IsmenePetrakisMD

Psychiatry • West Haven, CT

Addiction

Professor, Psychiatry, Yale University School of Medicine

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Office
950 Campbell Ave # 116a
West Haven, CT 06516
Phone+1 203-932-5711

Fax+1 203-937-4791
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Education & Training

Yale-New Haven Medical CenterResidency, Psychiatry, 1988 - 1989
Norwalk Hospital/Yale UniversityInternship, Internal Medicine, 1987 - 1988
University of Pittsburgh School of MedicineClass of 1987

Certifications & Licensure

CT State Medical License 1989 - 2024
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Addiction Psychiatry

Clinical Trials

Facilitation of NMDA Receptor Function in Patients With Schizophrenia and Co-morbid Alcoholism Start of enrollment: 2003 Jun 01
Completed
Phase 2
Naltrexone & SSRI in Alcoholics With Depression/PTSD Start of enrollment: 2001 Oct 01
Completed
Phase 3
Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients Start of enrollment: 2004 May 01
Completed
Phase 2
Treatment With Acamprosate in Patients With Schizophrenia and Comorbid Alcoholism Start of enrollment: 2006 Sep 01
Completed
Phase 3
The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder Start of enrollment: 2012 Jun 01
Withdrawn
Phase 3
Ketamine/Placebo Family History Positive Study Start of enrollment: 2001 Mar 01
Completed
Not Applicable
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence Start of enrollment: 2005 Nov 01
Completed
Not Applicable
Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism Start of enrollment: 2001 Mar 01
Completed
Not Applicable
Couples-based Behavioral Psychotherapy for Male Patients With Posttraumatic Stress Disorder and Alcohol Dependence Start of enrollment: 2008 Feb 01
Withdrawn
Phase 2, Phase 3
Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence Start of enrollment: 2008 Mar 01
Completed
Phase 2, Phase 3
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD). Start of enrollment: 2009 Jan 01
Completed
Phase 3
Ketamine for Depression and Alcohol Dependence Start of enrollment: 2012 Mar 01
Completed
Phase 1
Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence Start of enrollment: 2013 Jun 01
Completed
Phase 2
Minocycline's Effects on Alcohol Responses in Humans Start of enrollment: 2015 Jul 01
Completed
Phase 1
Varenicline + Prazosin for Heavy Drinking Smokers Start of enrollment: 2014 Jul 01
Completed
Early Phase 1
Fish Oil vs. Placebo on Subjective Effects of Alcohol Start of enrollment: 2017 Mar 02
Completed
Phase 1
Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) - Alcohol Interaction Study Start of enrollment: 2021 Nov 09
Completed
Phase 1
Effect of Allopregnanolone on Stress-induced Craving Start of enrollment: 2019 Jul 01
Completed
Phase 1
Roles: Contact
Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD Start of enrollment: 2019 May 20
Terminated
Phase 2
Roles: Contact
Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study Start of enrollment: 2024 Apr 29
Not yet recruiting
Phase 1
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Cognitive processing therapy (CPT) versus individual drug counseling (IDC) for PTSD for veterans with opioid use disorder maintained on buprenorphine.
Sarah Meshberg-Cohen, Charla Nich, Megan M Kelly, Tracy Claudio, Jane Serrita Jane, Emily Pisani, Elizabeth Ralevski, Ismene L Petrakis> ;The American Journal on Addictions. 2024 Apr 16
The Management of Posttraumatic Stress Disorder and Acute Stress Disorder: Synopsis of the 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clin...
Paula P Schnurr, Jessica L Hamblen, Jonathan Wolf, Rachael Coller, Claire Collie, Matthew A Fuller, Paul E Holtzheimer, Ursula Kelly, Ariel J Lang, Kate McGraw, Joshua...> ;Annals of Internal Medicine. 2024 Mar 1
Written exposure therapy for veterans with co-occurring substance use disorders and PTSD: Study design of a randomized clinical trial.
Sarah Meshberg-Cohen, Joan M Cook, Amirah Bin-Mahfouz, Ismene L Petrakis> ;Contemporary Clinical Trials. 2024 Apr 1
Problematic Alcohol Use Trajectories in U.S. Military Veterans during a Public Health Crisis: Results from a 3-year, Nationally Representative, Longitudinal Study.
Na, P., Fischer, I., Petrakis, I., Pietrzak, R.> ;The Psychiatric Quarterly. 2024 Mar 1
The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications.
MacKenzie R Peltier, Terril L Verplaetse, Margaret Altemus, Yasmin Zakiniaeiz, Elizabeth A Ralevski, Yann S Mineur, Ralitza Gueorguieva, Marina R Picciotto, Kelly P Co...> ;Frontiers in Neuroendocrinology. 2024 Jan 4
1 citations
Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder - A Pilot Study.
Ralevski, E., Newcomb, J., Pisani, E., DeNegre, D., Peltier, M., Jane, J., Yoon, G., Petrakis, I.> ;Journal of Dual Diagnosis. 2024 Feb 1
Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-ba...
Peter Na, Hang Zhou, Janitza L Montalvo-Ortiz, Brenda Cabrera-Mendoza, Ismene L Petrakis, John H Krystal, Renato Polimanti, Joel Gelernter, Robert H Pietrzak> ;Psychological Medicine. 2023 Dec 1
1 citations
Developing Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs.
Yasmin Zakiniaeiz, MacKenzie R Peltier, Yann S Mineur, Ralitza Gueorguieva, Marina R Picciotto, Ismene Petrakis, Kelly P Cosgrove, Sherry A McKee> ;Journal of Women's Health. 2023 Aug 1
Comorbid alcohol use disorder and posttraumatic stress disorder: A proof-of-concept randomized placebo-controlled trial of buprenorphine and naltrexone combination tre...
Lori L Davis, Ismene L Petrakis, Patricia D Pilkinton, Tracy Nolen, Nathan Vandergrift, Shawn Hirsch, Seth D Norrholm, Thomas R Kosten> ;Alcohol, Clinical & Experimental Research. 2023 Sep 1
3 citations
Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study.
Peter J Na, Janitza Montalvo-Ortiz, Ismene Petrakis, John H Krystal, Renato Polimanti, Joel Gelernter, Robert H Pietrzak> ;Drug and Alcohol Dependence. 2023 May 1
Analysis of Drugs in Saliva of US Military Veterans Treated for Substance Use Disorders Using Supported Liquid Extraction and Surface-Enhanced Raman Spectral Analysis.
Stuart Farquharson, Chetan Shende, Jenelle Newcomb, Ismene L Petrakis, Albert J Arias> ;Molecules. 2023 Feb 21
A systematic review evaluating PTSD treatment effects on intermediate phenotypes of PTSD.
Alexandra N Palmisano, Sarah Meshberg-Cohen, Ismene L Petrakis, Mehmet Sofuoglu> ;Psychological Trauma. 2023 Jan 2
9 citations
National trends of suicidal ideation and mental health services use among US adults with opioid use disorder, 2009-2020.
Peter J Na, Tanner J Bommersbach, Ismene L Petrakis, Taeho Greg Rhee> ;Eclinicalmedicine. 2022 Dec 1
1 citations
Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers.
Elizabeth Ralevski, Tamas L Horvath, Marya Shanabrough, Jenelle Newcomb, Emily Pisani, Ismene Petrakis> ;Alcohol and Alcoholism. 2023 Jan 9
17 citations
Why are women more likely to attempt suicide than men? Analysis of lifetime suicide attempts among US adults in a nationally representative sample.
Tanner J Bommersbach, Robert A Rosenheck, Ismene L Petrakis, Taeho Greg Rhee> ;Journal of Affective Disorders. 2022 Aug 15
3 citations
Academic Medical Centers and the U.S. Department of Veterans Affairs: A 75-Year Partnership Influences Medical Education, Scientific Discovery, and Clinical Care.
Ismene L Petrakis, Michael Kozal> ;Academic Medicine. 2022 Aug 1
33 citations
Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomize...
Chadi G Abdallah, John D Roache, Ralitza Gueorguieva, Lynnette A Averill, Stacey Young-McCaughan, Paulo R Shiroma, Prerana Purohit, Antoinette Brundige, William Murff,...> ;Neuropsychopharmacology. 2022 Jul 1
Correction to: Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-b...
Chadi G Abdallah, John D Roache, Ralitza Gueorguieva, Lynnette A Averill, Stacey Young-McCaughan, Paulo R Shiroma, Prerana Purohit, Antoinette Brundige, William Murff,...> ;Neuropsychopharmacology. 2022 Jul 1
4 citations
Rationale, design and methods of VA-BRAVE: a randomized comparative effectiveness trial of two formulations of buprenorphine for treatment of opioid use disorder in ve...
Ismene Petrakis, Sandra A Springer, Cynthia Davis, Elizabeth Ralevski, Lucy Gu, Robert Lew, John Hermos, Melynn Nuite, Adam J Gordon, Thomas R Kosten, Edward V Nunes, ...> ;Addiction Science & Clinical Practice. 2022 Jan 31
8 citations
PTSD symptom heterogeneity and alcohol-related outcomes in U.S. military veterans: Indirect associations with coping strategies.
Alexandra N. Palmisano, Sonya B. Norman, Kaitlyn E. Panza, Ismene L. Petrakis, Robert H. Pietrzak> ;Journal of Anxiety Disorders. 2022 Jan 1
5 citations
Psychotherapy-supported MDMA treatment for PTSD.
John H. Krystal, Benjamin Kelmendi, Ismene L. Petrakis> ;Cell Reports. Medicine. 2021 Aug 17
7 citations
Disentangling the association between PTSD symptom heterogeneity and alcohol use disorder: Results from the 2019–2020 National Health and Resilience in Veterans Study
Alexandra N. Palmisano, Brienna M. Fogle, Jack Tsai, Ismene L. Petrakis, Robert H. Pietrzak> ;Journal of Psychiatric Research. 2021 Aug 1
6 citations
Treatment outcomes in individuals diagnosed with comorbid opioid use disorder and Posttraumatic stress disorder: A review.
Sarah Meshberg-Cohen, R. Ross MacLean, Ashley M. Schnakenberg Martin, Mehmet Sofuoglu, Ismene L. Petrakis> ;Addictive Behaviors. 2021 Jun 23
16 citations
Prevalence, risk and protective factors of alcohol use disorder during the COVID-19 pandemic in U.S. military veterans.
Peter J Na, Sonya B. Norman, Brandon Nichter, Melanie L. Hill, Marc I. Rosen, Ismene L. Petrakis, Robert H. Pietrzak> ;Drug and Alcohol Dependence. 2021 Aug 1
9 citations
Sex Differences in Opioid Use Disorder Prevalence and Multimorbidity Nationally in the Veterans Health Administration.
MacKenzie R. Peltier, Mehmet Sofuoglu, Ismene L. Petrakis, Elina Stefanovics, Robert A. Rosenheck> ;Journal of Dual Diagnosis. 2021 May 13
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Journal Articles

The Hidden Epidemic of Opioid Overdoses During the Coronavirus Disease 2019 Pandemic
Thomas R Kosten, Ismene L Petrakis, JAMA Psychiatry

Press Mentions

Yale Psychiatry's Anti-Racism Task Force Seeks to Address Diversity, Equity, InclusionSeptember 9th, 2021
Saluting Excellence in Health Professions EducationJuly 27th, 2021
New VA Annex Dedicated to Treating Serious Mental Illness Opens in Orange, CTOctober 25th, 2020
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Hospital Affiliations

Veterans Affairs Connecticut Healthcare SystemWest Haven, Connecticut