JacobJSchlesingerMD

Infectious Disease • Rochester, NY

Physician

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Office
601 Elmwood Ave
Box Med
Rochester, NY 14642
Phone+1 585-275-5871

Fax+1 585-273-1055
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Summary

Dr. Jacob Schlesinger, MD is an infectious disease specialist in Rochester, New York. He is currently licensed to practice medicine in New York. He is affiliated with Rochester General Hospital.

Education & Training

Tufts Medical CenterResidency, Internal Medicine, 1972 - 1974
Icahn School of Medicine at Mount Sinai/Morningside/WestResidency, Internal Medicine, 1970 - 1972
Yale-New Haven Medical CenterResidency, Pathology-Anatomic and Clinical, 1968 - 1970
Yale School of MedicineClass of 1968

Certifications & Licensure

NY State Medical License 1970 - 2026
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease

Publications & Presentations

PubMed

46 citations
Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes
Zhihua Kou, Joanne Y.H. Lim, Martina Beltramello, Matthew Quinn, Huiyuan Chen, Shengyo ng Liu, Luis Martnez-Sobrido, Michael S. Diamond, Jacob J. Schlesinger, Aravinda...> ;Virology. 2011 Feb 5
49 citations
A tetravalent recombinant dengue domain III protein vaccine stimulates neutralizing and enhancing antibodies in mice.
Olivia K. T. Block, W. W. Shanaka I. Rodrigo, Matthew Quinn, Xia Jin, Robert C. Rose, Jacob J. Schlesinger> ;Vaccine. 2010 Nov 29
45 citations
Dengue virus neutralization is modulated by IgG antibody subclass and Fcγ receptor subtype
W. W. Shanaka I. Rodrigo, Olivia K. T. Block, Christopher Lane, Soila Sukupolvi-Petty, Ana P. Goncalvez, Syd Johnson, Michael S. Diamond, Ching Juh Lai, Robert C. Rose...> ;Virology. 2009 Nov 25
22 citations
Primary human endothelial cells support direct but not antibody-dependent enhancement of dengue viral infection
Maria T. Arévalo, Patricia J. Simpson-Haidaris, Zhihua Kou, Jacob J. Schlesinger, Xia Jin> ;Journal of Medical Virology. 2009 Mar 1
16 citations
Difference between the Abilities of Human Fcγ Receptor-Expressing CV-1 Cells To Neutralize American and Asian Genotypes of Dengue Virus 2
W. W. I. S. Rodrigo, D. C. Alcena, Zhihua Kou, Tadeusz J. Kochel, Kevin R. Porter, G. Comach, Robert C. Rose, Xia Jin, Jacob J. Schlesinger> ;Clinical and Vaccine Immunology. 2009 Feb 1
14 citations
Dengue vaccine development and dengue viral neutralization and enhancement assays.
Xia Jin, Olivia K. T. Block, Robert C. Rose, Jacob J. Schlesinger> ;Antiviral Therapy. 2009 Jan 1
35 citations
An Automated Dengue Virus Microneutralization Plaque Assay Performed in Human Fcγ Receptor-expressing CV-1 Cells
W. W. Shanaka, I. Rodrigo, Danielle C. Alcena, Robert C. Rose, Xia Jin, Jacob J. Schlesinger> ;The American Journal of Tropical Medicine and Hygiene. 2009 Jan 1
14 citations
Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells
Ramil Sapinoro, Ketna Volcy, W. W. Shanaka I. Rodrigo, Jacob J. Schlesinger, Stephen Dewhurst> ;Virology. 2008 Apr 10
146 citations
Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells
Zhihua Kou, Matthew Quinn, Huiyuan Chen, W. W. Shanaka I. Rodrigo, Robert C. Rose, Jacob J. Schlesinger, Xia Jin> ;Journal of Medical Virology. 2008 Jan 1
84 citations
Primary Human Splenic Macrophages, but Not T or B Cells, Are the Principal Target Cells for Dengue Virus Infection In Vitro
Shanley D. Blackley, Zhihua Kou, Huiyuan Chen, Matthew Quinn, Robert C. Rose, Jacob J. Schlesinger, Myra Coppage, Xia Jin> ;Journal of Virology. 2007 Dec 15
210 citations
Type- and Subcomplex-Specific Neutralizing Antibodies against Domain III of Dengue Virus Type 2 Envelope Protein Recognize Adjacent Epitopes
Soila Sukupolvi-Petty, S. Kyle Austin, Whitney E. Purtha, Theodore Oliphant, Grant E. Nybakken, Jacob J. Schlesinger, John T. Roehrig, Gregory D. Gromowski, Alan D.T. ...> ;Journal of Virology. 2007 Dec 1
9 citations
Flavivirus nonstructural protein NS1: Complementary surprises
Jacob J. Schlesinger> ;Proceedings of the National Academy of Sciences of the United States of America. 2006 Dec 12
96 citations
Differential Enhancement of Dengue Virus Immune Complex Infectivity Mediated by Signaling-Competent and Signaling-Incompetent Human FcγRIA (CD64) or FcγRIIA (CD32)
W. W. Shanaka I. Rodrigo, Xia Jin, Shanley D. Blackley, Robert C. Rose, Jacob J. Schlesinger> ;Journal of Virology. 2006 Oct 15
10 citations
Magnetically Responsive Carboxylated Magnetite-Polydipyrrole/Polydicarbazole Nanocomposites of Core−Shell Morphology. Preparation, Characterization, and Use in DNA Hyb...
Jean-Paul Lellouche, Govindaraji Senthil, Augustine Joseph, Ludmila Buzhansky, Ian J. Bruce, Erika R. Bauminger, Jacob Schlesinger> ;Journal of the American Chemical Society. 2005 Aug 10
58 citations
Extended-Spectrum Beta-Lactamases among Enterobacter Isolates Obtained in Tel Aviv, Israel
Jacob Schlesinger, Shiri Navon-Venezia, Inna Chmelnitsky, Orly Hammer-Munz, Azita Leavitt, Howard S. Gold, Mitchell J. Schwaber, Yehuda Carmeli> ;Antimicrobial Agents and Chemotherapy. 2005 Mar 1
3 citations
In-cell generation of antibody single-chain Fv transcripts by targeted RNA trans-splicing.
Jacob Schlesinger, Dina Arama, Hava Noy, Manar Dagash, Paula Belinky, Gideon Gross> ;Journal of Immunological Methods. 2003 Nov 1
38 citations
Yellow Fever Virus/Dengue-2 Virus and Yellow Fever Virus/Dengue-4 Virus Chimeras: Biological Characterization, Immunogenicity, and Protection against Dengue Encephalit...
Thomas J. Chambers, Yan Liang, Deborah A. Droll, Jacob J. Schlesinger, Andrew D. Davidson, Peter J. Wright, Xiaoshan Jiang> ;Journal of Virology. 2003 Mar 15
20 citations
Influence of the Human High-Affinity IgG Receptor FcγRI (CD64) on Residual Infectivity of Neutralized Dengue Virus
Jacob J. Schlesinger, Susan Chapman> ;Virology. 1999 Jul 20
36 citations
Yellow fever virus envelope protein has two discrete type-specific neutralizing epitopes.
Kate D. Ryman, T. N. Ledger, Ronald C. Weir, Jacob J. Schlesinger, Alan D.T. Barrett> ;The Journal of General Virology. 1997 Jun 1
42 citations
Replication of yellow fever virus in the mouse central nervous system: comparison of neuroadapted and non-neuroadapted virus and partial sequence analysis of the neuro...
Jacob J. Schlesinger, Susan Chapman, Ann Nestorowicz, Charles M. Rice, Tara E. Ginocchio, Thomas J. Chambers> ;The Journal of General Virology. 1996 Jun 1
47 citations
Neutralizing F(ab')2 fragments of protective monoclonal antibodies to yellow fever virus (YF) envelope protein fail to protect mice against lethal YF encephalitis
Jacob J. Schlesinger, Susan Chapman> ;The Journal of General Virology. 1995 Jan 1
34 citations
Immunization of Monkeys with Baculovirus-Dengue Type-4 Recombinants Containing Envelope and Nonstructural Proteins: Evidence of Priming and Partial Protection
Kenneth H. Eckels, Doria R. Dubois, P. L. Summers, Jacob J. Schlesinger, Mark Shelly, Sara B. Cohen, Y. M. Zhang, Ching-Ju Lai, Ichiro Kurane, Allan Rothman, Sherman H...> ;The American Journal of Tropical Medicine and Hygiene. 1994 Apr 1
130 citations
The Fc Portion of Antibody to Yellow Fever Virus NS1 Is a Determinant of Protection against YF Encephalitis in Mice
Jacob J. Schlesinger, Michael Foltzer, Susan Chapman> ;Virology. 1993 Jan 1
106 citations
Use of recombinant fusion proteins and monoclonal antibodies to define linear and discontinuous antigenic sites on the dengue virus envelope glycoprotein.
Françoise Mégret, J.P. Hugnot, Andrew K. I. Falconar, Mary K. Gentry, David M. Morens, Julie M. Murray, Jacob J. Schlesinger, Peter J. Wright, Paul R. Young, M.H.V. Va...> ;Virology. 1992 Apr 1
35 citations
Processing, secretion, and immunoreactivity of carboxy terminally truncated dengue-2 virus envelope proteins expressed in insect cells by recombinant baculoviruses.
Vincent Deubel, Martine Bordier, Françoise Mégret, Mary K. Gentry, Jacob J. Schlesinger, Marc Girard> ;Virology. 1991 Jan 1
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Hospital Affiliations

Rochester General HospitalRochester, New York