JamesKuang-JanLiaoMD

PubMed

• 1 citations
  Tie2-Cre-Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury.
  Pang-Yen Liu, Nobuaki Fukuma, Yukio Hiroi, Akiko Kunita, Hiroyuki Tokiwa, Kazutaka Ueda, Taro Kariya, Genri Numata, Yusuke Adachi, Miyu Tajima, Masayuki Toyoda, Yuxin ...> ;JACC. Basic to Translational Science. 2023 Jan 1
• 4 citations
  Involvement of Rho-Associated Coiled-Coil Containing Kinase (ROCK) in BCR-ABL1 Tyrosine Kinase Inhibitor Cardiovascular Toxicity.
  Brian Yu, Afaf E G Osman, Nikola Sladojevic, Nicole Prabhu, Haw-Chih Tai, Daiqing Chen, Gerardo Perla, Linus Park, Richard A Larson, James K Liao> ;JACC. Cardiooncology. 2022 Sep 1
• 9 citations
  Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation.
  Minghui Li, Xing Lyu, James Liao, Victoria P Werth, Ming-Lin Liu> ;Theranostics. 2022 Jan 1
• 3 citations
  Vascular Stiffening Mediated by Rho-Associated Coiled-Coil Containing Kinase Isoforms.
  Yuxin Li, Haw-Chih Tai, Nikola Sladojevic, Hyung-Hwan Kim, James K. Liao> ;Journal of the American Heart Association. 2021 Oct 6
• 3 citations
  Challenging Statin Pleiotropy: Preeclampsia.
  Janet Wei, James K. Liao, C. Noel Bairey Merz> ;Circulation. 2021 Aug 31
• 23 citations
  Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway.
  Qin Zhang, Mei Zheng, Cristian E Betancourt, Lifeng Liu, Albert Sitikov, Nikola Sladojevic, Qiong Zhao, John H. Zhang, James K. Liao, Rongxue Wu> ;Oxidative Medicine and Cellular Longevity. 2021 Mar 30
• 44 citations
  Emerging views of statin pleiotropy and cholesterol lowering.
  Dongbo Yu, James K. Liao> ;Cardiovascular Research. 2021 Feb 3
• SALAD-BAAR: A numerical risk score for hospital admission or emergency department presentation in ambulatory patients with cardiovascular disease.
  Emeka Anyanwu, Rhys Chua, Stephanie A. Besser, Deyu Sun, James K. Liao, Corey E. Tabit> ;Clinical Cardiology. 2021 Feb 1
• 5 citations
  Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus.
  Mei Zheng, Maura Knapp, Nikola Sladojevic, Qin Zhang, Lizhuo Ai, Devin L. Harrison, Anna Chen, Albert Sitikov, Le Shen, Frank J. Gonzalez, Qiong Zhao, Yun Fang, James ...> ;Frontiers in Cell and Developmental Biology. 2021 Jan 1
• 5 citations
  Regulator of G-Protein Signaling 5 Maintains Brain Endothelial Cell Function in Focal Cerebral Ischemia.
  Nikola Sladojevic, Brian Yu, James K. Liao> ;Journal of the American Heart Association. 2020 Sep 15
• 20 citations
  Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.
  Yurii Chinenov, Tania Pannellini, Danny Flores-Castro, Chao Ye, Sanjay Gupta, Michela Manni, James K. Liao, Alessandra B. Pernis> ;The Journal of Clinical Investigation. 2020 Jul 1
• 21 citations
  A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
  Lisa McKerracher, Robert Shenkar, Matthew D. Abbinanti, Ying Cao, Amy Peiper, James K. Liao, Rhonda Lightle, Thomas R. Moore, Nicholas Hobson, Carol J. Gallione, Joerg...> ;Translational Stroke Research. 2020 Jun 1
• 1 citations
  Community Health Workers Reduce Rehospitalizations and Emergency Department Visits for Low-Socioeconomic Urban Patients With Heart Failure.
  Adam S. Vohra, Rhys Chua, Stephanie A. Besser, Charina F Alcain, Sweta Basnet, Brenda Battle, Mitchell J. Coplan, James K. Liao, Corey E. Tabit> ;Critical Pathways in Cardiology. 2020 Mar 11
• 22 citations
  Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening
  Brian Yu, Nikola Sladojevic, John E.A. Blair, James K. Liao> ;Expert Opinion on Therapeutic Targets. 2020 Jan 9
• 52 citations
  Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial
  Sean P. Polster, Agnieszka Stadnik, Amy Akers, Ying Cao, Gregory A. Christoforidis, Maged D Fam, Kelly D. Flemming, Romuald Girard, Nicholas Hobson, James I. Koenig, J...> ;Neurosurgery. 2019 Dec 1
• 13 citations
  Association of Rising Violent Crime With Blood Pressure and Cardiovascular Risk: Longitudinal Evidence From Chicago, 2014-2016.
  Elizabeth L. Tung, Rhys Chua, Stephanie A. Besser, Stacy Tessler Lindau, Marynia Kolak, Emeka Anyanwu, James K. Liao, Corey E. Tabit> ;American Journal of Hypertension. 2019 Nov 15
• 47 citations
  The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia.
  Adam Oesterle, James K. Liao> ;Current Vascular Pharmacology. 2019 Jan 1
• 6 citations
  Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study.
  Shinji Kishimoto, Kenji Oki, Tatsuya Maruhashi, Masato Kajikawa, Shogo Matsui, Haruki Hashimoto, Yuji Takaeko, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Yoshiki Ai...> ;Journal of Hypertension. 2019 May 1
• 31 citations
  Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease
  Robert Shenkar, Amy Peiper, Heidy Pardo, Thomas R. Moore, Rhonda Lightle, Romuald Girard, Nicholas Hobson, Sean P. Polster, Janne Koskimäki, Dongdong Zhang, Seán B. Ly...> ;Stroke. 2019 Mar 1
• 15 citations
  Impaired Cognitive Performance in Endothelial Nitric Oxide Synthase Knockout Mice After Ischemic Stroke: A Pilot Study.
  Shanshan Li, Yao Wang, Ze Jiang, Yaping Huai, James K. Liao, Kaari A. Lynch, Ross Zafonte, Lisa Wood, Qing Mei Wang> ;American Journal of Physical Medicine & Rehabilitation. 2018 Jul 1
• 15 citations
  Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.
  Yukio Hiroi, Kensuke Noma, Hyung-Hwan Kim, Nikola Sladojevic, Corey E. Tabit, Yuxin Li, Guray Soydan, Salvatore Salomone, Michael A. Moskowitz, James K. Liao> ;Circulation Journal. 2018 Jan 19
• 70 citations
  The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.
  Rachel S. Knipe, Clemens K. Probst, David Lagares, Alicia Franklin, Jillian J Spinney, Patricia L. Brazee, Paula Grasberger, Linlin Zhang, Katharine E. Black, Norihiko...> ;American Journal of Respiratory Cell and Molecular Biology. 2017 Dec 6
• 35 citations
  ROCK as a therapeutic target for ischemic stroke
  Nikola Sladojevic, Brian Yu, James K. Liao> ;Expert Review of Neurotherapeutics. 2017 Oct 30
• 14 citations
  Cardiology Consultation in the Emergency Department Reduces Re-hospitalizations for Low-Socioeconomic Patients with Acute Decompensated Heart Failure.
  Corey E. Tabit, Mitchell J. Coplan, Kirk T. Spencer, Charina F Alcain, Thomas Spiegel, Adam S. Vohra, Daniel Adelman, James K. Liao, Rupa Sanghani> ;The American Journal of Medicine. 2017 Sep 1
• 52 citations
  Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction
  Toru Shimizu, Nikhil Narang, Phetcharat Chen, Brian Yu, Maura Knapp, Jyothi Janardanan, John E.A. Blair, James K. Liao> ;JCI Insight. 2017 Jul 6
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Journal Articles

• Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial  
  Amy L Akers, Kevin J Whitehead, Gregory A Christoforidis, Daniel F Hanley, Kelly D Flemming, Sean P Polster, James K Liao, Matthew Sorrentino, Cornelia Lee, Issam A Aw..., Neurosurgery
• The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis  
  Knipe RS, Tager AM, Liao JK, Pharmacol Rev, 1/1/2015
• Two functional polymorphisms of ROCK2 enhance arterial stiffening through inhibiting its activity and expression  
  Liao YC, Liu PY, Lin HF, Lin WY, Liao JK, Juo SH, J Mol Cell Cardiol, 1/1/2015
• Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism  
  Matsumoto T, Oki, K, Kajikawa M, Nakashima A, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Hidaka T, Kihara Y, Kohno N, Chayama K, Goto C, Aibara Y, Noma K, Liao JK, Higa..., Hypertension, 1/1/2015
• Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial  
  Maruhashi T, Noma K, Fujimura N, Kajikawa M, Matsumoto T, Hidaka T, Nakashima A, Kihara Y, Liao JK, Higashi Y, Hypertens Res, 1/1/2015
• ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice  
  Kasahara DI, Mathews JA, Park CY, Cho Y, Hung G, Wumbrand AP, Liao JK, Shore SA, Am J Physiol Lung Cell Mol Physiol, 1/1/2015
• Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome  
  Kajikawa M, Noma K, Nakashima A, aruhashi T, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N, Hidaka T, Kihara Y, Aibara Y, Chayama K, Sasaki S, Kato M, Dote K, Goto C, Liao ..., Hypertension, 1/1/2015
• Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis  
  Sawada N, Liao JK, Antioxid Redox Signal, 1/1/2014
• Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study  
  Zee RY, Wang QM, Chasman DI, Ridker PM, Liao JK, Clin Sci, 1/1/2014
• Evidence of pleiotropy by statins: leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome ...  
  Liu PY, Lee PT, Chang WT, Tai YL, Chao TH, Lee CH, Li YH, Chen JH, Tsai LM, Liao JK, Int J Cardiol, 1/1/2014
• Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells  
  Maruhashi T, Noma K, Iwamoto Y, Iwamoto A, Oda N, Jajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Liao JK, Higashi Y, PLoS One, 1/1/2014
• Abrogation of airway hyperresponsiveness but not inflammation by Rho kinase insufficiency  
  Kasahara DI, Ninin FM, Wurmbrand AP, Liao JK, Shore SA, Clin Exp Allergy, 1/1/2014
• ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression  
  Montalvo J, Spencer C, Hackathorn A, Masterjohn K, Perkins A, Coty C, Arumugam A, Ongusaha PP, Lakshmanaswamy R, Liao JK, Mitchell DC, Bryan BA, Curr Mol Med, 1/1/2013
• Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits rho-associated kinase activity in patients with hypertension  
  Fujimura N, Noma K, Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Mikami S, Maruhashi T, Iwamoto Y, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y, Clin Pharm Ther, 1/1/2012
• ROCK2 deficiency in bone marow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis  
  Zhou Q, Yu M, Shoji T, Han X, Kaminski K, Oh GT, Ongusaha PP, Zhang K, Schmitt H, Moser M, Bode C, Liao JK, Circulation, 1/1/2012
• Rho-associated coiled-coil forming kinase (ROCK): a potential target for the treatment of atherosclerosis and vascular disease  
  Zhou Q, Gensch C, Liao JK, Trends Pharm Sci, 1/1/2011
• Notch1 in bone marrow derived cells mediates cardiac repair after myocardial infarction  
  Li Y, Hiroi Y, Ngoy S, Okamoto R, Noma K, Wang CY, Wang HW, Zhou Q, Radtke F, Liao R, Liao JK, Circulation, 1/1/2011
• Measurement of Rho-associate kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil  
  Hata T, Goto C, Soga J, Hidaka T, Fujii Y, Idei N, Fujimura N, Maruhashi T, Mikami S, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y, Atherosclerosis, 1/1/2011
• Calcium channel blocker and Rhoassociated kinase activity in patients with hypertension  
  Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Noma K, Liao JK, Higashi Y, J Hypertens, 1/1/2011
• Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neurogenesis  
  Reis SA, Thompson MN, Lee JM, Fossale E, Kim HH, Liao JK, Moskowitz MA, Shaw SY, Dong L, Haggarty SJ, MacDonald ME, Seong IS, Human Mol Gen, 1/1/2011
• Role of rho kinase isoforms in murine allergic airway responses  
  Zhu M, Liu PY, Kasahara DI, Williams AS, Verbout NG, Halayko AJ, Fedulov A, Shoji T, Williams ES, Noma K, Shore SA, Liao JK, Eur Resp J, 1/1/2011
• Rho-associated kinase activity, endothelial function, and cardiovascular risk factors  
  Soga J, Noma K, Hata T, Hidaka T, Fujii Y, Idei N, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y, Arterioscl Thromb Vasc Biol, 1/1/2011
• Pleiotropic effects of statins - Basic research and clinical perspectives  
  Zhou Q, Liao JK, Circulation Journal, 1/1/2010
• NF-kappaB and innate immunity in ischemic stroke  
  Harari OA, Liao JK, Ann NY Acad Sci, 1/1/2010
• Noninvasive method for assessing the human circadian clock using hair follicle cells  
  Akashi M, Soma H, Yamamoto T, Tsugitomi A, Yamashita S, Nishida E, Yasuda A, Liao JK, Node K, Proc Natl Acad Sci, 1/1/2010
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Books/Book Chapters

• The endothelium: A comprehensive reference 
  Chapter: Diagnosis and treatment: Statins 
  Page 1668 - 1673Liao JKEditors: Aird W.Cambridge University Press, New York, NY2007
• The endothelium: A comprehensive reference 
  Chapter: Steroid hormones 
  Page 1674 - 1681Liao JKCambridge University Press, New York, NY2007
• Statins 
  Chapter: The pleiotropic effects of statins: Relevance to their salutary effects 
  Page 163 - 188Wolfrum S, Liao JKEditors: Mehta J.Elsevier Publishers (Saunders), Philadelphia, PA2004
• Clinical challenges in dyslipidemia management 
  Chapter: Role of statin pleiotropy in cardiovascular risk reduction 
  Page 1438 - 1459Liao JKEditors: Toth P, Sica, D.Atlas Medical Publishing, Ltd., Oxford, UK2003
• Encyclopedia of molecular medicine 
  Chapter: Statins 
  Page 3000 - 3002Liao JK, Moskowitz MAEditors: Creighton TE.John Wiley & Sons, Inc., New York, NY2002
• Milestones in drug therapy 
  Chapter: Pleiotropic effects of HMG-CoA reductase inhibitors on cells of the vascular wall 
  Page 81 - 98Node K, Liao JKEditors: Mehta JL.Birkhauser-Verlag Publishers2002
• Nitric oxide and inflammation 
  Chapter: Anti-inflammatory actions of nitric oxide 
  Page 99 - 116Spiecker M, Liao JKEditors: Billiar TR, Salvemini D.Birkhauser Publishers Ltd., New York, NY2001
• Basic science and clinical applications of nitric oxide 
  Chapter: Endothelial nitric oxide and vascular inflammation 
  Page 119 - 132Liao JKEditors: Cannon RO, Panza JA.Futura Publishing Co., Inc., Armonk, New York1999
• Methods in molecular medicine, vascular disease: Molecular biology and gene therapy protocols 
  Chapter: Nuclear run-on assay to study gene transcription in vascular cells 
  Page 1 - 7Laufs U, Liao JKEditors: Baker AH.Humana Press, Inc., Totowa, NJ1999
• Pathophysiology and clinical applications of nitric oxide 
  Page 99 - 120Liao JK, Libby PEditors: Rubanyi GM.Harwood Academic Publishers, Chur, Switzerland1998
• Pharmacology of cerebral ischemia 
  Chapter: Specific upregulation of endothelial nitric oxide synthase and its potential importance to cerebral ischemia 
  Page 299 - 307Endres M, Laufs U, Liao JK, Moskowitz MAEditors: Krieglstein J.Medpharm Scientific Publishers, Inc., Stuttgart, Germany1998
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Other

• Endothelial Function in Vascular Disease 
  Liao JK
  Iowa City, IA - 1/1/2015
• Chinese Cholesterol Education Program 
  Liao JK
  Beijing, China - 1/1/2015
• Cardiovascular Disease: Emerging Science and Therapeutics 
  Liao JK
  Taipei, Taiwan - 1/1/2015
• ROCK and Cellular Metabolism 
  Liao JK
  Chicago, IL - 1/1/2015
• Bench to Bedside Research 
  Liao JK
  Chicago, IL - 1/1/2015
• Challenges to Building a Successful Basic Science Program in Academic Cardiology 
  Liao JK
  Chicago, IL - 1/1/2015
• ROCK and Heart Failure 
  Liao JK
  Chicago, IL - 1/1/2015
• ROCK as a Novel Biomarker of CV Disease 
  Liao JK
  Chicago, IL, 2015; Beijing, China, 2015 - 1/1/2015
• Control of Metabolism by ROCK/ 
  Liao JK
  Phoenix, AZ - 1/1/2014
• Pharmacokinetic Properties of Statins: Mechanisms for Pleiotropic Effects 
  Liao JK
  San Diego, CA - 1/1/2014
• ROCK and Aortic Stiffness 
  Liao JK
  Kyoto, Japan - 1/1/2014
• ROCK and Vascular Aging 
  Liao JK
  Chicago, IL - 1/1/2014
• ROCK: From Bench to Bedside 
  Liao JK
  Chicago, IL - 1/1/2014
• Regulation of eNOS by ROCK 
  Liao JK
  Chicago, IL - 1/1/2014
• Update on Lipid Mangement 
  Liao JK
  Indianapolis, IN - 1/1/2013
• Lipid Treatment Goals 
  Liao JK
  Honolulu, HI - 1/1/2013
• ROCKs and Fibrosis 
  Liao JK
  San Diego, CA - 1/1/2013
• Rho Kinase as an Important Mediator of Age-related Aortic Stiffness 
  Liao JK
  Taipei, Taiwan - 1/1/2013
• Lipid Lowering and the Biology of Atherosclerosis 
  Liao JK
  Hong Kong, China - 1/1/2013
• Lipid Lowering and Atherosclerosis 
  Liao JK
  Wuhan, China - 1/1/2013
• Update on Lipid Management for Cardiovascular Disease 
  Liao JK
  Multiple Locations, 2013 - 1/1/2013
• Evolution of Antiplatelet Therapy in Acute Coronary Syndrome 
  Liao JK
  Hong Kong, China - 1/1/2013
• Management of Stable and Unstable Atherosclerotic Plaques 
  Liao JK
  Macau, China - 1/1/2013
• Management of Plaque Rupture in Acute Coronary Syndrome 
  Liao JK
  Multiple Locations, 2013 - 1/1/2013
• Brilinta Asia Speaker’s Summit 
  Liao JK
  Hong Kong, China - 1/1/2013
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