JamesHTonsgardMD

Neurology • Chicago, IL

Associate Professor of Pediatrics and Neurology, University of Chicago Medicine

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Office
5841 S. MARYLAND AVE.
M/C 3055
Chicago, IL 60637
Phone+1 773-702-6488

Fax+1 773-702-4786
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Education & Training

University of ChicagoResidency, Neurology, 1977 - 1981
Yale-New Haven Medical CenterResidency, Pediatrics, 1975 - 1977
Yale School of MedicineClass of 1975

Certifications & Licensure

IL State Medical License 1977 - 2026
American Board of Pediatrics Pediatrics

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2012-2014
Chicago Magazine: Top Doctors Castle Connolly, 2012, 2014

Clinical Trials

A Randomized Placebo-Controlled Study of Lovastatin in Children With Neurofibromatosis Type 1 Start of enrollment: 2009 Jul 01
Completed
Phase 2
Everolimus for Children With NF1 Chemotherapy-Refractory Radiographic Progressive Low Grade Gliomas Start of enrollment: 2010 Jul 10
Completed
Phase 2
Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Start of enrollment: 2013 May 15
Completed
Phase 2
MEK Inhibitor PD-0325901 Trial in Adolescents and Adults With NF1 Start of enrollment: 2014 Jun 01
Completed
Phase 2
Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 in Children and Adults Start of enrollment: 2014 Jun 01
Completed
Phase 2
Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs) Start of enrollment: 2015 Nov 13
Recruiting
MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas Start of enrollment: 2019 Sep 29
Active, not recruiting
Phase 2
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Publications & Presentations

PubMed

4 citations
Multicenter, prospective, phase II study of maintenance bevacizumab for children and adults with NF2-related schwannomatosis and progressive vestibular schwannoma.
Scott R Plotkin, Jeffrey Allen, Girish Dhall, Jian L Campian, D Wade Clapp, Michael J Fisher, Rakesh K Jain, James Tonsgard, Nicole J Ullrich, Coretta Thomas, Lloyd J ...> ;Neuro-Oncology. 2023 Aug 3
10 citations
Current Recommendations for Patient-Reported Outcome Measures Assessing Domains of Quality of Life in Neurofibromatosis Clinical Trials.
Pamela L. Wolters, Ana-Maria Vranceanu, Heather L. Thompson, Staci Martin, Vanessa L. Merker, Andrea Baldwin, Carolina Barnett, Kimberley S. Koetsier, Cynthia M. Hingt...> ;Neurology. 2021 Jul 6
244 citations
Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation.
Eric Legius, Ludwine Messiaen, Pierre Wolkenstein, P Pancza, Robert A. Avery, Yemima Berman, J. Blakeley, Dusica Babovic-Vuksanovic, Karin Soares Gonçalves Cunha, Rosa...> ;Genetics in Medicine. 2021 May 19
43 citations
NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexifor...
Brian Weiss, Pamela L. Wolters, Scott R. Plotkin, Brigitte C. Widemann, James H. Tonsgard, Jaishri O. Blakeley, Jeffrey C. Allen, Elizabeth K. Schorry, Bruce R. Korf, ...> ;Journal of Clinical Oncology. 2021 Jan 28
8 citations
Dural Ectasia in Neurofibromatosis 1: Case Series, Management, and Review.
Sean P. Polster, Mark C. Dougherty, Hussein A. Zeineddine, Seán B. Lyne, Heather L. Smith, Cynthia MacKenzie, Peter Pytel, Carina W. Yang, James H. Tonsgard, Peter C. ...> ;Neurosurgery. 2020 May 1
25 citations
Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1.
Jonathan M. Payne, Kristina M Haebich, Rachel MacKenzie, Karin S. Walsh, Stephen Hearps, David Coghill, Belinda Barton, Natalie A. Pride, Nicole J. Ullrich, James H. T...> ;Journal of Attention Disorders. 2021 Jun 1
58 citations
Multicenter, Prospective, Phase II and Biomarker Study of High-Dose Bevacizumab as Induction Therapy in Patients With Neurofibromatosis Type 2 and Progressive Vestibul...
Scott R. Plotkin, Dan G. Duda, Alona Muzikansky, Jeffrey C. Allen, Jaishri O. Blakeley, Tena Rosser, Jian Campian, D. Wade Clapp, Michael Fisher, James H. Tonsgard, Ni...> ;Journal of Clinical Oncology. 2019 Oct 18
63 citations
Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1
Jonathan M. Payne, Belinda Barton, Nicole J. Ullrich, Alan B. Cantor, Stephen Hearps, Gary Cutter, Tena Rosser, Karin S. Walsh, Gerard A. Gioia, Pamela L. Wolters, Jam...> ;Neurology. 2016 Dec 13
29 citations
Patient-reported outcomes of pain and physical functioning in neurofibromatosis clinical trials
Pamela L. Wolters, Staci Martin, Vanessa L. Merker, James H. Tonsgard, Sondra E Solomon, Andrea Baldwin, Amanda L. Bergner, Karin S. Walsh, Heather L. Thompson, Kathy ...> ;Neurology. 2016 Aug 16
119 citations
High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype-Phen...
Kitiwan Rojnueangnit, Jing Xie, Alicia Gomes, Angela Sharp, Tom Callens, Yunjia Chen, Ying Liu, Meagan E. Cochran, Mary Alice Abbott, Joan F. Atkin, Dusica Babovic-Vuk...> ;Human Mutation. 2015 Nov 1
96 citations
Sirolimus for progressive neurofibromatosis type 1–associated plexiform neurofibromas: a Neurofibromatosis Clinical Trials Consortium phase II study
Brian Weiss, Brigitte C. Widemann, Pamela L. Wolters, Eva Dombi, Alexander A. Vinks, Alan B. Cantor, John P. Perentesis, Elizabeth K. Schorry, Nicole J. Ullrich, David...> ;Neuro-Oncology. 2015 Apr 1
27 citations
Cognitive and psychosocial phenotype of young children with neurofibromatosis-1.
Bonita P. Klein-Tasman, Kelly M. Janke, Wen Luo, Christy L. Casnar, Scott J. Hunter, James H. Tonsgard, Pamela Trapane, Faye van der Fluit, Lorri A. Kais> ;Journal of the International Neuropsychological Society. 2014 Jan 1
33 citations
Patient-reported outcomes in neurofibromatosis and schwannomatosis clinical trials
Pamela L. Wolters, Staci Martin, Vanessa L. Merker, Kathy Gardner, Cynthia M. Hingtgen, James H. Tonsgard, Elizabeth K. Schorry, Andrea Baldwin> ;Neurology. 2013 Nov 19
26 citations
Expression profiling of 519 kinase genes in matched malignant peripheral nerve sheath tumor/plexiform neurofibroma samples is discriminatory and identifies mitotic reg...
Thomas Stricker, Kammi J. Henriksen, James H. Tonsgard, Anthony G. Montag, Thomas Krausz, Peter Pytel> ;Modern Pathology. 2013 Jul 1
11 citations
Neoplasms With Schwannian Differentiation Express Transcription Factors Known to Regulate Normal Schwann Cell Development
Peter Pytel, Theodore Karrison, Can Gong, James H. Tonsgard, Thomas Krausz, Anthony G. Montag> ;International Journal of Surgical Pathology. 2010 Dec 1
51 citations
Consensus Recommendations to Accelerate Clinical Trials for Neurofibromatosis Type 2
D. Gareth Evans, Michel Kalamarides, Kim Hunter-Schaedle, Jaishri O. Blakeley, Jeffrey C. Allen, Dusica Babovic-Vuskanovic, Allan J. Belzberg, Gideon Bollag, Ruihong C...> ;Clinical Cancer Research. 2009 Aug 15
143 citations
Clinical manifestations and management of neurofibromatosis type 1.
James H. Tonsgard> ;Seminars in Pediatric Neurology. 2006 Mar 1
24 citations
Decompressive hemicraniectomy in a 6-year-old male after unilateral hemispheric stroke. Case report and review.
Mac C. Lee, Jeffrey I. Frank, Madelyn Kahana, James H. Tonsgard, David M. Frim> ;Pediatric Neurosurgery. 2003 Mar 17
3 citations
Late‐onset neurofibromatosis in a liver transplant recipient
Martin B. Miller, James H. Tonsgard, Keyoumars Soltani> ;International Journal of Dermatology. 2000 May 1
6 citations
A child with neurofibromatosis-1 and a lumbar epidural arteriovenous malformation.
M Nadig, Ilyas Munshi, M. P. Short, James H. Tonsgard, C Sullivan, David M. Frim> ;Journal of Child Neurology. 2000 Apr 1
95 citations
Descriptive analysis of tibial pseudarthrosis in patients with neurofibromatosis 1.
David A. Stevenson, Patricia Birch, Jan M. Friedman, David Viskochil, Paolo Balestrazzi, Stefania Boni, Annegret Buske, Bruce R. Korf, Michihito Niimura, Eniko K. Pivn...> ;American Journal of Medical Genetics. 1999 Jun 11
106 citations
CT imaging in adults with neurofibromatosis-1 : Frequent asymptomatic plexiform lesions
James H. Tonsgard, S. M. Kwak, M. P. Short, A. H. Dachman> ;Neurology. 1998 Jun 1
20 citations
Omega-oxidation of monocarboxylic acids in rat brain.
Jessy J. Alexander, Ann K. Snyder, James H. Tonsgard> ;Neurochemical Research. 1998 Feb 1
92 citations
Do NF1 gene deletions result in a characteristic phenotype
James H. Tonsgard, Krishna K. Yelavarthi, Shana Cushner, M. Priscilla Short, Valerie Lindgren> ;American Journal of Medical Genetics. 1997 Nov 28
7 citations
Hyperammonemia increases serotonin 1A receptor expression in both rat hippocampus and a transfected hippocampal cell line, HN2-5.
Jessy J. Alexander, Probal Banerjee, Glyn Dawson, James H. Tonsgard> ;Journal of Neuroscience Research. 1995 May 1
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