
James Frederick Meschia MD (He/Him)
Vascular Neurology
Frances Bartlett Kinne, Ph.D. Professor at Mayo Clinic in Florida; Chair Emeritus, Department of Neurology, Mayo Clinic in Florida Chair, Personnel Committee, Mayo Clinic in Florida
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4500 San Pablo Rd SJacksonville, FL 32224
Phone+1 904-953-2000
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Summary
- James Meschia, MD, FAAN, FAHA, FANA is a Vascular Neurologist in the Cerebrovascular Division of the Department of Neurology in Mayo Clinic in Florida. He is board certified n Neurology and Vascular Neurology by the American Board of Psychiatry and Neurology.
Dr. Meschia's clinical expertise includes management of symptomatic and asymptomatic carotid disease, cerebral small vessel disease, and inherited stroke disorders, including CADASIL, CARASIL, and Fabry disease.
Dr. Meschia earned his bachelor's degree in chemistry from Columbia University in New York and his medical degree from the Johns Hopkins University School of Medicine. He completed his neurology residency at Washington University School of Medicine in St. Louis and his Vascular Neurology fellowship at Indiana University in Indianapolis. He then joined the faculty at Mayo Clinic in Florida where he founded the first accredited stroke center in the Mayo Clinic system and served as Chair for 9 years.
Dr. Meschia's research focuses on management of atherosclerotic carotid stenosis, primary prevention of stroke, and inherited stroke syndromes. He was a member of the Executive Committee of the CREST trial and is co-Principal Investigator of the CREST-2 trial of intensive medical therapy with or without carotid revascularization. He has served as chair of the Writing Group for the American Heart Association's Primary Prevention of Stroke Guidelines and Chair of the AHA Scientific Statement on inherited small vessel diseases. He currently serves as Chair of the Personnel Committee for the Mayo Clinic in Florida.
Education & Training
Indiana University School of MedicineFellowship, Vascular Neurology, 1996 - 1997
Washington University/B-JH/SLCH ConsortiumResidency, Neurology, 1993 - 1996
University of ColoradoInternship, Internal Medicine, 1992 - 1993
Johns Hopkins University School of MedicineClass of 1992
Certifications & Licensure
AZ State Medical License 2015 - 2027
FL State Medical License 1997 - 2027
IA State Medical License 2018 - 2027
MN State Medical License 2018 - 2027
WI State Medical License 2018 - 2025
MO State Medical License 2018 - 2020
GA State Medical License 2010 - 2019
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Vascular Neurology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification FirstNet, Cerner Corporation, 2014-2017
- CMS Meaningful Use Stage 2 Certification FirstNet (CQM), Cerner Corporation, 2014-2017
- CMS Meaningful Use Stage 2 Certification HealtheLife and PowerChart, Cerner Corporation, 2014-2017
Clinical Trials
Publications & Presentations
PubMed
- Outcomes After Intervention in Radiation-Induced Carotid Artery Stenosis: A Systematic Review and Meta-Analysis.Ekin Inal, James F Meschia, Suren Jeevaratnam, Diego Sanchez-Calderin, Kevin Barrett
Annals of Vascular Surgery. 2026-08-24 - Symptomatic ≤50% Carotid Artery Stenosis Is Associated with Higher Rates of Vulnerable Plaque Features and Acceptable Revascularization Outcomes: A Three-Stroke-Center...Camilo Polania-Sandoval, James F Meschia, Gyanendra Kumar, Robert D Brown Jr, Bernard R Bendok
Journal of Vascular Surgery. 2026-08-09 - Intracranial Atherosclerotic Disease Distribution Across Circle of Willis Segments: Insights from CREST-H.Pranjal Rai, John Huston 3rd, Thomas G Brott, Lloyd Edwards, George Howard
AJNR. American Journal of Neuroradiology. 2026-07-01
Journal Articles
- Ischaemic StrokeJ F Meschia, T Brott, European Journal of Neurology
Press Mentions
Long-Awaited CREST-2 Results Bolster Stents for Asymptomatic Carotid StenosisNovember 21st, 2025- ISC 2021 Session: Prognostication and Early Withdrawal of Care in Ischemic Stroke and ICHMarch 17th, 2021
Looking Back on 2020: A Successful Year of Research at Mayo Clinic in FloridaJanuary 5th, 2021
Grant Support
- Plaque morphologic characteristics that affect prevention of stroke by carotid revascularizationMAYO CLINIC JACKSONVILLE2026–2029
- Carotid Revascularization and Medical Management for Asymptomatic CarotidStenosis Trial - Hemodynamics (CREST-H)COLUMBIA UNIVERSITY HEALTH SCIENCES2017–2027
- Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical TrialMAYO CLINIC JACKSONVILLE2021–2026
- Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)MAYO CLINIC JACKSONVILLE2014–2026
- The Ninds International Stroke Genetics Consortium StudyNational Institute Of Neurological Disorders And Stroke2010–2011
External Links
- Refer a patienthttp://www.mayoclinic.org/medical-professionals/provider-relations/refer-a-patient
- Biohttps://www.mayoclinic.org/biographies/meschia-james-f-m-d/bio-20053766
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