BN Reid, WS Blaner L-S Huang, Diabetes, 1/1/2008
• Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice  
  Mzhavia N, S Yu, S Ikeda, TT Chu, IJ Goldberg, HM Dansky, Diabetes, 1/1/2008
• Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids and Ame...  
  Reid BN, GP Ables, OA Otlivanchik, G Schoiswohl, R Zechner, WS Blaner, IJ Goldberg, RF Schwabe, SC Chua, Jr., L-S Huang, J Biol Chem, 1/1/2008
• ABCG1 and HDL protect against endothelial dysfunction induced by a high-cholesterol diet  
  Terasaka N, S Yu, L Yvan-Charvet, N Wang, N Mzhavia, R Langlois, T Pagler, R Li, CL Welch, IJ Goldberg, AR. Tall, J Clin Invest, 1/1/2008
• Hypertriglyceridemia-induced pancreatitis created by oral estrogen and in vitro fertilization ovulation induction  
  Lee, J, IJ Goldberg, J Clin Lipid, 1/1/2008
• Challenges to the diagnosis, evaluation, treatment and management of clustered cardiometabolic risk factors  
  Wilson PWF, HR Black, A Fabricatore, IJ Goldberg, Journal of the CardioMetabolic Syndrome, 1/1/2008
• Lipoprotein lipase-derived fatty acids  
  Lee J, IJ Goldberg, Physiology and Dysfunction Current Hypertension Reports, 1/1/2008
• Effects of diabetes on murine lipoproteins and vascular disease  
  Dansky, HM, IJ Goldberg, Curr Drug Targets, 1/1/2007
• Lipids in the heart, a source of fuel and a source of toxins  
  Park, T-S, H Yamashita, WS Blaner, IJ Goldberg, Current Opinion in Lipidology, 1/1/2007
• Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction  
  Son N-H, K Okajima, H Yamashita, M Yokoyama, LA Huggins, S Homma, MJ Szabolcs, L-S Huang, IJ Goldberg, J Clin Invest, 1/1/2007
• Cholesterol uptake into heart and skeletal muscle of lipoprotein lipase transgenic mice: Evidence that statin therapy increases muscle lipid uptake  
  Yokoyama M, T Seo, T-S Park, H Yagyu, Y Hu, N-H Son, AS Augustus, RK Vikramadithyan, R Ramakrishnan, LK Pulawa, R H. Eckel, IJ Goldberg, J Lipid Res, 1/1/2007
• Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction  
  Noh H-L, K Okajima, JD Molkentin, S Homma, IJ Goldberg, A J Physio Endo/Metab, 1/1/2006
• Glucose intolerance in mice with dominant-negative mutation of CEACAM1  
  Park S-Y, Y-R Cho, H-J Kim, E-G Hong, T Higashimori, S J Lee, IJ Goldberg, GI Shulman, SM Najar, JK Kim, A J Physio Endo/Metab, 1/1/2006
• Diabetic vascular disease, an experimental objective  
  Goldberg IJ, HM Dansky, Arterio Thromb Vasc Biol, 1/1/2006
• Ins and outs modulating hepatic triglyceride and development of non-alcoholic fatty liver disease  
  Goldberg IJ and HN Ginsberg, Gastro, 1/1/2006
• Addition of dietary fat to cholesterol in the diets of LDL receptor knockout mice: Effects on plasma insulin, lipoproteins and atherosclerosis  
  Wu L, R Vikramadithyan, S Yu, C Pau, Y Hu, IJ Goldberg, HM Dansky, J Lipid Res, 1/1/2006
• Inhibition of pancreatic lipase by poloxamer 407 may provide an adjunct treatment strategy for weight loss  
  Johnston TP, IJ Goldberg, J Pharmacy Pharmacology, 1/1/2006
• Novel inflammatory role for glycogen synthase-3beta in the inhibition of TNF-alpha and IL-1beta induced inflammatory gene expression  
  Vines A, S Cahoon, I Goldberg, U Saxena U, S Pillarisetti, J. Biol Chem, 1/1/2006
• Commentary on OmniHeart Trial  
  Karmally W, and IJ Goldberg, Nature Clinical Practice Cardiovascular Medicine, 1/1/2006
• Perfusion of hearts with artificial lipid emulsions reproduces the metabolic abnormalities in lipotoxic cardiomyopathy  
  Pillutla P, YC Hwang, T Wright, A Augustus, M Yokoyama, TP Johnston, R Ramasamy, IJ Goldberg, Am J Physiol Endocrinol Metab, 1/1/2005
• Retinoid absorption and storage is impaired in mice lacking lecithin:retinal acyltransferase (LRAT)  
  O’Byrne SM, N Wong, JM Libien, S Vogel, IJ Goldberg, W Baehr, K Palczewski, WS Blaner, J Biol Chem, 1/1/2005
• Peroxisome Proliferator Activated Receptor Agonists Modulate Heart Function in Transgenic Mice with Lipotoxic Cardiomyopathy  
  Vikramadithyan RK, K Hirata, H Yagyu, A Augustus, Y Hu, S Homma, IJ Goldberg, J Pharmacol Exp Ther, 1/1/2005
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Books/Book Chapters

• Cardiac Energy Metabolism in Health and Disease. 
  Chapter: Lipoproteins: A Source of Cardiac Lipids. 
  Page 15 - 33K Drosatos, IJ GoldbergEditors: Gary D. Lopaschuk, Naranjan S.Dhalla.Springer2014
• Williams Endocrinology 
  Chapter: Chapter 37: Lipid and lipoprotein disorders. 
  Page 1633 - 1674Semenkovich C, A Goldberg, IJ Goldberg2011
• Therapeutic Lipidology 
  Chapter: Management of Hypertriglyceridemia. 
  Page 201 - 220Labossiere R and IJ GoldbergEditors: MH Davidson, PP Toth, KC Maki.Humana Press2007
• Principles of Diabetes Mellitus. 
  Chapter: Chapter 11: Hyperlipidemia: pathogenesis and management in diabetes mellitus. 
  Page 459 - 472Goldberg IJEditors: L Poretsky.Kluwer, Boston, MA2002
• Difficult cases in endocrinology. 
  Chapter: Disorders of lipoprotein metabolism. 
  Goldberg IJ, Bukberg PEditors: M. Molitch.Humana Press2002
• Handbook of Physiology 
  Chapter: The pancreas and lipoprotein metabolism. 
  Page 675 - 706Ginsberg HN and IJ Goldberg2001
• Principles and Practice of Endocrinology and Metabolism 
  Chapter: Chapter 165: Endocrine effects on lipids, 
  Page 1538 - 1543Ginsberg HN, IJ Goldberg, C TuckEditors: KL Becker.Lippincott Williams and Wilkins; Silverchair Science and Communications, Inc., Philadelphia, PA; Chalottesville, VA2001
• Harrison's Principles of Internal Medicine 
  Chapter: Chapter 344: Disorders of Lipoprotein Metabolism. 
  Page 2245 - 2256Ginsberg H.N. and I.J. GoldbergEditors: Fauci AS, E Braunwald, KJ Isselbacher, L Jameson, JB Martin, DL Kasper, SL Hauser and DL Longo.Edition 15th,2001
• Lipoproteins in Health and Diseases 
  Chapter: The VLDL cascade system. The assembly, secretion, and intravascular metabolism of apoprotein B containing lipoproteins. 
  Page 55 - 70Ginsberg HN, JL Dixon and IJ GoldbergEditors: Bretteridge JD, DR Illingsworth, and J Shephard.Arnold1999
• Plasma lipids and their role in disease. 
  Chapter: Endothelial lipases in disease. 
  Page 203 - 216Goldberg IJ and CH TuckEditors: P Barter and K-A Rye.Harwood Academic Publishers1999
• Atherosclerosis XI 
  Chapter: Lipoprotein association with cells and matrix: modulation by lipase and proteoglycans. 
  Page 887 - 894Goldberg IJ, S Pillarisetti, WS Blaner, WD Wagner and JC RutledgeEditors: Jacotot B, D. Mathe, J-C Fuchart.Elsevier, Amsterdam1998
• Harrison's Principles of Internal Medicine 
  Chapter: Disorders of Lipoprotein Metabolism. 
  Page 2138 - 2149Ginsberg H.N. and IJ GoldbergEditors: Fauci AS, E Braunwald, KJ Isselbacher, JD Wilson, JB Martin, DL Kasper, SL Hauser and DL Longo.Edition 14th,1997
• Atlas of Heart Disease 
  Chapter: Diabetes and vascular disease risk. 
  Goldberg, IJ and HN GinsbergEditors: W.V.Brown (Section Editor); E. Braunwald (Series Editor).Current Medicine, Philadelphia, PA1996
• Atherosclerosis X 
  Chapter: Lipoprotein lipse binding to endothelial cells: Specific protein-protein and protein glycosaminoglycan interactions. 
  Page 1075 - 1079Goldberg IJ, P Sivaram, SY Choi, N Parthasarathy, and WD WagnerEditors: FP Woodford, J Davignon, and A. Sniderman.Elsevier, Amsterdam1995
• Lipoprotein Disorders. 
  Chapter: Medical Knowledge Self-Assessment Program (MKSAP) X - Endo-crinology & Metabolism Section, 
  Page 1075 - 1079Goldberg IJEditors: L. Landsberg.American College of Physicians, Philadelphia, PA1995
• High density lipoproteins and atherosclerosis III. 
  Chapter: Role of the kidney in increased clearance of apolipoprotein A-I in subjects with reduced high density lipoprotein cholesterol concentrations. 
  Page 215 - 222Horowitz BS, IJ Goldberg, J Merab, T Vanni, R Ramakrishnan and HN GinsbergEditors: NE Miller and AR Tall.Elsevier Science Publishers BN1992
• Clinical management of high blood cholesterol and other lipid disorders: A case-oriented teaching program for the practicing physician. 
  Goldberg IJ, P Bukberg, L Clark, D Gemson, W Karmally, and S SheaAmerican Heart Association, New York City Affiliate1991
• Cardiovascular Pharmacology 
  Chapter: Pathophysiology and Therapy of Hyperlipidemia. 
  Page 485 - 514Ginsberg HN, Y Arad and IJ GoldbergEditors: J. Antonnaccio.Raven PressEdition 3rd,1990
• Clinical Biochemistry 
  Chapter: Dyslipoproteinemias in thyroid disease. 
  Page 231 - 244Ginsberg HN and IJ GoldbergEditors: JC Furchart and J Shepherd.Walter de Gruyter, New York1989
• Principals of Diabetes Management 
  Chapter: Pathophysiology and treatment of disorders of lipoprotein metabolism in diabetes mellitus. 
  Page 159 - 173Goldberg IJ and Ginsberg HNEditors: M. Bergman.Medical Examination Publishing Company, New York1987
• Lipid Research Methodology 
  Chapter: Measurements of heparin-releasable triacylglycerol lipases. 
  Page 241 - 286Gibson JC, JR Paterniti, Jr. and IJ GoldbergEditors: T. Storey. Alan R. Liss.New York1984
• Atherosclerosis 
  Chapter: The role of hepatic triglyceride lipase in primates. 
  Page 623 - 627Goldberg IJ, NA Le, JR Paterniti, HN Ginsberg, FT Lindgren and WV BrownEditors: G. Schettler.Springer-Verlag, New YorkEdition 6th,1983
• Encyclopedia of Science and Technology, Biochemistry 
  Chapter: Lipoproteins 
  Goldberg IJEditors: McGraw-Hill.McGraw-Hill
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Lectures

• Diabetes and Hypertriglyceridemia: Cardiovascular Risk, Mechanisms, and Indications for Treatment 
  ENDO 2019 - New Orleans, LA - 3/26/2019
• Hepatic Substrate Metabolism and Cardiometabolic Disease 
  ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/18/2018
• Endocrinology Board Review, Endocrinology Society 
  San Francisco - 9/2/2014
• Lipid metabolism in the heart. Invited Talk 
  1/1/2014
• Healthcare integrated biobanking and multiomics biomarker analysis. 
  Germany - 1/1/2014
• R Levine Diabetes Symposium 
  Los Angeles, CA - 1/1/2014
• 16th Annual Endocrinology & Metabolism Board Review 
  Cleveland Clinic Foundation Center for Continuing Medical Education, Cleveland, Ohio - 8/16/2013
• W.V. Brown Lecture 
  Callaway Gardens, GA - 1/1/2013
• Peter T. Kuo M.D. Lecture in Cardiology 
  R.W. Johnson Med School, New Brunswick, NJ - 1/1/2013
• Metabolism, obesity and obesity related diseases. 
  Suzhou, China - 1/1/2013
• Lipoprotein Metabolism (Speaker and Session Chair) 
  1/1/2012
• Basic CV Science 
  1/1/2011
• Lipotoxicity 
  Killarney, Ireland - 1/1/2011
• McGill Lipid Research Lecture 
  Montreal, Canada - 1/1/2009
• Frontiers of Clinical Investigation 
  San Diego, CA - 1/1/2009
• Triglycerides in the circulation, on the artery and in the heart. Plenary Talk 
  Atlanta, GA - 1/1/2008
• Targeting heart failure. 
  Keystone, CO - 1/1/2008
• Vascular Biology, Invited Talks 
  Washington, DC - 1/1/2007
• Cardiac Energy Metabolism in Heart Failure 
  Semiahmoo, WA - 9/1/2006
• Botanicals and Cardiovascular Risk. 
  Baton Rouge - 1/1/2006
• Severence Hospital Diabetes Symposium 
  Seoul, Korea - 1/1/2006
• Berrie Diabetes Symposium 
  New York, NY; Jerusalem (Sep 2005) - 11/1/2005
• Feeding the heart with fat. 
  Hyderabad, India - 1/1/2004
• Lipid delivery, from blood to cardiomyocyte (Inaugural lecture). 
  St. Louis, MO - 1/1/2004
• Science of diabetes complications. 
  University of Toronto - 1/1/2004
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