J MichaelMichaelMcintoshMD

PubMed

• Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters.
  Benjamin M Williams, Nathan D Steed, Joel T Woolley, Aubrey A Moedl, Christina A Nelson, Gavin C Jones, Matthew D Burris, Hugo R Arias, Oc-Hee Kim, Eun Young Jang, Ari...> ;ACS Chemical Neuroscience. 2024 Apr 13
• αO-Conotoxin GeXIVA[1,2] Reduced Neuropathic Pain and Changed Gene Expression in Chronic Oxaliplatin-Induced Neuropathy Mice Model.
  Huanbai Wang, Xiaodan Li, Yamin Qiao, Meiting Wang, Wen Wang, J Michael McIntosh, Dongting Zhangsun, Sulan Luo> ;Marine Drugs. 2024 Jan 19
• Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of α7 versus α3β4 nicotinic receptor subtypes in mouse hi...
  Amanda Jiménez-Pompa, Raquel L Arribas, J Michael McIntosh, Almudena Albillos> ;Biochemical and Biophysical Research Communications. 2023 Dec 3
• 22 citations
  Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation.
  Arik J Hone, J Michael McIntosh> ;Pharmacological Research. 2023 Apr 1
• 5 citations
  Role of α6-Nicotinic Receptors in Alcohol-Induced GABAergic Synaptic Transmission and Plasticity to Cholinergic Interneurons in the Nucleus Accumbens.
  Hillary A Wadsworth, Elizabeth Q Anderson, Benjamin M Williams, Joakim W Ronström, Janna K Moen, Anna M Lee, J Michael McIntosh, Jie Wu, Jordan T Yorgason, Scott C Ste...> ;Molecular Neurobiology. 2023 Jun 1
• 4 citations
  Cross Talk between α7 and α3β4 Nicotinic Receptors Prevents Their Desensitization in Human Chromaffin Cells.
  Amanda Jiménez-Pompa, Sara Sanz-Lázaro, Romidan Ewere Omodolor, José Medina-Polo, Carmen González-Enguita, Jesús Blázquez, J Michael McIntosh, Almudena Albillos> ;The Journal of Neuroscience. 2022 Feb 16
• 11 citations
  Comparison of the Anti-inflammatory Properties of Two Nicotinic Acetylcholine Receptor Ligands, Phosphocholine andCF3-diEPP.
  Katrin Richter, Roger L Papke, Clare Stokes, Danika C Roy, Eduardo S Espinosa, Philipp M K Wolf, Andreas Hecker, Juliane Liese, Vijay K Singh, Winfried Padberg, Klaus-...> ;Frontiers in Cellular Neuroscience. 2022 Jan 1
• 3 citations
  Application of alpha1-antitrypsin in a rat model of veno-arterial extracorporeal membrane oxygenation.
  Fabian Edinger, Christoph Schmitt, Christian Koch, J. Michael McIntosh, Sabina Janciauskiene, Melanie Markmann, Michael Sander, Winfried Padberg, Veronika Grau> ;Scientific Reports. 2021 Aug 4
• 8 citations
  Cy3-RgIA-5727 Labels and Inhibits α9-Containing nAChRs of Cochlear Hair Cells
  Fernando Fisher, Yuanyuan Zhang, Philippe F. Y. Vincent, Joanna Gajewiak, Thomas J. Gordon, Elisabeth Glowatzki, Paul A. Fuchs, J. Michael McIntosh> ;Frontiers in Cellular Neuroscience. 2021 Jul 23
• 4 citations
  Nicotinic Acetylcholine Receptor Partial Antagonist Polyamides from Tunicates and Their Predatory Sea Slugs
  Noemi D. Paguigan, Jortan O. Tun, Lee S. Leavitt, Zhenjian Lin, Kevin Chase, Cheryl Dowell, Cassandra E. Deering-Rice, Albebson L. Lim, Manju Karthikeyan, Ronald W. Hu...> ;ACS Chemical Neuroscience. 2021 Jul 21
• 14 citations
  Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment ...
  Nan Zheng, Sean Christensen, Cheryl Dowell, Landa Purushottam, Jack J. Skalicky, J. Michael McIntosh, Danny Hung-Chieh Chou> ;Journal of Medicinal Chemistry. 2021 Jul 8
• 14 citations
  Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.
  Joanna Gajewiak, Sean Christensen, Cheryl Dowell, Fuaad Hararah, Fernando Fisher, Peter N. Huynh, Baldomero M. Olivera, J. Michael McIntosh> ;Journal of Medicinal Chemistry. 2021 Jun 18
• 1 citations
  Therapeutic concentrations of varenicline increases exocytotic release of catecholamines from human and rat adrenal chromaffin cells in the presence of nicotine
  Amanda Jiménez-Pompa, Sara Sanz-Lázaro, Arik J. Hone, Lola Rueda-Ruzafa, José Medina-Polo, Carmen González-Enguita, Jesús Blázquez, Cristóbal de los Ríos, J. Michael M...> ;Neuropharmacology. 2021 Jun 4
• 1 citations
  Author Correction: Rapid multi-directed cholinergic transmission in the central nervous system.
  Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin L Murphy-Baum, Claudio Grosman, J. Michael McIntosh, Miao Jing, Yulong Li, David M. Berson, Kei...> ;Nature Communications. 2021 Apr 21
• 15 citations
  Rapid multi-directed cholinergic transmission in the central nervous system
  Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin L Murphy-Baum, Claudio Grosman, J. Michael McIntosh, Miao Jing, Yulong Li, David M. Berson, Kei...> ;Nature Communications. 2021 Mar 2
• 11 citations
  Computational and Functional Mapping of Human and Rat α6β4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs
  Arik J. Hone, Quentin Kaas, Ireland Kearns, Fuaad Hararah, Joanna Gajewiak, Sean Christensen, David J. Craik, J. Michael McIntosh> ;Journal of Medicinal Chemistry. 2021 Feb 1
• 16 citations
  The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model.
  Shakir D. AlSharari, Wisam Toma, Hafiz Majid Mahmood, J. Michael McIntosh, M. Imad Damaj> ;European Journal of Pharmacology. 2020 Sep 15
• 8 citations
  Amyloid Beta Peptide (Aβ1-42) Reverses the Cholinergic Control of Monocytic IL-1β Release.
  Katrin Richter, Raymond Ogiemwonyi-Schaefer, Sigrid Wilker, Anna I Chaveiro, Alisa Agné, Matthias Hecker, Martin Reichert, Anca-Laura Amati, Klaus-Dieter Schlüter, Iva...> ;Journal of Clinical Medicine. 2020 Sep 7
• 11 citations
  Efferent synaptic transmission at the vestibular type II hair cell synapse.
  Zhou Yu, J. Michael McIntosh, Soroush G. Sadeghi, Elisabeth Glowatzki> ;Journal of Neurophysiology. 2020 Aug 1
• 19 citations
  Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research
  Walden E. Bjørn-Yoshimoto, Iris Bea L Ramiro, Mark Yandell, J. Michael McIntosh, Baldomero M. Olivera, Lars Ellgaard, Helena Safavi-Hemami> ;Biomedicines. 2020 Jul 22
• 10 citations
  Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors.
  Nan Zheng, Sean Christensen, Alan Blakely, Cheryl Dowell, Landa Purushottam, J. Michael McIntosh, Danny Hung-Chieh Chou> ;Journal of Medicinal Chemistry. 2020 Jun 29
• 11 citations
  Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors.
  Peter N. Huynh, Peta J. Harvey, Joanna Gajewiak, David J. Craik, J. Michael McIntosh> ;Biochemical Pharmacology. 2020 Jun 25
• 8 citations
  αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish
  Matthew J Rybin, Henrik O'Brien, Iris Bea L Ramiro, Layla Azam, J. Michael McIntosh, Baldomero M. Olivera, Helena Safavi-Hemami, Doju Yoshikami> ;Toxins. 2020 Mar 21
• 11 citations
  Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists.
  Arik J. Hone, Lola Rueda-Ruzafa, Thomas J. Gordon, Joanna Gajewiak, Sean Christensen, Tino Dyhring, Almudena Albillos, J. Michael McIntosh> ;Journal of Neurochemistry. 2020 Jan 22
• 8 citations
  Behavioral and Molecular Basis of Cholinergic Modulation of Pain: Focus on Nicotinic Acetylcholine Receptors.
  Wisam Toma, Esad Ulker, Mashael Alqasem, Shakir D. AlSharari, J. Michael McIntosh, M. Imad Damaj> ;Current Topics in Behavioral Neurosciences. 2020 Jan 1
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Journal Articles

• Differential roles of alpha6beta2* and alpha4beta2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice  
  Sanjakdar SS, Maldoon PP, Marks MJ, Brunzell DH, Maskos U, McIntosh JM, Bowers MS, Damaj MI, Neuropsychopharmacology, 1/1/2015
• The alpha7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions  
  Bordia T, McGregor M, Papke RL, Decker MW, McIntosh JM, Quik M, Exp Neurol, 1/1/2015
• Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents  
  Kewin K, Jordan Cameron P, Klapczynski M, McIntosh JM, Crooks PA, Dwoskin LP, Lysakowski, J Neurosci, 1/1/2015
• Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via alpha6-containing nicotinic receptors  
  Engle SE, McIntosh JM, Drenan RM, Neuropharmacology, 1/1/2015
• Key residues in the nicotinic acetylcholine receptor beta2 subunit contribute to alpha-conotoxin LvIA binding  
  Zhangsun D, Zhu X, Wu Y, Hu Y, Kaas Q, Craik DJ, McIntosh JM, Luo S, J Biol Chem, 1/1/2015
• Molecular interaction of alphaconotoxin RgIA with the rat alpha9alpha10 nicotinic acetylcholine recepto  
  Azam L, Papakyriakou A, Zouridakis M, Giastas P, Tzartos SJ, McIntosh JM, Mol Pharmacol, 1/1/2015
• Evidence for a role for alpha6( *) nAChRs in ldopa- induced dyskinesias using Parkinsonian alpha6( *) nAChR gain-of-function mice  
  Bordia T, McGregor M, McIntosh JM, Drenan RM, Quik M, Neuroscience, 1/1/2015
• Cloning, synthesis, and characterization of alphaO-conotoxin GeXIVA, a potent alpha9alpha10 nicotinic acetylcholine receptor antagonist  
  Luo S, Zhangsun D, Harvey PJ, Kaas Q, Wu Y, Zhu X, Hu Y, Li X, Tsetlin VI, Christensen S, Romero HK, McIntyre M, Dowell C, Baxter JC, Elmslie KS, Craik DJ, McIntosh JM, Proc Natl Acad Sci U S A, 1/1/2015
• alphaS-conotoxin GVIIIB potently and selectively blocks alpha9alpha10 nicotinic acetylcholine receptors  
  Christensen SB, Bandyopadhyay PK, Olivera BM, McIntosh JM, Biochem Pharmacol, 1/1/2015
• alpha6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity  
  Berry JN, Engle SE, McIntosh JM, Drenan RM, Neuroscience, 1/1/2015
• r-bPiDI, an alpha6beta2* Nicotinic Receptor Antagonist, Decreases Nicotine- Evoked Dopamine Release and Nicotine Reinforcement  
  Beckmann JS, Meyer AC, Pivavarchyk M, Horton DB, Zheng G, Smith AM, Wooters TE, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP, Neurochem Res, 1/1/2015
• alpha-Conotoxins Identify the alpha3beta4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells  
  Hone AJ, McIntosh JM, Azam L, Lindstrom J, Lucero L, Whiteaker P, Passas J, Blazquez J, Albillos A, Mol Pharmacol, 1/1/2015
• Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula  
  Shih PY, McIntosh JM, Drenan RM, Mol Pharmacol, 1/1/2015
• Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits  
  Vieira-Brock PL, McFadden LM, Nielsen SM, Ellis JD, Walters ET, Stout KA, McIntosh JM, Wilkins DG, Hanson GR, Fleckenstein AE, J Pharmacol Exp Ther, 1/1/2015
• Limited efficacy of alpha-conopeptides  
  Wright AB, Norimatsu Y, McIntosh JM, Elmslie KS, eNeuro, 1/1/2015
• The influence of nondisclosure on the mental health of urban African- American adolescents exposed to community violence  
  Dinizulu SM, Grant KE, McIntosh JM, J Prev Interv Community, 1/1/2014
• Monkey Adrenal Chromaffin Cells Express alpha6beta4* Nicotinic Acetylcholine Receptors  
  Hernandez-Vivanco A, Hone AJ, Scadden ML, Carmona-Hidalgo B, McIntosh JM, Albillos A, PLoS ONE, 1/1/2014
• Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function alpha6* nAChRs  
  Wang Y, Lee JW, Oh G, Grady SR, McIntosh JM, Brunzell DH, Cannon JR, Drenan RM, J Neurochem, 1/1/2014
• ABT-089 and ABT-894 reduce levodopa-induced dyskinesias in a monkey model of Parkinson's disease  
  Zhang D, Bordia T, McGregor M, McIntosh JM, Decker MW, Quik M, Mov Disord, 1/1/2014
• A novel alpha4/7-conotoxin LvIA from Conus lividus that selectively blocks alpha3beta2 vs alpha6/alpha3beta2beta3 nicotinic acetylcholine receptors  
  Luo S, Zhangsun D, Schroeder CI, Zhu X, Hu Y, Wu Y, Weltzin MM, Eberhard S, Kaas Q, Craik DJ, McIntosh JM, Whiteaker P, FASEB J, 1/1/2014
• Discovery of a potent and selective alpha3beta4 nicotinic acetylcholine receptor antagonist from an alpha-conotoxin synthetic combinatorial library  
  Chang YP, Banerjee J, Dowell C, Wu J, Gyanda R, Houghten RA, Toll L, McIntosh JM, Armishaw CJ, J Med Chem, 1/1/2014
• Presence of multiple binding sites on alpha9alpha10 nAChR receptors alludes to stoichiometric-dependent action of the alphaconotoxin, Vc11  
  Indurthi DC, Pera E, Kim HL, Chu C, McLeod MD, McIntosh JM, Absalom NL, Chebib M, Biochem Pharmacol, 1/1/2014
• Acute Ethanol Inhibits Dopamine Release in the Nucleus Accumbens via alpha6 Nicotinic Acetylcholine Receptors  
  Schilaty ND, Hedges DM, Jang EY, Folsom RJ, Yorgason JT, McIntosh JM, Steffensen SC, J Pharmacol Exp Ther, 1/1/2014
• alpha6beta2*- subtype nicotinic acetylcholine receptors are more sensitive than alpha4beta2*-subtype receptors to regulation by chronic nicotine administration  
  Marks MJ, Grady SR, Salminen O, Paley MA, Wageman CR, McIntosh JM, Whiteaker P, J Neurochem, 1/1/2014
• The alpha3beta4* nicotinic Ach receptor subtype mediates physical dependence to morphine: mouse and human studies  
  Muldoon PP, Jackson KJ, Perez E, Harenza JL, Molas S, Rais B, Anwar H, Zaveri NT, Maldonado R, Maskos U, McIntosh JM, Dierssen M, Miles MF, Chen X, De Biasi M, Damaj MI, Br J Pharmacol, 1/1/2014
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Books/Book Chapters

• Neuronal Nicotinic Receptors 
  Chapter: Toxin antagonists of the neuronal nicotinic acetylcholine receptor 
  Page 455 - 476McIntosh JMEditors: Clementi F, Fornasari D, Gotti C.Springer-Verlag, Berlin, Germany2000
• Animal Toxins - Facts and Protocols 
  Chapter: Conus peptides and their iodinated derivatives as probes for ion channels and receptors 
  Page 74 - 89Cruz LJ, McIntosh JM, Imperial JS, Gray WREditors: Rochat H, Martin-Eauclaire MF.Birkhauser Verlag, Basel, Switzerland1999
• Aspects in Marine Pharmacology 
  Chapter: alpha-Conotoxins and nicotinic acetylcholine receptors 
  Page 28 - 33McIntosh JMEditors: Lazarovici P, Spira M, Zlotkin E.Alaken Inc., Fort Collins, CO1996
• Technologies in Protein Chemistry VI 
  Chapter: MS based scanning methodologies applied to Conus venom 
  Page 31 - 38Craig AG, Fischer WH, Rivier JE, McIntosh JM, Gray WREditors: Crabb JW.Academic Press, San Diego, CA1995
• Gene-Brain-Behaviour, Proceedings of the 21st Gottingen Neurobiology Conference 
  Chapter: Conus peptides as tools for the neuroscientist 
  Page 159 - 169Olivera BM, McIntosh JM, Cruz LJEditors: Elsner N, Heisenberg M.Georg Thieme Verlag, Stuttgart, Germany; New York, NY1993
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Abstracts/Posters

• alpha-Conotoxin ImI, a selective ligand for neuronal nAChRs
  McIntosh JM, Johnson DS, Yoshikami D, Mahe E, Nielsen DB, Rivier JE, Gray WR, Olivera BM, International Symposium on Nicotine: The Effects of Nicotine on Biological Systems, Basel, Switzerland, 1/1/1994

Lectures

• Nicotinic Acetylcholine Receptors as Therapeutic Targets 
  1/1/2010
• Natrual Peptides to Drugs 
  Zurmatt, Switzerland - 1/1/2008
• Nicotinic Acetylcholine Receptors 
  Cambridge UK - 1/1/2008
• Similar expression pattern of alpha-conotoxin MII sites and the dopamine transporter in control and MPTP lesioned monkey basal ganglia 
  1/1/2001
• Most mousebrain [125I]alpha-conotoxin MII-binding sites are unaffected by alpha3 nicotinic subunit-null mutation 
  Paris, France - 1/1/2001
• Nicotinic receptors on noradrenergic neurons in rat and human cortex 
  Lyon, France - 1/1/2001
• Effects of the nicotinic acetylcholine receptor b4 subunit null mutation on synaptosomal neurotransmitter release 
  Paris, France - 1/1/2001
• alpha-Conotoxin MII differentially inhibits nicotine-induced Ca2+ changes in rat striatal synaptosomes 
  1/1/2000
• New conotoxins which affect neuronal sodium channels in mammals 
  Germany - 1/1/1996
• alpha-Conotoxin MII blocks nicotine-stimulated dopamine release 
  1/1/1996
• The use of conotoxins for the study of sodium channels in Aplysia 
  1/1/1995
• Isolation and characterization of an alpha-conotoxin from Conus ermineus 
  1/1/1994
• The pharmacology of Conus peptides 
  1/1/1994
• Ontogenetic changes in N-type calcium channels of the human cerebellum, hippocampus and frontal cortex 
  1/1/1994
• Conotoxins targeted to voltage-sensitive sodium channels 
  1/1/1994
• Postnatal ontogeny of N-type calcium channels in rat brain: caudo-rostral evolution and transient expression 
  1/1/1993
• Purification and characterization of a novel phospholipase A2 from the venom of Conus magus 
  Bath, England - 1/1/1993
• Identification of a novel calcium channel antagonist from the venom of Conus magus 
  1/1/1992
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