James Matthew Luther MD MSCI

Hypertension, Renovascular Medicine, Clinical Pharmacology

Associate Professor of Medicine and Pharmacology

3601 21st Ave SNashville, TN 37232
Phone+1 615-322-3353
Fax+1 615-936-0605

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Summary

Dr. James M. Luther is Associate Professor of medicine and pharmacology at Vanderbilt University School of Medicine in Nashville, Tennessee. The focus of his translational research program is to investigate the pathophysiologic links between hypertension and metabolic complications. His clinical focus in the Vanderbilt Hypertension Clinic is to evaluate and treat resistant and secondary hypertension. He is board certified in Medicine and Nephrology.

Dr. Luther received his MD degree from Vanderbilt School of Medicine, where he also completed training in Internal Medicine, Clinical Pharmacology, and Nephrology before joining the faculty in the Division of Clinical Pharmacology. He also received a Masters in Clinical Investigation program at Vanderbilt, and now serves as faculty in the program.

Education & Training

Vanderbilt Univ Med Ctr2007 - 2008
Vanderbilt Univ Med Ctr2005 - 2007
Vanderbilt University Medical CenterResidency, Internal Medicine, 2001 - 2004
Vanderbilt University School of MedicineClass of 2001

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Certifications & Licensure

TN State Medical License 2003 - 2027
AL State Medical License 2020 - 2020
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Nephrology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification StarPanel, Vanderbilt University, 2014-2017
CMS Meaningful Use Stage 2 Certification BI-Clinical, CitiusTech, Inc., 2014-2017
CMS Meaningful Use Stage 2 Certification StarPanel, Vanderbilt University, 2014-2017

Clinical Trials

Aldosterone and Glucose Homeostasis Start of enrollment: 2008 Sep 01
Completed
Not Applicable
Aldosterone and the Metabolic Syndrome Start of enrollment: 2010 Mar 01
Completed
Phase 1
Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism Start of enrollment: 2013 Oct 01
Completed
Phase 4

Publications & Presentations

PubMed

Pressure in Practice: A New Clinical Case Series in.
Jennifer L Cluett, Steven D Crowley, Stella S Daskalopoulou, Neeraj Dhaun, James M Luther
Hypertension. 2026-05-01
1 citations
Adrenal histologic and genetic characteristics of primary aldosteronism in late adulthood.
Amy R Blinder, Dina Sapiro, Jessica E Baker, Zhaoping Qin, Irina Bancos
European Journal of Endocrinology. 2026-02-04
Approaching Drug Choices and Challenges for the Management of Hypertension.
Adam P Bress, James M Luther
Hypertension. 2025-10-01

Books/Book Chapters

Hypertension Secrets
Edgar V. Lerma, James M. Luther, Swapnil HiremathElsevierEdition 2nd,2022
The Cleveland Clinic Intensive Review of Internal Medicine
Chapter: Acid Base Disorders
Page 594 - 610Luther JM, Breyer-Lewis JBEditors: Stoller JK, Michota FA, Mandell BF.Lippincott Williams & Wilkins, PhiladelphiaEdition 5th,
Andreoli and Carptentier's Cecil Essentials of Medicine
Chapter: Vascular Diseases of the Kidney
Page 345 - 358Luther JM, Schulman GEditors: Andreoli TE, Benjamin IJ, Griggs RC, Wing EJ.Saunders, PhiladelphiaEdition 8th,

Press Mentions

What's Your Approach? MRAs and Chronic Kidney DiseaseJuly 30th, 2023
Diabetes Drug May Improve AsthmaFebruary 21st, 2023
Medicare Reimbursement Policy for Ambulatory Blood Pressure Monitoring: A Qualitative Analysis of Public Comments to the Centers for Medicare and Medicaid ServicesDecember 1st, 2019

Grant Support

Endogenous Aldosterone and glucose metabolismNIH/NIDDK, NHLBI2013–Present
Role of Eicosanoids in Renal FunctionNIH/NIDDK2009–Present
Islet Cell and ST2 Axis Dysregulation in Post-Transplant Diabetes MellitusVANDERBILT UNIVERSITY MEDICAL CENTER2018–2025
Aldosterone And Glucose MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2011