IsaacWilliamBrowderMD

General Surgery • Johnson City, TN

Trauma Surgery & Surgical Critical Care

Physician

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Office
325 N State Of Franklin Rd
3rd Floor
Johnson City, TN 37604
Phone+1 423-439-7201

Fax+1 423-439-7219
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Summary

Dr. Isaac Browder, MD is a general surgeon in Johnson City, Tennessee. He is currently licensed to practice medicine in Tennessee and Louisiana. He is affiliated with James H. Quillen Veterans Affairs Medical Center.

Education & Training

Louisiana State University School of MedicineResidency, Surgery, 1971 - 1977
Tulane University School of MedicineClass of 1971

Certifications & Licensure

TN State Medical License 1990 - 2024
LA State Medical License 1971 - 2022
American Board of Surgery Surgery

Publications & Presentations

PubMed

117 citations
Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload
Tuanzhu Ha, Yuehua Li, Fang Hua, Jinag Ma, Xiang Gao, Jim Kelley, Aiqiu Zhao, Georges E. Haddad, David L. Williams, I. William Browder, Race L. Kao, Chuanfu Li> ;Cardiovascular Research. 2005 Nov 1
81 citations
Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury
Fang Hua, Jing Ma, Tuanzhu Ha, Jim Kelley, David L. Williams, Race L. Kao, John Kalbfleisch, I. William Browder, Chuanfu Li> ;Journal of Neuroimmunology. 2008 Aug 13
167 citations
Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion
Fang Hua, Jing Ma, Tuanzhu Ha, Yeling Xia, Jim Kelley, David L. Williams, Race L. Kao, I. William Browder, John B. Schweitzer, John Kalbfleisch, Chuanfu Li> ;Journal of Neuroimmunology. 2007 Oct 1
136 citations
Protection against Myocardial Ischemia/Reperfusion Injury in TLR4-Deficient Mice Is Mediated through a Phosphoinositide 3-Kinase-Dependent Mechanism
Fang Hua, Tuanzhu Ha, Jing Ma, Yan Li, Jim Kelley, Xiang Gao, I. William Browder, Race L. Kao, David L. Williams, Chuanfu Li> ;Journal of Immunology. 2007 Jun 1
36 citations
Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice.
Tuanzhu Ha, Fang Hua, Daniel Grant, Yeling Xia, Jing Ma, Xiang Gao, Jim L. Kelley, David L. Williams, John Kalbfleisch, I. William Browder, Race L. Kao, Chuanfu Li> ;American Journal of Physiology. Heart and Circulatory Physiology. 2006 Oct 1
18 citations
The development of a novel mouse model of transient global cerebral ischemia.
Fang Hua, Jing Ma, Yan Li, Tuanzhu Ha, Yeling Xia, Jim Kelley, David L. Williams, I. William Browder, John B. Schweitzer, Chuanfu Li> ;Neuroscience Letters. 2006 May 29
68 citations
Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFκB activation in vivo
Tuanzhu Ha, Yuehua Li, Xiang Gao, Julie R. McMullen, Tetsuo Shioi, Seigo Izumo, Jim Kelley, Aiqiu Zhao, Georges E. Haddad, David L. Williams, I. William Browder, Race ...> ;Free Radical Biology & Medicine. 2005 Dec 15
54 citations
Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts.
Fang Hua, Tuanzhu Ha, Jing Ma, Xiang Gao, Jim Kelley, David L. Williams, I. William Browder, Race L. Kao, Chuanfu Li> ;Biochemical and Biophysical Research Communications. 2005 Dec 16
19 citations
Overexpression of TLR2 and TLR4 susceptibility to serum deprivation-induced apoptosis in CHO cells.
Wei Fan, Tuanzhu Ha, Yan Li, Tammy R. Ozment-Skelton, David L. Williams, Jim Kelley, I. William Browder, Chuanfu Li> ;Biochemical and Biophysical Research Communications. 2005 Nov 25
70 citations
Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo.
Tuanzhu Ha, Fang Hua, Yuehua Li, Jing Ma, Xiang Gao, Jim Kelley, Aiqiu Zhao, Georges E. Haddad, David L. Williams, I. William Browder, Race L. Kao, Chuanfu Li> ;American Journal of Physiology. Heart and Circulatory Physiology. 2006 Mar 1
2 citations
At low serum glucan concentrations there is an inverse correlation between serum glucan and serum cytokine levels in ICU patients with infections.
J.Andres Gonzalez, Justin Digby, Peter J. Rice, Kevin F. Breuel, W.Keith DePonti, John Kalbfleisch, I. William Browder, David L. Williams> ;International Immunopharmacology. 2004 Aug 1
137 citations
NF-κB activation is required for the development of cardiac hypertrophy in vivo
Yuehua Li, Tuanzhu Ha, Xiang Gao, Jim Kelley, David L. Williams, I. William Browder, Race L. Kao, Chuanfu Li> ;American Journal of Physiology. Heart and Circulatory Physiology. 2004 Oct 1
2 citations
Murine models of intestinal anastomoses.
David L. Williams, I. William Browder> ;Methods in Molecular Medicine. 2003 Jan 1
Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality.
Williams, D. L., Ha, T., Li, C., Kalbfleisch, J. H., Schweitzer, J., Vogt, W., Browder, I. W.> ;Crit Care Med. 2003 Jun
8 citations
Primary Aortogastric Fistula After Nissen Fundoplication: A Case Report and Review of Pertinent Literature
Panagiotis Kougias, Ulises Baltazar, Wayne J. Battle, Daniel S. Rush, I. William Browder, Tony Katras> ;Vascular and Endovascular Surgery. 2003 Mar 1
Human monocyte scavenger receptors are pattern recognition receptors for (1-->3)-beta-D-glucans.
Rice, P. J., Kelley, J. L., Kogan, G., Ensley, H. E., Kalbfleisch, J. H., Browder, I. W., Williams, D. L.> ;J Leukoc Biol. 2002 Jul
50 citations
Glucan stimulates human dermal fibroblast collagen biosynthesis through a nuclear factor-1 dependent mechanism.
Duo Wei, Leiying Zhang, David L. Williams, I. William Browder> ;Wound Repair and Regeneration. 2002 May 1
18 citations
Human vascular endothelial cells express pattern recognition receptors for fungal glucans which stimulates nuclear factor kappaB activation and interleukin 8 productio...
Elizabeth P Lowe, Duo Wei, Peter J. Rice, Chuanfu Li, John Kalbfleisch, I. William Browder, David L. Williams> ;The American Surgeon. 2002 Jun 1
29 citations
Subclavian arterial injury associated with blunt trauma.
Tony Katras, Ulises Baltazar, Daniel S. Rush, Duncan Davis, Teresa D. Bell, I. William Browder, Raymond P. Compton, Paul E. Stanton> ;Vascular Surgery. 2001 Jan 1
62 citations
Normal Human Fibroblasts Express Pattern Recognition Receptors for Fungal (1→3)-β-d-Glucans
Panagiotis Kougias, Duo Wei, Peter J. Rice, Harry E. Ensley, John Kalbfleisch, David L. Williams, I. William Browder> ;Infection and Immunity. 2001 Jun 1
167 citations
Glucans exhibit weak antioxidant activity, but stimulate macrophage free radical activity.
Ekaterini Tsiapali, Sarah Whaley, John Kalbfleisch, Harry E. Ensley, I. William Browder, David L. Williams> ;Free Radical Biology & Medicine. 2001 Feb 15
59 citations
Early activation of IKKβ during in vivo myocardial ischemia
Chuanfu Li, Race L. Kao, Tuanzhu Ha, Jim Kelley, I. William Browder, David L. Williams> ;American Journal of Physiology. Heart and Circulatory Physiology. 2001 Mar 1
Zenker's diverticulum in the elderly: a neurologic etiology?
Walters, D. N., Battle, J. W., Portera, C. A., Blizzard, J. D., Browder, I. W.> ;Am Surg. 1998 Sep
Receptor binding and internalization of a water-soluble (1-->3)-beta-D-glucan biologic response modifier in two monocyte/macrophage cell lines.
Müller, A., Rice, P. J., Ensley, H. E., Coogan, P. S., Kalbfleish, J. H., Kelley, J. L., Love, E. J., Portera, C. A., Ha, T., Browder, I. W., Williams, D. L.> ;J Immunol. 1996 May 1
57 citations
NMR spectral analysis of a water-insoluble (1 → 3)-β-d-glucan isolated from Saccharomyces cerevisiae
Harry E. Ensley, Tobias B, Henry A. Pretus, R B McNamee, Ernest L. Jones, Browder Iw, David L. Williams> ;Carbohydrate Research. 1994 May 20
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Grant Support

Surgical Sepsis--Modification By ImmunostimulationNational Institute Of Allergy And Infectious Diseases1985

Hospital Affiliations

James H. Quillen Veterans Affairs Medical CenterJohnson City, Tennessee