JamesGordonHeckerMDPhD

PubMed

• 3 citations
  Measuring aerosols in the operating theatre and beyond using a real-time sensor network.
  J G Hecker, J He, R Rochlin, C Brannen, S Teng, K Glenn, I Novosselov> ;Anaesthesia. 2022 Oct 1
• 4 citations
  Non-Viral Delivery of RNA Gene Therapy to the Central Nervous System.
  Ellen S Hauck, James G Hecker> ;Pharmaceutics. 2022 Jan 11
• 5 citations
  Inadvertent Burst Suppression During Total Intravenous Anesthesia in 112 Consecutive Patients Undergoing Spinal Instrumentation Surgery: A Retrospective Observational ...
  Abhijit V. Lele, Michele A. Furman, Jonathan Myers, Greg Kinney, Deepak Sharma, James G. Hecker> ;Journal of Neurosurgical Anesthesiology. 2021 Jan 19
• A Novel Approach to Investigating Brain Waste Removal in Humans.
  Li Li, Koichiro Nandate, James G. Hecker, Nathalie Bentov, G. A. Nagana Gowda, Daniel Raftery, Deepak Sharma> ;Journal of Neurosurgical Anesthesiology. 2019 Oct 23
• 8 citations
  Incidence and Risk Factors for Intraoperative Seizures During Elective Craniotomy.
  Rachel Kutteruf, Jen-Ting Yang, James G. Hecker, Gregory A. Kinney, Michele A. Furman, Deepak Sharma> ;Journal of Neurosurgical Anesthesiology. 2019 Apr 1
• 38 citations
  Guideline Adherence and Outcomes in Severe Adult Traumatic Brain Injury for the CHIRAG (Collaborative Head Injury and Guidelines) Study
  Deepak Gupta, Deepak Sharma, Nithya Kannan, Suchada Prapruettham, Charles Mock, Jin Wang, Qian Qiu, Ravindra Mohan Pandey, Ashok Kumar Mahapatra, Hari Har Dash, James ...> ;World Neurosurgery. 2016 May 1
• 19 citations
  Non-Viral, Lipid-Mediated DNA and mRNA Gene Therapy of the Central Nervous System (CNS): Chemical-Based Transfection
  James G. Hecker> ;Methods in Molecular Biology. 2016 Jan 1
• 8 citations
  Clinical experience with intraoperative jugular venous oximetry during pediatric intracranial neurosurgery
  Deepak Sharma, Arunotai Siriussawakul, Neil Dooney, James G. Hecker, Monica S. Vavilala> ;Paediatric Anaesthesia. 2013 Jan 1
• 4 citations
  Nonviral, cationic lipid-mediated delivery of mRNA.
  James G. Hecker> ;Methods in Molecular Biology. 2013 Jan 1
• 5 citations
  A single intrathecal injection of DNA and an asymmetric cationic lipid as lipoplexes ameliorates experimental autoimmune encephalomyelitis.
  Srikanth Yellayi, Brendan Hilliard, Mustafa Ghazanfar, Akivaga Tsingalia, Michael H. Nantz, Laura Bollinger, Fabian de Kok-Mercado, James G. Hecker> ;Molecular Pharmaceutics. 2011 Oct 3
• 52 citations
  Heat shock proteins as biomarkers for the rapid detection of brain and spinal cord ischemia: a review and comparison to other methods of detection in thoracic aneurysm...
  James G. Hecker, Michael L. McGarvey> ;Cell Stress & Chaperones. 2011 Mar 1
• 24 citations
  The benefit of hydrophobic domain asymmetry on the efficacy of transfection as measured by in vivo imaging.
  Michael Nantz, Christopher W. Dicus, Brendan Hilliard, Sri Yellayi, Shaomin Zou, James G. Hecker> ;Molecular Pharmaceutics. 2010 Jun 7
• 107 citations
  Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells.
  Shaomin Zou, Keith Scarfo, Michael H. Nantz, James G. Hecker> ;International Journal of Pharmaceutics. 2010 Apr 15
• 49 citations
  Antioxidant enzyme gene transfer for ischemic diseases
  Jian Wu, James G. Hecker, Nipavan Chiamvimonvat> ;Advanced Drug Delivery Reviews. 2009 Apr 28
• 16 citations
  Whole animal in vivo imaging after transient, nonviral gene delivery to the rat central nervous system.
  Ellen S. Hauck, Shaomin Zou, Keith Scarfo, Michael H. Nantz, James G. Hecker> ;Molecular Therapy. 2008 Nov 1
• 5 citations
  A Flexible Method for the Conjugation of Aminooxy Ligands to Preformed Complexes of Nucleic Acids and Lipids
  James G. Hecker, Gideon O. Berger, Keith Scarfo, Shaomin Zou, Michael H. Nantz> ;Chemmedchem. 2008 Sep 15
• 16 citations
  Heat shock proteins HSP70 and HSP27 in the cerebral spinal fluid of patients undergoing thoracic aneurysm repair correlate with the probability of postoperative paralysis
  James G. Hecker, Hari Sundram, Shaomin Zou, Amy Praestgaard, Joseph E. Bavaria, Sindhu Ramchandren, Michael L. McGarvey> ;Cell Stress & Chaperones. 2008 Apr 17
• 53 citations
  The carboxyl-terminal domain of inducible Hsp70 protects from ischemic injury in vivo and in vitro
  Yunjuan Sun, Yi Bing Ouyang, Lijun Xu, Ari Man Yi Chow, Robin L. Anderson, James G. Hecker, Rona G. Giffard> ;Journal of Cerebral Blood Flow and Metabolism. 2006 Jul 1
• 1 citations
  S-100 and NSE changes after cardiac surgery: evaluation of multiple single nucleotide polymorphisms.
  W. Andrew Kofke, Albert T. Cheung, John G.T. Augoustides, James G. Hecker, Joseph E. Bavaria> ;Anesthesia and Analgesia. 2006 Apr 1
• 1 citations
  Case 2-2006Catastrophic Cardiovascular Collapse During Carotid Endarterectomy
  James G. Hecker, Lawrence J. Laslett, Emily Campbell, Mark E. Nunnally, Anne M. O'Connor, John E. Ellis, Jonathan Frogel, Lee A. Fleisher> ;Journal of Cardiothoracic and Vascular Anesthesia. 2006 Apr 1
• 19 citations
  Rat brain DNA transcript profile of halothane and isoflurane exposure.
  Jonathan Z. Pan, Huafeng Wei, James G. Hecker, John W. Tobias, Roderic G. Eckenhoff, Maryellen F. Eckenhoff> ;Pharmacogenetics and Genomics. 2006 Mar 1
• 13 citations
  Heat shock protein modulation of KATP and KCa channel cerebrovasodilation after brain injury
  William M. Armstead, James G. Hecker> ;American Journal of Physiology. Heart and Circulatory Physiology. 2005 Sep 1
• 50 citations
  Stability of mRNA/Cationic Lipid Lipoplexes in Human and Rat Cerebrospinal Fluid: Methods and Evidence for Nonviral mRNA Gene Delivery to the Central Nervous System
  Dua M. Anderson, Leon L. Hall, Anitha R. Ayyalapu, Van R. Irion, Michael H. Nantz, James G. Hecker> ;Human Gene Therapy. 2003 Feb 10
• 6 citations
  A Versatile Linker for Nontoxic Polyamine-Mediated DNA Transfection
  Edmund J. Niedzinski, Scott K Fujii, Mike E. Lizarzaburu, James G Hecker, Michael H. Nantz> ;Molecular Therapy. 2002 Aug 1
• 41 citations
  Nonviral gene delivery to the lateral ventricles in rat brain: initial evidence for widespread distribution and expression in the central nervous system.
  James G Hecker, Leon L. Hall, Van R. Irion> ;Molecular Therapy. 2001 Mar 1
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Journal Articles

• Anesthesiology in 2037: A Look Back  
  Hecker, JG, Anesthesiology News, 5/5/2017
• Use of a mass spectrometer in the measurement of gas solubilities in blood.  
  Hecker JG and TA Massaro, Biomedical Engineering Vol. 21:157-158
• Characterization of gene expression during stress: implications for anesthesiology and critical care.  
  Hecker JG, Seminars in Anesthesia, Perioperative Medicine and Pain 17:3:187-194
• Awake fiberoptic intubation and intravenous anesthesia in patients with a history suggestive of malignant hyperthermia.  
  Hecker JG and JL Helkowski, The American Journal of Anesthesiology 3:129-131
• Unsymmetrical hydrophobic domains improve in vivo transfection efficiency.  
  Nantz MH, Dicus CW, Hilliard B, Yellayi S, Scarfo KA, Zou S, Hecker JG, Molecular Pharmaceutics 7(3):786-94
• Heat shock proteins as biomarkers for the rapid detection of brain and spinal cord ischemia: A review and comparison to other methods.  
  Hecker JG, McGarvey M, Cell Stress & Chaperones 16(2):119-31
• Clinical Experience with Intraoperative Jugular Venous Oximetry during Pediatric Intracranial Neurosurgery.  
  Sharma D, Siriussawakul A, Dooney N, Hecker JG, Vavilala MS, Pediatric Anesthesia
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Books/Book Chapters

• Microprobe Analysis of Biological Systems. 
  Chapter: Measurement of mass loss during microanalysis: methods and preliminary results 
  Hecker JG and TE HutchinsonEditors: Hutchinson TE and AP Somylo.Academic Press, San Francisco
• Anesthesia and Uncommon Diseases. 
  Chapter: Neurologic Diseases 
  Hecker JG, Baranov D, McClung, H, Kelton, T, Scarfo, KWB Saunders
• Essence of Anesthesia. 
  Chapter: Neuroprotection 
  LA Fleisher and M RoizenElsevierEdition 3rd,
• Fundamentals of Neuroanesthesia: A Physiologic Approach to Clinical Practice. 
  Chapter: Cerebral Ischemia and Neuroprotection 
  Hecker JGEditors: KJ Ruskin, SH Rosenbaum and IJ Rampil.Oxford University Press
• Methods in Molecular Biology, Volume dedicated to synthetic RNA as a tool for cell metabolism modulation. 
  Chapter: Lipid-mediated mRNA delivery 
  Hecker JGEditors: P Rabinovich.Humana Press
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Abstracts/Posters

• Non Viral Gene Delivery to the Primate CNS: Biodistribution and immune response. Oral Presentation, and Chair of Session, American Society for Gene Therapy.
  Hecker JG, 11th Annual Meeting, Boston
• HSP70 and HSP27 in the CSF of patients undergoing TAAA procedures predict post-operative paralysis.
  Hecker JG, McGarvey M, Association of University Anesthesiologists 57th Annual Meeting, Denver
• In vivo imaging after non-viral RNA delivery to brain.
  Hecker JG, Integrating Molecular Imaging in Drug Discovery and Development conference, Philadelphia
• Applications: When is Short Term Expression Better?
  Hecker JG, 5th Annual National Meeting of the American Society of Gene Therapy, Boston, MA
• Comparative analysis of cationic lipid-mediated RNA and DNA gene delivery in non-proliferating cells.
  Hall LL, Massey D, Hecker JG, 5th Annual National Meeting of the American Society of Gene Therapy, Boston, MA
• Optimization of non-viral DNA and mRNA gene delivery to the CNS following neurotrauma and pre-operatively for neuroprotection.
  Hall LL, Massey-Anderson D, Nantz MH, Hecker JG, Society for Neuroscience 32nd Annual Meeting, Orlando, FL
• Non-viral DNA and mRNA gene delivery to the CNS pre-operatively for neuroprotection and following neurotrauma.
  Hecker JG, American Society of Anesthesiologists National Meeting, San Francisco, CA
• Non-viral DNA and mRNA gene delivery to the CNS pre-operatively for neuroprotection and following neurotrauma.
  Hecker JG, Association of University Anesthesiologists 51st Annual Meeting, Sacramento, CA
• Non-Viral DNA and mRNA Gene Delivery to the CNS for Neuroprotection and Following Neurotrauma.
  Hecker JG, Tarantal AF, Nantz MH, 7th Annual Meeting of the American Society of Gene Therapy, Minneapolis, MN
• Non-Viral DNA and mRNA Gene Delivery to the CNS for Neuroprotection and Following Neurotrauma.
  Hecker JG, Tarantal AF, Nantz MH, Society for Neuroscience 34th Annual Meeting, San Diego, CA
• Distribution, Expression, and Inflammatory Response after Non-viral Gene Delivery to the Primate CNS: A Model for Operative Neuroprotection.
  Hecker JG, Association of University Anesthesiologists 52nd Annual Meeting, Baltimore, MD
• Gene delivery to primary neuronal cells.
  Zou S, Hauck ES, Nantz MH, Hecker JG, 8th Annual Meeting of the American Society of Gene Therapy, St. Louis
• In-vivo time course of reporter gene expression after nucleic acid delivery to the lateral ventricle in rat brain.
  Hauck ES, Zou S, Nantz MH, Hecker JG, 8th Annual Meeting of the American Society of Gene Therapy, St. Louis
• Distribution, time course, in-vivo imaging, expression and inflammatory response after non-viral gene delivery to rat and primate CNS.
  Hecker JG, Hauck ES, Nantz MH, Tarantal AF, 8th Annual Meeting of the American Society of Gene Therapy, St. Louis
• Non-Viral DNA and mRNA Gene Delivery to the CNS for Neuroprotection and Following Neurotrauma.
  Hecker JG, Tarantal AF, Nantz MH, Society for Neuroscience 35th Annual Meeting, Washington, DC
• Non-Viral DNA and mRNA Gene Delivery to the CNS for Neuroprotection.
  Hecker JG, Tarantal AF, Nantz MH, European Society for Gene Therapy, Prague, Czech Republic
• Elevated Heat Shock Proteins 70 and 27 are Correlated with CNS Injury in Surgical Patients Undergoing Deep Hypothermia Circulatory Arrest and Descending Thoracic Aorti...
  Hecker JG, Zou S, Augostides J, Ramachadron S, Thurber A, Bavaria JE, McGarvey M, Biomarkers Conference, Booth Bay, ME
• Non Viral Gene Delivery to the Primate CNS: A Model for Operative Neuroprotection.
  Hecker JG, Association of University Anesthesiologists 54th Annual Meeting, Chicago
• Overcoming the hurdle of nonviral gene delivery to non-proliferating cells by RNA based gene transfer.
  Zou, S, Hecker JG, American Society for Gene Therapy 10th Annual Meeting, Seattle
• Non Viral Gene Delivery to the Primate CNS: A Model for Pre-Operative Neuroprotection.
  Hecker JG, Nantz MH, Tarantal AF, American Society for Gene Therapy, 10th Annual Meeting, Seattle
• Elevated Heat Shock Proteins 70 and 27 are Correlated with CNS Injury in Surgical Patients Undergoing Deep Hypothermic Circulatory Arrest and Descending Thoracic Aorti...
  Hecker JG, Augostides J, Zou S, Ramachadron S, Bavaria, J, McGarvey M, World Stress Conference, Budapest, Hungary
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