JamesEdwardSheppeckMD

PubMed

• 28 citations
  Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase
  Jessica A. Wales, Cheng-Yu Chen, Linda Breci, Andrzej Weichsel, Sylvie G. Bernier, James E. Sheppeck, Robert Solinga, Takashi Nakai, Paul Allan Renhowe, Joon Jung, Wil...> ;The Journal of Biological Chemistry. 2017 Dec 8
• 5 citations
  Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design
  Hai-Yun Xiao, Scott H. Watterson, Charles M. Langevine, Anurag S. Srivastava, Soo S. Ko, Yanlei Zhang, Robert J. Cherney, Weiwei Guo, John L. Gilmore, James E. Sheppec...> ;Journal of Medicinal Chemistry. 2016 Oct 20
• 10 citations
  Discovery and Structure–Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1)
  John L. Gilmore, James E. Sheppeck, Scott H. Watterson, Lauren Haque, Parag Mukhopadhyay, Andrew J. Tebben, Michael Galella, Ding Ren Shen, Melissa Yarde, Mary Ellen C...> ;Journal of Medicinal Chemistry. 2016 Jul 1
• 5 citations
  Heterocyclic glucocorticoid receptor modulators with a 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core.
  Hai-Yun Xiao, Dauh-Rurng Wu, James E. Sheppeck, Sium Habte, Mark D. Cunningham, John E. Somerville, Joel C. Barrish, Steven G. Nadler, T. G. Murali Dhar> ;Bioorganic & Medicinal Chemistry Letters. 2013 Oct 15
• 8 citations
  Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.
  John L. Gilmore, James E. Sheppeck, Jim Wang, T. G. Murali Dhar, Cullen L. Cavallaro, Arthur M. Doweyko, Lorraine I. McKay, Mark D. Cunningham, Sium Habte, Steven G. N...> ;Bioorganic & Medicinal Chemistry Letters. 2013 Oct 1
• 11 citations
  Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists
  James E. Sheppeck, John L. Gilmore, Hai Yun Xiao, T. G. Murali Dhar, David S. Nirschl, Arthur M. Doweyko, Jack S. Sack, Martin J. Corbett, Mary F. Malley, Jack Z. Goug...> ;Bioorganic & Medicinal Chemistry Letters. 2013 Oct 1
• 31 citations
  Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
  James E. Sheppeck, John L. Gilmore, Andrew J. Tebben, Chu-Biao Xue, Rui-Qin Liu, Carl P. Decicco, Jingwu Duan> ;Bioorganic & Medicinal Chemistry Letters. 2007 May 15
• 18 citations
  A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE.
  James E. Sheppeck, Andrew J. Tebben, John L. Gilmore, Anle Yang, Zelda R. Wasserman, Carl P. Decicco, Jingwu Duan> ;Bioorganic & Medicinal Chemistry Letters. 2007 Mar 1
• 28 citations
  Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
  Jingwu Duan, Lihua Chen, Zhonghui Lu, Bin Jiang, Naoyuki Asakawa, James E. Sheppeck, Rui-Qin Liu, Maryanne B. Covington, William J. Pitts, Soong-Hoon Kim, Carl P. Decicco> ;Bioorganic & Medicinal Chemistry Letters. 2007 Jan 1
• 23 citations
  Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
  James E. Sheppeck, John L. Gilmore, Anle Yang, Xiao-Tao Chen, Chu-Biao Xue, John Roderick, Rui-Qin Liu, Maryanne B. Covington, Carl P. Decicco, Jingwu Duan> ;Bioorganic & Medicinal Chemistry Letters. 2007 Mar 1
• 13 citations
  The selective inhibition of phosphatases by natural toxins: the anhydride domain of tautomycin is not a primary factor in controlling PP1/PP2A selectivity
  Wen Liu, James E. Sheppeck, David A. Colby, Hsien-Bin Huang, Angus C. Nairn, A. Richard Chamberlin> ;Bioorganic & Medicinal Chemistry Letters. 2003 May 5
• 10 citations
  A new model of the tautomycin–PP1 complex that is not analogous to the corresponding okadaic acid structure
  David A. Colby, Wen Liu, James E. Sheppeck, Hsien-Bin Huang, Angus C. Nairn, A. Richard Chamberlin> ;Bioorganic & Medicinal Chemistry Letters. 2003 May 5
• 18 citations
  Synthesis of a statistically exhaustive fluorescent peptide substrate library for profiling protease specificity.
  James E. Sheppeck, Heidi Kar, Luke J. Gosink, Jeffrey B Wheatley, Erik Gjerstad, Siobhan M Loftus, Alexi R Zubiria, James W. Janc> ;Bioorganic & Medicinal Chemistry Letters. 2000 Dec 4
• 42 citations
  A molecular modeling analysis of the binding interactions between the okadaic acid class of natural product inhibitors and the Ser-Thr phosphatases, PP1 and PP2A
  Carla-Maria Gauss, James E. Sheppeck, Angus C. Nairn, Richard Chamberlin> ;Bioorganic & Medicinal Chemistry. 1997 Sep 1
• 111 citations
  Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins.
  James E. Sheppeck, Carla-Maria Gauss, A. Richard Chamberlin> ;Bioorganic & Medicinal Chemistry. 1997 Sep 1
• 19 citations
  Total Synthesis of the Serine/Threonine-Specific Protein Phosphatase Inhibitor Tautomycin(1).
  James E. Sheppeck, Wen Liu, A. Richard Chamberlin> ;The Journal of Organic Chemistry. 1997 Jan 24
• 20 citations
  Conversion of Allylic Alcohols into Allylic Nitromethyl Compounds via a Palladium-Catalyzed Solvolysis: An Enantioselective Synthesis of an Advanced Carbocyclic Nucleo...
  Donald R. Deardorff, Kenneth A. Savin, Craig J. Justman, Zarir E. Karanjawala, James E. Sheppeck, David C. Hager, Nebil Aydin> ;The Journal of Organic Chemistry. 1996 May 31
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