JamesAndrewClarkMD

PubMed

• Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases.
  Clark, J. D.,Flanagan, M. E.,Telliez, J. B.> ;J. Med. Chem.. 2014 Jan 15
• The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls.
  Ronninger, M., Guo, Y., Shchetynsky, K., Hill, A., Khademi, M., Olsson, T., Reddy, P.S., Seddighzadeh, M., Clark, J.D., Lin, L., O'Toole, M., Padyukov, L.> ;Genome Med. 2012
• Preclinical evaluation of an inhibitor of cytosolic phospholipase A2? for the treatment of asthma.
  Hewson, C.A., Patel, S., Calzetta, L., Campwala, H., Havard, S., Luscombe, E., Clarke, P.A., Peachell, P., Matera, M.G., Cazzola, M., Page, C., Abraham, W.M., Williams...> ;J Pharmacol Exp Ther. 2012 Mar
• Cytosolic Phospholipase A2{alpha} Blockade Abrogates Disease during the Tissue-Damage Effector Phase of Experimental Autoimmune Encephalomyelitis by Its Action on APCs.
  Thakker, P., Marusic, S., Stedman, N.L., Lee, K.L., McKew, J.C., Wood, A., Goldman, S.J., Leach, M.W., Collins, M., Kuchroo, V.K., Wolf, S.F., Clark, J.D., Hassan-Zahr...> ;J Immunol. 2011 Aug 15
• Effect of perzinfotel and a proprietary phospholipase A(2) inhibitor on kinetic gait and subjective lameness scores in dogs with sodium urate-induced synovitis.
  Budsberg, S.C., Torres, B.T., Zwijnenberg, R.J., Eppler, C.M., Clark, J.D., Cathcart, C.J., Reynolds, L.R., Al-Nadaf, S.> ;Am J Vet Res. 2011 Jun
• Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.
  Lin, T.H., Hegen, M., Quadros, E., Nickerson-Nutter, C.L., Appell, K.C., Cole, A.G., Shao, Y., Tam, S., Ohlmeyer, M., Wang, B., Goodwin, D.G., Kimble, E.F., Quintero, ...> ;Arthritis Rheum. 2010 Aug
• A human CXCL13-induced actin polymerization assay measured by fluorescence plate reader.
  Alley, J., Bloom, L., Kasaian, M., Gao, H., Berstein, G., Clark, J.D., Miao, W.> ;Assay Drug Dev Technol. 2010 Feb
• Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors.
  Chen, L., Wang, W., Lee, K.L., Shen, M.H., Murphy, E.A., Zhang, W., Xu, X., Tam, S., Nickerson-Nutter, C., Goodwin, D.G., Clark, J.D., McKew, J.C.> ;J Med Chem. 2009-02-26
• Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.
  Ramarao, M.K., Shen, M.H., Murphy, E.A., Duan, W., Zhao, Y., McKew, J., Lee, K.L., Thakker, P., Behnke, M.L., Clark, J.D.> ;Anal Biochem. 2008-12-15
• Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}eth...
  McKew, J.C., Lee, K.L., Shen, M.H., Thakker, P., Foley, M.A., Behnke, M.L., Hu, B., Sum, F., Tam, S., Hu, Y., Chen, L., Kirincich, S.J., Michalak, R., Thomason, J., Ip...> ;J Med Chem. 2008 Jun 26
• Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
  Hall, J.P., Kurdi, Y., Hsu, S., Cuozzo, J., Liu, J., Telliez, J., Seidl, K.J., Winkler, A., Hu, Y., Green, N., Askew, G.R., Tam, S., Clark, J.D., Lin, L.> ;J Biol Chem. 2007 Nov 16
• Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.
  Lee, K.L., Foley, M.A., Chen, L., Behnke, M.L., Lovering, F.E., Kirincich, S.J., Wang, W., Shim, J., Tam, S., Shen, M.H., Khor, S., Xu, X., Goodwin, D.G., Ramarao, M.K...> ;J Med Chem. 2007 Mar 22
• Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.
  McKew, J.C., Foley, M.A., Thakker, P., Behnke, M.L., Lovering, F.E., Sum, F., Tam, S., Wu, K., Shen, M.H., Zhang, W., Gonzalez, M., Liu, S., Mahadevan, A., Sard, H., K...> ;J Med Chem. 2006 Jan 12
• Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis.
  Marusic, S., Leach, M.W., Pelker, J.W., Azoitei, M.L., Uozumi, N., Cui, J., Shen, M.H., DeClercq, C.M., Miyashiro, J.S., Carito, B.A., Thakker, P., Simmons, D.L., Leon...> ;J Exp Med. 2005 Sep 19
• A fluorescence-based assay for fatty acid amide hydrolase compatible with high-throughput screening.
  Ramarao, M.K., Murphy, E.A., Shen, M.H., Wang, Y., Bushell, K.N., Huang, N., Pan, N., Williams, C., Clark, J.D.> ;Anal Biochem. 2005 Aug 1
• Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis.
  Hegen, M., Sun, L., Uozumi, N., Kume, K., Goad, M.E., Nickerson-Nutter, C.L., Shimizu, T., Clark, J.D.> ;J Exp Med. 2003 May 19
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