JamesHSegarsJr.MD

Obstetrics & Gynecology • Baltimore, MD

Reproductive Endocrinology & Infertility

Professor, Obstetrics & Gynecology, Johns Hopkins University School of Medicine

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Office
720 Rutland
Ross Bldg, 6th Floor, Rm 624
Baltimore, MD 21205
Phone+1 410-614-2000
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Education & Training

Vanderbilt University Medical CenterFellowship, Reproductive Endocrinology and Infertility, 1987 - 1989
Vanderbilt University Medical CenterResidency, Obstetrics and Gynecology, 1984 - 1987
University of Virginia Medical CenterInternship, Transitional Year, 1981 - 1982
Duke University School of MedicineClass of 1981

Certifications & Licensure

MD State Medical License 1990 - 2025
TN State Medical License 1984 - 1991
GA State Medical License 1982 - 1989
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Reproductive Endocrinology/Infertility

Awards, Honors, & Recognition

Fellow (FACOG) American Congress of Obstetricians and Gynecologists

Clinical Trials

Evaluation of Women With Endocrine and Reproductive-Related Conditions Start of enrollment: 1999 May 10
Terminated
Establishment of Fibroid Tissue Bank Start of enrollment: 2008 Jun 30
Terminated
Safety and Tolerability of Collagenase Clostridium Histolyticum (EN3835) to Treat Uterine Leiomyoma (Fibroids) Start of enrollment: 2016 Oct 27
Completed
Phase 1
Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids Start of enrollment: 2017 Jun 30
Active, not recruiting
Phase 3
Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance Start of enrollment: 2020 Oct 01
Recruiting
Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study) Start of enrollment: 2023 Nov 01
Recruiting
Roles: Principal Investigator, Contact
A Study to Investigate Efficacy and Safety of OG-6219 BID in 3 Dose Levels Compared With Placebo in Participants Aged 18 to 49 With Moderate to Severe Endometriosis-related Pain Start of enrollment: 2022 Oct 25
Recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

A European Perspective on a Turning Point for Embryo Status and IVF in the US.
Ophélie Sauzeau, James Segars> ;Fertility and Sterility. 2024 Apr 8
A Systematic Review of the Psychosocial Impact of Endometriosis before and after Treatment.
Ashley N Rempert, Trevor H Rempert, Amy Liu, Ana Hernández, Jaime Blanck, Bhuchitra Singh, James Segars> ;Reproductive Sciences. 2024 Mar 21
The impact of fibroid treatments on quality of life and mental health: a systematic review.
Neumann, B., Singh, B., Brennan, J., Blanck, J., Segars, J.> ;Fertility and Sterility. 2024 Mar 1
A systematic review of association between use of hair products and benign and malignant gynecological conditions.
Hajra Farooq, Pauras Mhatre, Riya Aggarwal, Mahalia T Robinson, Emily Joseph, James Segars, Bhuchitra Singh> ;European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2024 Apr 1
Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) - protocol for a randomised placebo-controlled U...
González, F., Zamah, M., Alkelani, H., Singh, B., Johnson, J., Huang, H., Zhang, H., Al-Hendy, A., Segars, J., Taylor, H., Siblini, H., Flores, V., Christman, G.> ;BMJ Open. 2024 Jan 12
A Systematic Review of Epigenetics of Endometriosis.
Laura Courtright, Jiahui Zhang, Morgan Snow, Isabela Landsteiner Sampaio Amendola, Elisabeth Nylander, Kamaria Cayton-Vaught, Bhuchitra Singh, Bronwyn S Bedrick, James...> ;F&S Reviews. 2024 Jan 1
Examination of newborn DNA methylation among women with polycystic ovary syndrome/hirsutism.
Kristen J Polinski, Sonia L Robinson, Diane L Putnick, Rajeshwari Sundaram, Erin Bell, Paule V Joseph, James Segars, Weihua Guan, Robert M Silver, Enrique F Schisterma...> ;Epigenetics. 2023 Dec 1
Biomarkers Assessing the Role of Cumulus Cells on IVF Outcomes: A Systematic Review.
Gaelle Massoud, Marcus Spann, Kamaria Cayton Vaught, Samarjit Das, Mark Dow, Richard Cochran, Valerie Baker, James Segars, Bhuchitra Singh> ;Journal of Assisted Reproduction and Genetics. 2024 Feb 1
The Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.
Isabela Landsteiner Sampaio Amendola, Marcus Spann, James Segars, Bhuchitra Singh> ;Reproductive Sciences. 2024 Feb 1
1 citations
A Systematic Review of Autoimmune Oophoritis Therapies.
Elizabeth Levit, Bhuchitra Singh, Elisabeth Nylander, James H Segars> ;Reproductive Sciences. 2024 Jan 1
3 citations
A Systematic Review of the Psychosocial Impact of Polycystic Ovarian Syndrome Before and After Treatment.
Ashley N Rempert, Isabella Sarria, Lindsay R Standeven, Elizabeth Nylander, James Segars, Bhuchitra Singh> ;Reproductive Sciences. 2023 Nov 1
1 citations
Beta blockers reduce uterine fibroid incidence in hypertensive women.
Nicole M Fischer, Tim O Nieuwenhuis, Kristin Voegtline, Bhuchitra Singh, James H Segars, Dana Hazimeh> ;European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2023 Aug 1
4 citations
Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids.
Md Soriful Islam, Maclaine Parish, Joshua T Brennan, Briana L Winer, James H Segars> ;Scientific Reports. 2023 May 25
7 citations
Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage?
Gaelle Massoud, Maclaine Parish, Bhuchitra Singh, James Segars, Md Soriful Islam, Dana Hazimeh> ;Nutrients. 2023 Mar 16
3 citations
Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm.
Kathleen E O'Neill, Jacqueline Y Maher, Monica M Laronda, Francesca E Duncan, Richard D LeDuc, Marla E Lujan, Kutluk H Oktay, Alison M Pouch, James H Segars, Elizabeth...> ;American Journal of Obstetrics and Gynecology. 2023 Mar 1
9 citations
Green Tea in Reproductive Cancers: Could Treatment Be as Simple?
Maclaine Parish, Gaelle Massoud, James Segars, Md Soriful Islam, Dana Hazimeh> ;Cancers. 2023 Jan 30
12 citations
Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women.
Hiba Siblini, Ayman Al-Hendy, James Segars, Frank González, Hugh S Taylor, Bhuchitra Singh, Ainna Flaminia, Valerie A Flores, Gregory M Christman, Hao Huang, Jeremy J ...> ;Nutrients. 2023 Jan 9
1 citations
The Utility and Impact of the Painful Periods Screening Tool (PPST) to Improve Healthcare Delivery for People with Symptoms of Pelvic Pain.
Bhuchitra Singh, Michelle Volovsky, Yanqing Xu, Ahmed M Soliman, Carol B Thompson, James H Segars, Berry, J.> ;Reproductive Sciences. 2023 May 1
3 citations
A Systematic Review of Minimally Invasive Approaches to Uterine Fibroid Treatment for Improving Quality of Life and Fibroid-Associated Symptoms.
Joshua M Morris, Angela Liang, Katarina Fleckenstein, Bhuchitra Singh, James Segars> ;Reproductive Sciences. 2023 May 1
1 citations
AKAP13 Enhances CREB1 Activation by FSH in Granulosa Cells.
Kamaria C Cayton Vaught, Dana Hazimeh, Kate Devine, Jacqueline Y Maher, Marcy Maguire, Elizabeth A McGee, Paul H Driggers, James H Segars, Ashlie Sewdass Carter> ;Reproductive Sciences. 2023 May 1
3 citations
A Systematic Review of Vitamin D and Fibroids: Pathophysiology, Prevention, and Treatment.
Abigail Combs, Bhuchitra Singh, Elisabeth Nylander, Md Soriful Islam, Ha Vi Nguyen, Elissa Parra, Ameerah Bello, James Segars> ;Reproductive Sciences. 2023 Apr 1
4 citations
Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial.
Hugh Taylor, Howard J Li, Sandra Carson, Valerie Flores, Lubna Pal, Jared Robbins, Nanette F Santoro, James H Segars, David Seifer, Hao Huang, Steven Young, Heping Zhang> ;BMJ Open. 2022 Jun 17
3 citations
The role of Hippo pathway signaling and A-kinase anchoring protein 13 in primordial follicle activation and inhibition.
Jacqueline Yano Maher, Md Soriful Islam, Ophelia Yin, Joshua Brennan, Ethan Gough, Paul Driggers, James Segars> ;F&S Science. 2022 May 1
A simplistic approach to fibroids is outdated.
Michelle Volovsky, James Segars> ;F&S Reports. 2022 Mar 1
2 citations
Hop and artichoke extracts inhibit expression of extracellular matrix components in uterine leiomyoma cells.
Md Soriful Islam, Stefania Greco, Giovanni Delli Carpini, Stefano Raffaele Giannubilo, James Segars, Andrea Ciavattini, Pasquapina Ciarmela> ;F&S Science. 2021 Nov 1
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Journal Articles

The Effect of Uterine Fibroids on Infertility: A Systematic Review
Rachel M Whynott, James H Segars, Seminars in Reproductive Medicine

Press Mentions

Fibroids Are 3x More Likely to Affect Black Women, and Research Funding Is LowMarch 15th, 2021
Zika Virus Forces Tough Choices on Couples Seeking Fertility TreatmentJune 8th, 2016
Detailed AgendaMarch 15th, 2016
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Grant Support

Reproductive Endocrinology And Infertility Clinical Training ProgramEunice Kennedy Shriver National Institute Of Child Health &Human Development2011
Reproductive Endocrinology And Infertility Clinical Training ProgramEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2010
Reproductive Endocrinology And Infertility Clinical Training ProgramEunice Kennedy Shriver National Institute Of Child Health &Human Development2007–2008
Reproductive Endocrinology And Infertility Clinical TraiEunice Kennedy Shriver National Institute Of Child Health &Human Development2002–2006
Reproductive Endocrinology And Infertility Clinical*Eunice Kennedy Shriver National Institute Of Child Health &Human Development2004
Reproductive Endocrinology And Infertility TrainingEunice Kennedy Shriver National Institute Of Child Health &Human Development2003
Endocrinology And Infertility Clinical Trail ProgramEunice Kennedy Shriver National Institute Of Child Health &Human Development2001
Endocrinology Of Reproduction In WomenEunice Kennedy Shriver National Institute Of Child Health &Human Development1996–1997