IrwinSingerMD

PubMed

• 29 citations
  11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
  Mingjuan Jane Luo, Rolf Thieringer, Martin S. Springer, Samuel D. Wright, Anne Hermanowski-Vosatka, Andrew S. Plump, James M. Balkovec, Kang Cheng, Gloria J.-F. Ding, ...> ;Physiological Genomics. 2013 Jan 1
• 53 citations
  CCR5 Blockade Modulates Inflammation and Alloimmunity in Primates
  Carsten Schröder, Richard N. Pierson, Bao Ngoc H. Nguyen, Douglas W. Kawka, Laurence B. Peterson, Guosheng Wu, Tianshu Zhang, Martin S. Springer, S J Siciliano, Susan ...> ;Journal of Immunology. 2007 Aug 15
• 31 citations
  Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium.
  Douglas W. Kawka, Marc Ouellet, Pierre-Olivier Hétu, Irwin I. Singer, Denis Riendeau> ;Biochimica Et Biophysica Acta. 2007 Jan 1
• 77 citations
  Sphingosine-1-Phosphate Agonists Increase Macrophage Homing, Lymphocyte Contacts, and Endothelial Junctional Complex Formation in Murine Lymph Nodes
  Irwin I. Singer, Min Tian, L. Alexandra Wickham, Jeffrey Lin, Scaria S. Matheravidathu, Michael J. Forrest, Suzanne M. Mandala, Elizabeth J. Quackenbush> ;Journal of Immunology. 2005 Dec 1
• 36 citations
  A Small Molecule Very Late Antigen–4 Antagonist Can Inhibit Ovalbumin-induced Lung Inflammation
  Gloria C. Koo, Kashmira Shah, Gloria J.-F. Ding, Jianying Xiao, Richard Wnek, George A. Doherty, Xin Chun Tong, R. Blake Pepinsky, Lin Kochung, William K. Hagmann, Dou...> ;American Journal of Respiratory and Critical Care Medicine. 2003 May 15
• 136 citations
  CCR5, CXCR4, and CD4 Are Clustered and Closely Apposed on Microvilli of Human Macrophages and T Cells
  Irwin I. Singer, S Scott, Douglas W. Kawka, Jayne Chin, Bruce L. Daugherty, Julie A. DeMartino, Jerry DiSalvo, Sandra L. Gould, Janet Lineberger, Lorraine Malkowitz, M...> ;Journal of Virology. 2001 Apr 15
• 59 citations
  Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction.
  J.B.J. van Meurs, P.L.E.M. van Lent, A.E.M. Holthuysen, J. Lambrou, Ellen K. Bayne, Irwin I. Singer, W.B. van den Berg> ;Journal of Immunology. 1999 Nov 15
• 92 citations
  Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 i...
  Joyce B. J. van Meurs, Peter L E M van Lent, Reinout Stoop, A.E.M. Holthuysen, Irwin I. Singer, Ellen K. Bayne, John S. Mudgett, Robin Poole, Clark Billinghurst, Peter...> ;Arthritis and Rheumatism. 1999 Oct 1
• 70 citations
  Immunohistochemical localization of types 1 and 2 5α‐reductase in human scalp
  Ellen K. Bayne, John G. Flanagan, M. Einstein, Julia M. Ayala, B. Chang, B. Azzolina, David A. Whiting, Richard A. Mumford, Diane Thiboutot, Irwin I. Singer, Georgiann...> ;The British Journal of Dermatology. 1999 Sep 1
• 370 citations
  Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease
  Irwin I. Singer, Douglas W. Kawka, Suzanne Schloemann, Teresa G. Tessner, Terrence E. Riehl, William F. Stenson> ;Gastroenterology. 1998 Aug 1
• 268 citations
  Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy
  Andrew G. Spencer, John Woods, Toshiya Arakawa, Irwin I. Singer, William L. Smith> ;The Journal of Biological Chemistry. 1998 Apr 17
• 51 citations
  Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis
  Joyce B. J. van Meurs, Peter L E M van Lent, Irwin I. Singer, Ellen K. Bayne, Fons A. J. van de Loo, Wim B. van den Berg> ;Arthritis and Rheumatism. 1998 Apr 1
• 22 citations
  A tacrolimus-related immunosuppressant with reduced toxicity
  Francis J. Dumont, Samuel Koprak, Mary Jo Staruch, A Talento, Gloria C. Koo, Carolyn DaSilva, Peter J. Sinclair, Frederick Wong, John R. Woods, Jeanne Barker, James V....> ;Transplantation. 1998 Jan 15
• 157 citations
  Susceptibility of stromelysin 1‐deficient mice to collagen‐induced arthritis and cartilage destruction
  John S. Mudgett, Nancy I. Hutchinson, Nicole A. Chartrain, A. J. Forsyth, Joseph McDonnell, Irwin I. Singer, Ellen K. Bayne, John G. Flanagan, Douglas W. Kawka, C. F. ...> ;Arthritis and Rheumatism. 1998 Jan 1
• 36 citations
  Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis
  Irwin I. Singer, S Scott, Douglas W. Kawka, Ellen K. Bayne, Jeffrey R. Weidner, Hollis R. Williams, Richard A. Mumford, Michael W. Lark, Joseph McDonnell, Amy J. Chris...> ;Osteoarthritis and Cartilage. 1997 Nov 1
• 472 citations
  Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease
  Irwin I. Singer, Douglas W. Kawka, S Scott, Jeffrey R. Weidner, Richard A. Mumford, TE Riehl, William F. Stenson> ;Gastroenterology. 1996 Oct 1
• 128 citations
  The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno...
  Irwin I. Singer, S Scott, Jayne Chin, Ellen K. Bayne, Guadalupe A. Limjuco, Jeffrey R. Weidner, Douglas K. Miller, Kevin T. Chapman, Matthew J. Kostura> ;The Journal of Experimental Medicine. 1995 Nov 1
• 152 citations
  5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.
  John Woods, Michael J. Coffey, Thomas G. Brock, Irwin I. Singer, Marc Peters-Golden> ;The Journal of Clinical Investigation. 1995 May 1
• 108 citations
  VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.
  Irwin I. Singer, Douglas W. Kawka, Ellen K. Bayne, Susan Donatelli, Jeffrey R. Weidner, Hollis R. Williams, Julia M. Ayala, Richard A. Mumford, Michael W. Lark, Tibor ...> ;The Journal of Clinical Investigation. 1995 May 1
• 317 citations
  5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.
  J. W. Woods, Jillian F. Evans, Diane Ethier, S Scott, Philip J. Vickers, L. Hearn, J A Heibein, Stella Charleson, Irwin I. Singer> ;The Journal of Experimental Medicine. 1993 Dec 1
• 38 citations
  Optimal humanization of 1B4, an anti-CD18 murine monoclonal antibody, is achieved by correct choice of human V-region framework sequences.
  Irwin I. Singer, Douglas W. Kawka, Julie A. DeMartino, Bruce L. Daugherty, Keith O. Elliston, K Alves, B L Bush, P M Cameron, G C Cuca, P Davies> ;Journal of Immunology. 1993 Apr 1
• 55 citations
  Recombinant human interleukin-1 β–induced increase in levels of proteoglycans, stromelysin, and leukocytes in rabbit synovial fluid
  Joseph McDonnell, Lori A. Hoerrner, Michael W. Lark, Coral Harper, Tanvi Dey, Julie Lobner, George J. Eiermann, D M Kazazis, Irwin I. Singer, Vernon L. Moore> ;Arthritis and Rheumatism. 1992 Jul 1
• 6 citations
  Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase induce reductase accumulation and altered lamellar bodies in rat forestomach keratinocytes.
  Irwin I. Singer, Douglas W. Kawka, S Scott, P Bailey, M W Kloss, J Majka, James S. MacDonald> ;Arteriosclerosis and Thrombosis. 1991 Sep 1
• 45 citations
  Polymerase chain reaction facilitates the cloning, CDR-grafting, and rapid expression of a murine monoclonal antibody directed against the CD18 component of leukocyte ...
  Bruce L. Daugherty, Julie A. DeMartino, Ming-Fan Law, Douglas W. Kawka, Irwin I. Singer, George E. Mark> ;Nucleic Acids Research. 1991 May 11
• 125 citations
  Adhesomes: specific granules containing receptors for laminin, C3bi/fibrinogen, fibronectin, and vitronectin in human polymorphonuclear leukocytes and monocytes.
  Irwin I. Singer, S Scott, Douglas W. Kawka, D M Kazazis> ;The Journal of Cell Biology. 1989 Dec 1
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