JamesARugglesMD

PubMed

• 24 citations
  Exenatide once weekly improved 24‐hour glucose control and reduced glycaemic variability in metformin‐treated participants with type 2 diabetes: a randomized, placebo‐...
  Juan P. Frías, Samer Nakhle, James Ruggles, Sergey B. Zhuplatov, Eric J. Klein, Rong Zhou, Poul Strange> ;Diabetes, Obesity & Metabolism. 2017 Jan 1
• 18 citations
  The effect of pramlintide on hormonal, metabolic or symptomatic responses to insulin‐induced hypoglycaemia in patients with type 1 diabetes
  Stephanie A. Amiel, Simon Heller, Ian A. Macdonald, Sherwyn Schwartz, L J Klaff, James A. Ruggles, Christian Weyer, Orville G. Kolterman, David G. Maggs> ;Diabetes, Obesity & Metabolism. 2005 Sep 1
• 52 citations
  Effects of Pramlintide on Postprandial Glucose Excursions and Measures of Oxidative Stress in Patients With Type 1 Diabetes
  Antonio Ceriello, Ludovica Piconi, Lisa Quagliaro, Yan Wang, Catherine A. Schnabel, James A. Ruggles, Maurice A. Gloster, David G. Maggs, Christian Weyer> ;Diabetes Care. 2005 Mar 1
• 312 citations
  Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus
  Orville G. Kolterman, Dennis Dong Hwan Kim, Larry Z. Shen, James A. Ruggles, Loretta L. Nielsen, Mark Fineman, Alain D. Baron> ;American Journal of Health-System Pharmacy. 2005 Jan 15
• Effect of pramlintide on weight in overweight and obese insulin-treated type 2 diabetes patients.
  Hollander, P., Maggs, D.G., Ruggles, J.A., Fineman, M., Shen, L., Kolterman, O.G., Weyer, C.> ;Obes Res. 2004 Apr
• 6 citations
  Emerging therapies: controlling glucose homeostasis, immunotherapy, islet transplantation, gene therapy, and islet cell neogenesis and regeneration
  James A. Ruggles, Donald Kelemen, Alain D. Baron> ;Endocrinology and Metabolism Clinics of North America. 2004 Mar 1
• 54 citations
  Pramlintide reduces postprandial glucose excursions when added to insulin lispro in subjects with type 2 diabetes: a dose-timing study.
  David G. Maggs, Mark Fineman, Jonathan Kornstein, Terrie Burrell, Sherwyn Schwartz, Yan Wang, James A. Ruggles, Orville G. Kolterman, Christian Weyer> ;Diabetes/metabolism Research and Reviews. 2004 Jan 1
• 71 citations
  Pramlintide reduces postprandial glucose excursions when added to regular insulin or insulin lispro in subjects with type 1 diabetes: a dose-timing study.
  Christian Weyer, Alan Gottlieb, Dennis Dong Hwan Kim, Karen Lutz, Sherwyn Schwartz, Maria Gutierrez, Yan Wang, James A. Ruggles, Orville G. Kolterman, David G. Maggs> ;Diabetes Care. 2003 Nov 1
• 196 citations
  A Randomized Study and Open-Label Extension Evaluating the Long-Term Efficacy of Pramlintide as an Adjunct to Insulin Therapy in Type 1 Diabetes
  Fred W. Whitehouse, Davida F. Kruger, Mark Fineman, Larry Z. Shen, James A. Ruggles, David G. Maggs, Christian Weyer, Orville G. Kolterman> ;Diabetes Care. 2002 Apr 1
• 39 citations
  Dimeric structure of the Oxytricha nova telomere end-binding protein |[alpha]|-subunit bound to ssDNA
  Olve B. Peersen, James A Ruggles, Steve C. Schultz> ;Nature Structural Biology. 2002 Mar 1
• 117 citations
  Adjunctive therapy with the amylin analogue pramlintide leads to a combined improvement in glycemic and weight control in insulin-treated subjects with type 2 diabetes.
  Robert E. Ratner, Laura L. Want, Mark Fineman, Maggie J. Velte, James A. Ruggles, Alan Gottlieb, Christian Weyer, Orville G. Kolterman> ;Diabetes Technology & Therapeutics. 2002 Jan 1
• 39 citations
  Crystal structure of the N-terminal domain of Oxytricha nova telomere end-binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA.
  Scott Classen, James A Ruggles, Steve C. Schultz> ;Journal of Molecular Biology. 2001 Dec 14
• 200 citations
  Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA.
  Martin P. Horvath, Viloya L Schweiker, Joanne M. Bevilacqua, James A Ruggles, Steve C. Schultz> ;Cell. 1998 Dec 23
• Kinetics of appearance and disappearance of classes of bacterial ice nuclei support an aggregation model for ice nucleus assembly.
  Ruggles, J. A., Nemecek-Marshall, M., Fall, R.> ;J Bacteriol. 1993 Nov
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