JamesThomasMD

Rheumatology • Nashville, TN

Professor, Medicine, Vanderbilt University School of Medicine

Join to view full profile

Dr. Thomas is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Thomas' full profile

Already have an account?

Office
21st Ave S
Nashville, TN 37232
Is this information wrong?

Education & Training

National Institutes of Health Clinical CenterFellowship, Clinical and Laboratory Immunology, 1978 - 1979
University of Alabama Medical CenterResidency, Internal Medicine, 1975 - 1976
University of TennesseeInternship, Internal Medicine, 1974 - 1975
University of Tennessee Health Science Center College of MedicineClass of 1973

Certifications & Licensure

TN State Medical License 1974 - 2022
TX State Medical License 1982 - 1991
MD State Medical License 1978 - 1991
American Board of Allergy and Immunology Allergy & Immunology
American Board of Internal Medicine Internal Medicine

Publications & Presentations

PubMed

Productive Germinal Center Responses Depend on the Nature of Stimuli Received by Anti-Insulin B Cells in Type 1 Diabetes-Prone Mice.
Dudley H McNitt, Bryan A Joosse, James W Thomas, Rachel H Bonami> ;Immunohorizons. 2023 Jun 1
2 citations
Btk Supports Autoreactive B Cell Development and Protects against Apoptosis but Is Expendable for Antigen Presentation.
Lindsay E. Nyhoff, Amber S Griffith, Emily S. Clark, James W. Thomas, Wasif N. Khan, Peggy L. Kendall> ;Journal of Immunology. 2021 Nov 19
3 citations
T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.
Rachel H. Bonami, Lindsay E. Nyhoff, Dudley H. McNitt, Chrys Hulbert, Jamie L. Felton, Peggy L. Kendall, James W. Thomas> ;Journal of Immunology. 2020 Nov 16
4 citations
Multimeric Insulin Desensitizes Insulin-Specific B Cells
Stephanie N. Johnson, J. Daniel Griffin, Chrys Hulbert, Brandon J. DeKosky, James W. Thomas, Cory Berkland> ;ACS Applied Bio Materials. 2020 Aug 11
3 citations
mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes
Ariel L. Raybuck, Keunwook Lee, Sung Hoon Cho, Jingxin Li, James W. Thomas, Mark Boothby> ;FASEB Journal. 2019 Sep 18
38 citations
Molecular regulation of peripheral B cells and their progeny in immunity.
Mark Boothby, Emily Hodges, James W. Thomas> ;Genes & Development. 2019 Jan 1
67 citations
Increased Reporting of Immune Checkpoint Inhibitor-Associated Diabetes.
Jordan J. Wright, Joe-Elie Salem, Douglas B. Johnson, Bénédicte Lebrun-Vignes, Angeliki M. Stamatouli, James W. Thomas, Kevan C. Herold, Javid Moslehi, Alvin C. Powers> ;Diabetes Care. 2018 Dec 1
177 citations
Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes
Federica Vecchio, Nicola Lo Buono, Angela Stabilini, Laura Nigi, Matthew J. Dufort, Susan Geyer, Paola M.V. Rancoita, Federica Cugnata, Alessandra Mandelli, Andrea Val...> ;JCI Insight. 2018 Sep 20
21 citations
Anti-Insulin B Cells Are Poised for Antigen Presentation in Type 1 Diabetes
Jamie L. Felton, Damian Maseda, Rachel H. Bonami, Chrys Hulbert, James W. Thomas> ;Journal of Immunology. 2018 Jun 27
58 citations
B Cell–Intrinsic mTORC1 Promotes Germinal Center–Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity
Ariel L. Raybuck, Sung Hoon Cho, Jingxin Li, Meredith C. Rogers, Keunwook Lee, Christopher L. Williams, Mark J. Shlomchik, James W. Thomas, Jin Chen, Mark Boothby> ;Journal of Immunology. 2018 Apr 15
56 citations
A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope
Tongqing Zhou, Anqi Zheng, Ulrich Baxa, Gwo-Yu Chuang, Ivelin S. Georgiev, Rui Kong, Sijy O'Dell, Syed Shahzad-ul-Hussan, Chen-Hsiang Shen, Yaroslav Tsybovsky, Robert ...> ;Immunity. 2018 Mar 20
14 citations
B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes.
Thomas A. Packard, Mia J. Smith, Francis J. Conrad, Sara A. Johnson, Andrew Getahun, Robin S. Lindsay, Rochelle M. Hinman, Rachel S. Friedman, James W. Thomas, John C....> ;Journal of Clinical Medicine. 2016 Nov 8
194 citations
Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system
Sung Hoon Cho, Ariel Raybuck, Kristy R. Stengel, Mei Wei, Thomas C. Beck, Emmanuel J. Volanakis, James W. Thomas, Scott W. Hiebert, Volker H. Haase, Mark Boothby> ;Nature. 2016 Sep 8
32 citations
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.
Xiaoxiao Wan, James W. Thomas, Emil R. Unanue> ;The Journal of Experimental Medicine. 2016 May 30
10 citations
Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice.
Rachel H. Bonami, James W. Thomas> ;Journal of Immunology. 2015 Oct 2
15 citations
Reversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes.
Jonathan M. Williams, Rachel H. Bonami, Chrys Hulbert, James W. Thomas> ;Journal of Immunology. 2015 Jun 24
4 citations
NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells.
Rachel H. Bonami, William T. Wolfle, James W. Thomas, Peggy L. Kendall> ;Molecular Immunology. 2014 Dec 1
60 citations
Requirement for Rictor in homeostasis and function of mature B lymphoid cells
Keunwook Lee, Lindsey Heffington, Julia Jellusova, Ki Taek Nam, Ariel Raybuck, Sung Hoon Cho, James W. Thomas, Robert C. Rickert, Mark Boothby> ;Blood. 2013 Oct 3
25 citations
B Cell-Intrinsic and-Extrinsic Regulation of Antibody Responses by PARP14,an Intracellular(ADP-Ribosyl)Transferase
Sung Hoon Cho, Ariel Raybuck, Mei Wei, John J. Erickson, Ki Taek Nam, Reagan G. Cox, Alyssa Trochtenberg, James W. Thomas, Mark Boothby> ;Journal of Immunology. 2013 Sep 15
24 citations
B Lymphocyte “Original Sin” in the Bone Marrow Enhances Islet Autoreactivity in Type 1 Diabetes–Prone Nonobese Diabetic Mice
Rachel A. Henry-Bonami, Jonathan M. Williams, Amita Rachakonda, Mariam Karamali, Peggy L. Kendall, James W. Thomas> ;Journal of Immunology. 2013 May 15
33 citations
Tolerant Anti-Insulin B Cells Are Effective APCs
Peggy L. Kendall, James Brett Case, Allison M. Sullivan, Jeff S. Holderness, K. Sam Wells, Edwin Liu, James W. Thomas> ;Journal of Immunology. 2013 Mar 15
50 citations
Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire.
Bryan Briney, Jordan R. Willis, Mark D. Hicar, James W. Thomas, James E. Crowe> ;Immunology. 2012 Sep 1
36 citations
Autoantigen-Specific B-Cell Depletion Overcomes Failed Immune Tolerance in Type 1 Diabetes
Rachel A. Henry, Peggy L. Kendall, James W. Thomas> ;Diabetes. 2012 Aug 1
10 citations
Autoreactive Preplasma Cells Break Tolerance in the Absence of Regulation by Dendritic Cells and Macrophages
Mileka R. Gilbert, Nikki J. Wagner, Shannon Z. Jones, Amanda B. Wisz, Jose R. Roques, Kristen N. Krum, Sang-Ryul Lee, Volker Nickeleit, Chrys Hulbert, James W. Thomas,...> ;Journal of Immunology. 2012 Jul 15
27 citations
Genome-wide analysis of copy number variation in type 1 diabetes.
Britney L. Grayson, Mary Ellen Smith, James W. Thomas, Lily Wang, Phil Dexheimer, Joy Jeffrey, Pamela R. Fain, Priyaanka Nanduri, George S. Eisenbarth, Thomas M. Aune> ;Plos One. 2010 Nov 15
Join now to see all

Journal Articles

Anti-Insulin B Cells Are Poised for Antigen Presentation in Type 1 Diabetes
Jamie L Felton, James W Thomas, The Journal of Immunology

Hospital Affiliations

Vanderbilt University Medical CenterNashville, Tennessee
Nashville General HospitalNashville, Tennessee