JamesAFerrendelliMD

Neurology • Houston, TX

Epilepsy, Dementia & Geriatrics

Professor, Neurology, University of Texas Medical School, Houston

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Office
6410 Fannin St
Ste 1014
Houston, TX 77030
Phone+1 832-325-7080

Fax+1 713-512-2239
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Education & Training

Case Western Reserve University/University Hospitals Cleveland Medical CenterResidency, Neurology, 1965 - 1968
University of Kentucky College of Medicine (Bowling Green)Internship, Transitional Year, 1962 - 1963
University of Colorado School of Medicine Anschutz Medical CampusClass of 1962

Certifications & Licensure

CO State Medical License 1963 - 2025
TX State Medical License 1996 - 2023
OH State Medical License 1966 - 1972
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
Top Doctors:SE Texas Castle Connolly, 2013
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2011
Super Doctor SuperDoctors.com
Whos Who in Medicine and Healthcare Marquis Whos Who
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Publications & Presentations

PubMed

What you see is not what you get: believing patient-reported seizure counts
Giridhar P. Kalamangalam, Jeremy D. Slater, James A. Ferrendelli> ;Archives of Neurology. 2007 Nov 1
6 citations
Enantioselectivity of α-Benzyl-α-methyl-γ-butyrolactone-Mediated Modulation of Anticonvulsant Activity and GABAA Receptor Function
Eric B. Gonzales, Cathy L. Bell-Horner, Maria Antonette M. de la Cruz, James A. Ferrendelli, Douglas F. Covey, Glenn H. Dillon> ;The Journal of Pharmacology and Experimental Therapeutics. 2004 May 1
57 citations
Use of levetiracetam in a population of patients aged 65 years and older: a subset analysis of the KEEPER trial.
James A. Ferrendelli, Jacqueline A. French, Ilo E. Leppik, Martha J. Morrell, A. Herbeuval, J. Han, L. Magnus> ;Epilepsy & Behavior. 2003 Dec 1
72 citations
The KEEPER trial: levetiracetam adjunctive treatment of partial-onset seizures in an open-label community-based study
Martha J. Morrell, Ilo E. Leppik, Jacqueline A. French, James A. Ferrendelli, J. Han, L. Magnus> ;Epilepsy Research. 2003 May 1
29 citations
Concerns with antiepileptic drug initiation: safety, tolerability, and efficacy.
James A. Ferrendelli> ;Epilepsia. 2001 Aug 1
6 citations
Pharmacology of antiepileptic drug polypharmacy.
James A. Ferrendelli> ;Epilepsia. 1999 May 1
15 citations
Structure-activity studies of fluoroaljyl-substituted γ-butyrolactone and γ-thiobutyrolactone modulators of GABAA receptor function
Daniel J. Canney, Hwang Fun Lu, Ann C. McKeon, Kong Woo Yoon, Kun Xu, Katherine D. Holland, Steven M. Rothman, James A. Ferrendelli, Douglas F. Covey> ;Bioorganic & Medicinal Chemistry. 1998 Jan 1
27 citations
Lactone Modulation of the γ-Aminobutyric Acid A Receptor: Evidence for a Positive Modulatory Site
Korwyn L. Williams, Joseph B. Tucker, Geoffrey G. White, David S. Weiss, James A. Ferrendelli, Douglas F. Covey, James E. Krause, Steven M. Rothman> ;Molecular Pharmacology. 1997 Jul 1
13 citations
Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones.
Robert A. Gross, Douglas F. Covey, James A. Ferrendelli> ;The Journal of Pharmacology and Experimental Therapeutics. 1997 Feb 1
22 citations
Synthesis and Anticonvulsant Activities of 3,3-Dialkyl- and 3-Alkyl-3-benzyl-2-piperidinones (δ-Valerolactams) and Hexahydro-2H-azepin-2-ones (ε-Caprolactams)
P. Amruta Reddy, Karen E. Woodward, Sarah M. McIlheran, B. C. H. Hsiang, Tammy Latifi, M. W. Hill, Steven M. Rothman, James A. Ferrendelli, Douglas F. Covey> ;Journal of Medicinal Chemistry. 1997 Jan 3
37 citations
3,3-Dialkyl- and 3-Alkyl-3-Benzyl-Substituted 2-Pyrrolidinones: A New Class of Anticonvulsant Agents
P. A. Reddy, B. C. H. Hsiang, Tammy Latifi, M. W. Hill, K. E. Woodward, Steven M. Rothman, James A. Ferrendelli, Douglas F. Covey> ;Journal of Medicinal Chemistry. 1996 Apr 26
14 citations
Physiological comparison of α-ethyl-α-methyl-γ-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors
G. C. Mathews, A. M. Bolos-Sy, Douglas F. Covey, Steven M. Rothman, James A. Ferrendelli> ;Neuropharmacology. 1996 Feb 1
3 citations
Use of rational polypharmacy to treat epilepsy.
James A. Ferrendelli> ;Epilepsy Research. Supplement. 1996 Jan 1
17 citations
Dual modulation of the gamma-aminobutyric acid type A receptor/ionophore by alkyl-substituted gamma-butyrolactones.
Katherine D. Holland, G. C. Mathews, A. M. Bolos-Sy, Joseph B. Tucker, P. A. Reddy, Douglas F. Covey, James A. Ferrendelli, Steven M. Rothman> ;Molecular Pharmacology. 1995 Jun 1
26 citations
Relating pharmacology to clinical practice: the pharmacologic basis of rational polypharmacy.
James A. Ferrendelli> ;Neurology. 1995 Mar 1
75 citations
Developmental alteration in GABAA receptor structure and physiological properties in cultured cerebellar granule neurons.
Gregory C. Mathews, Annabel M. Bolos-Sy, Katherine D. Holland, Keith E. Isenberg, Douglas F. Covey, James A. Ferrendelli, Steven M. Rothman> ;Neuron. 1994 Jul 1
12 citations
Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubsti...
Eileen M. Peterson, Kun Xu, Katherine D. Holland, Ann C. McKeon, Steven M. Rothman, James A. Ferrendelli, Douglas F. Covey> ;Journal of Medicinal Chemistry. 1994 Jan 21
15 citations
Alkyl-substituted γ-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABAA receptor complex
Katherine D. Holland, Michael G. Bouley, Douglas F. Covey, James A. Ferrendelli> ;Brain Research. 1993 Jun 25
47 citations
Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents.
Katherine D. Holland, Ann C. McKeon, Daniel J. Canney, Douglas F. Covey, James A. Ferrendelli> ;Epilepsia. 1992 Nov 1
23 citations
Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.
Daniel J. Canney, Katherine D. Holland, Jeffrey A. Levine, Ann C. McKeon, James A. Ferrendelli, Douglas F. Covey> ;Journal of Medicinal Chemistry. 1991 Apr 1
20 citations
Gamma-butyrolactone antagonism of the picrotoxin receptor: comparison of a pure antagonist and a mixed antagonist/inverse agonist.
Katherine D. Holland, Kong Woo Yoon, James A. Ferrendelli, Douglas F. Covey, Steven M. Rothman> ;Molecular Pharmacology. 1991 Jan 1
Electroencephalographic effects of intracisternally injected nonionic x-ray contrast media in rats.
Max D. Adams, William H. Ralston, J. W. Miller, James A. Ferrendelli> ;Investigative Radiology. 1990 Sep 1
23 citations
Binding interactions of convulsant and anticonvulsant gamma-butyrolactones and gamma-thiobutyrolactones with the picrotoxin receptor.
Katherine D. Holland, Ann C. McKeon, Douglas F. Covey, James A. Ferrendelli> ;The Journal of Pharmacology and Experimental Therapeutics. 1990 Aug 1
52 citations
Characterization of GABAergic seizure regulation in the midline thalamus.
John W. Miller, James A. Ferrendelli> ;Neuropharmacology. 1990 Jul 1
27 citations
Physiological regulation of the picrotoxin receptor by gamma- butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons
Katherine D. Holland, James A. Ferrendelli, Douglas F. Covey, Steven M. Rothman> ;The Journal of Neuroscience. 1990 Jun 1
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Grant Support

Molecular &Behavioral Neuropharmacology Of Butyrolactones &Related CompoundsNational Institute Of Neurological Disorders And Stroke1997–1999
Basic Mechanisms Of SeizuresNational Institute Of Neurological Disorders And Stroke1995–1999
Basic Mechanisms Of SeizuresNational Institute Of Neurological Disorders And Stroke1985–1994
Biochemistry And Pharmacology Of The RetinaNational Eye Institute1985