JamesKnoxWillsonJr.MD

Oncology • Austin, TX

Gastrointestinal Cancer, Hematologic Oncology

Professor of Oncology, University Tex SW Dallas

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Office
1701 Congress Ave
Ste 6-127
Austin, TX 78701
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Education & Training

National Institutes of Health Clinical CenterFellowship, Medical Oncology, 1978 - 1980
Johns Hopkins UniversityResidency, Internal Medicine, 1976 - 1978
University of Alabama School of MedicineClass of 1976

Certifications & Licensure

TX State Medical License 2006 - 2023
OH State Medical License 1987 - 2011
WI State Medical License 1981 - 1987
MD State Medical License 1971 - 1983
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2012

Publications & Presentations

PubMed

54 citations
Induction of KIAA1199/CEMIP is associated with colon cancer phenotype and poor patient survival
Stephen P. Fink, Lois Myeroff, Revital Kariv, Petra Platzer, Baozhong Xin, Debra Mikkola, Earl Lawrence, Nathan Morris, Arman Nosrati, James K V Willson, Joseph Willis...> ;Oncotarget. 2015 Oct 1
190 citations
Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration
Yongyou Zhang, Amar Desai, S. Yang, Ki Beom Bae, Monika I. Antczak, Stephen P. Fink, Shruti Tiwari, Joseph Willis, Noelle S. Williams, Dawn M. Dawson, David N. Wald, W...> ;Science. 2015 Jun 12
1 citations
Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.
Kishore Guda, Martina L. Veigl, Vinay Varadan, Arman Nosrati, Lakshmeswari Ravi, James Lutterbaugh, Lydia Beard, James K V Willson, W. David Sedwick, Zhenghe John Wang...> ;Proceedings of the National Academy of Sciences of the United States of America. 2015 Jun 2
92 citations
Novel recurrently mutated genes in African American colon cancers
Kishore Guda, Martina L. Veigl, Vinay Varadan, Arman Nosrati, Lakshmeswari Ravi, James Lutterbaugh, Lydia Beard, James K V Willson, W. David Sedwick, Zhenghe John Wang...> ;Proceedings of the National Academy of Sciences of the United States of America. 2015 Jan 27
666 citations
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Jihye Yun, Carlo Rago, Ian Cheong, Ray Pagliarini, Philipp Angenendt, Harith Rajagopalan, Kerstin Schmidt, James K V Willson, Sandy D. Markowitz, Shibin Zhou, Luis A. ...> ;Science. 2009 Sep 18
123 citations
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers
Kishore Guda, Helen Moinova, Jian He, Oliver Jamison, Lakshmeswari Ravi, Leanna Natale, James Lutterbaugh, Earl Lawrence, Susan Lewis, James K V Willson, John B. Lowe,...> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Aug 4
340 citations
The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers.
Chunguang Guo, Jerome F. Sah, Lydia Beard, James K V Willson, Sanford D. Markowitz, Kishore Guda> ;Genes, Chromosomes & Cancer. 2008 Nov 1
210 citations
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers
Rebecca J. Leary, Jimmy Lin, Jordan M. Cummins, Simina M. Boca, Laura D. Wood, D. Williams Parsons, Siân Jones, Tobias Sjöblom, Ben Ho Park, Ramon Parsons, Joseph Will...> ;Proceedings of the National Academy of Sciences of the United States of America. 2008 Oct 21
63 citations
The impact of resection margin status and postoperative CA19-9 levels on survival and patterns of recurrence after postoperative high-dose radiotherapy with 5-FU-based...
Timothy J. Kinsella, Yuji Seo, Joseph Willis, Thomas A. Stellato, Christopher T. Siegel, Deborah Harpp, James K V Willson, Joseph Gibbons, Juan Sanabria, Jeffrey M. Ha...> ;American Journal of Clinical Oncology. 2008 Oct 1
31 citations
Ugene, a Newly Identified Protein That Is Commonly Overexpressed in Cancer and Binds Uracil DNA Glycosylase
Chunguang Guo, Xiao-Dong Zhang, Stephen P. Fink, Petra Platzer, Keith T. Wilson, James K V Willson, Zhenghe John Wang, Sanford D. Markowitz> ;Cancer Research. 2008 Aug 1
230 citations
Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer.
William M. Grady, Rachael K. Parkin, Patrick S. Mitchell, Jun Ho Lee, Young Ho Kim, Karen D. Tsuchiya, Mary Kay Washington, C Paraskeva, James K V Willson, Andrew M. K...> ;Oncogene. 2008 Jun 19
54 citations
Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming g...
Swati Biswas, Patricia Trobridge, Judith Romero-Gallo, Dean Billheimer, Lois Myeroff, James K V Willson, Sanford D. Markowitz, William M. Grady> ;Genes, Chromosomes & Cancer. 2008 Feb 1
54 citations
Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis
Jing Wang, Karen K. Kuropatwinski, Jennie Hauser, Michael R. Rossi, Yunfei Zhou, Alexis Conway, Julie L.C. Kan, Neil W. Gibson, James K V Willson, John K. Cowell, Mich...> ;Molecular Cancer Therapeutics. 2007 Mar 1
40 citations
A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo.
Ashwani Rajput, Alan P. Koterba, Jeffrey I. Kreisberg, Jason M. Foster, James K V Willson, Michael G. Brattain> ;Cancer Research. 2007 Jan 15
77 citations
Blockade of EGFR and ErbB2 by the Novel Dual EGFR and ErbB2 Tyrosine Kinase Inhibitor GW572016 Sensitizes Human Colon Carcinoma GEO Cells to Apoptosis
Yunfei Zhou, Song Li, Yi P. Hu, Jing Wang, Jennie Hauser, Alexis Conway, Michelle A. Vinci, Lisa E. Humphrey, Elizabeth Zborowska, James K V Willson, Michael G. Brattain> ;Cancer Research. 2006 Jan 1
448 citations
Colorectal cancer: mutations in a signalling pathway.
D. Williams Parsons, Tian Li Wang, Yardena Samuels, Alberto Bardelli, Jordan M. Cummins, Laura DeLong, Natalie Silliman, Janine Ptak, Steve Szabo, James K V Willson, S...> ;Nature. 2005 Aug 11
280 citations
Detection in Fecal DNA of Colon Cancer–Specific Methylation of the Nonexpressed Vimentin Gene
Wei Dong Chen, Z. James Han, Joel Skoletsky, Jeff Olson, Jerome Frank Sah, Lois Myeroff, Petra Platzer, Shilong Lu, Dawn M. Dawson, Joseph Willis, Theresa P. Pretlow, ...> ;Journal of the National Cancer Institute. 2005 Aug 3
19 citations
Reorganization of ErbB Family and Cell Survival Signaling after Knock-down of ErbB2 in Colon Cancer Cells
Yi Peter Hu, Srinivas Venkateswarlu, Natalia Sergina, Gillian M. Howell, Patricia J. St. Clair, Lisa E. Humphrey, Wenhui Li, Jennie Hauser, Elizabeth Zborowska, James ...> ;The Journal of Biological Chemistry. 2005 Jul 22
17 citations
Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia
Baozhong Xin, Petra Platzer, Stephen P. Fink, Lisa Reese, Arman Nosrati, James K V Willson, Keith T. Wilson, Sanford D. Markowitz> ;Oncogene. 2005 Jan 20
196 citations
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-β-induced suppressor of human gastrointestinal cancers
Min Yan, Ronald M. Rerko, Petra Platzer, Dawn M. Dawson, Joseph Willis, Min Tong, Earl Lawrence, James Lutterbaugh, Shilong Lu, James K V Willson, Guangbin Luo, Jack O...> ;Proceedings of the National Academy of Sciences of the United States of America. 2004 Dec 14
406 citations
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Zhenghe Wang, Dong Shen, D. Williams Parsons, Alberto Bardelli, Jason Sager, Steve Szabo, Janine Ptak, Natalie Silliman, Brock A. Peters, Michiel S. van der Heijden, G...> ;Science. 2004 May 21
138 citations
Three classes of genes mutated in colorectal cancers with chromosomal instability.
Zhenghe Wang, Jordan M. Cummins, Dong Shen, Daniel P. Cahill, Prasad V. Jallepalli, Tian Li Wang, D. Williams Parsons, Giovanni Traverso, Mark M. Awad, Natalie Sillima...> ;Cancer Research. 2004 May 1
2735 citations
High frequency of mutations of the PIK3CA gene in human cancers
Yardena Samuels, Zhenghe Wang, Alberto Bardelli, Natalie Silliman, Janine Ptak, Steve Szabo, Hai Yan, Adi F. Gazdar, Steven M. Powell, Gregory J. Riggins, James K V Wi...> ;Science. 2004 Apr 23
10 citations
ErbB family targeting.
Jennifer D. Black, Michael G. Brattain, Smitha A. Krishnamurthi, Dawn M. Dawson, James K V Willson> ;Current Opinion in Investigational Drugs. 2003 Dec 1
30 citations
The Role of Transforming Growth Factor α in Determining Growth Factor Independence
Rana A. Awwad, Natalia Sergina, Haisu Yang, Barry L. Ziober, James K V Willson, Elizabeth Zborowska, Lisa E. Humphrey, Robert S. Fan, Tien C. Ko, Michael G. Brattain, ...> ;Cancer Research. 2003 Aug 1
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Press Mentions

Meet Dallas-Fort Worth’s Newest Crop of High risk/high Impact Cancer ResearchersAugust 30th, 2021
Texas Medical Center Launches Inaugural Accelerator for Cancer Therapeutics ProgramJanuary 26th, 2021
MD Anderson and UT Austin Collaboration to End Cancer Welcomed Enthusiastically by State and Federal StakeholdersNovember 3rd, 2020
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