Jaap JanBoelensMDPhD

Pediatric Hematology & Oncology • New York, NY

Chief, Transplantation and Cellular Therapies

Overview of Dr. Boelens

Dr. Jaap Jan Boelens is a pediatric-oncologist in New York, NY at Memorial Sloan Kettering Cancer Center and New York-Presbyterian Hospital. He is Prof of Pediatrics at WCMC. He has experience in hematopoietic cell transplantation for sickle cell disease, lysosomal storage diseases and refractory leukemias. Research: PKPD and immune reconstitution and has >280 publications and >15K citings.

Office
Memorial Sloan Kettering Cancer Center New York
1275 York Avenue
New York, NY 10021
Book by Phone+1(929) 254-4497
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Education & Training

Utrecht University Faculty of MedicineClass of 1996

Certifications & Licensure

FL State Medical License 2022 - Present
NY State Medical License 2019 - 2025

Clinical Trials

US Study of ECT-001-CB in Pediatric and Young Adult Patients With High-Risk Myeloid Malignancies Start of enrollment: 2021 Dec 01
Recruiting
Phase 1, Phase 2
Roles: Contact
Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders Start of enrollment: 2020 Nov 20
Recruiting
Phase 2
Roles: Contact
Conditioning SCID Infants Diagnosed Early Start of enrollment: 2018 Oct 22
Recruiting
Phase 2
Roles: Principal Investigator, Contact
Safety and Efficacy of SMART101 in Pediatric and Adult Patients With Hematological Malignancies After T Cell Depleted Allo-HSCT Start of enrollment: 2022 Mar 31
Recruiting
Phase 1, Phase 2
A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT) Start of enrollment: 2023 Feb 09
Recruiting
Phase 2
Roles: Contact
Uproleselan With Pre-Transplant Conditioning in Hematopoietic Stem Cell Transplantation for AML Start of enrollment: 2022 Oct 06
Recruiting
Phase 1, Phase 2
Roles: Contact
A Study of Treatment of Inflammation Before Stem Cell Transplant in People With a Primary Immune Regulatory Disorder (PIRD) and/or an Autoinflammatory Condition Start of enrollment: 2023 Mar 15
Recruiting
Phase 2
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Publications & Presentations

PubMed

1 citations
Inventory of current practices regarding hematopoietic stem cell transplantation in metachromatic leukodystrophy in Europe and neighboring countries.
Daphne H Schoenmakers, Fanny Mochel, Laura A Adang, Jaap-Jan Boelens, Valeria Calbi, Erik A Eklund, Sabine W Grønborg, Francesca Fumagalli, Samuel Groeschel, Caroline ...> ;Orphanet Journal of Rare Diseases. 2024 Feb 7
9 citations
CRISPR-Cas9 Editing of theandPromoters to Treat Sickle Cell Disease.
Akshay Sharma, Jaap-Jan Boelens, Maria Cancio, Jane S Hankins, Prafulla Bhad, Marjohn Azizy, Andrew Lewandowski, Xiaojun Zhao, Shripad Chitnis, Radhika Peddinti, Yan Z...> ;The New England Journal of Medicine. 2023 Aug 31
Association between busulfan exposure and survival in patients undergoing a CD34+ selected stem cell transplantation.
Roni Tamari, Michael Scordo, Binni M Kunvarjee, Anthony Proli, Andrew Lin, Jessica Flynn, Christina Cho, Sean Devlin, Elizabeth Klein, Farid Boulad, Maria I Cancio, Ke...> ;Blood Advances. 2023 Sep 26
1 citations
Predictors of outcomes in hematopoietic cell transplantation for Fanconi anemia.
Maria Cancio, Alexandre G Troullioud Lucas, Marc Bierings, Elizabeth Klein, Moniek A de Witte, Frans J Smiers, Dorine Bresters, Jaap Jan Boelens, Stephanie E Smetsers> ;Bone Marrow Transplantation. 2024 Jan 1
1 citations
T-cell depleted allogeneic hematopoietic stem cell transplant for the treatment of Fanconi anemia and MDS/AML.
Alexandra M Satty, Elizabeth Klein, Audrey Mauguen, Binni Kunvarjee, Jaap Jan Boelens, Maria Cancio, Kevin J Curran, Nancy A Kernan, Susan E Prockop, Andromachi Scarad...> ;Bone Marrow Transplantation. 2024 Jan 1
1 citations
Excellent leukemia control after second hematopoietic cell transplants with unrelated cord blood grafts for post-transplant relapse in pediatric patients.
Alexandre G Troullioud Lucas, Jaap Jan Boelens, Susan E Prockop, Kevin J Curran, Dorine Bresters, Wouter Kollen, Birgitta Versluys, Marc B Bierings, Anne Archer, Eric ...> ;Frontiers in Oncology. 2023 Jan 1
2 citations
Clinical decision support for chemotherapy-induced neutropenia using a hybrid pharmacodynamic/machine learning model.
Jasmine H Hughes, Dominic M H Tong, Vanessa Burns, Bobby Daly, Pedram Razavi, Jaap J Boelens, Srijib Goswami, Ron J Keizer> ;CPT. 2023 Nov 1
3 citations
Emapalumab as bridge to hematopoietic cell transplant for STAT1 gain-of-function mutations.
Binni Kunvarjee, Alan Bidgoli, Rebecca Pellett Madan, Esther Vidal, Devin McAvoy, Kinga K Hosszu, Andromachi Scaradavou, Barbara G Spitzer, Kevin J Curran, Maria Canci...> ;The Journal of Allergy and Clinical Immunology. 2023 Sep 1
3 citations
Early immune reconstitution as predictor for outcomes after allogeneic hematopoietic cell transplant; a tri-institutional analysis.
Alexandre G Troullioud Lucas, Caroline A Lindemans, Senthil Velan Bhoopalan, Rana Dandis, Susan E Prockop, Swati Naik, Dinesh Keerthi, Coco de Koning, Akshay Sharma, S...> ;Cytotherapy. 2023 Sep 1
5 citations
Neurodegenerative disease after hematopoietic stem cell transplantation in metachromatic leukodystrophy.
Murtadha Al-Saady, Shanice Beerepoot, Bonnie C Plug, Marjolein Breur, Hristina Galabova, Petra J W Pouwels, Jaap-Jan Boelens, Caroline Lindemans, Peter M van Hasselt, ...> ;Annals of Clinical and Translational Neurology. 2023 Jul 1
Novel insights into GVHD and immune reconstitution after allogeneic hematopoietic cell transplantation.
Takanori Teshima, Jaap Jan Boelens, Ken-Ichi Matsuoka> ;Blood Cell Therapy. 2023 May 25
International Society for Cell & Gene Therapy Stem Cell Engineering Committee: Cellular therapies for the treatment of graft-versus-host-disease after hematopoietic st...
Garcia-Rosa, M., Abraham, A., Bertaina, A., Bhoopalan, S., Bonfim, C., Cohen, S., DeZern, A., Louis, C., Oved, J., Pavel-Dinu, M., Purtill, D., Ruggeri, A., Russell, A...> ;Cytotherapy. 2023 Jun 1
1 citations
Pharmacotherapy in Pediatric Hematopoietic Cell Transplantation
R. Admiraal, J. J. Boelens> ;Handbook of Experimental Pharmacology. 2019 Aug 3
33 citations
Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes.
Jurgen Langenhorst, C. van Kesteren, E. M. van Maarseveen, Thomas P. C. Dorlo, Stefan Nierkens, Caroline A. Lindemans, M. A. de Witte, A. van Rhenen, Reinier A P Raijm...> ;Blood Advances. 2019 Jul 23
28 citations
Population Pharmacokinetics of Alemtuzumab (Campath) in Pediatric Hematopoietic Cell Transplantation: Towards Individualized Dosing to Improve Outcome
Rick Admiraal, Cornelia M. Jol-van der Zijde, Juliana Silva, Catherijne A. J. Knibbe, Arjan C. Lankester, Jaap Jan Boelens, Goeff Hale, Aniekan Etuk, Melanie Wilson, S...> ;Clinical Pharmacokinetics. 2019 Dec 1
8 citations
Allogeneic Haematopoietic Cell Transplantation for Epidermolysis Bullosa: the Dutch Experience.
Katarzyna B. Gostynska, Vamsi K Yenamandra, Caroline A. Lindemans, José C. Duipmans, Antoni Gostyński, Marcel F. Jonkman, Jaap-Jan Boelens> ;Acta Dermato-Venereologica. 2019 Mar 1
Transplant for non-malignant disorders: an International Society for Cell & Gene Therapy Stem Cell Engineering Committee report on the role of alternative donors, stem...
Orly R Klein, Carmem Bonfim, Allistair Abraham, Annalisa Ruggeri, Duncan Purtill, Sandra Cohen, Robert Wynn, Athena Russell, Akshay Sharma, Rachele Ciccocioppo, Susan ...> ;Cytotherapy. 2023 May 1
4 citations
Lower probability of relapse after myeloablative cord blood transplantation for patients with refractory AML.
Andromachi Scaradavou, Jaap Jan Boelens> ;British Journal of Haematology. 2023 Mar 1
Cord blood power and the definition of success after BMT.
Jaap Jan Boelens, Andromachi Scaradavou> ;Blood Advances. 2023 May 9
3 citations
Durable Engraftment and Excellent Overall Survival After CD34-Selected Peripheral Blood Stem Cell Boost in Pediatric Patients With Poor Graft Function Following Alloge...
Ellen Fraint, Sana Farooki, Elizabeth Klein, Audrey Mauguen, Susan E Prockop, Andromachi Scaradavou, Kevin Curran, Maria Cancio, Barbara Spitzer, Jaap Jan Boelens, Jos...> ;Transplantation and Cellular Therapy. 2023 Jan 1
5 citations
Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells.
Laura E P Huyveneers, Anke Bruns, Arjen Stam, Pauline Ellerbroek, Dorien de Jong, Noémi A Nagy, Stephanie B H Gumbs, Kiki Tesselaar, Kobus Bosman, Maria Salgado, Gero ...> ;Viruses. 2022 Sep 17
11 citations
Hematopoietic Cell Transplantation in the Treatment of Pediatric Acute Myelogenous Leukemia and Myelodysplastic Syndromes: Guidelines from the American Society of Tran...
Katherine Tarlock, Maria Luisa Sulis, Joseph H Chewning, Jessica A Pollard, Todd Cooper, Alan Gamis, Shalini Shenoy, Matthew Kutny, John Horan, Soheil Meshinchi, Jaap-...> ;Transplantation and Cellular Therapy. 2022 Sep 1
4 citations
Letermovir for Cytomegalovirus Prevention in Adolescent Patients Following Hematopoietic Cell Transplantation.
Nicole P Daukshus, Anthony Cirincione, Molly Siver, Sherry Mathew, Binni Kunvarjee, Amelia Chan, Jaap Jan Boelens, Susan K Seo, Genovefa A Papanicolaou, Nancy A Kernan> ;Journal of the Pediatric Infectious Diseases Society. 2022 Jul 21
3 citations
An ISCT Stem Cell Engineering Committee Position Statement on Immune Reconstitution: the importance of predictable and modifiable milestones of immune reconstitution t...
Alice Bertaina, Allistair Abraham, Carmem Bonfim, Sandra Cohen, Duncan Purtill, Annalisa Ruggeri, Daniel Weiss, Robert Wynn, Jaap Jan Boelens, Susan Prockop> ;Cytotherapy. 2022 Apr 1
17 citations
Individualised dosing of anti-thymocyte globulin in paediatric unrelated allogeneic haematopoietic stem-cell transplantation (PARACHUTE): a single-arm, phase 2 clinica...
Rick Admiraal, Stefan Nierkens, Marc B Bierings, Robbert G M Bredius, Ineke van Vliet, Yilin Jiang, Marta Lopez-Yurda, A Birgitta Versluijs, C Michel Zwaan, Caroline A...> ;The Lancet. Haematology. 2022 Feb 1
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Abstracts/Posters

Allogeneic CD34-Selected HSCT Following CAR T-Cells Is Associated with Low TRM and Favorable OS in Pediatric/Young Adult Patients with Relapsed/Refractory B-ALL
Jaap Jan Boelens, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019