JamesKevillMaloneMD(He/Him)

Endocrinology • Milpitas, CA

Diabetes

Chief Medical Officer

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Office
1820 McCarthy Blvd
Milpitas, CA 95035
Phone+1 408-716-5600
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Summary

CMO at Bigfoot Biomedical since 2020.

Education & Training

Joslin Diabetes CenterFellowship, Fellowship, Diabetes, 1984 - 1985
The Methodist Hospitals - NorthlakeResidency, Internal Medicine, 1981 - 1984
Indiana University School of MedicineClass of 1981, MD
Butler UniversityBA, Chemistry, Sigma Xi Society, 1974 - 1977

Certifications & Licensure

IN State Medical License 1981 - 2025
American Board of Internal Medicine Internal Medicine

Clinical Trials

Safety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using Thiazolidinediones or Thiazolidinediones and Metformin Start of enrollment: 2004 May 01
Completed
Phase 3
Study of the Safety of Substituting Exenatide for Insulin in Patients Using Insulin and Oral Antidiabetic Agents Start of enrollment: 2004 Feb 01
Completed
Phase 2
Comparing Exenatide and Insulin Glargine in Type 2 Diabetes Patients for Whom Insulin is the Next Appropriate Therapy Start of enrollment: 2004 Sep 01
Completed
Phase 3
An Evaluation of Exenatide and Rosiglitazone in Subjects With Type 2 Diabetes Mellitus Start of enrollment: 2005 Oct 01
Completed
Phase 3
Effect of Exenatide on 24-Hour Blood Glucose Profile Compared With Placebo in Patients With Type 2 Diabetes Start of enrollment: 2005 Oct 01
Completed
Phase 2
The Effects of Exenatide on Oral Contraceptive Pharmacokinetics in Healthy Females Start of enrollment: 2005 Nov 01
Completed
Phase 1
Safety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using Metformin or Sulfonylureas and Metformin Start of enrollment: 2006 Jan 01
Completed
Phase 3
Exenatide Versus Glimepiride in Patients With Type 2 Diabetes Start of enrollment: 2006 Sep 01
Completed
Phase 3
Comparison of Exenatide Taken Before Lunch and Dinner With Before Breakfast and Dinner in Patients With Type 2 Diabetes Start of enrollment: 2006 Sep 01
Completed
Phase 3
Effect on Weight Loss of Exenatide Versus Placebo Start of enrollment: 2006 Sep 01
Completed
Phase 3
Safety and Efficacy of Exenatide as Monotherapy Start of enrollment: 2006 Sep 01
Completed
Phase 3
A Study to Assess the Effect on Glucose Control and Safety and Tolerability of LY2148568 In Japanese Patients With Type 2 Diabetes Start of enrollment: 2006 Sep 01
Completed
Phase 2
A Pilot Study of Effects of Exenatide on Body Weight in Non-Diabetic, Obese Patients Start of enrollment: 2007 Jun 01
Completed
Phase 2
A Study by Scintigraphy to Evaluate the Effect of Exenatide on Gastric Emptying in Subjects With Type 2 Diabetes Start of enrollment: 2005 Jan 01
Completed
Phase 1
CHOICE: CHanges to Treatment and Outcomes in Patients With Type 2 Diabetes Initiating InjeCtablE Therapy Start of enrollment: 2008 Jan 01
Completed
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Publications & Presentations

PubMed

21 citations
Human regular U-500 insulin via continuous subcutaneous insulin infusion versus multiple daily injections in adults with type 2 diabetes: The VIVID study.
George Grunberger, Anuj Bhargava, Trang T. Ly, Howard Zisser, Liza L. Ilag, James Malone, Ludi Fan, Shuyu Zhang, Jennal Johnson> ;Diabetes, Obesity & Metabolism. 2020 Mar 1
17 citations
Concentrated insulins: History and critical reappraisal.
Lutz Heinemann, John Michael Beals, James Malone, James H. Anderson, Jennie G. Jacobson, Vikram Sinha, Sheila M. Corrigan> ;Journal of Diabetes. 2019 Apr 1
5 citations
Global Standards to Expedite Learning From Medical Research Data.
Lynn D. Hudson, Rebecca Daniels Kush, Eileen Navarro Almario, Nathalie Seigneuret, Tammy Jackson, Barbara Jauregui, David Jordan, Ronald Fitzmartin, F. Liz Zhou, James...> ;Clinical and Translational Science. 2018 Jul 1
2 citations
Simulation-Based Evaluation of Dose-Titration Algorithms for Rapid-Acting Insulin in Subjects with Type 2 Diabetes Mellitus Inadequately Controlled on Basal Insulin an...
Xiaosu Ma, Jenny Y. Chien, Jennal Johnson, James Malone, Vikram Sinha> ;Diabetes Technology & Therapeutics. 2017 Aug 1
4 citations
Crossover design and its application in late-phase diabetes studies
Tao Wang, James Malone, Haoda Fu, Cory R. Heilmann, Yongming Qu, William J. Huster> ;Journal of Diabetes. 2016 Sep 1
167 citations
Glucagon-Like Peptide 1 Receptor Agonist or Bolus Insulin With Optimized Basal Insulin in Type 2 Diabetes
Michaela Diamant, Michael A. Nauck, Rimma M. Shaginian, James Malone, Simon Cleall, Matthew Reaney, Danielle de Vries, Byron J. Hoogwerf, Leigh MacConell, Bruce H. R. ...> ;Diabetes Care. 2014 Oct 1
9 citations
Exenatide Once Weekly for the Treatment of Type 2 Diabetes Mellitus: Clinical Results in Subgroups of Patients Using Different Concomitant Medications
Richard Pencek, Steven C Brunell, Yan Li, Byron J. Hoogwerf, James Malone> ;Postgraduate Medicine. 2012 Jul 1
12 citations
Use of Concomitant Glucose-Lowering Therapies and Associated Treatment Results Observed in Clinical Trials of Twice-Daily Exenatide
Richard Pencek, Steven C Brunell, Yan Li, Byron J. Hoogwerf, James Malone> ;Endocrine Practice. 2012 Mar 23
92 citations
DURATION-2: efficacy and safety of switching from maximum daily sitagliptin or pioglitazone to once-weekly exenatide.
C. Wysham, Richard M. Bergenstal, Jaret Malloy, Ping Yan, Brandon Walsh, James Malone, Kristin Taylor> ;Diabetic Medicine. 2011 Jun 1
469 citations
Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised ...
Richard M. Bergenstal, Carol Wysham, Leigh MacConell, Jaret Malloy, Brandon Walsh, Ping Yan, Ken Wilhelm, James Malone, Lisa Porter> ;Lancet. 2010 Aug 7
102 citations
Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus: a double-blind, placebo-controlled, randomized pilot study
Anne M. Gill, Byron J. Hoogwerf, Jude Burger, Simon Bruce, Leigh MacConell, Ping Yan, Daniel K. Braun, Joseph M Giaconia, James Malone> ;Cardiovascular Diabetology. 2010 Jan 28
30 citations
Exenatide once weekly for the treatment of type 2 diabetes.
James Malone, Michael E. Trautmann, Ken Wilhelm, Kristin Taylor, David M. Kendall> ;Expert Opinion on Investigational Drugs. 2009 May 9
Prandial premixed insulin analogue regimens versus basal insulin analogue regimens in the management of type 2 diabetes: an evidence-based comparison.
Ilag, L.L., Kerr, L., Malone, J.K., Tan, M.H.> ;Clin Ther. 2007 Jun
14 citations
Premeal insulin lispro plus bedtime NPH or twice-daily NPH in patients with type 2 diabetes : acute postprandial and chronic effects on glycemic control and cardiovasc...
Antonio Ceriello, Stefano Del Prato, Juliana M. Bue-Valleskey, Scott D. Beattie, Jeffrey R. Gates, Amparo de la Peña, James Malone> ;Journal of Diabetes and Its Complications. 2007 Jan 1
Prandial premixed insulin analogue regimens versus basal insulin analogue regimens in the management of type 2 diabetes: an evidence-based comparison.
Ilag, L.L., Kerr, L., Malone, J.K., Tan, M.H.> ;Clin Ther. 2007
15 citations
Comparison of insulin lispro mixture 25/75 with insulin glargine during a 24-h standardized test-meal period in patients with Type 2 diabetes
Peter J. Roach, J. K. Malone> ;Diabetic Medicine. 2006 Jul 1
25 citations
Functionality and acceptability of a new electronic insulin injection pen with a memory feature.
Willem J. R. R. Venekamp, Lisa Kerr, Sherie A. Dowsett, Patricia A. Johnson, Deborah Wimberley, Christopher Paul Mckenzie, James Malone, Zvonko Milicevic> ;Current Medical Research and Opinion. 2006 Jan 5
113 citations
Twice-daily pre-mixed insulin rather than basal insulin therapy alone results in better overall glycaemic control in patients with Type 2 diabetes
J. K. Malone, S. Bai, B. N. Campaigne, J. Reviriego, B. Augendre-Ferrante> ;Diabetic Medicine. 2005 Apr 1
140 citations
Combined therapy with insulin lispro Mix 75/25 plus metformin or insulin glargine plus metformin: a 16-week, randomized, open-label, crossover study in patients with t...
James Malone, Lisa Kerr, Barbara N. Campaigne, Richard A Sachson, John H. Holcombe> ;Clinical Therapeutics. 2004 Dec 1
40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004.
Veitenhansl M, Stegner K, Hierl F, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJM, Shankhdhar K, Shankhdhar L,...> ;Diabetologia. 2004-08-01
19 citations
Therapy after single oral agent failure: adding a second oral agent or an insulin mixture?
James Malone, Scott D. Beattie, Barbara N. Campaigne, Patricia A. Johnson, Andrew S. Howard, Zvonko Milicevic> ;Diabetes Research and Clinical Practice. 2003 Dec 1
65 citations
A comparison of insulin lispro Mix25 and human insulin 30/70 in the treatment of type 2 diabetes during Ramadan.
Vinod Mattoo, Zvonko Milicevic, James Malone, M. Schwarzenhofer, A. Ekangaki, L.K. Levitt, L.H.C. Liong, N. Rais, H. Tounsi> ;Diabetes Research and Clinical Practice. 2003 Feb 1
17 citations
Patient acceptance and reliability of new Humulin/Humalog 3.0 ml pre-filled insulin pen in ten Croatian diabetes centres.
John Wyatt, Nadia Mincheva, Ante Petrusic, Ante Ivandic, Tomislav Cabrijan, Eduard Galic, Mate Sucic, Zvonko Milicevic, James Malone> ;Medical Science Monitor. 2002 Mar 8
18 citations
Humalog Mix25 offers better mealtime glycemic control in patients with type 1 or type 2 diabetes.
James Malone, Yang H, Woodworth, Huang J, Campaigne Bn, Halle Jp, Jean-François Yale, Grossman Ld> ;Diabetes & Metabolism. 2000 Dec 1
35 citations
Improved postprandial glycemic control with Humalog Mix75/25 after a standard test meal in patients with type 2 diabetes mellitus.
James Malone, James R. Woodworth, Vipin Arora, Haichen Yang, Barbara N. Campaigne, Jean-Pierre Hallé, Jean-François Yale, Loren D. Grossman> ;Clinical Therapeutics. 2000 Feb 1
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JamesKevillMaloneMD(He/Him)

Dr. Malone is on Doximity

Summary

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

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