
James W. Jakub MD
Breast, Melanoma, Surgical Oncology (Other than Breast)
Professor of Surgery Division of Surgical Oncology
Join to view full profile
4500 San Pablo Rd SJacksonville, FL 32224
Phone+1 904-953-2000
Dr. Jakub is on Doximity
As a Doximity member, you’ll join more than three million U.S. healthcare professionals—including 85+% of physicians, and 2/3 of all NPs and PAs—in a private, secure network.
- Gain access to free telehealth tools, such as our “call shielding” and one-way patient texting.
- Connect with colleagues in the same hospital or clinic.
- Read the latest clinical news, personalized to your specialty.
Summary
- Dr Jakub is a high volume surgical oncologist, with a primary focus on breast cancer and melanoma.
Dr Jakub has been an early adopter and championed dissemination of a number of novel surgical innovations. He has been recognized by receiving the Mayo Clinic Innovation in Education Award and Outstanding Course Directors for our Radioguided Breast Surgery course which has trained over 500 individuals; many of them adopting this new procedure into clinical practice. He is a leader in disseminating the novel technique of minimally invasive inguinal lymph node dissection for melanoma, for which he lead a 12 site multi-institutional trial melanoma. Dr Jakub is currently PI on a prospective trial investigating the role of axillary reverse mapping and lympho-venous bypass at the time of axillary lymph node dissection with the goal of preventing one of the greatest fears patients have of the operation, lymphedema. He is actively exploring the role of robotic breast surgery. He is the course director for a Mayo Clinic CME course Innovation, Disruptive Technologies and Early Adopters in Breast Cancer Care: Tomorrows Technologies Today as well as a co-course director for the highly successful Mayo Clinic Annual Practical Course in Dermoscopy & Update on Malignant Melanoma.
He feels very fortunate to be working in a physician lead organization with a large clinical volume, significant institutional infrastructure and a collaborative team approach whose primary value is the needs of the patients come first.
Clinical Expertise
- Sentinel lymph node biopsy, Melanoma, Breast cancer, Lymphadenectomy
Education & Training
H. Lee Moffitt Cancer Center and Research InstituteFellowship, Breast Surgical Oncology, 2001 - 2002
Prisma Health/University of South Carolina SOM Columbia (Columbia)Residency, Surgery, 1995 - 2000
MCP-Hahnemann College of MedicineClass of 1995
Certifications & Licensure
FL State Medical License 2002 - 2028
MN State Medical License 2008 - 2027
SC State Medical License 1996 - 2003
American Board of Surgery Surgery
Awards, Honors, & Recognition
- Outstanding Course Directors Award - 15th Annual Practical Course in Dermoscopy and Update on Malignant Melanoma Mayo Clinic, 2021
- CMS Meaningful Use Stage 1 Certification Centricity Enterprise (CE), GE Healthcare, 2014
- CMS Meaningful Use Stage 1 Certification Centricity Enterprise, GE Healthcare, 2014
Clinical Trials
- Minimally Invasive Groin Dissection for Melanoma Start of enrollment: 2012 Jun 01
- Second Echelon Node Study With Methylene Blue Start of enrollment: 2013 Apr 01
- Preventing Lymphedema in Axillary Lymph Node Dissection Start of enrollment: 2018 Apr 10
Publications & Presentations
PubMed
- Accuracy of Index Lymph Node Pathology in Predicting Overall Response to Neoadjuvant Immunotherapy for Clinical Stage III Melanoma: Results From the Prospective NeoACT...Tina J Hieken, Thomas J Flotte, David Zahrieh, Jeffrey E Johnson, Mara A Piltin
Annals of Surgical Oncology. 2026-08-01 - ASO Visual Abstract: Improved Oncologic Outcomes with Trimodality Therapy for Radiation-Associated Angiosarcoma of the Breast.Saskia J Leonard, Tanya Hoskin, Brittany L Siontis, Safia Ahmed, Tina J Hieken
Annals of Surgical Oncology. 2026-07-25 - ASO Visual Abstract: A Prospective, Multi-Center Randomized Controlled Trial (RCT) of the da Vinci SP Surgical System Versus Open Surgery in Nipple Sparing Mastectomy ...Katherine Kopkash, Mara Piltin, James Jakub, Sara Javid, Meghan R Flanagan
Annals of Surgical Oncology. 2026-07-23
Journal Articles
- Decreasing Use of Axillary Dissection in Node-Positive Breast Cancer Patients Treated with Neoadjuvant ChemotherapyJames W Jakub, Amy C Degnim, Tina J Hieken, Judy C Boughey, Annals of Surgical Oncology
- Breast Cancer Litigation in the 21st CenturyJames W Jakub, Martin D Zielinski, Brittany L Murphy, Annals of Surgical Oncology
Press Mentions
Mayo Clinic Leads 4 Decades of Advances in Breast Cancer CareOctober 2nd, 2025
Embracing Precision Medicine for Advanced Melanoma with Tumor-Infiltrating Lymphocyte (TIL) TherapySeptember 23rd, 2025
Breast Cancer Surgery Program in JacksonvilleAugust 14th, 2025
Committees
- Corporate Relations Committee, American Society of Breast Surgeons 2022 - Present
- Board Member, Mayo Clinic eTumor Steering Committee 2020 - Present
- Program Committee Member, Western Surgical Association 2019 - Present
- Editorial Board Member - Melanoma Section, Annals of Surgical Oncology 2018 - Present
- Editorial Board Member - Melanoma Section, Journal of Surgical Oncology 2016 - Present
Professional Memberships
- Member
- Society of Surgical Oncology - SSOMember
- Member
External Links
- Bio page Mayo Clinichttps://www.mayoclinic.org/biographies/jakub-james-w-m-d/bio-20055124
- Breast Innovation Coursehttps://ce.mayo.edu/surgical-specialties/content/breast-cancer-care-innovation-disruptive-technologies-and-early-adopters-2022
Viewing the full profile is available to verified healthcare professionals only.
Find your profile and take control of your online presence:










