JamesPhilipMorganMD

Cardiology • Dorchester, MA

Adult Congenital Heart Disease

Professor, Medicine, Tufts Medical Center

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Office
2100 Dorchester Ave
Steward Carney Hospital
Dorchester, MA 02124
Phone+1 617-296-4000

Fax+1 617-474-3860
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Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Cardiovascular Disease, 1979 - 1983
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1976 - 1979
University of Cincinnati College of MedicineClass of 1976

Certifications & Licensure

MA State Medical License 1983 - 2025
OH State Medical License 1970 - 1998
MN State Medical License 1977 - 1998
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1992
Whos Who in Medicine and Healthcare Marquis Whos Who

Clinical Trials

Diabetes Mellitus Community Based Screening in Minority Populations Start of enrollment: 2012 Jun 01
Unknown status

Publications & Presentations

PubMed

8 citations
Cardiomyocyte transcription is controlled by combined MR and circadian clock signalling.
Elizabeth K. Fletcher, Monica Kanki, James P. Morgan, David W. Ray, Lea M.D. Delbridge, Peter J. Fuller, Colin Clyne, Morag J. Young> ;The Journal of Endocrinology. 2019 Jan 1
11 citations
Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice.
Laura A. Bienvenu, James P. Morgan, Melissa E. Reichelt, Lea M.D. Delbridge, Morag J. Young> ;Journal of Molecular and Cellular Cardiology. 2017 Nov 1
13 citations
Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice
Elizabeth K. Fletcher, James P. Morgan, David R Kennaway, Laura A. Bienvenu, Amanda J. Rickard, Lea M.D. Delbridge, Peter J. Fuller, Colin Clyne, Morag J. Young> ;Endocrinology. 2017 Sep 1
23 citations
Different Sequences of Fractionated Low-Dose Proton and Single Iron-Radiation-Induced Divergent Biological Responses in the Heart
Sharath P. Sasi, Xinhua Yan, Marian Zuriaga-Herrero, Hannah Gee, Juyong Lee, Raman Mehrzad, Jin Song, Jillian Onufrak, James P. Morgan, Heiko Enderling, Kenneth Walsh,...> ;Radiation Research. 2017 Jun 14
47 citations
Cardiac Tissue Injury and Remodeling Is Dependent Upon MR Regulation of Activation Pathways in Cardiac Tissue Macrophages
Jimmy Shen, James P. Morgan, Greg H. Tesch, Amanda J. Rickard, Sophocles Chrissobolis, Grant R Drummond, Peter J. Fuller, Morag J. Young> ;Endocrinology. 2016 Jun 1
Correction: Cardiovascular Risks Associated with Low Dose Ionizing Particle Radiation.
Xinhua Yan, Sharath P. Sasi, Hannah Gee, Juyong Lee, Yongyao Yang, Raman Mehrzad, Jillian Onufrak, Jin Song, Heiko Enderling, Akhil Agarwal, Layla Rahimi, James P. Mor...> ;Plos One. 2015 Nov 6
5 citations
Aldosterone-mediated renal sodium transport requires intact mineralocorticoid receptor DNA binding in the mouse
Tim J Cole, Luke Robert Terella, James P. Morgan, Maria Alexiadis, Yi-Zhou Yao, Pablo Enriori, Morag J. Young, Peter J. Fuller> ;Endocrinology. 2015 Jun 11
4 citations
The developing role of Neuregulin1 in cardiac regenerative stem cell therapy
Christopher P. Blomberg, Juyong Lee, James P. Morgan> ;Current Pharmaceutical Design. 2014 Aug 31
Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed ...
Armani A, Cinti F, Marzolla V, Morgan J, Cranston GA, Antelmi A, Carpinelli G, Canese R, Pagotto U, Quarta C, Malorni W, Matarrese P, Marconi M, Fabbri A, Rosano G, Ci...> ;FASEB J.. 2014-08-01
92 citations
Endothelial Cell Mineralocorticoid Receptors Regulate Deoxycorticosterone/Salt-Mediated Cardiac Remodeling and Vascular Reactivity But Not Blood Pressure
Amanda J. Rickard, James P. Morgan, Sophcoles Chrissobolis, Alyson A. Miller, Christopher G. Sobey, Morag J. Young> ;Hypertension. 2014 May 1
38 citations
CCL2-Dependent Macrophage Recruitment Is Critical for Mineralocorticoid Receptor-Mediated Cardiac Fibrosis, Inflammation, and Blood Pressure Responses in Male Mice
Jimmy Shen, James P. Morgan, Gregory H Tesch, Peter J. Fuller, Morag J. Young> ;Endocrinology. 2014 Jan 15
78 citations
Cardiomyocyte Mineralocorticoid Receptors Are Essential for Deoxycorticosterone/Salt-Mediated Inflammation and Cardiac Fibrosis
Amanda J. Rickard, James P. Morgan, Laura A. Bienvenu, Elizabeth K. Fletcher, Greg A. Cranston, Jimmy Shen, Melissa E. Reichelt, Lea M.D. Delbridge, Morag J. Young> ;Hypertension. 2012 Dec 1
89 citations
Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis
Laura A. Bienvenu, James P. Morgan, Amanda J. Rickard, Greg H. Tesch, Greg A. Cranston, Elizabeth K. Fletcher, Lea M.D. Delbridge, Morag J. Young> ;Endocrinology. 2012 May 31
19 citations
Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart.
Giannoula Klement, David A. Goukassian, Lynn Hlatky, Joseph P. Carrozza, James P. Morgan, Xinhua Yan> ;Frontiers in Pharmacology. 2012 Jun 27
7 citations
The dilemma of implantable cardioverter-defibrillator therapy in the geriatric population.
Diana Revenco, James P. Morgan, Lana Tsao> ;Journal of Geriatric Cardiology. 2011 Sep 1
37 citations
Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display.
Jun Yang, Ching-Yi Chang, Rachid Safi, James P. Morgan, Donald P. McDonnell, Peter J. Fuller, Colin Clyne, Morag J. Young> ;Molecular Endocrinology. 2011 Apr 20
237 citations
Deletion of Mineralocorticoid Receptors From Macrophages Protects Against Deoxycorticosterone/Salt-Induced Cardiac Fibrosis and Increased Blood Pressure
Amanda J. Rickard, James P. Morgan, Gregory H Tesch, John W. Funder, Peter J. Fuller, Morag J. Young> ;Hypertension. 2009 Sep 1
38 citations
Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart.
Peter C. Wilson, James P. Morgan, John W. Funder, Peter J. Fuller, Morag J. Young> ;Clinical Science. 2009 May 1
23 citations
Mechanisms underlying ischemic diastolic dysfunction: relation between rigor, calcium homeostasis, and relaxation rate.
Niraj Varma, James P. Morgan, Carl S. Apstein> ;American Journal of Physiology. Heart and Circulatory Physiology. 2003 Mar 1
76 citations
Method for non-invasively recording electrocardiograms in conscious mice
Victor Chu, Jose M. Otero, Orlando Lopez, James P. Morgan, Ivo Amende, Thomas G. Hampton> ;BMC Physiology. 2001 Jun 25
5 citations
Metoprolol attenuates postischemic depressed myocardial function in papillary muscles isolated from normal and postinfarction rat hearts
Jiang-Yong Min, Bo Ding, Ju-Feng Wang, Matthew F. Sullivan, James P. Morgan> ;European Journal of Pharmacology. 2001 Jun 22
5 citations
Can cocaine abuse exacerbate the cardiac toxicity of human immunodeficiency virus
Geetha Soodini, James P. Morgan> ;Clinical Cardiology. 2001 Mar 1
10 citations
Point Mutations in α-Subunit of Human Cardiac Na+ Channels Alter Na+ Current Kinetics
Yong-Fu Xiao, Qingen Ke, Sho-Ya Wang, Yinke Yang, Ging Kuo Wang, James P. Morgan, Alexander Leaf> ;Biochemical and Biophysical Research Communications. 2001 Feb 16
6 citations
Evidence for cocaine and methylecgonidine stimulation of M2 muscarinic receptors in cultured human embryonic lung cells
Yinke Yang, Qingen Ke, Jingbo Cai, Yong-Fu Xiao, James P. Morgan> ;British Journal of Pharmacology. 2001 Jan 1
19 citations
Importance of an intact growth hormone/insulin-like growth factor 1 axis for normal post-infarction healing: studies in dwarf rats.
Antonio Cittadini, Jessica D. Grossman, Hinrik Strömer, Sarah Katz, James P. Morgan, Pamela S. Douglas> ;Endocrinology. 2001 Jan 1
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Other

Cardiotoxicity of anthracycline-like chemotherapy agents
Morgan JP, Floyd J
http://www.uptodate.com/contents/cardiotoxicity-of-anthracycline-like-chemotherapy-agents
UpToDate, Wolters Kluwer Health - 2013-01-24
Cellular mechanisms of diastolic dysfunction
Morgan JP
http://www.uptodate.com/contents/cellular-mechanisms-of-diastolic-dysfunction
UpToDate, Wolters Kluwer Health - 2012-01-28
Cardiotoxicity of trastuzumab
Morgan JP, Perez EA
http://www.uptodate.com/contents/cardiotoxicity-of-trastuzumab
UpToDate, Wolters Kluwer Health - 2013-02-11
Actions of angiotensin II on the heart
Morgan JP, Smith TW
http://www.uptodate.com/contents/actions-of-angiotensin-ii-on-the-heart
UpToDate, Wolters Kluwer Health - 2012-06-18
Management of cardiac risk for noncardiac surgery
Morgan JP, Shammash JB, Kimmel SE
http://www.uptodate.com/contents/management-of-cardiac-risk-for-noncardiac-surgery
UpToDate, Wolters Kluwer Health - 2013-01-28
Excitation-contraction coupling in myocardium
Morgan JP, Smith TW
http://www.uptodate.com/contents/excitation-contraction-coupling-in-myocardium
UpToDate, Wolters Kluwer Health - 2012-10-02
Differences between angiotensin converting enzyme inhibitors and receptor blockers
Morgan JP, Smith TW
http://www.uptodate.com/contents/differences-between-angiotensin-converting-enzyme-inhibitors-and-re
UpToDate, Wolters Kluwer Health - 2013-01-02
Estimation of cardiac risk prior to noncardiac surgery
Morgan JP, Shammash JB, Kimmel SE
http://www.uptodate.com/contents/estimation-of-cardiac-risk-prior-to-noncardiac-surgery
UpToDate, Wolters Kluwer Health - 2012-07-23
Evaluation and management of the cardiovascular complications of cocaine abuse
Morgan JP
http://www.uptodate.com/contents/evaluation-and-management-of-the-cardiovascular-complications-of-co
UpToDate, Wolters Kluwer Health - 2012-07-12
Causes of dilated cardiomyopathy
Morgan JP, Weigner M
http://www.uptodate.com/contents/causes-of-dilated-cardiomyopathy
UpToDate, Wolters Kluwer Health - 2012-01-06
Cardiotoxicity of nonanthracycline cancer chemotherapy agents
Morgan JP, Floyd J
http://www.uptodate.com/contents/cardiotoxicity-of-nonanthracycline-cancer-chemotherapy-agents
UpToDate, Wolters Kluwer Health - 2013-01-03
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Grant Support

Cardiac Angiotensin: Hypertrophy And FailureNational Heart, Lung, And Blood Institute2003–2004
Cardiovascular Research Training ProgramNational Heart, Lung, And Blood Institute1993–2004
Mechanisms Of Cocaine Induced Exaccerbation Of Viral MyoNational Institute On Drug Abuse1999–2003
Core--Mouse PhysiologyNational Heart, Lung, And Blood Institute2000–2002
Core--Small Animal PhysiologyNational Heart, Lung, And Blood Institute1999–2002
Cellular Mechanisms Of Crack Cocaines Cardiac ToxicityNational Institute On Drug Abuse1998–2000
Hypoxia, Ischemia, And Calcium In Cardiac HypertrophyNational Heart, Lung, And Blood Institute1994–1996
Clinical Cardiovascular Toxicity Of CocaineNational Institute On Drug Abuse1991–1993
Pathophysiology Of Animal And Human Cardiac HypertrophyNational Heart, Lung, And Blood Institute1991–1992
Cardiac &Vascular Toxicity Of CocaineNational Institute On Drug Abuse1987–1991
Pathophysiology Of Cardiac HypertrophyNational Heart, Lung, And Blood Institute1985–1990
Pathophysiology Of Cardiac HypertrophyNational Heart, Lung, And Blood Institute1985–1989