JamesBBusselMD

Pediatric Hematology & Oncology • New York, NY

Professor of Pediatrics, Cornell University-Weill Medical College

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Office
525 E 68th St # P-695

New York, NY 10021
Phone+1 212-746-3400

Fax+1 212-746-3988
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Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Hematology and Medical Oncology, 1980 - 1981
Cincinnati Children's Hospital Medical CenterResidency, Pediatrics, 1975 - 1978
Columbia University Vagelos College of Physicians and SurgeonsClass of 1975

Certifications & Licensure

NY State Medical License 1978 - 2026
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
Top Doctors: New York Metro Area Castle Connolly, 2002-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
New York Magazine: Top Doctors Castle Connolly, 2002-2013
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2013
Whos Who in Medicine and Healthcare Marquis Whos Who
Super Doctor SuperDoctors.com
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Clinical Trials

Optimal Platelet Dose Strategy for Management of Thrombocytopenia Start of enrollment: 2004 Jul 01
Completed
Phase 3
A Trial to Treat Patients With ITP Who Do Not Achieve a Durable Response to Rituxan Alone Start of enrollment: 2004 Feb 01
Withdrawn
Phase 2
A Trial of Antenatal Treatment of Alloimmune Thrombocytopenia Start of enrollment: 2001 Apr 01
Completed
Phase 2, Phase 3
Rapid Infusion Of Immune Globulin Intravenous (IGIV) In Patients With ITP Start of enrollment: 2003 Jul 01
Completed
Phase 2
Fresh-Frozen Plasma Infusions to Reduce Risk of Bleeding Related to Invasive Procedures Start of enrollment: 2006 Mar 01
Withdrawn
Phase 3
Anti-D for Treating Thrombocytopenia in Adults Infected With Hepatitis C Virus With or Without HIV Co-Infection Start of enrollment: 2005 Mar 01
Terminated
Phase 4
Use of Rituximab Treatment in Addition to Standard Care for Newly Presenting Thrombotic Thrombocytopenic Purpura Start of enrollment: 2005 Nov 01
Withdrawn
Phase 1, Phase 2
Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study) Start of enrollment: 2008 Apr 01
Completed
Phase 3
Higher Dose of Rituxan Versus Standard Doses of Rituxan With Cyclophosphamide, Vincristine, and Prednisone in Subjects With Chronic ITP Start of enrollment: 2003 Nov 01
Completed
Phase 2, Phase 3
Evaluating the Effectiveness of Adding Rituximab to Standard Treatment for Thrombotic Thrombocytopenic Purpura (TTP) Start of enrollment: 2009 Apr 01
Terminated
Phase 3
Eltrombopag and the Bcl-extra-large (xL) Pathway in Idiopathic Thrombocytopenic Purpura (ITP) Start of enrollment: 2009 Jan 01
Completed
Phase 2
Thrombocytopenia and Bleeding in Wiskott-Aldrich Syndrome (WAS) Patients Start of enrollment: 2009 Jun 01
Terminated
Phase 2
Red Cell Storage Duration Study Start of enrollment: 2010 Jan 01
Completed
Phase 3
Initial Treatment of Patients With Immune Thrombocytopenic Purpura Start of enrollment: 2010 Jan 01
Terminated
Phase 3
Heparin-Induced Thrombocytopenia - Retrospective Analysis of Data on Incidence and Outcomes Study Start of enrollment: 2010 Jun 01
Completed
End of EXTEND: Discontinuation of Medication for Patients With Immune Thrombocytopenia Start of enrollment: 2011 Jun 01
Terminated
Genome-Wide Gene Expression Profiling of Patients With ITP Receiving Thrombopoietin Mimetics Start of enrollment: 2012 Jul 01
Completed
Safety and Efficacy of Eltrombopag at Escalated Doses Start of enrollment: 2013 Feb 01
Completed
Phase 2
ICON1: Treatment Decisions and Outcomes in Pediatric Refractory ITP Start of enrollment: 2013 Aug 01
Completed
A Chart Review of Rituximab Plus Repeated Cycles of Dexamethasone Start of enrollment: 2011 Jan 01
Terminated
A Efficacy and Safety Study of R935788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) Start of enrollment: 2014 Jul 14
Completed
Phase 3
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Publications & Presentations

PubMed

5 citations
Complement activation negatively affects the platelet response to thrombopoietin receptor agonists in patients with immune thrombocytopenia: a prospective cohort study.
Alexander Åkesson, James B Bussel, Myriam Martin, Anna M Blom, Jenny Klintman, Waleed Ghanima, Eva Zetterberg, Lamya Garabet> ;Platelets. 2023 Dec 1
2 citations
Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised, placebo-...
Catherine M Broome, Vickie McDonald, Yoshitaka Miyakawa, Monica Carpenedo, David J Kuter, Hanny Al-Samkari, James B Bussel, Marie Godar, Jaume Ayguasanosa, Kristof De ...> ;Lancet. 2023 Nov 4
12 citations
The role of CD8+ T-cell clones in immune thrombocytopenia.
Amna Malik, Anwar A Sayed, Panpan Han, Michelle M H Tan, Eleanor Watt, Adela Constantinescu-Bercu, Alexander T H Cocker, Ahmad Khoder, Rocel C Saputil, Emma Thorley, A...> ;Blood. 2023 May 18
SARS-CoV-2 Vaccination: Long-Term Follow-Up of Pre-existing and De Novo Immune Thrombocytopenia.
Marina Beltrami Moreira, James B Bussel, Eun Ju Lee> ;Thrombosis and Haemostasis. 2023 Apr 1
1 citations
Fetal and neonatal alloimmune thrombocytopenia in 2022.
James B Bussel, Emilie L Vander Haar, Richard L Berkowitz> ;American Journal of Obstetrics and Gynecology. 2023 Jun 1
1 citations
Effects of COVID-19 vaccination on platelet counts and bleeding in children, adolescents, and young adults with immune thrombocytopenia.
Shipra Kaicker, Kirsten Martinko, James B Bussel> ;Pediatric Blood & Cancer. 2023 Jan 1
Rilzabrutinibplacebo in adults and adolescents with persistent or chronic immune thrombocytopenia: LUNA 3 phase III study.
David J Kuter, James B Bussel, Waleed Ghanima, Nichola Cooper, Terry Gernsheimer, Michele P Lambert, Michelle Lee, Hailing Guo, Ahmed Daak, Liebman, H., Tarantino, M.> ;Therapeutic Advances in Hematology. 2023 Jan 1
1 citations
Why should intramuscular anti-D be different from intravenous anti-D?
James B Bussel> ;British Journal of Haematology. 2023 Feb 1
9 citations
Romiplostim use in pregnant women with immune thrombocytopenia.
James B Bussel, Nichola Cooper, Tatiana Lawrence, Marc Michel, Emilie Vander Haar, Kejia Wang, Hongmei Wang, Hossam Saad> ;American Journal of Hematology. 2023 Jan 1
4 citations
A narrative review of anti-SARS-CoV-2 vaccines and immune thrombocytopenia: be aware, but reassured.
Marina Beltrami-Moreira, James B Bussel> ;Clinical Advances in Hematology & Oncology. 2022 Sep 1
2 citations
Therapeutic plasma exchange practices in immune thrombocytopenia related hospitalizations: Results from a nationally representative sample.
Sarah S Makhani, Joseph Schwartz, Ljiljana V Vasovic, Robert A DeSimone, Shipra Kaicker, James Bussel, Elizabeth P Crowe, Evan M Bloch, Aaron A R Tobian, Ruchika Goel> ;Journal of Clinical Apheresis. 2022 Oct 1
Should dexamethasone alone or in combination be the initial steroid for adult ITP: Still a relevant question.
Barbara Skopec, James B Bussel> ;British Journal of Haematology. 2023 Jan 1
4 citations
Diagnosis of immune thrombocytopenia, including secondary forms, and selection of second-line treatment.
James B Bussel, Christine A Garcia> ;Haematologica. 2022 Sep 1
1 citations
Hemolysis after high-dose intravenous immunoglobulin: An under-appreciated sequelae.
Donald R Branch, Ruqayyah J Almizraq, James B Bussel> ;American Journal of Hematology. 2022 May 1
1 citations
A single-arm, long-term efficacy and safety study of subcutaneous romiplostim in children with immune thrombocytopenia.
John Grainger, James Bussel, Michael Tarantino, Nichola Cooper, Donald Beam, Jenny Despotovic, Alexey Maschan, Kejia Wang, Melissa Eisen, Charles Bowers> ;Blood Advances. 2023 Feb 14
1 citations
Low-dose rituximab in immune thrombocytopenia: One and done.
Marina Beltrami-Moreira, James B Bussel> ;American Journal of Hematology. 2022 Apr 1
2 citations
An "ATRA-ctive" new treatment of ITP?
Eun-Ju Lee, James B Bussel> ;Blood. 2022 Jan 20
13 citations
Immune thrombocytopenia.
James Bussel, Nichola Cooper, Ralph Boccia, Francesco Zaja, Adrian Newland> ;Expert Review of Hematology. 2021 Nov 1
2 citations
Iron Status Influences the Response of Cord Blood Megakaryocyte Progenitors to Eltrombopag in Vitro.
Liu Z-J., Emoke Deschmann, Haley E. Ramsey, Henry A. Feldman, Bethan Psaila, Nichola Cooper, E Vlachodimtropoulou Koumoutsea, John B. Porter, James B. Bussel, Michael ...> ;Blood Advances. 2021 Oct 15
39 citations
SARS-CoV-2 Vaccination and Immune Thrombocytopenia in de novo and pre-existing ITP patients.
Eun-Ju Lee, Marina Beltrami Moreira, Hanny Al-Samkari, Adam Cuker, Jennifer DiRaimo, Terry Gernsheimer, Alexandra Kruse, Craig M. Kessler, Caroline Kruse, Andrew D. Le...> ;Blood. 2021 Sep 29
Heritable platelet disorders: an enigma even guidelines can't unravel.
James B. Bussel, Ellinor I.B. Peerschke> ;British Journal of Haematology. 2021 Sep 7
Treatment of immune thrombocytopenia with eltrombopag in patients who had and who had not received prior rituximab: post-hoc analysis of the EXTEND study.
Oliver Meyer, Raymond S.M. Wong, Abderrahim Khelif, Miona Stankovic, Joan Maier, Mansoor N. Saleh, James B. Bussel> ;British Journal of Haematology. 2021 Aug 30
1 citations
Familial thrombocythaemia - a distinct entity from essential thrombocythaemia.
James B. Bussel, Nicole Kucine> ;British Journal of Haematology. 2021 Aug 2
5 citations
Clinical Outcomes in 8 Patients with Immune Thrombocytopenia Each Treated with the 3 Approved Thrombopoietin Receptor Agonists.
Eun-Ju Lee, Madhav Seshadri, James B. Bussel> ;American Journal of Hematology. 2021 Jun 21
22 citations
COVID-19 vaccination and immune thrombocytopenia.
Allyson M. Pishko, James B. Bussel, Douglas B. Cines> ;Nature Medicine. 2021 Jan 1
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Abstracts/Posters

Hyper-Sialylated IgG M254, an Innovative Therapeutic Candidate, Evaluated in Healthy Volunteers and in Patients with Immune Thrombocytopenia Purpura: Safety, Tolerabil...
James B. Bussel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Dose-Dependent Iron Chelating Effects of Eltrombopag on in Vitro Human Megakaryopoiesis
James B. Bussel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Rozanolixizumab, an Anti-FcRn Antibody: Final Results from a Phase II, Multiple-Dose Study in Patients with Primary Immune ThrombocytopeniaClinically Relevant Abstract
James B. Bussel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Updated Results from the Single-Arm, Open-Label, Long-Term Efficacy and Safety Study of Subcutaneous (SC) Romiplostim in Children with Immune Thrombocytopenia (ITP)Cli...
James B. Bussel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Enhanced Responses to Fostamatinib As Second-Line Therapy and in Persistent Immune Thrombocytopenia (ITP) Patients
James B. Bussel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
The Burden of Disease and IMPACT of Immune Thrombocytopenia (ITP) on Patients: Results from an ITP Survey
James B. Bussel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
PhysiciansÍ and PatientsÍ Perspectives on Treatments in ITP _ a Multi-Country Perspective: Results from the ITP World Impact Survey (I-WISh)
James B. Bussel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

Potentiating the Power of Platelets: Examining the Clinical Utility of Multiple Thrombopoietin Receptor Agonists in ITP, Chemotherapy Induced Thrombocytopenia and Live...
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Patients with Immune Thrombocytopenia (ITP) Frequently Experience Severe Fatigue but Is It Under-Recognized By Physicians: Results from the ITP World Impact Survey (I-...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Platelets 2012 International Symposium
Jonathan Wood & Associates, Beverly, Massachusetts - 6/7/2012

Other

Clinical manifestations and diagnosis of immune thrombocytopenia (ITP) in children
Bussel JB
http://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-immune-thrombocytopenia-it
UpToDate, Wolters Kluwer Health - 2013-03-29

Press Mentions

Dramatic Increase in Response with Combination for Relapsed/Resistant ITPJanuary 28th, 2022
Adding Mycophenolate Mofetil Improves Outcomes in ITPSeptember 1st, 2021
The Faces I’ll Remember, Long After I Put My Notebook DownJune 18th, 2021
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Grant Support

Novel Therapies In Hemostasis And TransfusionNational Heart, Lung, And Blood Institute2007–2009
Novel Therapies In Hemostasis And Transfusion MedicineNational Heart, Lung, And Blood Institute2002–2006
Rituxan Comparison Standard VS Combination With CVP In ITPNational Center For Research Resources2005
OPEN Label, Phase I/II Trial Of Rituximab For Chronic, Severe, Idiopathic ThromNational Center For Research Resources2005