JamesHMacDougallMD

PubMed

• 4 citations
  Psychometric validation of symptom severity measures in irritable bowel syndrome with constipation.
  Valerie Williams, Lauren Nelson, Sheri Fehnel, James E. MacDougall, Robyn T. Carson, Stavros Tourkodimitris, Caroline B. Kurtz, Mollie J. Baird, Jeffrey M. Johnston> ;Alimentary Pharmacology & Therapeutics. 2014 Aug 1
• 49 citations
  Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation
  Satish S.C. Rao, Eamonn Martin Quigley, S J Shiff, Bernard J. Lavins, Caroline B. Kurtz, James E. MacDougall, Mark G. Currie, Jeffrey M. Johnston> ;Clinical Gastroenterology and Hepatology. 2014 Apr 1
• 17 citations
  Responders vs clinical response: a critical analysis of data from linaclotide phase 3 clinical trials in IBS-C.
  Brian E. Lacy, Anthony Lembo, James E. MacDougall, S J Shiff, Caroline B. Kurtz, M Currie, Jeffrey M. Johnston> ;Neurogastroenterology and Motility. 2014 Mar 1
• 195 citations
  Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate.
  Joel Castro, Andrea M. Harrington, Patrick A. Hughes, Christopher M. Martin, Pei Ge, Courtney Shea, Hong Jin, Sarah Jacobson, Gerhard Hannig, Elizabeth A. Mann, Mitche...> ;Gastroenterology. 2013 Dec 1
• 20 citations
  An evaluation of the FDA responder endpoint for IBS-C clinical trials: analysis of data from linaclotide Phase 3 clinical trials.
  James E. MacDougall, Jeffrey M. Johnston, Bernard J. Lavins, Lauren Nelson, Valerie Williams, Robyn T. Carson, S J Shiff, Kelvin Shi, Caroline B. Kurtz, Mollie J. Bair...> ;Neurogastroenterology and Motility. 2013 Jun 1
• 279 citations
  A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With ...
  Satish S.C. Rao, Anthony Lembo, S J Shiff, Bernard J. Lavins, Mark G. Currie, Xinwei D. Jia, Kelvin Shi, James E. MacDougall, James Z. Shao, Paul Eng, Susan M. Fox, Ha...> ;The American Journal of Gastroenterology. 2012 Nov 1
• 312 citations
  Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety
  William D. Chey, Anthony Lembo, Bernard J. Lavins, S J Shiff, Caroline B. Kurtz, Mark G. Currie, James E. MacDougall, Xinwei D. Jia, James Z. Shao, Donald A. Fitch, Mo...> ;The American Journal of Gastroenterology. 2012 Nov 1
• 167 citations
  Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation
  Jeffrey M. Johnston, Caroline B. Kurtz, James E. MacDougall, Bernard J. Lavins, Mark G. Currie, Donald A. Fitch, Chris O'Dea, Mollie J. Baird, Anthony Lembo> ;Gastroenterology. 2010 Dec 1
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