James Tahara Handa MD
Retinal Disease, Ocular Oncology
Professor of Ophthalmology, Johns Hopkins University School of Medicine; Robert Bond Welch Professor
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1800 Orleans StreetMaumenee LobbyBaltimore, MD 21287
Phone+1 410-955-5080
Fax+1 410-955-0869
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Education & Training
Sidney Kimmel Medical College at Thomas Jefferson University/Wills Eye HospitalResidency, Ophthalmology, 1987 - 1990
Graduate HospitalInternship, Internal Medicine, 1986 - 1987
Perelman School of Medicine at the University of PennsylvaniaClass of 1986
Certifications & Licensure
CA State Medical License 1991 - Present
MD State Medical License 2001 - 2026
NC State Medical License 1990 - 1998
NV State Medical License 1994 - 1995
PA State Medical License 1988 - 1990
American Board of Ophthalmology Ophthalmology
Awards, Honors, & Recognition
- America's Top Doctors Castle Connolly, 2007-2014
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013-2014
- America's Top Doctors for Cancer Castle Connolly, 2006-2013
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Clinical Trials
- SAR 1118 in Human Subjects Undergoing Pars Plana Vitrectomy Start of enrollment: 2009 Aug 01
- Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma Start of enrollment: 2011 Mar 01
Publications & Presentations
PubMed
- Dissecting the biological complexity of age-related macular degeneration: Is it one disease, multiple separate diseases, or a spectrum?Jason M L Miller, Benjamin R Thompson, James T Handa, Philip Luthert, Usha Chakravarthy
Experimental Eye Research. 2025-05-01 - 1 citationsActivated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice.Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu
Aging Cell. 2025-02-17 - Cigarette smoke and biological age induce degenerative heterogeneity in retinal pigment epithelium.Krishna Singh, Yang Jin, Ming-Wen Hu, Isabella Palazzo, Marisol Cano
Biorxiv. 2025-01-28
Journal Articles
- A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular DegenerationJiang Qian, James T Handa, Investigative Ophthalmology and Visual Science
- The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-Neovascular AMDJames Handa, MD, ScienceDirect
Press Mentions
Novel Therapies and New Biomarkers for Geographic AtrophyFebruary 1st, 2023
Grant Support
- Does age/stress-induced mitochondrial dysfunction induce variations in RPE phenotype in AMD?TULANE UNIVERSITY OF LOUISIANA2024–2028
- Does age/stress-induced mitochondrial dysfunction induce variations in RPE phenotype in AMD?TULANE UNIVERSITY OF LOUISIANA2024–2028
- The Wilmer Institute Mentored Clinician Scientist Scholar ProgramJOHNS HOPKINS UNIVERSITY2003–2027
- The Wilmer Institute Mentored Clinician Scientist Scholar ProgramJOHNS HOPKINS UNIVERSITY2003–2027
- The Wilmer Institute Mentored Clinician Scientist Scholar ProgramJOHNS HOPKINS UNIVERSITY2003–2027
- The role of epigenetics in RPE heterogeneity with early AMDJOHNS HOPKINS UNIVERSITY2022–2026
- The role of epigenetics in RPE heterogeneity with early AMDJOHNS HOPKINS UNIVERSITY2022–2026
- The role of epigenetics in RPE heterogeneity with early AMDJOHNS HOPKINS UNIVERSITY2022–2026
- Targeting lysosome/RPE heterogeneity in AMD pathobiology as a novel therapyUNIVERSITY OF PITTSBURGH AT PITTSBURGH2021–2025
- Targeting lysosome/RPE heterogeneity in AMD pathobiology as a novel therapyUNIVERSITY OF PITTSBURGH AT PITTSBURGH2021–2025
- Targeting lysosome/RPE heterogeneity in AMD pathobiology as a novel therapyUNIVERSITY OF PITTSBURGH AT PITTSBURGH2021–2025
Professional Memberships
- Fellow
External Links
- Johns Hopkins Physicianshttp://www.hopkinsmedicine.org/james-handa
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