IsraelDavidGoldmanMD

PubMed

• 4 citations
  A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation
  He Qin Zhan, Mitra Najmi, Kai Lin, Srinivas Aluri, Andras Fiser, I. David Goldman, Rongbao Zhao> ;The Journal of Biological Chemistry. 2020 Nov 13
• 28 citations
  Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha
  Camille Alam, Susanne Aufreiter, Constantine J. Georgiou, Tozammel Hoque, Richard H. Finnell, Deborah L O'Connor, I. David Goldman, Reina Bendayan> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 Aug 27
• 6 citations
  Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation.
  Srinivas Aluri, Rongbao Zhao, Daniel Sanghoon Shin, Andras Fiser, I. David Goldman> ;The Journal of Biological Chemistry. 2019 May 3
• 6 citations
  Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1)
  Srinivas Aluri, Rongbao Zhao, Andras Fiser, I. David Goldman> ;American Journal of Physiology. Cell Physiology. 2018 Mar 1
• 5 citations
  Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer.
  Rongbao Zhao, Mitra Najmi, Srinivas Aluri, David C. Spray, I. David Goldman> ;Molecular Pharmacology. 2018 Jan 1
• 11 citations
  Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1.
  Srinivas Aluri, Rongbao Zhao, Charlotte M A Lubout, Susanna M. I. Goorden, Andras Fiser, I. David Goldman> ;Blood Advances. 2018 Jan 9
• 10 citations
  Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and...
  Srinivas Aluri, Rongbao Zhao, Andras Fiser, I. David Goldman> ;Biochimica Et Biophysica Acta. Biomembranes. 2017 Nov 1
• 35 citations
  Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier.
  Camille Alam, Tozammel Hoque, Richard H. Finnell, I. David Goldman, Reina Bendayan> ;Molecular Pharmaceutics. 2017 Sep 26
• 7 citations
  Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation
  Rongbao Zhao, Mitra Najmi, Srinivas Aluri, I. David Goldman> ;American Journal of Physiology. Cell Physiology. 2017 Jan 25
• 45 citations
  The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.
  Rongbao Zhao, Srinivas Aluri, I. David Goldman> ;Molecular Aspects of Medicine. 2017 Feb 1
• 5 citations
  Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function
  Mitra Najmi, Rongbao Zhao, Andras Fiser, I. David Goldman> ;American Journal of Physiology. Cell Physiology. 2016 Jul 1
• 14 citations
  Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.
  Rongbao Zhao, Mitra Najmi, Andras Fiser, I. David Goldman> ;The Journal of Biological Chemistry. 2016 Apr 8
• 6 citations
  Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis.
  Rongbao Zhao, Michele Visentin, I. David Goldman> ;Cancer Chemotherapy and Pharmacology. 2015 Apr 7
• 16 citations
  Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1)
  Michele Visentin, Ersin Selcuk Unal, Mitra Najmi, Andras Fiser, Rongbao Zhao, I. David Goldman> ;American Journal of Physiology. Cell Physiology. 2015 Apr 15
• 6 citations
  The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro
  Michele Visentin, Ersin Selcuk Unal, I. David Goldman> ;Cancer Chemotherapy and Pharmacology. 2014 Mar 29
• 13 citations
  Enhanced Receptor-mediated Endocytosis and Cytotoxicity of a Folic Acid-desacetylvinblastine Monohydrazide Conjugate in a Pemetrexed-Resistant Cell Line Lacking Folate...
  Rongbao Zhao, Ndeye Diop-Bove, I. David Goldman> ;Molecular Pharmacology. 2014 Feb 1
• 103 citations
  The Intestinal Absorption of Folates
  Michele Visentin, Ndeye Diop-Bove, Rongbao Zhao, I. David Goldman> ;Annual Review of Physiology. 2014 Feb 10
• 29 citations
  The proton-coupled folate transporter: physiological and pharmacological roles.
  Rongbao Zhao, I. David Goldman> ;Current Opinion in Pharmacology. 2013 Dec 1
• A novel deletion mutation in the proton-coupled folate transporter (PCFT; SLC46A1) in a Nicaraguan child with hereditary folate malabsorption.
  Diop-Bove, N.,Jain, M.,Scaglia, F.,Goldman, I. D.> ;Gene. 2013 Sep 25
• 14 citations
  Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.
  Rongbao Zhao, Michele Visentin, Sylvia O. Suadicani, I. David Goldman> ;Molecular Pharmacology. 2013 Jul 1
• 15 citations
  The membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitor.
  Michele Visentin, Ersin Selcuk Unal, Rongbao Zhao, I. David Goldman> ;Cancer Chemotherapy and Pharmacology. 2013 Jul 24
• 21 citations
  Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method
  Daniel Sanghoon Shin, Rongbao Zhao, Andras Fiser, I. David Goldman> ;American Journal of Physiology. Cell Physiology. 2013 Jun 15
• 119 citations
  Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.
  Rongbao Zhao, I. David Goldman> ;Molecular Aspects of Medicine. 2013 Apr 1
• 28 citations
  Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)
  Rongbao Zhao, Daniel Sanghoon Shin, Andras Fiser, I. David Goldman> ;American Journal of Physiology. Cell Physiology. 2012 Sep 15
• 18 citations
  Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate
  Michele Visentin, Rongbao Zhao, I. David Goldman> ;Molecular Pharmacology. 2012 Aug 1
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