JamieEChaftMD

Thoracic Cancer

Associate Attending Physician, Memorial Sloan-Kettering Cancer Center

Overview of Dr. Chaft

Dr. Jamie Chaft is an oncologist in New York, NY and is affiliated with multiple hospitals in the area, including Memorial Sloan Kettering Cancer Center and Memorial Sloan Kettering Monmouth. She received her medical degree from New York University Grossman School of Medicine and has been in practice 11 years. Dr. Chaft accepts several types of health insurance, listed below. She is one of 465 doctors at Memorial Sloan Kettering Cancer Center and one of 14 doctors at Memorial Sloan Kettering Monmouth who specialize in Oncology. She has more than 100 publications and over 500 citings.

Office
Memorial Sloan Kettering Cancer Center Monmouth
480 Red Hill Road
New York, NY 10021
Book by Phone+1(847) 754-4259
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Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Hematology and Medical Oncology, 2009 - 2012
New York Presbyterian Hospital (Cornell Campus)Residency, Internal Medicine, 2006 - 2009
New York University School of MedicineClass of 2006

Certifications & Licensure

FL State Medical License 2021 - Present
NY State Medical License 2008 - 2025
NJ State Medical License 2017 - 2025
NC State Medical License 2020 - 2022
American Board of Internal Medicine Medical Oncology

Clinical Trials

A Pilot Phase 2 Trial of the Immunogenicity, and Safety of GI-4000; an Inactivated Recombinant S. Cerevisiae Expressing Mutant Ras Protein, as Consolidation Therapy Following Curative Treatment for Stage I-III Non-Small Cell Lung Cancer (NSCLC) With Tumor Sequence Confirmation of K-ras Mutation Start of enrollment: 2008 Apr 01
Completed
Phase 2
Neoadjuvant Platinum-based Chemotherapy for Patients With Resectable , Non-small Cell Lung Cancer With Switch to Chemotherapy Alternative in Nonresponders (NEOSCAN) Start of enrollment: 2011 Oct 01
Completed
Phase 2
Afatinib In Combination With Cisplatin Or Carboplatin + Pemetrexed In Patients With EGFR-Mutant Lung Cancers Undergoing Definitive Chemoradiation Start of enrollment: 2013 Apr 01
Withdrawn
Phase 1
Trametinib, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery Start of enrollment: 2013 Oct 28
Terminated
Phase 1
An Open-Label, Randomized, Phase 3 Trial of Nivolumab Versus Investigator's Choice Chemotherapy as First-Line Therapy for Stage IV or Recurrent PD-L1+ Non-Small Cell Lung Cancer (CheckMate 026) Start of enrollment: 2014 Mar 27
Completed
Phase 3
Neoadjuvant Nivolumab, or Nivolumab in Combination With Ipilimumab, in Resectable NSCLC Start of enrollment: 2014 Sep 01
Active, not recruiting
Phase 2
Determining Whether Durvalumab in Combination With Radiation Therapy Can Prevent the Progression of Non-Small Cell Lung Cancer Start of enrollment: 2019 Jul 19
Active, not recruiting
Phase 2
Roles: Contact
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Publications & Presentations

PubMed

Pathologic response in resectable non-small cell lung cancer: a systematic literature review and meta-analysis.
Nathalie A Waser, Melanie Quintana, Bernd Schweikert, Lindsay Berry, Ahmed Adam, Lien Vo, John R Penrod, Joseph Fiore, Donald A Berry, Sarah Goring, Jamie E Chaft> ;JNCI Cancer Spectrum. 2024 Mar 23
AnF-FDG PET/CT and Mean Lung Dose Model to Predict Early Radiation Pneumonitis in Stage III Non-Small Cell Lung Cancer Patients Treated with Chemoradiation and Immunot...
Maria Thor, Chen Lee, Lian Sun, Purvi Patel, Aditya Apte, Milan Grkovski, Annemarie F Shepherd, Daphna Y Gelblum, Abraham J Wu, Charles B Simone 2nd, Jamie E Chaft, An...> ;Journal of Nuclear Medicine. 2024 Apr 1
1 citations
Immune-Related Colitis Is Associated with Fecal Microbial Dysbiosis and Can Be Mitigated by Fecal Microbiota Transplantation.
Elkrief, A., Waters, N., Smith, N., Dai, A., Slingerland, J., Aleynick, N., Febles, B., Gogia, P., Socci, N., Lumish, M., Giardina, P., Chaft, J., Eng, J., Motzer, R.,...> ;Cancer Immunology Research. 2024 Mar 4
Induction therapy for non-small cell lung cancer.
Alissa Cooper, Jamie E Chaft, Matthew J Bott> ;The Journal of Thoracic and Cardiovascular Surgery. 2024 Feb 12
The Emerging Role of Immunotherapy in Resectable Non-Small Cell Lung Cancer.
Dunne, E., Fick, C., Isbell, J., Chaft, J., Altorki, N., Park, B., Spicer, J., Forde, P., Gomez, D., Iyengar, P., Harpole, D., Stinchcombe, T., Liberman, M., Bott, M.,...> ;The Annals of Thoracic Surgery. 2024 Feb 3
Author Correction: Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial.
Owen, D. H., Jamie E Chaft, Filiz Oezkan, Mark G Kris, Paul A Bunn, Ignacio I Wistuba, David J Kwiatkowski, Dwight H Owen, Yan Tang, Bruce E Johnson, Jay M Lee, Gerard...> ;Nature Medicine. 2024 Jan 1
1 citations
Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma.
Luo, J., Sanchez, M., Lee, E., Hertzler, H., Luong, N., Mazzola, E., Finstein, B., Tamen, R., Brisbane, G., Nguyen, T., Paik, P., Chaft, J., Cheng, M., Khalil, H., Pih...> ;Journal of Thoracic Oncology. 2023 Dec 27
Stereotactic Body Radiation Therapy for Stage IIA to IIIA Inoperable Non-Small Cell Lung Cancer: A Phase 1 Dose-Escalation Trial.
Rimner, A., Gelblum, D., Wu, A., Shepherd, A., Mueller, B., Zhang, S., Cuaron, J., Shaverdian, N., Flynn, J., Fiasconaro, M., Zhang, Z., von Reibnitz, D., Li, H., McKn...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Dec 26
Lung resection after initial nonoperative treatment for non-small cell lung cancer.
Dunne, E., Fick, C., Tan, K., Toumbacaris, N., Mastrogiacomo, B., Adusumilli, P., Rocco, G., Molena, D., Huang, J., Park, B., Bott, M., Rusch, V., Sihag, S., Isbell, J...> ;The Journal of Thoracic and Cardiovascular Surgery. 2023 Nov 30
Exploring published and novel pre-treatment CT and PET radiomics to stratify risk of progression among early-stage non-small cell lung cancer patients treated with ste...
Thor, M., Fitzgerald, K., Apte, A., Oh, J., Iyer, A., Odiase, O., Nadeem, S., Yorke, E., Chaft, J., Wu, A., Offin, M., Simone Ii, C., Preeshagul, I., Gelblum, D., Gome...> ;Radiotherapy and Oncology. 2024 Jan 1
1 citations
Multi-institutional analysis of aneuploidy and outcomes to chemoradiation and durvalumab in stage III non-small cell lung cancer.
Joao V Alessi, Adam Price, Allison L Richards, Biagio Ricciuti, Xinan Wang, Arielle Elkrief, Federica Pecci, Alessandro Di Federico, Malini M Gandhi, Emily S Lebow, Pa...> ;Journal for Immunotherapy of Cancer. 2023 Nov 1
1 citations
A Brief Report on the Patterns of Mediastinal Nodal Failure in Resectable Stage IB-IIIA NSCLC Treated With Neoadjuvant Immunotherapy Combinations, a Secondary Analysis...
Serena Mao, Samuel Rosner, Patrick M Forde, Jamie E Chaft, David R Jones, Jonathan Spicer, Russell Kenneth Hales, Jinny Suk Ha, Chen Hu, Khinh Ranh Voong> ;Clinical Lung Cancer. 2024 Jan 1
Superior sulcus non-small cell lung cancers (Pancoast tumors): Current outcomes after multidisciplinary management.
Kaitlin McLaughlin, Kay See Tan, Joe Dycoco, Monica F Chen, Jamie E Chaft, Nikhil P Mankuzhy, Andreas Rimner, Rania G Aly, Rachel E Fanaroff, William D Travis, Mark Bi...> ;The Journal of Thoracic and Cardiovascular Surgery. 2023 Dec 1
5 citations
Impact of TMB/PD-L1 expression and pneumonitis on chemoradiation and durvalumab response in stage III NSCLC.
Joao V Alessi, Biagio Ricciuti, Xinan Wang, Federica Pecci, Alessandro Di Federico, Giuseppe Lamberti, Arielle Elkrief, Scott J Rodig, Emily S Lebow, Jordan E Eicholz,...> ;Nature Communications. 2023 Jul 15
8 citations
Neoadjuvant Targeted Therapy in Resectable NSCLC: Current and Future Perspectives.
Jay M Lee, Ciaran J McNamee, Eric Toloza, Marcelo V Negrao, Jules Lin, Elaine Shum, Amy L Cummings, Mark G Kris, Boris Sepesi, Ilze Bara, Nino Kurtsikidze, Katja Schul...> ;Journal of Thoracic Oncology. 2023 Nov 1
3 citations
Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non-Small Cell Lung Cancer.
Rohit Thummalapalli, Biagio Ricciuti, Chaitanya Bandlamudi, Daniel Muldoon, Hira Rizvi, Arielle Elkrief, Jia Luo, Joao V Alessi, Federica Pecci, Giuseppe Lamberti, Ale...> ;Clinical Cancer Research. 2023 Nov 1
1 citations
Efficacy of PD-(L)1 blockade monotherapy compared with PD-(L)1 blockade plus chemotherapy in first-line PD-L1-positive advanced lung adenocarcinomas: a cohort study.
Arielle Elkrief, Joao M Victor Alessi, Biagio Ricciuti, Samantha Brown, Hira Rizvi, Isabel R Preeshagul, Xinan Wang, Federica Pecci, Alessandro Di Federico, Giuseppe L...> ;Journal for Immunotherapy of Cancer. 2023 Jul 1
4 citations
The American Association for Thoracic Surgery (AATS) 2023 Expert Consensus Document: Staging and multidisciplinary management of patients with early-stage non-small ce...
, Biniam Kidane, Matthew Bott, Jonathan Spicer, Leah Backhus, Jamie Chaft, Neel Chudgar, Yolonda Colson, Thomas A D'Amico, Elizabeth David, Jay Lee, Sara Najmeh, Boris...> ;The Journal of Thoracic and Cardiovascular Surgery. 2023 Sep 1
Brief Report: Safety and Antitumor Activity of Durvalumab Plus Tremelimumab in Programmed Cell Death-(Ligand)1-Monotherapy Pretreated, Advanced NSCLC: Results From a P...
Edward B Garon, Alexander I Spira, Sarah B Goldberg, Jamie E Chaft, Vassiliki Papadimitrakopoulou, Tina Cascone, Scott J Antonia, Julie R Brahmer, D Ross Camidge, John...> ;Journal of Thoracic Oncology. 2023 Aug 1
3 citations
Randomized Phase 2 Placebo-Controlled Trial of Nintedanib for the Treatment of Radiation Pneumonitis.
Andreas Rimner, Zachary R Moore, Stephanie Lobaugh, Alexander Geyer, Daphna Y Gelblum, Raja-Elie E Abdulnour, Annemarie F Shepherd, Narek Shaverdian, Abraham J Wu, Joh...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Aug 1
4 citations
Early-stage anaplastic lymphoma kinase ()-positive lung cancer: a narrative review.
Monica F Chen, Jamie E Chaft> ;Translational Lung Cancer Research. 2023 Feb 28
14 citations
Five-Year Clinical Outcomes after Neoadjuvant Nivolumab in Resectable Non-Small Cell Lung Cancer.
Samuel Rosner, Joshua E Reuss, Marianna Zahurak, Jiajia Zhang, Zhen Zeng, Janis Taube, Valsamo Anagnostou, Kellie N Smith, Joanne Riemer, Peter B Illei, Stephen R Brod...> ;Clinical Cancer Research. 2023 Feb 16
6 citations
Analysis of Tumor Mutational Burden, Progression-Free Survival, and Local-Regional Control in Patents with Locally Advanced Non-Small Cell Lung Cancer Treated With Che...
Emily S Lebow, Annemarie Shepherd, Jordan E Eichholz, Michael Offin, Daphna Y Gelblum, Abraham J Wu, Charles B Simone 2nd, Adam J Schoenfeld, David R Jones, Andreas Ri...> ;JAMA Network Open. 2023 Jan 3
6 citations
Primary endpoints to assess the efficacy of novel therapeutic approaches in epidermal growth factor receptor-mutated, surgically resectable non-small cell lung cancer:...
Collin M Blakely, Walter Weder, Lukas Bubendorf, Jianxing He, Margarita Majem, Yu Shyr, Jamie E Chaft> ;Lung Cancer. 2023 Mar 1
Clinicopathologic outcomes of preoperative targeted therapy in patients with clinical stage I to III non-small cell lung cancer.
Harry B Lengel, Junting Zheng, Kay See Tan, Corinne C Liu, Bernard J Park, Gaetano Rocco, Prasad S Adusumilli, Daniela Molena, Helena A Yu, Gregory J Riely, Manjit S B...> ;The Journal of Thoracic and Cardiovascular Surgery. 2023 May 1
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Journal Articles

Effect of Osimertinib and Bevacizumab on Progression-Free Survival for Patients with Metastatic EGFR-Mutant Lung Cancers
Helena A Yu, Adam J Schoenfeld, Jamie E Chaft, Gregory J Riely, JAMA Oncology
Differential Regulation of PD-L1 Expression by Immune and Tumor Cells in NSCLC and the Response to Treatment with Atezolizumab (Anti–PD-L1)
Alan Sandler, David S Shames, Hartmut Koeppen, Jamie Chaft, Scott N Gettinger, Alexander Spira, Daniel S Chen, Naiyer A Rizvi, David R Spigel, Proceedings of the National Academy of Sciences
Pathologic Features of Response to Neoadjuvant Anti-PD-1 in Resected Non-Small Cell Lung Carcinoma: A Proposal for Quantitative Immune-Related Pathologic Response Crit...
J M Isbell, N Rekhtman, J D Wolchok, J E Chaft, Annals of Oncology
YES1 Amplification Is a Mechanism of Acquired Resistance to EGFR Inhibitors Identified by Transposon Mutagenesis and Clinical Genomics
Emmet J Jordan, Helena A Yu, Yelena Y Janjigian, Mark G Kris, Paul K Paik, Jamie E Chaft, Lu Wang, Gregory J Riely, Proceedings of the National Academy of Sciences
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Lectures

Randomized phase II study of adjuvant afatinib for three months versus two years in patients with resected stage I-III EGFR mutant NSCLC.
2019 ASCO Annual Meeting - 6/1/2019
EA5142 adjuvant nivolumab in resected lung cancers (ANVIL).
2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018

Press Mentions

Moving the Goal Posts for Pre-Op and Post-Op Chemotherapy for Resectable NSCLCJuly 8th, 2022
Clinical Challenges: Small Cell Lung CancerNovember 15th, 2019
Cisplatin-Based Chemo: Still on Track in NSCLCSeptember 7th, 2019
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Hospital Affiliations

Memorial Sloan Kettering Cancer CenterNew York, New York
Memorial Sloan Kettering MonmouthMiddletown, New Jersey

Insurance Accepted

GHI PPO
United Healthcare - Direct Choice Plus POS
United Healthcare - Direct Options PPO
Please verify your coverage with the provider's office directly when scheduling an appointment