JamesTKurnickMD

Pathology • Beverly, MA

Anatomic Pathology, Clinical Pathology

Associate Clinical Professor of Pathology, Massachusetts General Hospital

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Office
100 Cummings Ctr
Suite 430c
Beverly, MA 01915
Phone+1 978-232-1243

Fax+1 617-724-5317
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Education & Training

University of ColoradoResidency, Pathology-Anatomic and Clinical, 1975 - 1976
University of Colorado School of MedicineInternship, Transitional Year, 1973 - 1974
Tufts University School of MedicineClass of 1973

Certifications & Licensure

CA State Medical License 1979 - Present
MA State Medical License 1980 - 2024

Publications & Presentations

PubMed

Assembly of Biologically Functional Structures by Nucleic Acid Templating: Implementation of a Strategy to Overcome Inhibition by Template Excess.
Matthew M Lawler, James T Kurnick, Leah Fagundes St Pierre, Estelle E Newton, Lenora B Rose, Ian S Dunn> ;Molecules. 2022 Oct 12
27 citations
Integrins: Integrating the Biology and Therapy of Cell-cell Interactions.
Franco Pandolfi, Laura Franza, Simona Altamura, Claudia Mandolini, Rossella Cianci, Aftab A. Ansari, James T. Kurnick> ;Clinical Therapeutics. 2017 Dec 1
19 citations
Heat Shock Protein-90 Inhibitors Enhance Antigen Expression on Melanomas and Increase T Cell Recognition of Tumor Cells
Timothy J. Haggerty, Ian S. Dunn, Lenora B. Rose, Estelle E. Newton, Franco Pandolfi, James T. Kurnick> ;Plos One. 2014 Dec 12
7 citations
A screening assay to identify agents that enhance T-cell recognition of human melanomas.
Timothy J. Haggerty, Ian S. Dunn, Lenora B. Rose, Estelle E. Newton, James T. Kurnick> ;Assay and Drug Development Technologies. 2012 Apr 12
26 citations
Topoisomerase inhibitors modulate expression of melanocytic antigens and enhance T cell recognition of tumor cells.
Timothy J. Haggerty, Ian S. Dunn, Lenora B. Rose, Estelle E. Newton, Sunil Martin, James L. Riley, James T. Kurnick> ;Cancer Immunology, Immunotherapy. 2011 Jan 1
60 citations
Expression of cell adhesion molecules in human melanoma cell lines and their role in cytotoxicity mediated by tumor-infiltrating lymphocytes.
F Pandolfi, Livio Trentin, Lenora A. Boyle, Ivan Stamenkovic, H. Randolph Byers, Robert B. Colvin, James T. Kurnick> ;Cancer. 2010 Aug 2
13 citations
T cell heterogeneity in patients with common variable immunodeficiency as assessed by abnormalities of T cell subpopulations and T cell receptor gene analysis.
F Pandolfi, Livio Trentin, J.E. San Martin, Johnson T. Wong, James T. Kurnick, R A Moscicki> ;Clinical and Experimental Immunology. 2008 Jun 28
5 citations
T cell receptor gene rearrangements and cytotoxic activities of clones isolated from tumour-infiltrating lymphocytes (TIL) from melanoma patients
F Pandolfi, Lenora A. Boyle, Livio Trentin, Alessandra Oliva, James T. Kurnick> ;Clinical and Experimental Immunology. 2008 Jun 28
24 citations
Enhancement of Human Melanoma Antigen Expression by IFN-β
Ian S. Dunn, Timothy J. Haggerty, Michihiro Kono, Paul J. Durda, David Butera, David B. Macdonald, Elizabeth M. Benson, Lenora B. Rose, James T. Kurnick> ;Journal of Immunology. 2007 Aug 15
116 citations
Role of the mitogen-activated protein kinase signaling pathway in the regulation of human melanocytic antigen expression.
Michihiro Kono, Ian S. Dunn, Paul J. Durda, David Butera, Lenora B. Rose, Timothy J. Haggerty, Elizabeth M. Benson, James T. Kurnick> ;Molecular Cancer Research. 2006 Oct 1
22 citations
Induction of "antigen silencing" in melanomas by oncostatin M: down-modulation of melanocyte antigen expression.
Paul J. Durda, Ian S. Dunn, Lenora B. Rose, David Butera, Elizabeth M. Benson, Franco Pandolfi, James T. Kurnick> ;Molecular Cancer Research. 2003 Apr 1
46 citations
A Novel Autocrine Pathway of Tumor Escape from Immune Recognition: Melanoma Cell Lines Produce a Soluble Protein That Diminishes Expression of the Gene Encoding the Me...
James T. Kurnick, Teresa Ramirez-Montagut, Lenora A. Boyle, David Andrews, Franco Pandolfi, Paul J. Durda, David Butera, Ian S. Dunn, Elizabeth M. Benson, Sam J. P. Go...> ;Journal of Immunology. 2001 Aug 1
54 citations
Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum.
Judith Hellman, Paul M. Loiselle, Megan M. Tehan, Jennifer E. Allaire, Lenora A. Boyle, James T. Kurnick, David Andrews, Kwang Sik Kim, H. Shaw Warren> ;Infection and Immunity. 2000 May 1
41 citations
Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5.
Judith Hellman, Paul M. Loiselle, E M Zanzot, Jennifer E. Allaire, Megan M. Tehan, Lenora A. Boyle, James T. Kurnick, H. Shaw Warren> ;The Journal of Infectious Diseases. 2000 Mar 1
15 citations
Melanoma antigen recognition by tumour-infiltrating T lymphocytes (TIL): effect of differential expression of melan-A/MART-1.
T Ramirez-Montagut, David Andrews, A Ihara, Shazib Pervaiz, Franco Pandolfi, P.J. van den Elsen, R Waitkus, Lenora A. Boyle, M Hishii, James T. Kurnick> ;Clinical and Experimental Immunology. 2000 Jan 1
28 citations
Studies of the mechanism of cytolysis by tumour-infiltrating lymphocytes
M Hishii, James T. Kurnick, T Ramirez-Montagut, Franco Pandolfi> ;Clinical and Experimental Immunology. 1999 Jun 1
10 citations
Oligoclonality of Vdelta1 and Vdelta2 cells in human peripheral blood mononuclear cells: TCR selection is not altered by stimulation with gram-negative bacteria.
Jian Shen, David Andrews, F Pandolfi, Lenora A. Boyle, Catalina M. Kersten, Robert N. Blatman, James T. Kurnick> ;Journal of Immunology. 1998 Mar 15
24 citations
Antiserum against Escherichia coli J5 Contains Antibodies Reactive with Outer Membrane Proteins of Heterologous Gram-Negative Bacteria
Judith Hellman, E M Zanzot, Paul M. Loiselle, Stephen Amato, K M Black, Yimin Ge, James T. Kurnick, H. Shaw Warren> ;The Journal of Infectious Diseases. 1997 Nov 1
2 citations
T cell receptor usage by HLA-DR3-specific T cell clones isolated from a renal allograft
Makiko Kumagai-Braesch, Lenora A. Boyle, Peter J. van den Elsen, James T. Kurnick> ;Transplant Immunology. 1997 Jun 1
38 citations
In vivo accumulation of the same anti-melanoma T cell clone in two different metastatic sites
Makoto Hishii, David Andrews, Lenora A. Boyle, Johnson T. Wong, Franco Pandolfi, Peter J. van den Elsen, James T. Kurnick> ;Proceedings of the National Academy of Sciences of the United States of America. 1997 Feb 18
18 citations
Escherichia coli and Pseudomonas aeruginosa induce expansion of V delta 2 cells in adult peripheral blood, but of V delta 1 cells in cord blood.
C M Kersten, McCluskey Rt, Lenora A. Boyle, James T. Kurnick> ;Journal of Immunology. 1996 Aug 15
75 citations
T cell receptors in rheumatoid arthritis.
Linda Struyk, Gail E. Hawes, May K. Chatila, Ferdinand C. Breedveld, James T. Kurnick, Peter J. van den Elsen> ;Arthritis and Rheumatism. 1995 May 1
7 citations
Responses of human T cells to dominant discrete protein antigens of Escherichia coli and Pseudomonas aeruginosa.
C M Kersten, R. T. Mccluskey, H. Shaw Warren, James T. Kurnick> ;Scandinavian Journal of Immunology. 1994 Aug 1
197 citations
Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR reper...
Spyros A. Kalams, R P Johnson, Alicja Trocha, M J Dynan, H S Ngo, Richard T. D'Aquila, James T. Kurnick, Bruce D. Walker> ;The Journal of Experimental Medicine. 1994 Apr 1
6 citations
T Lymphocyte Responses to Antigens of Gram-Negative Bacteria in Pyelonephritis
S W Wilz, James T. Kurnick, F Pandolfi, Robert H. Rubin, H S Warren, Richard Goldstein, C M Kersten, McCluskey Rt> ;Clinical Immunology and Immunopathology. 1993 Oct 1
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Grant Support

Cardiac Infiltrating T Cells In Rejection &MyocarditisNational Heart, Lung, And Blood Institute1990–1994
Clonal Dominance Of T-Lymphocytes In ArthritisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1989–1991
T Lymphocytes In Rheumatoid ArthritisFogarty International Center1990
Characterization Of In Vivo Activated Human LymphocytesNational Cancer Institute1986–1989
Human T Cells Specific For Soluble AntigensNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985