JamesAMuldowneyIIIMD

Cardiology • Nashville, TN

Echocardiography, Cardiac Critical Care

Assistant Professor of Medicine

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Office
3601 21st Ave
Nashville, TN 37232
Phone+1 615-322-3000
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Education & Training

Vanderbilt Univ Med Ctr2006
University of Pennsylvania Health SystemResidency, Internal Medicine, 2001
University of Pennsylvania Health SystemInternship, Internal Medicine, 1999 - 2000
Vanderbilt University School of MedicineClass of 1999

Certifications & Licensure

TN State Medical License 2006 - 2026
KY State Medical License 2014 - 2025
AL State Medical License 2020 - 2020
PA State Medical License 2000 - 2001
American Board of Internal Medicine Cardiovascular Disease

Clinical Trials

Diurnal Variation of Plasminogen Activator Inhibitor-1 Start of enrollment: 2007 Apr 01
Completed
Phase 4
Defining Strategies for Improving Endothelial and Fibrinolytic Dysfunction in Obesity Start of enrollment: 2006 May 01
Terminated
Phase 4
The Effects of Pentoxifylline on PAI-1 in an Obese Population Start of enrollment: 2003 May 01
Completed
Phase 4
Intracoronary Bradykinin Mediated t-PA Release in Heart Transplant Recipients Start of enrollment: 2008 Oct 01
Withdrawn
Not Applicable
Characterization of Brachial Arterial t-PA Release, Endothelial Function, Obesity and Inflammation Start of enrollment: 2007 Jan 01
Terminated
Not Applicable
Brachial Artery t-PA Release in Heart Transplant Recipients Start of enrollment: 2008 Oct 01
Withdrawn
Not Applicable
Monitoring and Adjustment of Medication Therapy for Patients With Heart Disease Start of enrollment: 2010 Nov 01
Unknown status
Not Applicable
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Publications & Presentations

PubMed

18 citations
Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem.
Artur Fedorowski, Fabrizio Ricci, Viktor Hamrefors, Kristin E Sandau, Tae Hwan Chung, James A S Muldowney, Rakesh Gopinathannair, Brian Olshansky> ;Circulation. Arrhythmia and Electrophysiology. 2022 Mar 1
5 citations
Management of Orthostatic Hypotension in the Hospitalized Patient. A Narrative Review.
Amr Wahba, Cyndya A. Shibao, James A.S. Muldowney, Amanda Peltier, Ralf Habermann, Italo Biaggioni> ;The American Journal of Medicine. 2021 Aug 18
Evaluation of a Clinical Pharmacist Specialist Transition of Care Pathway to Manage Heart Failure Readmissions During a Provider Shortage
Cassandra D Benge, Jonathon D. Pouliot, James A.S. Muldowney> ;Journal of Pharmacy Practice. 2021 Jun 1
11 citations
Local Passive Heat for the Treatment of Hypertension in Autonomic Failure
Luis E. Okamoto, Jorge E Celedonio, Emily C Smith, Alfredo Gamboa, Cyndya A. Shibao, André Diedrich, Sachin Y. Paranjape, Bonnie K. Black, James A.S. Muldowney, Amanda...> ;Journal of the American Heart Association. 2021 Apr 6
3 citations
Management of neurogenic orthostatic hypotension in the heart failure patient.
Debra Dixon, James A.S. Muldowney> ;Autonomic Neuroscience. 2020 Jun 6
11 citations
Cardiovascular Safety Considerations in the Treatment of Neurogenic Orthostatic Hypotension.
Brian Olshansky, James A.S. Muldowney> ;The American Journal of Cardiology. 2020 Feb 8
25 citations
Blood Pressure Management in Afferent Baroreflex Failure: JACC Review Topic of the Week.
Italo Biaggioni, Cyndya A. Shibao, André Diedrich, James A.S. Muldowney rd, Cheryl L. Laffer, Jens Jordan> ;Journal of the American College of Cardiology. 2019 Dec 10
14 citations
Aerobic exercise training improves hepatic and muscle insulin sensitivity, but reduces splanchnic glucose uptake in obese humans with type 2 diabetes
Justin M. Gregory, James A.S. Muldowney, Brian G. Engelhardt, Regina Tyree, Pam Marks-Shulman, Heidi J. Silver, E. Patrick Donahue, Dale S. Edgerton, Jason J. Winnick> ;Nutrition & Diabetes. 2019 Sep 2
11 citations
Initiation of droxidopa during hospital admission for management of refractory neurogenic orthostatic hypotension in severely ill patients.
Katherine E McDonell, Brock A. Preheim, André Diedrich, James A.S. Muldowney, Amanda C. Peltier, David Robertson, Italo Biaggioni, Cyndya A. Shibao> ;Journal of Clinical Hypertension. 2019 Sep 1
Angiotensin-Neprilysin Inhibition in Acute Decompensated Heart Failure.
Velazquez EJ, Morrow DA, DeVore AD, Duffy CI, Ambrosy AP, McCague K, Rocha R, Braunwald E, PIONEER-HF Investigators> ;The New England journal of medicine. 2018-11-11
34 citations
A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1β3) in Patients With Systolic Dysfunction and Heart Failure
Daniel J. Lenihan, Sarah A. Anderson, Carrie Geisberg Lenneman, Evan L. Brittain, James A.S. Muldowney, Lisa A. Mendes, Ping Z. Zhao, Jennifer Iaci, Stephen Frohwein, ...> ;JACC. Basic to Translational Science. 2016 Dec 1
The Impact of Inpatient Versus Outpatient Initiation on Early Warfarin Dosing
Scott E. Kasner, Le Wang, Benjamin French, Steven R. Messé, Richard B. Horenstein, Emile R. Mohler, James A.S. Muldowney, Jonas H. Ellenberg, Stephen E. Kimmel> ;American Journal of Cardiovascular Drugs. 2015 Jun 3
18 citations
Consuming a balanced high fat diet for 16 weeks improves body composition, inflammation and vascular function parameters in obese premenopausal women
Heidi J. Silver, Hakmook Kang, Charles D. Keil, James A.S. Muldowney, Heidi Kocalis, Sergio Fazio, Douglas E. Vaughan, Kevin D. Niswender> ;Metabolism. 2014 Apr 1
31 citations
Circadian variability of fibrinolytic markers and endothelial function in patients with obstructive sleep apnea.
Kanika Bagai, James A.S. Muldowney, Yanna Song, Lily Wang, Jayant Bagai, Kay Artibee, Douglas E. Vaughan, Beth A. Malow> ;Sleep. 2014 Feb 1
528 citations
A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing
Stephen E. Kimmel, Benjamin French, Scott E. Kasner, Julie A. Johnson, Jeffrey L. Anderson, Brian F. Gage, Yves Rosenberg, Charles S. Eby, Rosemary Madigan, Robert B. ...> ;The New England Journal of Medicine. 2013 Dec 11
1 citations
The pharmacokinetics and pharmacodynamics of valsartan in the post-myocardial infarction population.
Cassandra D Benge, James A.S. Muldowney> ;Expert Opinion on Drug Metabolism & Toxicology. 2012 Oct 16
11 citations
Pentoxifylline lowers plasminogen activator inhibitor 1 levels in obese individuals: a pilot study.
James A.S. Muldowney, Qingxia Chen, Dana L. Blakemore, Douglas E. Vaughan> ;Angiology. 2012 Feb 17
Statistical design of personalized medicine interventions: the Clarification of Optimal Anticoagulation through Genetics (COAG) trial.
French, B., Joo, J., Geller, N. L., Kimmel, S. E., Rosenberg, Y., Anderson, J. L., Gage, B. F., Johnson, J. A., Ellenberg, J. H.> ;Trials. 2010
2 citations
Combination therapy with clopidogrel and proton-pump inhibitors
James A.S. Muldowney, Cassandra D Benge> ;Lancet. 2010 Jan 2
A very late stent thrombosis in a patient with diabetes: a call for lifelong dual anti-platelet therapy.
Chad V. Pecot, Michael Fuller, James A.S. Muldowney, Sumathi Misra> ;Tennessee Medicine. 2009 May 1
10 citations
The clinical pharmacology of eplerenone
James As Muldowney, John A. Schoenhard, Cassandra D Benge> ;Expert Opinion on Drug Metabolism & Toxicology. 2009 Apr 21
3 citations
Plasminogen activator inhibitor-1 has a circadian rhythm in blind individuals.
John A. Schoenhard, James A.S. Muldowney, Jonathan S. Emens, Alfred J. Lewy, Douglas E. Vaughan> ;Thrombosis and Haemostasis. 2007 Aug 1
24 citations
Acute tissue-type plasminogen activator release in human microvascular endothelial cells: The roles of Gαq, PLC-β, IP3 and 5,6-epoxyeicosatrienoic acid
James A.S. Muldowney, Corrie A. Painter, Elaine Sanders-Bush, Nancy J. Brown, Douglas E. Vaughan> ;Thrombosis and Haemostasis. 2007 Feb 1
49 citations
Antiproliferative Agents Alter Vascular Plasminogen Activator Inhibitor-1 Expression A Potential Prothrombotic Mechanism of Drug-Eluting Stents
James A.S. Muldowney, John R. Stringham, Shawn Levy, Linda A. Gleaves, Mesut Eren, Robert N. Piana, Douglas E. Vaughan> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2006 Dec 7
9 citations
Endogenous NO Regulates Plasminogen Activator Inhibitor-1 During Angiotensin-Converting Enzyme Inhibition
Nancy J. Brown, James A.S. Muldowney, Douglas E. Vaughan> ;Hypertension. 2006 Mar 1
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