J. RandolphHechtMD

PubMed

• 1 citations
  Fecal and Tissue Microbiota Are Associated with Tumor T-Cell Infiltration and Mesenteric Lymph Node Involvement in Colorectal Cancer.
  Kayti Luu, Jason Y Ye, Venu Lagishetty, Fengting Liang, Megan Hauer, Farzaneh Sedighian, Mary R Kwaan, Kevork K Kazanjian, J Randolph Hecht, Anne Y Lin, Jonathan P Jacobs> ;Nutrients. 2023 Jan 9
• 3 citations
  Preclinical and Clinical Trial Results Using Talazoparib and Low-Dose Chemotherapy.
  Zev A Wainberg, Arun S Singh, Gottfried E Konecny, Kelly E McCann, J Randolph Hecht, Jonathan Goldman, Bartosz Chmielowski, Richard S Finn, Neil O'Brien, Erika Von Euw...> ;Clinical Cancer Research. 2023 Jan 4
• 9 citations
  Discovery and characterization of circulating tumor cell clusters in neuroendocrine tumor patients using nanosubstrate-embedded microchips.
  Na Sun, Yingying Yang, Hui Miao, Peter Redublo, Hongtao Liu, Wenfei Liu, Yen-Wen Huang, Pai-Chi Teng, Ceng Zhang, Ryan Y Zhang, Matthew Smalley, Peng Yang, Shih-Jie Ch...> ;Biosensors & Bioelectronics. 2022 Mar 1
• 17 citations
  A Randomized Phase 2 Study Of Nivolumab Monotherapy Or Nivolumab Combined with Ipilimumab In Patients with Advanced Gastrointestinal Stromal Tumors
  Arun S. Singh, J. Randolph Hecht, Lee S. Rosen, Zev A. Wainberg, Xiaoyan Wang, Michael Douek, Anahis Hagopian, Rachel Andes, Lauren Sauer, Sandra Brackert, Warren Chow...> ;Clinical Cancer Research. 2021 Aug 18
• 2 citations
  Impact of geography on prognostic outcomes of 21,509 patients with metastatic colorectal cancer enrolled in clinical trials: an ARCAD database analysis
  Jun Yin, Shaheenah Dawood, Romain Cohen, Jeffrey P. Meyers, John Zalcberg, Takayuki Yoshino, Matthew T. Seymour, Tim Maughan, Leonard B. Saltz, Eric Van Cutsem, Alan P...> ;Therapeutic Advances in Medical Oncology. 2021 Jun 30
• 1 citations
  Survival Advantage of Yttrium-90 Radioembolization to Systemic Therapy in Patients with Hepatic Metastases from Colorectal Cancer in the Salvage Setting: Results of a ...
  Zachary Haber, Edward Lee, Megan Price, Zev A. Wainberg, J. R. Hecht, James Sayre, Siddharth A. Padia> ;Academic Radiology. 2021 Jun 4
• 689 citations
  Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
  Al B. Benson, Alan P. Venook, Mahmoud M. Al-Hawary, Mustafa A. Arain, Yi Jen Chen, Kristen K. Ciombor, Stacey Cohen, Harry S. Cooper, Dustin A. Deming, Linda Farkas, I...> ;Journal of the National Comprehensive Cancer Network. 2021 Mar 2
• 48 citations
  Randomized Phase III Study of FOLFOX Alone or With Pegilodecakin as Second-Line Therapy in Patients With Metastatic Pancreatic Cancer That Progressed After Gemcitabine...
  J. Randolph Hecht, Sara Lonardi, Johanna C. Bendell, Hao-Wen Sim, Teresa Macarulla, Charles D. Lopez, Eric Van Cutsem, Andres J. Muñoz Martin, Joon Oh Park, Richard Gr...> ;Journal of Clinical Oncology. 2021 Feb 8
• 19 citations
  Threshold Change in CEA as a Predictor of Non-Progression to First-Line Systemic Therapy in Metastatic Colorectal Cancer Patients With Elevated CEA
  Prateek Gulhati, Jun Yin, Levi Pederson, Hans-Joachim Schmoll, Paulo M. Hoff, Jean-Yves Douillard, J. Randolph Hecht, Christophe Tournigand, Niall Tebbut, Benoist Chib...> ;Journal of the National Cancer Institute. 2020 Nov 1
• 2 citations
  CAUTION ADVISED USING COMBINATION KETOCONAZOLE AND PD-1 INHIBITORS.
  Yingying Yang, J. R. Hecht, Sandy T. Liu, Melissa J. Cohen, Steven D. Hart, Hanlin L. Wang, Anthony P. Heaney> ;AACE Clinical Case Reports. 2020 Sep 21
• 8 citations
  Immunologic and tumor responses of pegilodecakin with 5-FU/LV and oxaliplatin (FOLFOX) in pancreatic ductal adenocarcinoma (PDAC).
  J. Randolph Hecht, Kyriakos P. Papadopoulos, Gerald Steven Falchook, Manish R. Patel, Jeffrey R. Infante, Raid Aljumaily, Deborah J. Wong, Karen A. Autio, Zev A. Wainb...> ;Investigational New Drugs. 2021 Feb 1
• 18 citations
  Meta-analysis examining overall survival in patients with pancreatic cancer treated with second-line 5-fluorouracil and oxaliplatin-based therapy after failing first-l...
  Zev A. Wainberg, Kynan Feeney, Myung Ah Lee, Andrés Muñoz, Antonio Cubillo Gracian, Sara Lonardi, Baek Yeol Ryoo, Annie Hung, Yong Lin, Johanna C. Bendell, J. Randolph...> ;BMC Cancer. 2020 Jul 8
• 6 citations
  Evaluation of Continuous Tumor-Size-Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer.
  Tomasz Burzykowski, Elisabeth Coart, Everardo D. Saad, Qian Shi, Dirkje W. Sommeijer, Carsten Bokemeyer, Eduardo Díaz-Rubio, Jean-Yves Douillard, Alfredo Falcone, Char...> ;JAMA Network Open. 2019 Sep 4
• 68 citations
  Talimogene laherparepvec: review of its mechanism of action and clinical efficacy and safety.
  Steven S. Raman, J. R. Hecht, Emily Chan> ;Immunotherapy. 2019 May 2
• 77 citations
  Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project.
  Katrin Marie Sjoquist, Lindsay A. Renfro, R. John Simes, Niall C. Tebbutt, Stephen Clarke, Matthew T. Seymour, Richard Adams, Tim Maughan, Leonard B. Saltz, Richard M....> ;Journal of the National Cancer Institute. 2018 Jun 1
• 15 citations
  A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy and Safety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients w...
  Axel Grothey, Jonathan R. Strosberg, Lindsay A. Renfro, Herbert Hurwitz, John L. Marshall, Howard Safran, Michael J. Guarino, George P. Kim, J. R. Hecht, Susan C. Weil...> ;Clinical Cancer Research. 2018 Jan 15
• 55 citations
  Phase I/II Trial of Labetuzumab Govitecan (Anti-CEACAM5/SN-38 Antibody-Drug Conjugate) in Patients With Refractory or Relapsing Metastatic Colorectal Cancer
  Efrat Dotan, Steven J. Cohen, Alexander Starodub, Christopher H. Lieu, Wells A. Messersmith, Pamela S. Simpson, Michael J. Guarino, John L. Marshall, Richard M Goldber...> ;Journal of Clinical Oncology. 2017 Aug 17
• 23 citations
  Most of the Intended Management Changes After 68Ga-DOTATATE PET/CT Are Implemented.
  Jeremie Calais, Johannes Czernin, Matthias Eiber, Wolfgang P. Fendler, Jeannine Gartmann, Anthony P. Heaney, Andrew Eugene Hendifar, Joseph R. Pisegna, J. Randolph Hec...> ;Journal of Nuclear Medicine. 2017 May 4
• 82 citations
  Final analysis of the randomised PEAK trial: overall survival and tumour responses during first-line treatment with mFOLFOX6 plus either panitumumab or bevacizumab in ...
  Fernando Rivera, Meinolf Karthaus, J. Randolph Hecht, Isabel Sevilla, Frédéric Forget, Gianpiero Fasola, Jean-Luc Canon, Xuesong Guan, Gaston Demonty, Lee S. Schwartzberg> ;International Journal of Colorectal Disease. 2017 Apr 19
• 30 citations
  Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Diges...
  Lindsay A. Renfro, Richard M. Goldberg, Axel Grothey, Alberto Sobrero, Richard Adams, Matthew T. Seymour, Volker Heinemann, Hans-Joachim Schmoll, Jean-Yves Douillard, ...> ;Journal of Clinical Oncology. 2017 Apr 17
• 101 citations
  A Phase II Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First-Line Treatment of Pancreatic Adeno...
  Al B. Benson, Zev A. Wainberg, J. Randolph Hecht, Dmitry Vyushkov, Hua Dong, Johanna C. Bendell, Fred Kudrik> ;The Oncologist. 2017 Mar 1
• 75 citations
  A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second-Line Treatment of Metastatic KRAS Mutant Colore...
  J. Randolph Hecht, Al B. Benson, Dmitry Vyushkov, Yingsi Yang, Johanna C. Bendell, Udit Verma> ;The Oncologist. 2017 Mar 1
• 22 citations
  It Is Time to Stop Using Epirubicin to Treat Any Patient With Gastroesophageal Adenocarcinoma.
  Elena Elimova, Yelena Y. Janjigian, Mary F. Mulcahy, Daniel V.T. Catenacci, Mariela A. Blum, Khaldoun Almhanna, J. Randolph Hecht, Jaffer A. Ajani> ;Journal of Clinical Oncology. 2017 Feb 1
• 33 citations
  HER2 Status in Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma for Entry to the TRIO-013/LOGiC Trial of Lapatinib.
  Michael F. Press, Catherine E. Ellis, Robert C. Gagnon, Tobias Grob, Marc Buyse, Ivonne Villalobos, Zhiyong Liang, Shafei Wu, Yung-Jue Bang, S. Qin, Hyun Cheol Chung, ...> ;Molecular Cancer Therapeutics. 2017 Jan 1
• 67 citations
  Association of Proton Pump Inhibitors and Capecitabine Efficacy in Advanced Gastroesophageal Cancer Secondary Analysis of the TRIO-013/LOGiC Randomized Clinical Trial
  Michael P. Chu, J. Randolph Hecht, Dennis J. Slamon, Zev A. Wainberg, Yung-Jue Bang, Paulo M. Hoff, Alberto Sobrero, Shukui Qin, Karen Afenjar, Vincent Houe, Karen Kin...> ;JAMA Oncology. 2017 Jun 1
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Lectures

• A phase 1b/2, multicenter, open-label trial to evaluate the safety of talimogene laherparepvec (T-VEC) injected into primary and metastatic liver tumors alone and in c... 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018
• Overall survival of PEGylated pegilodecakin with 5-FU/LV and oxaliplatin (FOLFOX) in metastatic pancreatic adenocarcinoma (PDAC). 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018