ItaloBiaggioniMD

Internal Medicine • Nashville, TN

Clinical Pharmacology

Professor, Medicine, Vanderbilt University School of Medicine

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Office
3601 Tvc
Nashville, TN 37232
Phone+1 615-322-3000
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Education & Training

Cayetano Heredia UniversityClass of 1980

Certifications & Licensure

TN State Medical License 1987 - 2024
AL State Medical License 2020 - 2020

Clinical Trials

Nitric Oxide and the Autonomic Nervous System Start of enrollment: 2002 Aug 01
Completed
Not Applicable
AMP as a Better Delivery System of Adenosine Start of enrollment: 2003 Oct 01
Terminated
Phase 1
The Autonomic Nervous System and Obesity Start of enrollment: 2003 Apr 01
Completed
Phase 1
Treatment of Orthostatic Hypotension in Autonomic Failure Start of enrollment: 2002 Mar 01
Completed
Phase 1
Treatment of Supine Hypertension in Autonomic Failure Start of enrollment: 2001 Jan 01
Completed
Phase 1
Autonomic Nervous System and Chronic Fatigue Syndrome Start of enrollment: 2007 Apr 01
Completed
Phase 1
Role of Adenosine in the Release of VEGF and Cytokines Start of enrollment: 2007 Jun 01
Terminated
Phase 1
The Autonomic Nervous System and the Metabolic Syndrome Start of enrollment: 2008 Aug 01
Completed
Not Applicable
Treatment of Orthostatic Hypotension Start of enrollment: 2004 Jan 01
Terminated
Phase 2, Phase 3
Pathophysiology of Orthostatic Intolerance Start of enrollment: 1996 Dec 01
Recruiting
Not Applicable
Nebivolol in the Supine Hypertension of Autonomic Failure Start of enrollment: 2010 Jan 01
Completed
Not Applicable
The Role of Endothelin in the Supine Hypertension of Autonomic Failure Start of enrollment: 2010 May 01
Withdrawn
Phase 1
Pathophysiology of Cardiometabolic Risk Factors in African Americans Start of enrollment: 2010 Jan 01
Completed
Phase 1
Autonomic Nervous System and Nitric Oxide Interactions Start of enrollment: 2010 Jun 01
Completed
Phase 1
Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure Start of enrollment: 2011 Mar 01
Terminated
Phase 1
Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension Start of enrollment: 2011 Mar 01
Completed
Magnetic Resonance Spectroscopy in Autonomic Failure Start of enrollment: 2012 Jul 01
Terminated
Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake Start of enrollment: 2012 Aug 01
Completed
Phase 1
High Sodium Diet and External Abdominal Compression in POTS Start of enrollment: 2012 Dec 01
Terminated
Phase 1
Modafinil and Cognitive Function in POTS Start of enrollment: 2014 Oct 01
Active, not recruiting
Early Phase 1
Cardiovascular Effects of Angiotensin (1-7) in Essential Hypertension Start of enrollment: 2015 Jan 01
Terminated
Phase 1
Local Heat Stress in Autonomic Failure Patients With Supine Hypertension Start of enrollment: 2015 Apr 01
Completed
Not Applicable
Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension Start of enrollment: 2015 Apr 01
Active, not recruiting
Phase 1
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure Start of enrollment: 2015 Apr 01
Recruiting
Phase 1
TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) Start of enrollment: 2017 Sep 09
Completed
Phase 2
Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic Start of enrollment: 2016 Apr 01
Active, not recruiting
Phase 1
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Start of enrollment: 2016 Sep 01
Recruiting
Phase 1
Autonomic Blockade and Endogenous Glucose Production Start of enrollment: 2017 Apr 17
Withdrawn
Phase 1
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension Start of enrollment: 2017 Jan 30
Recruiting
Not Applicable
Vagal Stimulation in POTS Start of enrollment: 2017 Sep 30
Active, not recruiting
Phase 1
Treatment of Supine Hypertension in Autonomic Failure (CPAP) Start of enrollment: 2017 Sep 21
Recruiting
Not Applicable
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity Start of enrollment: 2017 Oct 24
Recruiting
Phase 1
Sympathetic Mechanisms in the Cardiovascular and Metabolic Alterations of Obesity Start of enrollment: 2021 Feb 23
Suspended
Phase 1
Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure Start of enrollment: 2020 Aug 21
Recruiting
Not Applicable
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Publications & Presentations

PubMed

David Herlie Robertson, MD.
David G Harrison, Cyndya A Shibao, Italo Biaggioni> ;Hypertension. 2024 May 1
Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study.
Millar Vernetti, P., Norcliffe-Kaufmann, L., Palma, J., Biaggioni, I., Shibao, C., Peltier, A., Freeman, R., Gibbons, C., Goldstein, D., Low, P., Singer, W., Coon, E.,...> ;Brain. 2024 Feb 15
In memoriam: a celebration of the autonomic contributions of David Robertson (1947-2024).
Italo Biaggioni, Amy C Arnold, Bonnie Black, Andre Diedrich, Raffaello Furlan, Alfredo Gamboa, Emily Garland, Giris Jacob, Jens Jordan, Luis E Okamoto, Satish R Raj, K...> ;Clinical Autonomic Research. 2024 Feb 1
When Blood Pressure Increases with Standing: Consensus Definition for Diagnosing Orthostatic Hypertension.
Jens Jordan, Italo Biaggioni, Guido Grassi, Artur Fedorowski, Kazuomi Kario> ;Blood Pressure. 2023 Dec 1
Engaging patients in the management of orthostatic intolerance.
Juan Idiaquez, Juan Carlos Casar, Juan Francisco Idiaquez Rios, Italo Biaggioni> ;Clinical Autonomic Research. 2023 Dec 1
Raising awareness for cardiovascular autonomic dysfunction: the 2023 European Society of Hypertension guidelines revisited.
Jens Jordan, Italo Biaggioni> ;Clinical Autonomic Research. 2023 Dec 1
Long-Term Outcomes of Hyperadrenergic Orthostatic Hypotension.
Robert Alexander Castro, Patricio Millar Vernetti, Italo Biaggioni, Satish R Raj, Horacio Kaufmann, Cyndya A Shibao> ;Research Square. 2023 Sep 11
2 citations
Impaired parasympathetic function in long-COVID postural orthostatic tachycardia syndrome - a case-control study.
Stefano Rigo, Vasile Urechie, Andrè Diedrich, Luis E Okamoto, Italo Biaggioni, Cyndya A Shibao> ;Bioelectronic Medicine. 2023 Sep 6
All orthostatic hypotension is neurogenic.
Italo Biaggioni> ;Clinical Autonomic Research. 2023 Aug 1
Orthostatic hypertension-too much of a good thing.
Italo Biaggioni, Jens Jordan> ;Clinical Autonomic Research. 2023 Aug 1
Adrenal gland response to adrenocorticotropic hormone is intact in patients with postural orthostatic tachycardia syndrome.
Jill K H Laurin, Oyebimbola A Oyewunmi, Emily M Garland, Alfredo Gamboa, Victor C Nwazue, Sachin Y Paranjape, Bonnie K Black, Luis E Okamoto, Cyndya A Shibao, Italo Bi...> ;Autonomic Neuroscience. 2023 Sep 1
1 citations
Symptoms of postural orthostatic tachycardia syndrome in pregnancy: a cross-sectional, community-based survey.
Kate M Bourne, Kara A Nerenberg, Lauren E Stiles, Cyndya A Shibao, Luis E Okamoto, Emily M Garland, Alfredo Gamboa, Amanda Peltier, André Diedrich, Italo Biaggioni, Ro...> ;BJOG. 2023 Aug 1
1 citations
Post-COVID-19 Afferent Baroreflex Failure.
Khaled Elkholey, Amr Wahba, Sachin Y Paranjape, Mohammad Saleem, Annet Kirabo, Karen M Joos, André Diedrich, Cyndya A Shibao, Italo Biaggioni> ;Hypertension. 2023 May 1
1 citations
Use of Valsalva Maneuver to Detect Late-Onset Delayed Orthostatic Hypotension.
Jin-Woo Park, Luis E Okamoto, Sung-Hwan Kim, Seol-Hee Baek, Joo Hye Sung, Namjoon Jeon, Alfredo Gamboa, Cyndya A Shibao, André Diedrich, Byung-Jo Kim, Italo Biaggioni> ;Hypertension. 2023 Apr 1
1 citations
Continuous Positive Airway Pressure for the Treatment of Supine Hypertension and Orthostatic Hypotension in Autonomic Failure.
Luis E Okamoto, Jorge E Celedonio, Emily C Smith, Sachin Y Paranjape, Bonnie K Black, Amr Wahba, Jin-Woo Park, Cyndya A Shibao, André Diedrich, Italo Biaggioni> ;Hypertension. 2023 Mar 1
5 citations
Consensus statement on the definition of orthostatic hypertension endorsed by the American Autonomic Society and the Japanese Society of Hypertension.
Jens Jordan, Italo Biaggioni, Vasilios Kotsis, Peter Nilsson, Guido Grassi, Artur Fedorowski, Kazuomi Kario> ;Hypertension Research. 2023 Feb 1
11 citations
Consensus statement on the definition of orthostatic hypertension endorsed by the American Autonomic Society and the Japanese Society of Hypertension.
Jens Jordan, Italo Biaggioni, Vasilios Kotsis, Peter Nilsson, Guido Grassi, Artur Fedorowski, Kazuomi Kario> ;Clinical Autonomic Research. 2023 Feb 1
2 citations
Management of Patients With Hypertension and Orthostatic Hypotension. Parallel Progress.
Stephen P Juraschek, Italo Biaggioni> ;Hypertension. 2022 Nov 1
Correction to: Effect of nitroglycerin on splanchnic and pulmonary blood volume.
Luis E Okamoto, William D Dupont, Italo Biaggioni, Marvin W Kronenberg> ;Journal of Nuclear Cardiology. 2022 Apr 1
7 citations
Advances in the Pathophysiology and Management of Supine Hypertension in Patients with Neurogenic Orthostatic Hypotension.
Jin-Woo Park, Luis E Okamoto, Italo Biaggioni> ;Current Hypertension Reports. 2022 Mar 1
1 citations
Evaluation and Diagnosis of Afferent Baroreflex Failure.
Italo Biaggioni, Cyndya A Shibao, Jens Jordan> ;Hypertension. 2022 Jan 1
4 citations
Effect of nitroglycerin on splanchnic and pulmonary blood volume
Luis E. Okamoto, William D. Dupont, Italo Biaggioni, Marvin W. Kronenberg, Amy K Wright> ;Journal of Nuclear Cardiology. 2021 Nov 2
7 citations
Safety and efficacy of ampreloxetine in symptomatic neurogenic orthostatic hypotension: a phase 2 trial
Horacio Kaufmann, Ross Vickery, Whedy Wang, Jitendra Kanodia, Cyndya A. Shibao, Lucy Norcliffe-Kaufmann, Brett Haumann, Italo Biaggioni> ;Clinical Autonomic Research. 2021 Oct 17
2 citations
Blood pressure regulation in autonomic failure by dietary sodium, blood volume and posture.
Italo Biaggioni> ;Autonomic Neuroscience. 2021 Oct 6
16 citations
Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome.
André Diedrich, Vasile Urechie, Dana Shiffer, Stefano Rigo, Maura Minonzio, Beatrice Cairo, Emily C Smith, Luis E. Okamoto, Franca Barbic, Andrea Bisoglio, Alberto Por...> ;Autonomic Neuroscience. 2021 Sep 29
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Press Mentions

Long-Term Effects of COVID-19 on Heart, Cardiovascular System Under Study After AHA GrantApril 16th, 2022
$Initiation of Droxidopa During Hospital Admission for Management of Refractory Neurogenic Orthostatic Hypotension in Severely Ill Patients$
Initiation of Droxidopa During Hospital Admission for Management of Refractory Neurogenic Orthostatic Hypotension in Severely Ill PatientsSeptember 1st, 2019
Awards Honor Profound Impact of Research StaffJune 20th, 2019
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Grant Support

Cardiovascular Regulations Autonomic/Metabolic MechanismsNational Heart, Lung, And Blood Institute2012
Clinical CoreNational Heart, Lung, And Blood Institute2007–2012
Cardiovascular Reguations: Autonomic/Metbolic MechanismsNational Heart, Lung, And Blood Institute2010–2011
Project 2 - Autonomic RARE Diseases Clinical Research ConsortiumNational Institute Of Neurological Disorders And Stroke2009–2011
Autonomic Nervous System In Chronic Fatigue SyndromeNational Institute Of Neurological Disorders And Stroke2006–2009
Oxide And Autonomic MechanismsNational Center For Research Resources2005–2008
The Autonomic Nervous System And ObesityNational Center For Research Resources2004–2008
Adenosine And Nitric Oxide Interaction In Vascular RegulationNational Center For Research Resources2004–2008
Etiology And Pathophysiology Of Autonomic FailureNational Center For Research Resources1993–2008
Cardiovascular Regulations: Autonomic/Metabolic MechanismsNational Heart, Lung, And Blood Institute2007
Role Of Adenosine And Nitric Oxide On The Mechanism Of Action Of AggrenoxNational Center For Research Resources2004
Oxide And Autonomic Mechanisms .National Center For Research Resources2004
Adenosine And Nitric Oxide DeficiencyNational Heart, Lung, And Blood Institute2001–2004
Pharmacologic Probes In Neurally-Mediated SyncopeNational Heart, Lung, And Blood Institute2002–2003
Nitric Oxide In Autonomic FailureNational Center For Research Resources2000–2002
Renal Denervation In Orthostatic IntoleranceNational Center For Research Resources1999–2002
Adenosine In Exercise Pressor ReflexNational Center For Research Resources1998–2002
Adenosine A2B Receptors In Human MAST CellsNational Center For Research Resources1998–2002
Core--AnalyticalNational Heart, Lung, And Blood Institute1997–2002
Cardiovascular Regulation--Autonomic/Metabolic MechanismsNational Heart, Lung, And Blood Institute1997–2002
Cardiovascular Effects Of CocaineNational Center For Research Resources1993–1995
Adenosine And Neural Mechanisms Of Cardiovascular ControlNational Heart, Lung, And Blood Institute1991–1994
Effect Of ACE Inhibition On Sympathetic ActivityNational Center For Research Resources1992
Circulatory Control In Chronic Hypotensive StatesNational Center For Research Resources1992
Autonomic Dysfuntion--Taxonomy And TherapyNational Center For Research Resources1990–1991
DOPA As An Endogenous NeurohormoneNational Center For Research Resources1990
Adenosine And MAST Cell ActivationNational Center For Research Resources1989
Determinants Of The Hemodynamic Effects Of AdenosineNational Center For Research Resources1987–1989

Hospital Affiliations

Vanderbilt University Medical CenterNashville, Tennessee