JamesC.BarrowMDMBA, FACOG

PubMed

• 5 citations
  Post-weaning social isolation increases ΔFosB/FosB protein expression in sex-specific patterns in the prelimbic/infralimbic cortex and hippocampus in mice.
  Michael Noback, Gongliang Zhang, Noelle White, James C. Barrow, Gregory V. Carr> ;Neuroscience Letters. 2021 Jan 1
• 8 citations
  Erratum: Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2 (Inositol Pyrophosphates Mediate the DNA-...
  Feng Rao, Ji-Young Cha, Jing Xu, Risheng Xu, M. Scott Vandiver, Richa Tyagi, Robert Tokhunts, Michael A. Koldobskiy, Chenglai Fu, Roxanne K. Barrow, Mingxuan Wu, Dorot...> ;Molecular Cell. 2020 Aug 20
• 6 citations
  Inhibition of Catechol-O-methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice.
  Adrienne DeBrosse, Abigail M. Wheeler, James C. Barrow, Gregory V. Carr> ;Frontiers in Behavioral Neuroscience. 2020 May 21
• 9 citations
  Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility
  Spencer Byers, Ingrid P. Buchler, Michael DePasquale, Helen L. Rowley, Rajiv Kulkarni, Lucy Pinder, Anna Kolobova, Cailian Li, Vinh Au, Daniel Akuma, Gongliang Zhang, ...> ;Psychopharmacology. 2020 May 30
• 73 citations
  Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
  Emily E. Burke, Josh G. Chenoweth, Joo Heon Shin, Leonardo Collado-Torres, Suel Kee Kim, Nicola Micali, Yanhong Wang, Carlo Colantuoni, Richard E. Straub, Daniel J. Ho...> ;Nature Communications. 2020 Jan 23
• 13 citations
  Synthesis and characterization of novel isoform-selective IP6K1 inhibitors.
  Michael Wormald, Glen Ernst, Huijun Wei, James C. Barrow> ;Bioorganic & Medicinal Chemistry Letters. 2019 Oct 1
• 11 citations
  Development of a PC12 Cell Based Assay for Screening Catechol-O-methyltransferase Inhibitors.
  Gongliang Zhang, Ingrid P. Buchler, Michael DePasquale, Michael Wormald, Gangling Liao, Huijun Wei, James C. Barrow, Gregory V. Carr> ;ACS Chemical Neuroscience. 2019 Oct 16
• 3 citations
  A Medicinal Chemist's Perspective on Transitioning from Industry to Academic Drug Discovery.
  James C. Barrow> ;ACS Medicinal Chemistry Letters. 2019 Apr 15
• 5 citations
  Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening.
  Roland Bürli, Huijun Wei, Glen Ernst, Abigail Mariga, Ian M. Hardern, Kara Herlihy, Alan J. Cross, Steven Wesolowski, Hongming Chen, Ronald D.G. McKay, Daniel R. Weinb...> ;Bioorganic & Medicinal Chemistry Letters. 2018 Oct 15
• 12 citations
  Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.
  Ingrid P. Buchler, Daniel Akuma, Vinh Au, Gregory V. Carr, Pablo De León, Michael DePasquale, Glen Ernst, Yifang Huang, Martha Kimos, Anna Kolobova, Michael S. Poslusn...> ;Journal of Medicinal Chemistry. 2018 Oct 1
• 17 citations
  Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity.
  Michael Wormald, Gangling Liao, Martha Kimos, James C. Barrow, Huijun Wei> ;Plos One. 2017 Nov 29
• 58 citations
  Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.
  Qingzhang Zhu, Sarbani Ghoshal, Ana Rodrigues, Su Gao, Alice Asterian, Theodore M. Kamenecka, James C. Barrow, Anutosh Chakraborty> ;The Journal of Clinical Investigation. 2016 Nov 1
• 44 citations
  TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.
  Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty> ;Molecular Metabolism. 2016 Oct 1
• 6 citations
  Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors.
  Zhijian Zhao, Scott T. Harrison, Jeffrey W. Schubert, John M. Sanders, Stacey L. Polsky-Fisher, Nanyan Rena Zhang, Debra McLoughlin, Christopher R. Gibson, Ronald G. R...> ;Bioorganic & Medicinal Chemistry Letters. 2016 Jun 15
• 12 citations
  Development of an HTRF Assay for the Detection and Characterization of Inhibitors of Catechol-O-Methyltransferase
  Martha Kimos, Maggi Burton, David Urbain, Didier Caudron, Murielle Martini, Michel Famelart, Michel Gillard, James C. Barrow, Martyn D. Wood> ;Journal of Biomolecular Screening. 2016 Jun 1
• 28 citations
  Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.
  Paul C. Scherer, Yan Ding, Zhiqing Liu, Jing Xu, Haibin Mao, James C. Barrow, Ning Wei, Ning Zheng, Solomon H. Snyder, Feng Rao> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Mar 29
• 16 citations
  Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening.
  Nicholas E. Calcaterra, Daniel J. Hoeppner, Huijun Wei, Andrew E. Jaffe, Brady J. Maher, James C. Barrow> ;Scientific Reports. 2016 Feb 16
• 21 citations
  KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia.
  Gregory V. Carr, Jingshan Chen, Feng Yang, Ming Ren, Peixiong Yuan, Qingjun Tian, Audrey Bebensee, Grace Y Zhang, Jing Du, Paul Glineburg, Randy Xun, Omoye Akhile, Dan...> ;Molecular Psychiatry. 2016 Feb 9
• 7 citations
  Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency.
  Melissa S. Egbertson, Georgia B. McGaughey, Steven M. Pitzenberger, Shaun R. Stauffer, Craig A. Coburn, Shawn J. Stachel, Wenjin Yang, James C. Barrow, Lou Anne Neilso...> ;Bioorganic & Medicinal Chemistry Letters. 2015 Nov 1
• 31 citations
  Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel S...
  William D. Shipe, Steven S. Sharik, James C. Barrow, Georgia B. McGaughey, Cory R. Theberge, Jason M. Uslaner, Youwei Yan, John J. Renger, Sean M. Smith, Paul J. Colem...> ;Journal of Medicinal Chemistry. 2015 Sep 25
• 11 citations
  Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).
  Harrison, S. T., Poslusney, M. S., Mulhearn, J. J., Zhao, Z., Kett, N. R., Schubert, J. W., Melamed, J. Y., Allison, T. J., Patel, S. B., Sanders, J. M., Sharma, S., S...> ;ACS medicinal chemistry letters. 2015 Mar 31
• 69 citations
  Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1
  Feng Rao, Jing Xu, Chenglai Fu, Jiyoung Y. Cha, Moataz M. Gadalla, Risheng Xu, James C. Barrow, Solomon H. Snyder> ;Proceedings of the National Academy of Sciences of the United States of America. 2015 Feb 10
• 15 citations
  Design, Synthesis, and Structure–Activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors
  Laureen Colis, Glen Ernst, Sara Sanders, Hester Liu, Paul Sirajuddin, Karita Peltonen, Michael DePasquale, James C. Barrow, Marikki Laiho> ;Journal of Medicinal Chemistry. 2014 Jun 12
• 54 citations
  DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response
  Laureen Colis, Karita Peltonen, Paul Sirajuddin, Hester Liu, Sara Sanders, Glen Ernst, James C. Barrow, Marikki Laiho> ;Oncotarget. 2014 May 28
• 43 citations
  Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.
  Feng Rao, Jiyoung Cha, Jing Xu, Risheng Xu, M Scott Vandiver, Richa Tyagi, Robert Tokhunts, Michael A Koldobskiy, Chenglai Fu, Roxanne Barrow, Mingxuan Wu, Dorothea Fi...> ;Molecular Cell. 2014 Apr 10
• Join now to see all