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- 1500 East Medical Center DrUniversity Hospital - Im Nephrology InpatientAnn Arbor, MI 48109 
- Phone+1 734-888-2871 
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Education & Training
 Washington University/B-JH/SLCH ConsortiumFellowship, Nephrology, 1985 - 1985 Washington University/B-JH/SLCH ConsortiumFellowship, Nephrology, 1985 - 1985
 Washington University/B-JH/SLCH ConsortiumFellowship, Nephrology, 1983 - 1984 Washington University/B-JH/SLCH ConsortiumFellowship, Nephrology, 1983 - 1984
 Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 1980 - 1983 Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 1980 - 1983
 Washington University in St. Louis School of MedicineClass of 1980 Washington University in St. Louis School of MedicineClass of 1980
Certifications & Licensure
 MI State Medical License 1986 - 2026 MI State Medical License 1986 - 2026
 American Board of Internal Medicine Internal Medicine American Board of Internal Medicine Internal Medicine
 American Board of Internal Medicine Nephrology American Board of Internal Medicine Nephrology
Awards, Honors, & Recognition
- Elected Member The American Society for Clinical Investigation, 1994
- Fellow (ASNF) American Society of Nephrology
Publications & Presentations
PubMed
- Degradation of oxidized phospholipids by lysosomal phospholipase A2 regulates pulmonary fibrosis.Doyun Kwak, Song Ling, Natalya Subbotina, James A Shayman, Tomas H Sisson
 American Journal of Physiology. Lung Cellular and Molecular Physiology. 2025-08-01
- 3 citationsHepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV.Jessica W Davidson, Raghav Jain, Thomas Kizzar, Gisela Geoghegan, Daniel J Nesbitt
 Cell Metabolism. 2025-06-03
- Isomerization of bis(monoacylglycero)phosphate by acyl migration.Akira Abe, Vania Hinkovska-Galcheva, Rakesh Verma, James A Shayman
 Journal of Lipid Research. 2025-05-01
Press Mentions
 Protalix’s Phase III Asset for Fabry Could Struggle to Demonstrate Superiority over Fabrazyme but Immunogenicity Benefits Support Regulatory Chances, Experts SayFebruary 5th, 2021 Protalix’s Phase III Asset for Fabry Could Struggle to Demonstrate Superiority over Fabrazyme but Immunogenicity Benefits Support Regulatory Chances, Experts SayFebruary 5th, 2021
 Sanofi Pivotal Trial to Target Driver of Cyst Growth in PKDNovember 12th, 2018 Sanofi Pivotal Trial to Target Driver of Cyst Growth in PKDNovember 12th, 2018
 Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis from the HALT-PKD TrialsJanuary 4th, 2018 Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis from the HALT-PKD TrialsJanuary 4th, 2018
Grant Support
- Lysosomal Phospholipase A2 In Autoimmune DiseaseNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2010–2012
- The Pharmacological Treatment Of Fabry DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2012
- The Pharmacologic Treatment Of Fabry DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2008
- Glycosphingolipids In Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases1995–1999
- Glycosphingolipid And Renal CarcinomaNational Institute Of Diabetes And Digestive And Kidney Diseases1996–1997
- Sphingolipids And Polycystic Kidney DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases1995–1997
- Renal Polyol MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases1990–1994
- Peptide Hormone Stimulated Inositol MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases1986–1989
- Peptide Hormone Stimulated Inositol MetabolismNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985
Professional Memberships
- Fellow
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