JamesCPowersMD

PubMed

• 36 citations
  Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis
  Christian S. Lentz, Alvaro A. Ordonez, Paulina Kasperkiewicz, Florencia La Greca, Anthony J. O’Donoghue, Christopher J. Schulze, James C. Powers, Charles S. Craik, Mar...> ;ACS Infectious Diseases. 2016 Jul 15
• 29 citations
  Elastase Inhibitors for Treatment of Emphysema
  James C. Powers, Zakir H. Bengali> ;The American Review of Respiratory Disease. 2015 Oct 4
• 17 citations
  Synthetic Elastase Inhibitors: Prospects for Use in the Treatment of Emphysema1–3
  James C. Powers> ;The American Review of Respiratory Disease. 2015 May 14
• 16 citations
  The moderation of elastase-induced emphysema in the hamster by intratracheal pretreatment or post-treatment with succinyl alanyl alanyl prolyl valine chloromethyl ketone.
  Phillip J. Stone, Edgar C. Lucey, James D. Calore, Gordon L. Snider, Carl Franzblau, Mario J. Castillo, James C. Powers> ;The American Review of Respiratory Disease. 1981 Jul 1
• 47 citations
  Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion
  Matthew A. Child, Carolyn I. Hall, Josh R. Beck, Leslie O. Ofori, Victoria E. Albrow, Megan Garland, Paul W. Bowyer, Peter J. Bradley, James C. Powers, John C. Boothro...> ;Nature Chemical Biology. 2013 Oct 1
• 45 citations
  Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis
  Sarina Gloeckl, Vanissa A. Ong, Pooja Patel, Joel D. A. Tyndall, Peter Timms, Kenneth W. Beagley, John A. Allan, Charles W. Armitage, Lynne Turnbull, Cynthia B. Whitch...> ;Molecular Microbiology. 2013 Aug 1
• 11 citations
  An effective prodrug strategy to selectively enhance ocular exposure of a cannabinoid receptor (CB1/2) agonist.
  Nello Mainolfi, Powers James J, Jakal Amin, Debby Long, Wendy Lee, Margaret E. McLaughlin, Bruce D Jaffee, Christopher Thomas Brain, Jason Elliott, Jeremy M Sivak> ;Journal of Medicinal Chemistry. 2013 Jun 19
• 38 citations
  Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors.
  Elizabeth L. Ponder, Victoria E. Albrow, Brittany A. Leader, Miklós Békés, Jowita Mikolajczyk, Urša Pečar Fonović, Aimee Shen, Marcin Drag, Junpeng Xiao, Edgar Deu, Am...> ;Chemistry & Biology. 2011 Jun 24
• 18 citations
  Peptidyl α-Ketoamides with Nucleobases, Methylpiperazine, and Dimethylaminoalkyl Substituents as Calpain Inhibitors
  Asli Ovat, Zhao Zhao Li, Christina Y. Hampton, Seneshaw Asress, Facundo M. Fernández, Jonathan D. Glass, James C. Powers> ;Journal of Medicinal Chemistry. 2010 Aug 6
• 28 citations
  Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases).
  Asli Ovat, Fanuel Muindi, Crystal Fagan, Michelle Brouner, Elizabeth Hansell, Jan Dvorák, Daniel Sojka, Petr Kopáček, James H. McKerrow, Conor R. Caffrey, James C. Powers> ;Journal of Medicinal Chemistry. 2009 Oct 22
• 59 citations
  Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin
  Aimee Shen, Patrick J. Lupardus, Victoria E. Albrow, Andrew Guzzetta, James C. Powers, K. Christopher Garcia, Matthew Bogyo> ;Nature Chemical Biology. 2009 Jul 1
• 37 citations
  Substrate specificity of transthyretin: identification of natural substrates in the nervous system
  Márcia A. Liz, Carolina E Fleming, Ana Nunes, Maria Rosário Almeida, Fernando M. Mar, Youngchool Choe, Charles S. Craik, James C. Powers, Matthew Bogyo, Mónica Mendes ...> ;The Biochemical Journal. 2009 Apr 15
• 34 citations
  Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions.
  Jin Qian, Dominic Cuerrier, Peter L. Davies, Zhaozhao Li, James C. Powers, Robert L. Campbell> ;Journal of Medicinal Chemistry. 2008 Sep 11
• 20 citations
  Human leucocyte elastase and cathepsin G: structural and functional characteristics.
  James Travis, P.J. Giles, L. Porcelli, C.F. Reilly, Robert J. Baugh, James C. Powers> ;Ciba Foundation Symposium. 2008 May 30
• 33 citations
  Aza-peptidyl Michael Acceptors. A New Class of Potent and Selective Inhibitors of Asparaginyl Endopeptidases (Legumains) from Evolutionarily Diverse Pathogens
  Marion G. Götz, Karen Ellis James, E. Hansell, Jan Dvořák, Amritha Seshaadri, Daniel Sojka, Petr Kopáček, James H. McKerrow, Conor R. Caffrey, James C Powers> ;Journal of Medicinal Chemistry. 2008 Apr 17
• 182 citations
  Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum.
  Shirin Arastu-Kapur, Elizabeth L. Ponder, Urša Pečar Fonović, Sharon Yeoh, Fang Yuan, Marko Fonović, Munira Grainger, Carolyn I Phillips, James C. Powers, Matthew Bogyo> ;Nature Chemical Biology. 2008 Mar 1
• 7 citations
  MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition.
  Jerry J. Buccafusco, James C. Powers, Maria Hernandez, Mark A. Prendergast, Alvin V. Terry, Ramamohana R. Jonnala> ;Neurochemical Research. 2007 Apr 3
• 33 citations
  Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase
  Ting-Wai Lee, Maia M. Cherney, Jie Liu, Karen Ellis James, James C. Powers, Lindsay D. Eltis, Michael N.G. James> ;Journal of Molecular Biology. 2007 Feb 23
• 52 citations
  Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and -10
  Özlem Doğan Ekici, Zhao Zhao Li, Amy J. Campbell, Karen Ellis James, Juliana L Asgian, Jowita Mikolajczyk, Guy S. Salvesen, Rajkumar Ganesan, Stjepan Jelakovic, Markus...> ;Journal of Medicinal Chemistry. 2006 Aug 23
• 20 citations
  Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors.
  Rajkumar Ganesan, Stjepan Jelakovic, Amy J. Campbell, Zhao Zhao Li, Juliana L. Asgian, James C. Powers, Markus G. Grütter> ;Biochemistry. 2006 Jul 7
• 117 citations
  Crystal Structures of the Main Peptidase from the SARS Coronavirus Inhibited by a Substrate-like Aza-peptide Epoxide
  Ting-Wai Lee, Maia M. Cherney, Carly Huitema, Jie Liu, Karen Ellis James, James C. Powers, Lindsay D. Eltis, Michael N.G. James> ;Journal of Molecular Biology. 2005 Nov 11
• 9 citations
  Fluorescently labeled inhibitors detect localized serine protease activities in Drosophila melanogaster pole cells, embryos, and ovarian egg chambers.
  Rasmus Kragh Jakobsen, Shin Ono, James C. Powers, Robert DeLotto> ;Histochemistry and Cell Biology. 2005 Jan 1
• 27 citations
  Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases.
  Marion G. Götz, Conor R. Caffrey, Elizabeth Hansell, James H. McKerrow, James C. Powers> ;Bioorganic & Medicinal Chemistry. 2004 Oct 1
• 31 citations
  Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C).
  Chih Min Kam, Marion G. Götz, Gretchen Koot, Michael J. McGuire, Dwain L Thiele, Dorothy Hudig, James C. Powers> ;Archives of Biochemistry and Biophysics. 2004 Jul 15
• 39 citations
  Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice
  Patrick L.J.M. Zeeuwen, Ivonne M.J.J. van Vlijmen-Willems, Diana Olthuis, Harald T. Johansen, Kiyotaka Hitomi, Ikuko Hara-Nishimura, James C. Powers, Karen Ellis James...> ;Human Molecular Genetics. 2004 May 15
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