JamesMcDonnellDO

Anesthesiology • Richmond, VA

Professor, Ophthalmology, Loyola University Chicago Stritch School of Medicine

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Office
10800 Midlothian Tpke
Suite 265
Richmond, VA 23235
Phone+1 804-594-2622

Fax+1 804-594-0915
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Summary

Dr. James McDonnell, DO is a board certified anesthesiologist in Richmond, Virginia. He is currently licensed to practice medicine in Virginia and Pennsylvania. He is affiliated with Bon Secours St. Francis Medical Center and is a Professor at Loyola University Chicago Stritch School of Medicine.

Education & Training

Des Moines University College of Osteopathic MedicineClass of 1989

Certifications & Licensure

VA State License 1997 - 2024
PA State License 1990 - 1998
AOA Board of Anesthesiology Anesthesiology

Publications & Presentations

PubMed

Evaristo et al. reply.
Evaristo J, Jasechko S, McDonnell JJ> ;Nature. 2016-08-25
Cometary science. Dust measurements in the coma of comet 67P/Churyumov-Gerasimenko inbound to the Sun.
Rotundi A, Sierks H, Della Corte V, Fulle M, Gutierrez PJ, Lara L, Barbieri C, Lamy PL, Rodrigo R, Koschny D, Rickman H, Keller HU, López-Moreno JJ, Accolla M, Agarwal...> ;Science. 2015-01-23
43 citations
Human immunoglobulin E flexes between acutely bent and extended conformations
Nyssa Drinkwater, Benjamin P. Cossins, Anthony H. Keeble, Michael John Wright, Katharine Cain, Hanna Hailu, Amanda K. F. Oxbrow, Jean Delgado, Lindsay K. Shuttleworth,...> ;Nature Structural & Molecular Biology. 2014 Apr 1
13 citations
Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.
B. Dhaliwal, Marie O. Y. Pang, Daopeng Yuan, Norhakim Yahya, Stella M. Fabiane, James M. McDonnell, Hannah J. Gould, Andrew J. Beavil, Brian J. Sutton> ;Molecular Immunology. 2013 Dec 31
25 citations
Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E.
Daopeng Yuan, Anthony H. Keeble, Richard G. Hibbert, Stella M. Fabiane, Hannah J. Gould, James M. McDonnell, Andrew J. Beavil, Brian J. Sutton, B. Dhaliwal> ;The Journal of Biological Chemistry. 2013 Jul 26
20 citations
Mapping of the CD23 Binding Site on Immunoglobulin E (IgE) and Allosteric Control of the IgE-FcϵRI Interaction
Susmita Borthakur, Richard G. Hibbert, Marie O. Y. Pang, Norhakim Yahya, Heather J. Bax, Michael W. Kao, Alison M. Cooper, Andrew J. Beavil, Brian J. Sutton, Hannah J....> ;The Journal of Biological Chemistry. 2012 Sep 7
62 citations
Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI
B. Dhaliwal, Daopeng Yuan, Marie O. Y. Pang, Alistair James Henry, Katharine Cain, Amanda K. F. Oxbrow, Stella M. Fabiane, Andrew J. Beavil, James M. McDonnell, Hannah...> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul 31
52 citations
Soluble CD23 Controls IgE Synthesis and Homeostasis in Human B Cells
Alison M. Cooper, Philip S. Hobson, Mark R. Jutton, Michael W. Kao, Binia Drung, Boris Schmidt, David J. Fear, Andrew J. Beavil, James M. McDonnell, Brian J. Sutton, H...> ;Journal of Immunology. 2012 Apr 1
26 citations
MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.
Anna Watson, Junfeng Liu, Karim Bennaceur, Catherine J. Drummond, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Karen Haggerty, Xiaohong Lu, James M. McDonne...> ;Bioorganic & Medicinal Chemistry Letters. 2011 Oct 1
26 citations
Structural and Functional Studies on the N-terminal Domain of the Shigella Type III Secretion Protein MxiG
Melanie A. Mcdowell, Steven Johnson, Janet E. Deane, Martin P Cheung, A. Dorothea Roehrich, Ariel J. Blocker, James M. McDonnell, Susan M. Lea> ;The Journal of Biological Chemistry. 2011 Sep 2
17 citations
Basis of the intrinsic flexibility of the Cε3 domain of IgE.
Susmita Borthakur, Gabriela Andrejeva, James M. McDonnell> ;Biochemistry. 2011 May 31
90 citations
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI
M.D. Holdom, Anna M. Davies, Joanne E. Nettleship, Sarah C. Bagby, Balvinder Dhaliwal, Enrico Girardi, James Hunt, Hannah J. Gould, Andrew J. Beavil, James M. McDonnel...> ;Nature Structural & Molecular Biology. 2011 May 1
12 citations
Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.
Christiane Riedinger, Martin E.M. Noble, David J. Wright, Florian F. Mulks, Ian R. Hardcastle, Jane A. Endicott, James M. McDonnell> ;Chemical Biology & Drug Design. 2011 May 1
12 citations
Recombinant complement receptor 2 radiolabeled with [99mTc(CO)3]+: a potential new radiopharmaceutical for imaging activated complement.
Adam Badar, Sarah DeFreitas, James M. McDonnell, Norhakim Yahya, David Thakor, Reza Razavi, Richard A. G. Smith, Steven H. Sacks, Gregory E. D. Mullen> ;Plos One. 2011 Apr 6
72 citations
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency
Ian R. Hardcastle, Junfeng Liu, Eric Valeur, Anna Watson, Shafiq U. Ahmed, Timothy J. Blackburn, Karim Bennaceur, William Clegg, Catherine J. Drummond, Jane A. Endicot...> ;Journal of Medicinal Chemistry. 2011 Feb 11
25 citations
Inhibitors of MDM2 and MDMX: a structural perspective
Christiane Riedinger, James M. McDonnell> ;Future Medicinal Chemistry. 2009 Sep 21
53 citations
Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction.
Christiane Riedinger, Jane A. Endicott, Stuart J. Kemp, Lynette A. Smyth, Anna Watson, Eric Valeur, Bernard T. Golding, Roger John Griffin, Ian R. Hardcastle, Martin E...> ;Journal of the American Chemical Society. 2008 Oct 30
50 citations
Structural and Functional Characterization of a Novel T Cell Receptor Co-regulatory Protein Complex, CD97-CD55
Rachel J.M. Abbott, Ian Spendlove, Pietro Roversi, Hannah Fitzgibbon, V Knott, Peter Teriete, James M. McDonnell, Penny A. Handford, Susan M. Lea> ;The Journal of Biological Chemistry. 2007 Jul 27
9 citations
The intrinsic flexibility of IgE and its role in binding FcepsilonRI.
Naomi E. Harwood, James M. McDonnell> ;Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2007 Jan 1
17 citations
Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3
Simon A. Fry, Philippe E. Van den Steen, Louise Royle, Mark R. Wormald, Anthony J. C. Leathem, Ghislain Opdenakker, James M. McDonnell, Raymond A. Dwek, Pauline M. Rudd> ;Biochemistry. 2006 Dec 6
7 citations
NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL
Hong Ji, Alexander Shekhtman, Ranajeet Ghose, James M. McDonnell, David Cowburn> ;Magnetic Resonance in Chemistry. 2006 Jul 1
30 citations
Direct analysis of a GPCR-agonist interaction by surface plasmon resonance
Peter J. Harding, Hadingham Timothy C, James M. McDonnell, Anthony Watts> ;European Biophysics Journal. 2006 May 18
3 citations
Catalytic folding of the Cε3 domain by its high affinity receptor
Naomi E. Harwood, Nicholas C. Price, James M. McDonnell> ;FEBS Letters. 2006 Apr 3
A soft solid surface on Titan as revealed by the Huygens Surface Science Package.
Zarnecki JC, Leese MR, Hathi B, Ball AJ, Hagermann A, Towner MC, Lorenz RD, McDonnell JAM, Green SF, Patel MR, Ringrose TJ, Rosenberg PD, Atkinson KR, Paton MD, Banasz...> ;Nature. 2005-12-08
In situ measurements of the physical characteristics of Titan's environment.
Fulchignoni M, Ferri F, Angrilli F, Ball AJ, Bar-Nun A, Barucci MA, Bettanini C, Bianchini G, Borucki W, Colombatti G, Coradini M, Coustenis A, Debei S, Falkner P, Fan...> ;Nature. 2005-12-08
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Press Mentions

Brain’s Navigation Center Calls on Mental State as Well as Physical Environment, Stanford Researchers FindAugust 6th, 2021
Hugo Named Director of Medical Physics DivisionAugust 3rd, 2021

Professional Memberships

American Osteopathic Association - AOA
Member

Hospital Affiliations

Bon Secours St. Francis Medical CenterMidlothian, Virginia